BIOCONJUGATE CHEMISTRY
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2016
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IF 4.5
Tieyan Wang,Qixian Chen,Hongguang Lu,Wei Li,Zaifen Li,Jianbiao Ma,Hui Gao
The dilemma of poly(ethylene glycol) surface modification (PEGylation) inspired us to develop an intracellularly sheddable PEG palisade for synthetic delivery systems. Here, we attempted to conjugate PEG to polyethylenimine (PEI) through tandem linkages of disulfide-bridge susceptible to cytoplasmic reduction and an azobenzene/cyclodextrin inclusion complex responsive to external photoirradiation. The subsequent investigations revealed that facile PEG detachment could be achieved in endosomes upon photoirradiation, consequently engendering exposure of membrane-disruptive PEI for facilitated endosome escape. The liberated formulation in the cytosol was further subjected to complete PEG detachment relying on disulfide cleavage in the reductive cytosol, thus accelerating dissociation of electrostatically assembled PEI/DNA polyplex to release DNA by means of polyion exchange reaction with intracellularly charged species, ultimately contributing to efficient gene expression.
研究领域:
基因治疗
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药物递送系统
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纳米医学
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生物材料
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分子生物学
✓ 已验证
DOI
高影响因子
CARBOHYDRATE POLYMERS
·
2014
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IF 3.916
Zesheng Lv,Longlong Chang,Xingwen Long,Jianping Liu,Yuzhang Xiang,Jinjian Liu,Jianfeng Liu,Hongzhang Deng,Liandong Deng,Anjie Dong
In this work, a new hydrogel was constructed using poly(ɛ-caprolactone-co-1,4,8-trioxa[4.6]spiro-9-undecanone)–poly(ethylene glycol)–poly(ɛ-caprolactone-co-1,4,8-trioxa[4.6]spiro-9-undecanone) tri-block copolymers (PECT) with hyaluronic acid (HA) in order to expand application scopes of PECT hydrogel. The rheological and sol–gel phase transition behaviors were investigated by rheometer and test tube inversion method, and the interior morphologies of hydrogel systems were observed by scanning electron microscope (SEM). With the introduction of HA, certain properties of PECT hydrogel, such as viscosity and morphology, have present trends with regularity. Furthermore, with the participation of HA, the degradation and release of acetylsalicylic acid was slightly affected, however, the drug release mechanism of hydrogel has not been changed. PECT/HA hydrogel is confirmed to be non-toxic through a test to NIH3T3 cells. In conclusion, blending with HA is a feasible and safe method to tune properties of PECT hydrogel.
研究领域:
生物材料
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高分子科学
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药物递送
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组织工程
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生物医学工程
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DOI
高影响因子
ChemistrySelect
·
2025
·Vol. 10
·期 46
·e04751
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IF 2
Zhiyan Ma,Like Dou,Hai Liang,Weifang Han
Phase change materials (PCMs) typically exhibit low thermal conductivity (TC) and limited light absorption, which restrict their application in solar thermal utilization. In this study, boron nitride microrod-supported copper (Cu@BNR) was developed as a multifunctional filler and incorporated into polyethene glycol (PEG) to fabricate PEG-based composite PCMs. The incorporation of Cu promotes the formation of a continuous thermal network and enhances photothermal conversion capability. Due to this unique structure, the PEG/Cu@BNRs composite containing 10 wt% Cu@BNRs achieves a TC of 1.344 W·m −1 K −1 , representing 5.1-fold and 2.2-fold increase compared to pure PEG and PEG/BNRs, respectively. Under simulated sunlight (100 mW cm −2 ), the PEG/Cu@BNRs composite reaches a photothermal conversion efficiency of 91.2% and demonstrates excellent shape stability and cycling reliability. As a thermal interface material in LED systems, the PEG/Cu@BNRs composite significantly reduces operating temperatures, confirming its practical thermal management capabilities. Consequently, the prepared composite PCMs integrate solar energy conversion, efficient heat conduction, and thermal storage functions, making them suitable for sustainable energy applications. Graphical Boron nitride microrod-supported copper (Cu@BNR) was developed as a multifunctional filler and incorporated into polyethene glycol (PEG) to fabricate PEG-based composite PCMs. The PEG/Cu@BNRs composite PCMs exhibit excellent heat transfer performance and high photothermal conversion efficiency.
研究领域:
材料科学
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纳米技术
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能量转换
·
热管理
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产品关联
DOI
高影响因子
Frontiers in Chemistry
·
2020
·
IF 3.693
Pang Zekun,Zhou Jiayan,Sun Chunyang
The development of the nanosized delivery systems with targeting navigation and efficient cargo release for cancer therapy has attracted great attention in recent years. Herein, a folic acid (FA) modified PEGylated polycaprolactone containing ditelluride linkage was synthesized through a facile coupling reaction. The hydrophobic doxorubicin (DOX) can be encapsulated into the polymeric micelles, and such nanoparticles (F-TeNPDOX) exhibited redox-responsive drug release under abundant glutathione (GSH) condition due to the degradation of ditelluride bonds. In addition, flow cytometric analyses showed that the FA ligands on F-TeNPDOX could facilitate their cellular uptake in 4T1 breast cancer cells. Therefore, F-TeNPDOX led to the promoted drug accumulation and enhanced growth inhibition on 4T1 tumor in vivo. The obtained results suggest F-TeNPDOX excellent potential as nanocarriers for anticancer drug delivery.
研究领域:
纳米技术
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癌症研究
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聚合物化学
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药物递送系统
✓ 已验证
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
·
2011
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IF 2.78
Zhiyun Zhang,Jianchun Wang,Qin Tu,Nan Nie,Jun Sha,Wenming Liu,Rui Liu,Yanrong Zhang,Jinyi Wang
The current paper reports the synthesis of a highly hydrophilic, antifouling dendronized poly(3,4,5-tris(2-(2-(2-hydroxylethoxy)ethoxy)ethoxy)benzyl methacrylate) (PolyPEG) brush using surface initiated atom transfer radical polymerization (SI-ATRP) on PDMS substrates. The PDMS substrates were first oxidized in H 2 SO 4 /H 2 O 2 solution to transform the Si–CH 3 groups on their surfaces into Si–OH groups. Subsequently, a surface initiator for ATRP was immobilized onto the PDMS surface, and PolyPEG was finally grafted onto the PDMS surface via copper-mediated ATRP. Various characterization techniques, including contact angle measurements, attenuated total reflection infrared spectroscopy, and X-ray photoelectron spectroscopy, were used to ascertain the successful grafting of the PolyPEG brush onto the PDMS surface. Furthermore, the wettability and stability of the PDMS–PolyPEG surface were examined by contact angle measurements. Anti-adhesion properties were investigated via protein adsorption, as well as bacterial and cell adhesion studies. The results suggest that the PDMS–PolyPEG surface exhibited durable wettability and stability, as well as significantly anti-adhesion properties, compared with native PDMS surfaces. Additionally, our results present possible uses for the PDMS–PolyPEG surface as adhesion barriers and anti-fouling or functional surfaces in biomedical applications.
研究领域:
材料科学
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生物医学工程
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DOI
高影响因子
Journal of Materials Chemistry A
·
2015
·Vol. 3
·期 13
·7139-7144
·
IF 7.443
Guanchao Wang,Yanqing Lai,Zhian Zhang,Jie Li,Zhiyong Zhang
As one of the most promising high-energy lithium batteries, the commercialization of lithium–sulfur (Li–S) batteries remains a huge challenge due to their poor rate performance and low cycle stability, which originate partly from the dissolution of polysulfides and their migration from the S cathode to the Li anode through the separator. Novel sulfur-based composite cathodes have been constantly put forward to restraint the dissolution of polysulfides; however, less attention has been paid to modifying the separator. In this work, a multi-walled carbon nanotube@polyethylene glycol (MCNT@PEG) composite is designed and prepared to modify the commercial Celgard separator. With the bifunctional MCNT@PEG-modified separator, Li–S cells possess a high initial discharge capacity of 1283 mA h g−1 at 0.5 C and undertake a long charge/discharge process of 500 cycles at 1 C with 0.12% capacity fading per cycle. Moreover, when the rate is increased to 5 C, the cells can also deliver a discharge capacity of 657 mA h g−1. These encouraging electrochemical results highlight the excellent rate capability and high cycle stability of Li–S cells, which could be attributed to the strong chemical and physical absorption properties and high electron conductivity of the MCNT@PEG layer. This facile approach to restrain the shuttle effect of polysulfides makes further progress in obtaining the enhanced performance of Li–S batteries.
研究领域:
储能技术
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材料科学
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电化学
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纳米材料
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DOI
高影响因子
Green Processing and Synthesis
·
2023
·Vol. 12
·期 1
·
IF 4.3
Xin Zhang,Xutong Zhu,Lifa Huang,Zupeng Chen,Yuchen Wang,Yajun Liu,Ruihan Pan,Ling Lv
Tanshinone IIA has a potential therapeutic effect on cerebral ischemia/reperfusion injury (CIRI). In this study, tanshinone IIA was encapsulated in poly(lactic- co -glycolic acid)-block-poly (ethylene glycol)-carboxylic acid (PLGA-PEG-COOH) nanoparticles, and its therapeutic efficacy on CIRI was investigated. Morphology and dynamic light scattering analyses were performed to identify and optimize nano-formulations. A drug release test was conducted using the dialysis method. The cytotoxic effect of tanshinone IIA on human neuroblastoma cells (SH-SY5Y) and brain endothelial capillary cells (hCMEC/D3) was measured using the MTT assay. The protective effect of PLGA-PEG-COOH-encapsulated tanshinone IIA against CIRI was evaluated in oxygen and glucose deprivation/reoxygenation-induced SH-SY5Y/IR cells and middle cerebral artery occlusion (MCAO) rats. Results showed that PLGA-PEG-COOH-encapsulated tanshinone IIA promoted viability and inhibited apoptosis of SH-SY5Y/IR cells ( P < 0.01). Moreover, PLGA-PEG-COOH-encapsulated tanshinone IIA facilitated the invasion of SH-SY5Y/IR cells and repressed inflammation in MCAO rats ( P < 0.01). Noteworthy, PLGA-PEG-COOH-encapsulated tanshinone IIA combined with angiopep-2 peptide presented a better inhibitory effect on CIRI than tanshinone IIA alone ( P < 0.01). Angiopep-2 peptide contributes to traversing blood–brain barrier by recognizing lipoprotein-related protein expressed in the brain capillary endothelial cells. In conclusion, PLGA-PEG-COOH-encapsulated tanshinone IIA plus angiopep-2 peptide holds promising therapeutic potential toward CIRI.
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产品关联
DOI
高影响因子
International Journal of Nanomedicine
·
2023
·
IF 8
Dongyu Duan,Aiping Wang,Ling Ni,Liping Zhang,Xiuju Yan,Ying Jiang,Hongjie Mu,Zimei Wu,Kaoxiang Sun,Youxin Li
Introduction Nanoparticles (NPs) modified with bio-ligands represent a promising strategy for active targeted drug delivery to tumour. However, many targeted ligands, such as trastuzumab (TMAB), have high molecular weight, limiting their application for targeting. In this study, we prepared Fab’ (antigen-binding fragments cut from TMAB)-modified NPs (Fab′-NPs) with curcumin (Cur) as a model drug for more effective targeting of human epidermal growth factor receptor 2 (HER2/ErbB2/Neu), which is overexpressed on breast cancer cells.Material and methods The release kinetics was conducted by dialysis bags. The ability to kill HER2-overexpressing BT-474 cells of Fab′-Cur-NPs compared with TMAB-Cur-NPs was conducted by cytotoxicity experiments. Qualitative and quantitative cell uptake studies using coumarin-6 (fluorescent probe)-loaded NPs were performed by fluorescence microscopy and flow cytometry. Pharmacokinetics and biodistribution experiments in vivo were assessed by liquid chromatography–tandem mass spectrometry (LC-MS/MS).Results The release kinetics showed that both Fab′-Cur-NPs and TMAB-Cur-NPs provided continuous, slow release of curcumin for 72 h, with no significant difference. In vitro cytotoxicity experiments showed that Fab′-Cur-NPs manifested prominent ability to kill HER2-overexpressing BT-474 cells compared with TMAB-Cur-NPs. Qualitative and quantitative cell uptake studies indicated that the accumulation of Fab′-NPs was greater than that of TMAB-NPs in BT-474 (HER2+) cells; However, there was no significant difference in MDA-MB-231 (HER2−) cells. Pharmacokinetics and biodistribution experiments in vivo demonstrated that the half-life (t1/2) and area under the blood concentration-time curve (AUC0-t) of Fab′-Cur-NPs increased 5.30-fold and 1.76-fold relative to those of TMAB-Cur-NPs, respectively. Furthermore, the tumor accumulation of Fab′-Cur-NPs was higher than that of TMAB-Cur-NPs.Conclusion Fab′ fragment has greater capacity than the intact antibody to achieve tumor targeting through NP-based delivery.
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DOI
PubMed
高影响因子
ENERGY
·
2023
·
IF 9
Lin Qiu,Kening Yan,Yanhui Feng,Xianglei Liu
The low thermal conductivity and easy leakage of phase change materials are the shortcomings that hinder their further application for thermal energy storage . It is crucial how to properly match skeleton materials and phases to improve heat transfer in order to solve the above problem. Here, we systematically investigate the effects of nano additives on the phase change and thermal properties of bionic hierarchical porous aluminum nitride-polyethylene glycol (PEG/AlN) composites. Alumina (Al 2 O 3 ) nanoparticles were found to have the largest enhancement effect for the thermal conductivity of PEG (84% for 4 wt% addition) compared to silica , titanium dioxide, and boron nitride . For these additives, the thermal conductivity and stability of the nano additives-enhanced PEG increase with the increase of their mass fraction. After 100 heating/cooling cycles, the thermal response curve shows that the Al 2 O 3 -enhanced PEG can maintain the phase transition behavior, and the measured phase transition temperature agrees well with the differential scanning calorimeter results. The thermal conductivity of the PEG/AlN enhanced with 4 wt% Al 2 O 3 is 20.41 W/m·K, and the melting point and phase change enthalpy are 55.93 °C and 81.05 J/g. In addition to the great improvement in thermal response, the heat storage rate also increases by 36.10%.
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产品关联
DOI
高影响因子
Asian Journal of Pharmaceutical Sciences
·
2023
·
IF 10.2
Ka Hong Wong,Zhaopei Guo,Di Jiang,Xingzhi Zhou,Lizhu Lin,Denggao Zhao,Meiwan Chen
Nano drug delivery systems have made significant progress in delivering anticancer drugs camptothecin (CPT). However, many challenges for CPT delivery remain, including low drug loading efficiency, premature drug leakage, and poor cellular internalization. Herein, we report a novel dual-sensitive polypeptide-based micelle with remarkably high drug loading of CPT for cancer therapy. This self-assembled micelle possesses the following essential components for CPT: (1) pH-sensitive PEG (OHC-PEG-CHO) for prolonging blood circulation and allowing biocompatibility by shielding the cationic micelles, which can be detached under the tumor acidic microenvironment and facilitates the cellular uptake; (2) polypeptide polylysine-polyphenylalanine (PKF) synthesized via ring-opening polymerization for micelle formation and CPT analogue loading; (3) dimeric CPT (DCPT) with redox-sensitive linker for increasing CPT loading and ensuring drug release at tumor sites. Interestingly, the linear-like morphology of PEG-PKF/DCPT micelles was able to enhance their cellular internalization when compared with the spherical blank PKF micelles. Also, the anticancer efficacy of DCPT against lung cancer cells was significantly improved by the micelle formation. In conclusion, this work provides a promising strategy facilitating the safety and effective application of CPT in cancer therapy.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MATERIALS & DESIGN
·
2022
·
IF 9.417
Zhenyu Yang,Xueqiao Yu,Pengfei Wei,Yiqian Huang,Shuai Zhou,Wei Jing,Yan Zhang,Liya Sun,Guoqiang Bao,Xianli He,Bo Zhao
Pancreatic leakage is severe and life-threatening when happening pancreatitis or conducting pancreatectomy on patients, which easily induces bleeding, infection and even death. Commercial tissue adhesives cannot meet the demands for pancreatic leakage sealing due to the weak adhesiveness, potential toxicity and inability to degrade. Few reports have been feasibly paid attention to pancreas sealants due to the complicated conditions such as enzymatic microenvironments, mechanical dynamics and pre-infections. Herein, we prepared a rapid high-adhesion, antibacterial, biodegradable and injectable bioadhesive based on the FDA-approved polyethylene glycol to seal the pancreatic leakage for clinical translations and commercial applications. The tetra-armed poly(ethylene glycol) succinimidyl glutarate (PEG-SG), tetra-armed poly(ethylene glycol) amine (PEG-NH 2 ) and tannic acid (TA) were integrated to rapidly form the adhesive hydrogel (gelling time < 5 seconds) for convenient operations, while this bioadhesive achieved tough tissue adhesion (∼ 30 kPa), robust antibacterial activity (∼ 95% efficiency) and biocompatibility, revealing the excellent performances for pancreatic wound closure. In the established pre-clinical pancreatectomy using Bama miniature pig model, the bioadhesive presented efficient outcomes on pancreatic leakage, and this indicated the promising feasibility of the bioadhesive for clinical trials and translations.
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DOI
高影响因子
MATERIALS TECHNOLOGY
·
2022
·
IF 3.297
Xin Tian,Xiangling He,Anqi Yao,Yalan You,Fan Yang,Keke Chen,Chengguang Zhu,Minhui Zeng,Qin Shi,Wenfang Tang,Xuelong Fan,Xiaojun Tao
Hydrophobically modified amino-pullulan polymers (CHPNH2) were modified with polyethylene glycol (PEG) through the connective arms of succinic anhydride (SA) and cis aconite anhydride (CA) to form three polymers, namely, PCCN1, PCCN2 and PSCN, respectively. The structure of the polymer was identified by 1H NMR, and the degree of substitution (DS) values of hydrophobic groups were calculated. Three types of nanoparticles (NPs) were prepared by the dialysis method, and the average particle sizes by dynamic light scattering (DLS) were 166.9 nm, 118.9 nm and 118.7 nm. The drug release experiment showed that the three drug-loaded nanoparticles all had a slow-release effect. The results of the MTT experiment showed that the cell survival rates of free cisplatin and the three types of drug-loaded nanoparticles were 42.30%, 40.17%, 37.53% and 53.34% after 48 h at the maximum drug concentration, indicating that PCCN1 nanoparticles have the strongest cytotoxicity. They also had the highest cell uptake rate in cell uptake experiments .
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高影响因子
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