PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY
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2021
·
IF 3.133
Ya-Wen Zhang,Ling-Lan Tu,Zhan Tang,Qiao Wang,Gao-Li Zheng,Li-Na Yin
Oral absorption of peptides/proteins is usually compromised by various gastrointestinal tract barriers. To improve delivery efficiency, chitosan-conjugated deoxycholic acid (CS-DCA) coupled with sodium alginate (ALG) was prepared to load insulin into pH-sensitive nanoparticles. The insulin-loaded chitosan-deoxycholic acid/alginate nanoparticles (CDA NPs) were characterized by size (143.3 ± 10.8 nm), zeta potential (19.5 ± 1.6 mV), entrapment efficiency (61.14 ± 1.67%), and insulin drug loading (3.36 ± 0.09%). The CDA NPs exhibited pH-triggered release characteristics in vitro and protected the wrapped insulin from gastric degradation. Stability of the CDA NPs in enzyme-containing simulated gastrointestinal fluids suggested that the NPs could partially protect the wrapped insulin from enzymatic degradation. Additionally, CS-DCA-modified NPs promoted the permeability of Caco-2 cells and enhanced intracellular absorption of FITC-labeled insulin by 9.4 and 1.2-folds, when compared to insulin solution and unmodified NPs, respectively. The positively charged NPs increased intestinal villi adhesion and enhanced insulin absorption in the intestines of diabetic rat models. Furthermore, the hypoglycemic test showed that CDA NPs prolonged insulin release in vivo and exerted a remarkable hypoglycemic effect on diabetic rats with an oral bioavailability of 15%. In conclusion, CDA NPs is a potential oral insulin delivery system.
研究领域:
药剂学
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生物医学工程
·
糖尿病治疗
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DOI
高影响因子
Journal of Applied Spectroscopy
·
2024
·Vol. 91
·期 4
·921-927
·
IF 0.8
Wang Bin,Zhang Xiao,Ma Xiangmei
Exploring new material structures of low photocatalytic degradation activity for ultraviolet screening is one of the important methods for improving polyvinylchloride (PVC) performance. As an important kind of ultraviolet (UV) shielding agent material, nano zinc oxide (ZnO) has been applied extensively in many fields due to its outstanding properties. However, the severe aggregation behavior between nanoparticles (NPs) and photocatalytic activity greatly limits the application. In this work, surface modification of ZnO with hydroxyapatite and chitosan (ZnO–Hap/CS) was fabricated. Then via a solution casting technique dispersed within the PVC matrix. The results demonstrated that the obtained composite exhibited the best ultraviolet screening performance greatly decreasing the photocatalytic degradation activity of ZnO. It is expected that this approach is prospective for the large-scale preparation of nano ZnO with excellent UV-blocking performance and low photocatalytic degradation activity.
研究领域:
材料科学
·
高分子化学
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DOI
高影响因子
International Journal of Minerals Metallurgy and Materials
·
2024
·Vol. 31
·期 11
·2518-2527
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IF 5.6
Chen Wencan,Li Chao,Tao Yehan,Lu Jie,Du Jian,Wang Haisong
Although biopolymers have been widely utilized as triboelectric materials for the construction of self-powered sensing systems, the annihilation of triboelectric charges at high temperatures restricts the output signals and sensitivity of the assembled sensors. Herein, a novel chitosan/montmorillonite/lignin (CML) composite film was designed and employed as a tribopositive layer in the assembly of a self-powered sensing system for use under hot conditions (25–70°C). The dense contact surface resulting from the strong intermolecular interaction between biopolymers and nanofillers restrained the volatilization of induced electrons. The optimized CML-TENG delivered the highest open-circuit voltage ( V oc ) of 262 V and maximum instantaneous output power of 429 mW/m 2 . Pristine CH-TENG retained only 39% of its initial V oc at 70°C, whereas the optimized CM 5 L 3 -TENG retained 66% of its initial V oc . Our work provides a new strategy for suppressing the annihilation of triboelectric charges at high temperatures, thus boosting the development of self-powered sensing devices for application under hot conditions.
研究领域:
材料科学
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生物医学工程
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DOI
高影响因子
ACS Applied Polymer Materials
·
2021
·
IF 4.089
Jie Zhang,Zihuayuan Yang,Yan-Hong Li,Samran Durrani,Ai-Ping Pang,Yichen Gao,Fu-Gen Wu,Fengming Lin
Establishing antimicrobial photodynamic therapy (PDT) approaches to enhance antimicrobial activities of insoluble photosensitizers in terms of their solubility, stability, and safety is highly desirable yet challenging. Here, we reported super-stable carboxymethyl chitosan-polyethyleneimine-protoporphyrin IX nanoparticles (CMCS-PEI-PpIX NPs) for effective photodynamic inactivation of bacteria and fungi with excellent biocompatibility. CMCS-PEI-PpIX self-assembled into NPs in solution with significantly improved singlet oxygen generation. Consequently, NPs exhibited exceptional photoinactivation toward a broad range of microbes with record low minimal bactericidal concentrations. NPs were highly stable after 28 days of storage. Furthermore, NPs exhibited negligible cytotoxicity without hemolysis on red blood cells. NPs can efficiently attach to the microbial cell through electrostatic interaction to generate singlet oxygen with light irradiation, which caused severe damage to the cell membrane, causing microbial cell death. Overall, the development of CMCS-PEI-PpIX NPs provides a route for improving the microbicidal PDT efficacy, benefiting the clinic treatment of microbial infections.
研究领域:
药剂学
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微生物学
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纳米技术
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治疗学
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DOI
高影响因子
CARBOHYDRATE POLYMERS
·
2021
·
IF 9.381
Min Mu,Xiaoyan Liang,Di Chuan,Shasha Zhao,Wei Yu,Rangrang Fan,Aiping Tong,Na Zhao,Bo Han,Gang Guo
The safe and effective drug delivery system is important for cancer therapy. Here in, we first constructed a delivery system Cabazitaxel(Cab)@MPN/CS between metal-polyphenol (MPN) and chitosan (CS) to deliver Cab for melanoma therapy. The preparation process is simple, green, and controllable. After introducing CS coating, the drug loading was improved from 7.56 % to 9.28 %. [email protected] /CS NPs released Cab continuously under acid tumor microenvironment. The zeta potential of [email protected] /CS NPs could be controlled by changing the ratio of [email protected] and CS solutions. The positively charged [email protected] /CS accelerate B16F10 cell internalization. After internalized, [email protected] /CS NPs could escape from lysosomes via the proton sponge effect. The permeability of CS promotes the penetration of [email protected] /CS to the deeper B16F10 tumor spheroids. In vivo results showed that [email protected] /CS NPs have a longer retention time in tumor tissues and significantly inhibit tumor growth by up-regulating TUNEL expression and down-regulating KI67 and CD31 expression. Thus, this delivery system provides a promising strategy for the tumor therapy in clinic.
研究领域:
药学
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肿瘤学
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生物医学工程
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DOI
PubMed
高影响因子
JOURNAL OF MATERIALS RESEARCH
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2018
·Vol. 33
·期 17
·2586-2597
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IF 1.495
Haochao Huang,Haiwei Wu,Yongrui Huang,Shuangying Zhang,Yuetwai Lam,Ningjian Ao
N-(3-Carboxypropyl) triphenylphosphonium bromide chitosan (TPPB-CS) was synthesized and characterized by FTIR, 1H NMR spectrometer, and Zeta potential. TPPB-CS showed a selectivity-toxicity among cancer cell lines (MG-63 and HepG2 cells) and mouse embryonic fibroblast cells (NIH3T3 cells). A significant effect on inhibiting cell migration in HepG2 cells was observed in vitro, and TPPB-CS could effectively inhibit tumor growth in H22-bearing mice in vivo. Furthermore, the distribution of cell cycle, the level of reactive oxygen species (ROS), mitochondrial transmembrane potential (∆ψm), the expression of tumor necrosis factor α (TNF-α), and vascular endothelial growth factor (VEGF) were examined to investigate the antitumor mechanism of TPPB-CS. The results suggested that the antitumor activity of TPPB-CS may be attributed to delay the cell cycle in S phase, alter the ROS and ∆ψm level, as well as regulate the TNF-α and VEGF secretion. TPPB-CS can become a promising anticancer drug for clinical therapy.
研究领域:
药理学
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肿瘤学
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生物化学
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DOI
高影响因子
JOURNAL OF SOL-GEL SCIENCE AND TECHNOLOGY
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2023
·Vol. 106
·期 3
·877-894
·
IF 2.5
Hao Pei Yan,Zhou Hui Yun,Ren Li Jun,Zheng Hui Jie,Tong Jia Nan,Chen Ya Wei,Park Hyun Jin
Abstract The chitosan hydrogel has been widely appraised for drug delivery systems. However, its long gel formation time, poor drug release effect, and low drug loading capacity for hydrophobic drugs limited its wide application. Herein, the β-cyclodextrin-grafted chitosan (CD-g-CS) with different degrees of substitution (DS) was successfully synthesized from O-p-toluenesulfonyl-β-cyclodextrin (Ts-CD) and chitosan (CS). The novel thermosensitive β-cyclodextrin-grafted chitosan/glycerophosphate (CD-g-CS/GP) hydrogels were prepared in the presence of αβ-glycerophosphate (GP). The CD-g-CS/GP hydrogels had a gel time of less than 6 min and performed great injection performance. In vitro release studies revealed that the hydrogels not only had a sustained release but also enhanced the solubility and bioavailability of curcumin (CUR). And the CD-g-CS/GP hydrogel had suitable swelling behavior, porosity, and degradation rate. In addition, the hydrogels exhibited good hemocompatibility. The evaluation of the antibacterial activity indicated that CUR@CD-g-CS/GP hydrogels were effective antibacterial materials for Staphylococcus aureus and Escherichia coli . In summary, the results suggested that the CD-g-CS/GP hydrogel might be used as a potential biodegradable smart drug-sustained release system for the controlled release of hydrophobic drugs, which has broad application prospects in the field of biomedicine. Graphical Abstract
Preparation of CUR@CD-g-CS/GP hydrogel. First, the prepared CD-g-CS was dissolved in 0.1 M HAc solution. The GP powder was dissolved in distilled water to prepare a GP solution of 50% (w/v). Next, the GP solution was added dropwise to the CD-g-CS solution and stirred in an ice bath. Finally, the CD-g-CS/GP hydrogel was obtained. The hydrogel-loaded CUR (CUR@CD-g-CS/GP) was prepared by adding CUR to the CD-g-CS solution. After incubation at 37 °C, the system changed from a sol to a gel state. The gel was placed in a release medium and the drug molecules were released from the system.
研究领域:
药学
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生物医学工程
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材料科学
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DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2017
·
IF 3.671
Haichen Yan,Lei Jiang,Xiaozhou Xu,Yanbao Li,Yuesong Shen,Shemin Zhu
Chitosan (CS) has attracted significant interest in various fields due to its outstanding functional properties (especially, its chain with positive charge). However, wide-range applications of CS are severely limited because of its poor mechanical properties. Ultrastrong composite film of CS and silica-coated graphene oxide sheets (GO@SiO 2 ) were prepared by a simple solution casting method in this article. GO@SiO 2 was prepared by the hydrolysis of tetraethyl orthosilicate (TEOS) in GO ethanol solution. Compared with the pure CS film, the tensile strength of the CS/GO@SiO 2 composite film with incorporation of 1.75 wt% GO@SiO 2 fillers was significantly increased 158% from 55 ± 4 to 142 ± 24 MPa. Such high tensile strength may be caused synergistically by strong interaction between two components and high crystallinity of the CS matrix. CS based composite with ultrastrong strength may have more potential applications in biomedical fields.
研究领域:
材料科学
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生物医学工程
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DOI
高影响因子
Frontiers in Pharmacology
·
2026
·
IF 5.4
Zhixiang Wu,Yanjuan He,Hao Deng,Yue Tan,Wangzi Gao,Jiaxin Yin,Ziqin Zeng,Jing Sun,Lijuan Zhang,Yue Li,Shentang Li
Chronic kidney disease (CKD), whose prevalence is rising substantially, has become a major global health challenge. In this study, we developed linagliptin-loaded chitosan nanoparticles (HCS-LGP NPs) for the treatment of renal fibrosis. The synthesized nanoparticles exhibited a uniform particle size of 178.8 ± 4.4 nm and a zeta potential of −29.9 ± 2.5 mV, along with acid-responsive drug release properties. In vitro , the HCS-LGP NPs showed efficient cellular uptake in TGF-β1-induced HK-2 cells and significantly inhibited cell proliferation by downregulating the expression of TGF-β1 and Collagen I. In vivo studies demonstrated effective renal accumulation of HCS-LGP NPs in rats with renal fibrosis. Treatment with HCS-LGP NPs significantly reduced serum creatinine, blood urea nitrogen, and the protein levels of TGF-β1 and Collagen I. Notably, the administration of HCS-LGP NPs promoted marked recovery from renal injury and markedly reduced collagen fiber deposition in rats with renal fibrosis. Histopathological analysis confirmed excellent biocompatibility, with no observable damage to the heart, liver, spleen, or lungs. These findings indicate that HCS-LGP NPs hold great potential as a targeted therapy for renal fibrosis, offering enhanced efficacy and a favorable safety profile.
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产品关联
DOI
PubMed
高影响因子
ACS Applied Polymer Materials
·
2026
·
IF 5.2
Xin-Li Jiang,Jing-Yan Liu,Yan-Ping Hu,Xu Lin,Yun-Wu Zheng,De-Fa Hou,Fu-Lin Yang,Long Yang,Can Liu
Natural rubber (NR) is a strategic biomaterial whose latex-based products are widely used in biomedical and hygienic applications. However, the inherent susceptibility of NR to microbial colonization limits its service life and poses safety concerns. To impart intrinsic antibacterial functionality, we designed a cationic-modified chitosan derivative (CS-GTA) by grafting quaternary ammonium groups onto the chitosan backbone via chemical bonding. This molecular tailoring significantly enhanced the solubility of chitosan under alkaline latex conditions. The resulting CS-GTA was introduced as a functional antibacterial filler into natural rubber latex, forming a stable and homogeneous NR/CS-GTA composite system. The modified latex retained favorable processability and curing characteristics. Using Dunlop foaming, casting methods and mechanical ball milling, we fabricated latex foam and thin-film materials, both of which exhibited remarkable inhibitory effects against Escherichia coli, Staphylococcus aureus, and Candida albicans, demonstrating broad-spectrum antibacterial performance. This study offers a sustainable and effective strategy for developing high-performance antibacterial natural rubber materials, with potential implications for advancing the value-added applications of NR-based products.
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DOI
高影响因子
CARBOHYDRATE POLYMERS
·
2019
·
IF 6.044
Dedai Lu,Hongsen Wang,Xiangya Wang,Yunfei Li,Hongyun Guo,Shaobo Sun,Xiaolong Zhao,Zhiwang Yang,Ziqiang Lei
Inspired by the mussel foot protein and chitosan-based macromolecular adhesives, a series of chitosan- graft -polypeptides were synthesized by ring-opening polymerization of three N -carboxyanhydrides (NCAs) - 3,4-dihydroxyphenylalanine- N -carboxyanhydride (DOPA-NCA), cysteine-NCA (Cys-NCA) and arginine-NCA (Arg-NCA) - using partial-NH 2 -protected chitosan as an initiator. These copolymers demonstrated good biodegradability and low cytotoxicity. The results of lap-shear adhesion test showed that the maximum lap-shear adhesion strength on the porcine skin and aluminum sheet were 195.97 ± 21.1 kPa and 3080 ± 320 kPa, respectively, and the maximum tensile adhesion strength on bone was 642.70 ± 61.1 kPa. The rat experiment in vivo showed that these copolymers exhibited good hemostatic performance and can promote the healing of skin wound and bone fracture. It is expected that thesecopolymeric adhesives will have broad applications in hemostasis and soft tissue adhesions.
✓ 已验证
DOI
高影响因子
Desalination and Water Treatment
·
2024
·
IF 1
Weili Wang,Yangyang Du,Mingyu Liu,Mengmeng Yang,Runping Han
Chitosan (CS) modified multi-walled carbon nanotubes (MWCNTs) were used as adsorbents (CS-MWCNTs) to adsorb Congo red (CR, anionic dye) from solution in batch mode. The structure and morphology of CS-MWCNTs were characterized by TEM, FTIR, Raman and XPS. The results from analysis of FTIR and XPS showed that CS was successfully loaded onto the MWCNTs. Raman analysis showed that the basic structure of MWCNTs after CS modification did not change. Adsorption studies were performed at different pH, coexisted ions concentrations, contact time and CR concentrations in the batch mode. Results showed that the pH of CR solution at 4.0 was best for the adsorption and the adsorption capacity could reach up to 623 mg-g -1 at 303K. The adsorption of the CR solution reached equilibrium within 8 h. Adsorption equilibrium data can be predicted by the Freundlich model while the kinetic adsorption data follow a pseudo-second-order model. Thermodynamic results showed that the adsorption process was spontaneous, and endothermic. The CR-loaded adsorbent can be regenerated using a 0.01 mol-L -1 NaOH solution, the regeneration rate can still reach 71% after three cycles. CS-MWCNTs may be available in removal of anionic dyes from solution.
研究领域:
环境科学
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材料科学
·
化学工程
·
水处理
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DOI
高影响因子
危险品化学品经营许可证（带存储）