Bio-Design and Manufacturing
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2022
·Vol. 5
·期 2
·233-248
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IF 5.887
Su Tingshu,Zheng Ao,Cao Lingyan,Peng Lingjie,Wang Xiao,Wang Jie,Xin Xianzhen,Jiang Xinquan
Following dental implantation, the characteristic bacterial milieu of the oral cavity may lead to peri-implant inflammation, which can negatively impact osseointegration and cause implant failure. To improve soft tissue sealing around the implant, enhance osseointegration, and improve implant success rates, this paper proposes a composite multifunctional coating (PHG) prepared using gelatin and polydopamine/hydroxyapatite nanoparticles, investigates the effects of this novel coating on cell adhesion, proliferation, antibacterial activity, osteogenic differentiation, and evaluates its immune-related properties. The PHG coating was proved to have satisfactory hydrophilicity and wettability for cell attachment. Furthermore, it improved the expression of adhesion-related genes and proteins in human gingival fibroblasts, indicating its adhesion-promoting effect. Additionally, bone marrow mesenchymal stem cells exhibited strong osteogenic differentiation potential and mineralization on PHG-coated surfaces. Notably, the PHG coating exhibited antibacterial activity against Streptococcus mutans , as well as anti-inflammatory effects, potentially via the regulation of macrophages. Therefore, the proposed PHG coating may promote soft tissue sealing and bone bonding, providing a potential strategy for the surface modification of dental implants.
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CHINESE JOURNAL OF POLYMER SCIENCE
·
2022
·Vol. 40
·期 10
·1233-1241
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IF 3.815
Han Jian-Chen,Wang Shao-Fei,Deng Ran,Wu Qing-Yun
Forward osmosis (FO) as an energy-saving membrane process has attracted much attention in food concentration, water treatment, and desalination. Thin film composite (TFC) membrane is the most popular FO membrane, but it suffers from the internal concentration polarization (ICP), which significantly limits the water flux and FO efficiency. In this report, we demonstrate a novel and high-performing thin film nanocomposite (TFN) membrane that employs a hydrophilic interlayer composed of imogolite nanotubes (INTs) and polydopamine (PDA). The INTs can be adhered to the porous substrate by the self-polymerization of PDA, and the as-prepared PDA/INTs interlayer displays a nanostructured network with outstanding hydrophilicity. The detailed investigation was conducted to understand the relationship between the structure and property of the PDA/INTs interlayer and the morphology and performance of the TFN membrane. The TFN membrane with the PDA/INTs interlayer performs a thinner and smoother polyamide selective layer. Correspondingly, the TFN membrane shows a water flux of 18.38 L·m −2 ·h −1 , which is 2.18 times of the pristine TFC membrane. Moreover, the TFN membrane has a minimized structural parameter (577 µm), almost a half of that of the pristine one (949 ·m). It reveals that the ICP effect of TFC membrane can be effectively alleviated by using a hydrophilic PDA/INTs interlayer. This TFN membrane with a satisfactory water permeability is promising in terms of future applications.
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CHEMICAL ENGINEERING JOURNAL
·
2022
·
IF 16.744
Zhongyang Zheng,Heping Li,Fangjian Li,Liyu Zheng,Shenming Yin,Xinyun Wang,Youwei Yan
Two-dimensional materials, impermeable to various mediums, have ignited the great interest in developing multifunction nanocomposite coatings. Even though Al 2 O 3 has excellent thermal and chemical stability, it is hard to obtain Al 2 O 3 nanosheets from their non-lamellar structured bulk counterparts. In this work, we have developed a bottom–up strategy to synthesize several-nanometer thick Al 2 O 3 nanosheets by taking graphene oxide as the templates, and further improved their dispersibility by modifying them with poly-dopamine (PDA). These PDA-modified Al 2 O 3 nanosheets were then successfully integrated into the nanosized ZrO 2 coating to enhance its anti-corrosion and gas permeation reduction properties. With the Al 2 O 3 nanosheets inserted, corrosion resistance and deuterium resistance of the ZrO 2 coating were increased by 1000% and 1557%, respectively, both of which were above two orders of magnitude higher than that of the 321 steel substrate. The significant improvements achieved by Al 2 O 3 nanosheets demonstrate their capacity to effectively block the diffusion of both ions and deuterium atoms. This work not only offers a new platform for fabricating nanosheets from non-lamellar structured materials, but also indicates tremendous potential of Al 2 O 3 nanosheets as a novel filler for developing high-performance functional coatings.
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Particuology
·
2022
·
IF 3.251
Yukui Gou,Yuanye Hao,Weilong Cai,Jianying Huang,Yuekun Lai
Particulate matter (PM) is a significant danger to both environment and human health. Despite the development of a series of air filters, they do not work well in harsh environment such as high temperature, high humidity or long-time filtration. To make a three-dimensional (3D) particle capture device, a sacrificial template approach was used to manufacture polydimethylsiloxane (PDMS) sponge, and then zeolite imidazole framework-8 (ZIF-8) was grown in situ on the 3D network of PDMS sponge. The removal efficiency of PM 2.5 or PM 10 is greater than 99.8% because of the high specific surface area and porous network structure of PDMS sponge, as well as the large number of metal sites of ZIF-8. In addition, the sponge filter has long-term filtration stability and still achieves excellent performance after 65 h of filtration. The composite sponge can adapt to harsh environments such as high temperature (250 °C) and high humidity (90% RH). Composite sponge filter has a regular shape, and it may be customized to any shape as required. This study provides a new idea for designing 3D high-efficiency air filters that can adapt to harsh environments.
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Journal of Environmental Chemical Engineering
·
2021
·
IF 5.909
Yong Xue,Jing Shao,Guoqi Sui,Yuqin Ma,Hongji Li
In this paper, a novel SERS imprinted composite material was successfully synthesized with the aid of surface enhanced Raman scattering technology and molecular imprinting technology, which could be suitable for specific detection of organic dyes in the river. The UIO-66(NH 2 ) was wrapped with a thin layer of polydopamine (PDA), after loading Ag nanoparticles on rough surface, Ag@UIO-66(NH 2 )/PDA was synthesized and applied as the SERS substrate. In order to promote the ability of selective detection property in the practical sample, the molecularly imprinted polymer (Ag@UIO-66(NH 2 )/PDA-MIPs) was proposed. When the concentrations range changed between 10 −8 mol/L and 10 −10 mol/L, the intensity of characteristic peak at 1596 cm −1 exhibited a linear relationship with OII concentrations increasing. The limit of detection was low than 10 −10 mol/L, the correlation coefficient was 0.9985. The prepared SERS substrate could be available to the practical sample detection, which expanded SERS detection fields.
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Biomaterials Science
·
2021
·Vol. 9
·期 20
·6830-6841
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IF 6.843
Liming Ruan,Gao Song,Xueya Zhang,Tianqi Liu,Yanfang Sun,Junlan Zhu,Zhiyong Zeng,Guohua Jiang
The development of multifunctional nanoformulations (NFs) include several features in a single nanosystem for these devices to overcome the disadvantages of inefficiency and undesirable toxicity of traditional therapies and provide new opportunities in the management of tumors. Herein, multifunctional CaO2@Mn-PDA NFs with a core–shell structure, integrating the photothermal conversion properties of Mn-PDA, the chemodynamic properties of doped Mn ions, and relieving hypoxia in the tumor microenvironment (TME) were developed. The as-fabricated CaO2@Mn-PDA NFs were embedded in microneedles (MNs) for transdermal delivery into tumor sites, leading to the generation of a new minimally invasive and synergistic therapeutic strategy against skin melanoma. Under near-infrared (NIR) light irradiation, the CaO2@Mn-PDA NFs exhibited a synergistic therapeutic effect, including photothermal therapy (PTT), chemodynamic therapy (CDT), and modulating hypoxia due to their high photothermal conversion efficiency, boosted intracellular production of reactive oxygen species, excellent chemodynamic reactions, etc. Therefore, the developed MN platform, which can build implanted multifunctional characteristics for on-demand NIR-induced synergistic therapy, have a bright future in tumor suppression.
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PubMed
高影响因子
Journal of Materials Chemistry B
·
2021
·Vol. 9
·期 48
·9961-9970
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IF 6.331
Shuhan Hui,Qiqi Liu,Yandong Han,Lijuan Zhang,Jun Yang,Shan Jiang,Haisheng Qian,Wensheng Yang
Bacterial infection has increasingly affected people's lives, therefore it is significant to explore novel antibacterial agents and strategies for efficient disinfection. Herein, we designed ZIF-8 based composites ICG@ZIF-8/PDA/Ag, which encapsulate photothermal agent indocyanine green (ICG) and grow polydopamine (PDA) on their surface for in situ reduction to generate Ag nanoparticles. With 20 min of 808 nm laser irradiation at 1.5 W cm−2, 100 μg mL−1 ICG@ZIF-8/PDA/Ag exhibited 100% bactericidal effects toward E. coli and S. aureus bacteria resulting from both hyperthermia of ICG and PDA and chemical toxicity of the released Ag and Zn ions. When the bacterial incubation period was extended to 12 h, the minimum bactericidal concentration (MBC) of ICG@ZIF-8/PDA/Ag was reduced to 6.25 μg mL−1, and this extremely low MBC was due to the long-term chemo-photothermal combinational effect induced by NIR irradiation. Additionally, the composites successfully promote the healing of S. aureus infected wounds on mice. This work constructed photo-responsive antibacterial composites that realize chemo-photothermal synergistic therapy.
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PubMed
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RSC Advances
·
2021
·Vol. 11
·期 22
·13624-13634
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IF 3.361
Yadong Wang,Jinxin Ma,Nan Zhang,Delun Chen,Jinchun Tu,Yang Cao,Qiang Wu,Xiaolin Zhang,Wanjun Hao
Developing photoelectrochemical biosensors via efficient photogenerated-charge separation remains a challenging task in biomolecular detection. In this study, we utilised a simple approach for constructing an efficient photoactive organic–inorganic heterojunction interface composed of SrTiO3 with high photocatalytic activity and polydopamine (PDA) with high biocompatibility and electrical conductivity. Gold nanoparticles with dense electron cloud properties were introduced as a bridge between SrTiO3 and PDA (SrTiO3/Au/PDA). The Au bridge allowed the PDA to uniformly and tightly attach on the surface of SrTiO3 electrodes and also provided a separate transmission channel for electrons from PDA to SrTiO3. The rapidly transmitted electrons were captured by a signal-acquisition system, thereby improving the photocurrent signal output. The 3D hollowed out SrTiO3/Au/PDA biosensor manufactured herein was used for glucose detection. The biosensor achieved ultrahigh sensitivities reaching 23.7 μA mM−1 cm−2, an extended linear range (1–20 mM), and a low detection limit (0.012 mM). The excellent results of glucose analysis in serum samples further confirmed the feasibility of the biosensor in clinical applications. In summary, the proposed strategy allowed for the use of an electronic cloud bridge in the construction of glucose biosensors with satisfactory performances, which is promising for the future fabrication of high-performance biosensors.
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CHEMICAL ENGINEERING JOURNAL
·
2020
·
IF 10.652
Luyu Wang,Yunling Wu,Gaojie Li,Hui Xu,Junkuo Gao,Qichun Zhang
The detection of hexanal vapor in ppb (part per billion) concentration is an unresolved and indispensable issue. Here we report a polydopamine-polyethyleneimine (PDA-PEI) copolymer film with rich imino groups to sense 50 ppb hexanal vapor through the formation of the reversible hydrogen bonds with hexanal. We found that the water-resistance could be further improved by attaching superhydrophobic n-octadecylsiloxane (PODS) onto the surface of PDA-PEI film. The chemical adsorption mode and the core role of imino group for the hexanal detection have been validated by combining experiment methods with theory calculations. A quartz crystal microbalance (QCM) platform modified with this film was employed as a hexanal vapor sensor under ambient conditions, which possessed several advantages including the high response of 34.8 Hz to 250 ppb hexanal, low detection limit of 50 ppb hexanal at 25 °C, and good water-resistance.
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CHEMICAL ENGINEERING JOURNAL
·
2020
·
IF 10.652
Bailong Tao,Chuanchuan Lin,Zhang Yuan,Ye He,Maowen Chen,Ke Li,Jingwei Hu,Yulu Yang,Zengzilu Xia,Kaiyong Cai
The development of antibacterial and rapid hemostatic wound dressing with good biocompatibility is urgently required for promoting non-healing wounds. In this work, a multifunctional near infrared (NIR) laser-induced hydrogel for infected wound healing is presented. The hydrogel was composed of dibenzaldehyde-grafted poly (ethylene glycol) (PEGDA), lauric acid-terminated chitosan (Chi-LA), and curcumin (Cur)-loaded mesoporous polydopamine nanoparticles ( [email protected] ) via Schiff base and/or Michael addition reaction. The Cur could rapidly release from [email protected] hydrogel under NIR laser irradiation with on-demand release property. Meanwhile, NIR irradiation could activate the photothermal PDA NPs in [email protected] hydrogel and generate local hyperthermia for killing Escherichia coli and Staphylococcus aureus . It was realized by inducing the “out-diffusion” of K + , inactivating the respiratory chain dehydrogenase and β-galactosidase activity, causing cellular components leakage (protein, DNA and RNA, etc.), reducing the ATP level, and destroying bacterial membrane. Moreover, the [email protected] hydrogel exhibited good biocompatibility. Furthermore, in vivo treatment in a S. aureus -infected full-thickness skin defect model revealed that the [email protected] hydrogel presented good hemostatic function, prominent antibacterial ability, strong anti-inflammatory effect, and good wound healing capacity.
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ANALYTICAL BIOCHEMISTRY
·
2024
·
IF 2.6
Nanfei Yang,Yuncheng Bei,Yahong Huang,Wei Zheng,Jiehua Ma,Jiangqiong Ke
Serum Cystatin C (CysC) is an impressive marker for early diagnosis of renal dysfunction. In this work, we established a novel electrochemical immunosensor based on Fe 3 O 4 /AuNPs-MWCNTs@PDA nanocomposite for the detection of CysC. The Fe 3 O 4 /AuNPs-MWCNTs@PDA nanozyme complex by polydopamine encapsulation can not only carry massive detection antibodies, but also bind the electroactive substance toluidine blue (TB) through electrostatic adsorption. By immobilizing AuNPs onto the electrode to bind the capture antibody (Ab1), we constructed a sandwich electrochemical immunosensor with low cost, high sensitivity, and repeatability. The detection range is 3.9–125.0 ng/mL with a significant linear relationship between the current peak difference (ip) and logarithm of the CysC concentration. Moreover, the detection limit of the immunosensor is 0.157 ng/mL. We have successfully utilized this novel immunosensor to detect CysC in human serum samples, and these results have implications for its potential use in clinical application.
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高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2024
·
IF 2.7
Fenghui Xie,Wei Wu,Huanbo Hu,Junjian Ye,Lu Cui,Zhengyi Wang,Wenxue Zhang
In order to enhance the mechanical properties of lattice structure parts made of thermoplastic polyurethane elastomer (TPU) prepared by selective laser sintering (SLS) technology, this study employed the oxidative self-polymerization of dopamine (DA) to prepare polydopamine-modified silicon carbide whiskers (PDA-SiC) fillers with a core-shell structure. These fillers were uniformly dispersed in a waterborne polyurethane (WPU) to form a coating solution, which was then used to prepare TPU printed parts with a uniform PDA-SiC/WPU coating structure through post-treatment impregnating-curing processes. The coated TPU parts exhibited tensile strength, elongation at break, and room temperature compressive strength of 8.37 MPa, 610.2%, and 1.062 MPa, respectively, representing improvements of 40.9%, 33.2%, and 353.3% compared to pure TPU parts. This approach effectively enhanced the mechanical performance of SLS-formed TPU parts, strengthening their application in the field of flexible lattice structure parts.
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