Materials Science & Engineering C-Materials for Biological Applications
·
2017
·
IF 4.164
Cong Zheng,Pan Wei,Wei Dai,Linlin Wang,Botao Song,Pengxiang Jia,Yongkuan Gong
In this paper, a series of random copolymers poly(methacrylic acid - co -2-methacryloyloxyethyl phosphorylcholine) P(MAA- co -MPC) were synthesized firstly via RAFT living polymerization. The P(MAA- co -MPC) copolymer side chains bear cell membrane phosphorylcholine zwitterions to endow biocompatibility and carboxylic groups to confer coordination with metal ions. Thus, the copolymer was adopted to modify Fe 3 O 4 nanoparticle by a one-pot coprecipitation approach. The effects of the copolymer composition as well as the ratio between the copolymers and iron ions on the performances of the magnetite nanoparticles were researched. The diameters of the nanoparticles could be easily tuned by changing the initial copolymer amount. Moreover, a long-term colloidal stability of magnetite particles was obtained after P(MAA- co -MPC) modification. Biocompatibility of the P(MAA- co -MPC) copolymer coated magnetite nanoparticles was investigated by protein adsorption, in vitro cytotoxicity and cell uptake studies. It was found that the copolymer content of magnetite nanoparticles correlates with its biocompatibility. Excellent biocompatibility could be obtained when the content of the copolymer in the composite nanoparticles reached to 54%.
研究领域:
材料科学
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纳米技术
·
生物医学工程
·
高分子化学
✓ 已验证
DOI
PubMed
高影响因子
Polymer Chemistry
·
2021
·Vol. 12
·期 12
·1768-1775
·
IF 5.582
Jamshid Kadirkhanov,Cheng-Lin Yang,Zi-Xuan Chang,Ren-Man Zhu,Cai-Yuan Pan,Ye-Zi You,Wen-Jian Zhang,Chun-Yan Hong
In comparison with the post-polymerization cross-linking strategy, in situ cross-linking by divinyl comonomers in polymerization-induced self-assembly (PISA) is a more straightforward and convenient approach to produce structurally stabilized nano-objects. However, cross-linking usually lowers the chain mobility and hence prevents morphology transition, so formation of higher order morphologies (worm-like micelles or vesicles) by the in situ cross-linking strategy in PISA has always been a great challenge. In this work, not only cross-linked structures but also a promoting effect on morphology transition has been observed during the in situ cross-linking PISA. Worm-like micelles, lamella and vesicles with stabilized (cross-linked) structures are produced by RAFT dispersion copolymerization of 2-(diisopropylamino)ethyl methacrylate (DIPEMA) and the divinyl comonomer cystaminebismethacrylamide (CBMA). The morphology transition is not prevented due to the slower consumption of CBMA than that of the DIPEMA, and the cross-linking process is mostly delayed to the late stage of polymerization. What is surprising, compared with RAFT dispersion polymerization of DIPEMA in the absence of CBMA, is that polymeric nano-objects with higher order morphologies are generated in most cases of the RAFT dispersion copolymerization of DIPEMA and CBMA. The slower consumption of CBMA generates branched structures of the solvophobic blocks, which significantly promote the morphology transition. Cleavage of the cross-linkers (disulfide linkage) by incubating with glutathione (GSH) leads to the morphology transition of the nano-objects to the lower order ones, which further demonstrates the promoting effect on morphology transition in in situ cross-linking PISA.
研究领域:
高分子化学
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材料科学
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纳米技术
✓ 已验证
DOI
高影响因子
MACROMOLECULES
·
2024
·
IF 5.1
Ying Cao,Ran Zhang,Xiaoyue Xu,Xiyu Wang,Yuting Li,Xinhua Lu,Yuanli Cai
Biomimetic synthesis represents a cutting-edge topic in chemical and materials sciences. Herein, we present an approach to bioinspired polymerization autocatalysis using a single amino acid monomer in water. Similar to biomolecular condensates, this monomer undergoes an entropically driven liquid–liquid phase separation (LLPS)-mode self-assembly involving densely charged molecular clusters formation, LLPS of charged monomer clusters leading to submicron-scale droplets, crystallization of charged monomer clusters within droplet crowding environments resulting in dynamic nanocrystals@droplets and finally less dynamic aged-lamellae. Supramolecular chirality inversion and nanocrystal disassembly into charged monomer clusters occur upon doping of a minor RAFT agent. Autocatalysis with solvent-tuned H+-feedback and covalent-driven chirality inversion is achieved using extremely dynamic nanocrystals@droplets. Decelerated kinetics upon deionization/ion-pairing underscore the vital importance of LLPS for the “higher charge repulsion leads to more rapid polymerization”, yielding polymer nanoparticles with protein-like structural complexity up to >98% conversion in 2-min-propagation period. This autocatalysis provides new insights into bioinspired efficient synthesis of polymer nanoparticles.
研究领域:
化学科学
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材料科学
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聚合物化学
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纳米技术
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生物物理学
✓ 已验证
DOI
高影响因子
Journal of Materials Chemistry C
·
2016
·Vol. 4
·期 29
·7083-7092
·
IF 5.066
Yajiao Song,Jianhua Lü,Bingxin Liu,Changli Lü
Thermo-responsive block copolymer brushes of PNIPAM-b-P(MQ-co-GMA) were successfully grafted from graphene oxide (GO) by consecutive reversible addition–fragmentation chain transfer (RAFT) polymerization based on the monomers of N-isopropylacrylamide (NIPAM), 5-(2-methacryloyl-ethyloxymethyl)-8-quinolinol (MQ) and glycidyl methacrylate (GMA). The 8-hydroxyquinoline units in the polymer brushes could coordinate with Al3+ to form green luminescent copolymer brushes containing tris(8-hydroxyquinoline)aluminum (Alq3) on the GO surface. The resulting fluorescent hybrid could be used as a nano-platform for the sensitive and robust detection of 2,4,6-trinitrophenol (TNP). The green fluorescence of the polymer brush modified GO hybrid in aqueous solution could be quenched by TNP via charge transfer and the observed linear fluorescence intensity change allowed the quantitative detection of TNP with a detection limit down to 2.38 × 10−9 M. The fluorescent nanohybrids exhibited a robust temperature-responsive behavior as a result of the conformation change in PNIPAM chains of polymer brushes.
研究领域:
材料科学
·
高分子化学
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纳米技术
·
分析化学
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环境科学
✓ 已验证
DOI
高影响因子
Polymer Chemistry
·
2024
·
IF 4.1
Shiya Cao,Wenyi Liu,Bicai Yang,Yuan Zheng,Shaoliang Lin,Binbin Xu
Heterografted molecular brushes (HMBs) bearing two or more types of side chains have attracted tremendous attention because of their asymmetric structures and multiple functionalities. However, the controlled synthesis of HMBs with three types of side chains remains a challenge. The structure–property–application correlations of HMBs with three types of side chains are still not clear. Herein, based on the multivalent monomer strategy, we report the synthesis of well-defined asymmetric HMBs comprising three different side chains by sequential reversible addition–fragmentation chain transfer (RAFT) polymerization, atom transfer radical polymerization (ATRP), thiol–epoxy coupling reaction, and ring-opening polymerization (ROP). PA-g-PAzo/PEG/PLA with a polyacrylate (PA) backbone, hydrophobic poly(azobenzene-methacrylate) (PAzo) brush, hydrophilic polyethylene glycol (PEG) brush, and hydrophobic polylactide (PLA) brush was synthesized and characterized. The self-assembly behavior of PA-g-PAzo/PEG/PLA with a short backbone and relatively strong intermolecular association in solutions was investigated. Well-defined platelets with tunable morphologies were constructed. Subsequently, PA-g-PFA/PEG/PLA with a fluorophilic poly(pentafluoropropyl acrylate) (PFA) brush, hydrophilic PEG brush, and lipophilic PLA brush was synthesized and further used as an efficient surfactant for the stabilization of different emulsions. Our study offers a platform for exploring the unique properties of asymmetric HMBs.
研究领域:
高分子化学
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材料科学
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纳米技术
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胶体科学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）