INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Chen-Chen Wang,Bao-Qiu Yang,Ran Feng,Han Tao,Bao-Cai Xu,Bao Zhang
In this study, biotin esterified debranched starch (Bio-DBS) nanoparticles with different molecular weights were prepared to improve the stability and antioxidant activity of resveratrol. The molecular weights of branched starch (DBS 3 , DBS 9 and DBS p ) determined by high-performance size-exclusion chromatography (HPSEC) were 3306, 3696, and 4688, respectively. Biotin was covalently coupled to DBS through the esterification reaction as a new material to prepare nanoparticles. The morphology, particle size, and loading capacity of Bio-DBS nanoparticles were all related to the molecular weights of DBS. The 1 H NMR results indicated that there was a hydrogen bonding interaction between Bio-DBS and resveratrol, which contributed to the photochemical and antioxidant activity of resveratrol in the nanoparticles. The highest encapsulation efficiency (78.9 %) and loading capacity (15.78 %) of resveratrol were observed in Bio-DBS 3 nanoparticles. Additionally, the cell viability was over 80 % when the concentration of Bio-DBS 3 reached to 200 μg/mL. The Bio-DBS nanoparticles significantly improved the thermal stability, photostability, and antioxidant properties of resveratrol. Therefore, the Bio-DBS nanoparticles prepared in this study can be used as a promising carrier to improve the stability and antioxidant activity of resveratrol and may have potential applications in oral delivery.
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FOOD CHEMISTRY
·
2025
·
IF 9.8
Dami Li,Yaoyao Zhang,Xing Qiao,Shangde Sun
Resveratrol monoesters, synthesized by esterifying with lipophilic groups, excel in lipophilicity, antioxidant activity, and bioavailability. This study selectively acylated resveratrol at 3-OH and 4’-OH using lipozyme RMIM (from Rhizomucor miehei ). Seven 3-resveratrol monoesters (3-RC 2:0 – 18:0 ) and seven 4’-RC 2:0 – 18:0 were prepared, purified and identified. Their antioxidant capacity and bioaccessibility were innovatively studied, focusing on substitution and acyl chain length effects. Results showed that 3-RC 2:0 – 18:0 consistently outperformed 4’-RC 2:0 – 18:0 in SET assays for antioxidant activity. Notably, 4’-RC 2:0 – 8:0 performed better oxygen radical absorption capacity than 3-RC 18:0 . 3-RC 2:0 even showed better ABTS radical scavenging capacity than Trolox and TBHQ. 3-RC 2:0 /RC 4:0 displayed higher antioxidant efficacy than medium- and long-chain counterparts, excluding 3-RC 16:0 . In the gastric and intestinal phases, 4’-RC 2:0 – 18:0 showed slightly higher retention due to enhanced lipophilicity compared to 3-RC 2:0 – 18:0 . RC 2:0 /RC 12:0 – 18:0 showed better retention properties during digestion. In summary, 3-RC 2:0/16:0 exhibited exceptional antioxidant capacity and digestive stability. These findings suggest resveratrol derivatives' potential in lipid-based foods, pharmaceuticals, and cosmetics.
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RSC Advances
·
2024
·Vol. 14
·期 43
·31768-31776
·
IF 3.9
Jiawei Zhao,Li Lu,Qiwei Chai,Wei Jin,Min Zhu,Shengqi Qi,Jiali Shentu,Yuyang Long,Dongsheng Shen
The unique capacity of certain plant endophytes to degrade organic pollutants has garnered considerable interest in recent years. However, it remains uncertain whether endophytes can maintain high degradation activity after in vitro culture and whether they can be used directly in the remediation of contaminated soils. This study reveals that resveratrol, a plant secondary metabolite, selectively boosts the degradation of polycyclic aromatic hydrocarbons (PAHs) by endophytic Methylobacterium extorquens C1 (C1) in vitro, while exerting negligible effects on the activity of indigenous soil bacteria. For the first time, a combined application of C1 and resveratrol was employed in the remediation of polycyclic aromatic hydrocarbon (PAH)-contaminated soil. The findings indicate that the sole use of resveratrol failed to promote the removal of PAHs by indigenous soil microorganisms, whereas sole application of C1 boosted Methylobacterium-related PAH-degrading bacterial abundance, enhancing PAH removal, yet concurrently reduced overall soil microbial diversity. The combination of resveratrol and C1 not only stimulated the PAH removal but also mitigated the impact of C1 on the soil microbial community structure when C1 was applied individually. Specifically, the optimal removal efficacy was achieved with a treatment combination of 5 mg kg−1 resveratrol and 1.2 × 107 CFU kg−1 of C1, leading to a 130% and 231% increase in the removal of phenanthrene and acenaphthene, respectively, over a 15 days period. This study proposes a novel approach for the bioremediation of organic-contaminated soil by using the specific biological response of plant endophytic bacteria to secondary metabolites.
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CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Yong Tang,Xiyu Zhang,Zheng Liu,Xiaoya Liu,Xiaojie Li
Epoxy resin is renowned for its admirable comprehensive properties, but its inherent brittleness and poor fire safety severely limit its practical application in high-tech fields. Therefore, improving the fire safety and toughness of epoxy thermosets while maintaining their strength and thermal stability is both urgent and challenging. In this study, a novel hyperbranched polymer (HBPDR-DPP) has been synthesized via a one-pot, two-step process using dichlorodiphenylsilane, resveratrol, and diphenylphosphinic chloride. This polymer was then incorporated into high-performance epoxy thermosets. The resulting thermoset, containing 4 wt% HBPDR-DPP, exhibited an impressive limiting oxygen index (LOI) of 30.2 %, along with a 26.0 % decrease in peak heat release rate (PHRR) and a 10.9 % reduction in total smoke production (TSP) compared to the unmodified epoxy thermoset. These notable improvements can be primarily attributed to the synergistic carbonization effects of the silicon- and phosphorus-containing segments in HBPDR-DPP. Meanwhile, the 4 wt% HBPDR-DPP-modified epoxy thermoset exhibited significant improvements in mechanical properties, with tensile strength, flexural strength, and impact strength increasing by 37.8 %, 54.6 %, and 83.4 %, respectively. These enhancements can be attributed to the hyperbranched structure and the combination of rigid aromatic units with flexible Si-O chains in HBPDR-DPP. Moreover, the EP/HBPDR-DPP thermoset demonstrated excellent thermal stability. This study presents a simple and effective strategy for enhancing both the fire safety and mechanical properties of epoxy thermosets, offering valuable insights for the development of high-performance thermosetting materials.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Juan Huang,Dongchen Liu,Qingding Wang,Mengting Xu,Shennan An,Lanling Chu,Tingxuan Yan
The study developed microcapsules by membrane emulsification and complex coacervation methods with whey protein (WP)-flaxseed gum (FG) and monodiglyceride fatty acids (MFA) to be used for resveratrol (RES) encapsulation. The effects of MFA and WP/FG ratios (1:0–1:0.15) on the properties of microcapsules were investigated. Zeta potential and infrared spectra analysis indicated the possible electrostatic attraction and hydrogen bonding between WP and FG. Fluorescence further confirmed the formation of WP/FG complex coacervates. Confocal laser scanning microscopy, X-ray diffraction and differential scanning calorimetry studies demonstrated that RES dissolved in MFA was encapsulated by the complex of WP and FG. The microcapsules exhibited an appearance of irregular flakes or blocks with folds and a high encapsulation efficiency (EE, > 96 %). MFA and FG increased the EE of RES. In vitro release study displayed that MFA and FG decreased the release rate of RES from the microcapsules. Due to the isolation effect of MFA and the wall materials, microcapsules had good photostability. The antioxidant ability of RES was enormously improved by the complexation with WP and FG. These findings provide an effective carrier to deliver polyphenols like RES and could be useful in the developments of foods and medicine.
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POLYMER
·
2025
·
IF 4.5
Yunran Zhang,Guangjian Dai,Aoyun Kang,Wenjie Yang,Heng Zhang,Chunxiang Wei,San-E Zhu,Hongdian Lu,Bin Yu,Wei Yang
Thiol-ene photocurable resins have demonstrated significant potential for applications in flexible electronic packaging owing to their tunable mechanical properties, low polymerization energy requirements, and excellent dielectric characteristics. However, most of these resins are flammable with lots of fire hazards. To address this issue, we employed resveratrol, rich in aromatic ring structures and hydroxyl functional groups, to synthesize a biomass-derived monomer with carbon-carbon double bonds, namely RST. In addition, eugenol was used to react with hexachlorocyclotriphosphazene (HCCTP), yielding a reactive bio-based flame retardant additive (HECTP). It was cross-linked with pentaerythritol tetrakis(3-mercaptopropionate) (PETMP) containing four thiol groups to prepare RST/4SH/HECTP resins. The results showed that the addition of HECTP remarkably enhanced the char formation ability and self-extinguishing performance. In particular, the total heat release (THR) declined from 19.2 kJ/g for RST/4SH to 13.6 kJ/g for RST/4SH/HECTP10 % with a reduction of 29.2 %. The loading of HECTP also enhanced the tensile strength and storage modulus of RST/4SH due to the improved crosslinking density of RST/4SH/HECTP resins. Moreover, the dielectric constant of RST/4SH was significantly reduced with the addition of HECTP. For RST/4SH/HECTP10 %, there was a dielectric constant of 1.78 that was lower than most reported results, highlighting its potential for electronic packaging materials.
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Phenomics
·
2025
·
IF 6.2
Hu Hongye,Wu Yanzhi,Hong Jingwei,Wang Huiying,Zhang Xiaohua,Huang Guanli,Zhu Xiaofang
Breast cancer (BC) remains the predominant form of cancer among women. Arsenic trioxide (ATO), an element in traditional Chinese medicine, has shown potential for treating BC, particularly when combined with resveratrol. However, the exact mechanisms of their combined action are not fully understood. This study aims to clarify their combined mechanisms through network pharmacology and experimental validation. In vitro experiments confirmed that compared with either agent alone, the combination of ATO and resveratrol more effectively inhibited the production of estrogen receptor 1 ( ESR1 ), tumor protein P53 ( TP53 ), and v-AKT murine thymoma viral oncogene homolog 1 ( AKT1 ) in MCF-7 cells. Our findings indicate that the combination of ATO and resveratrol significantly promotes cell apoptosis by suppressing ESR1 , TP53 , and AKT1 . Thus, ATO and resveratrol together may offer a promising strategy for BC treatment.
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Research
·
2022
·
IF 11.036
Yiqiu Fei,Shuobo Zhang,Shengyi Han,Bo Qiu,Yanmeng Lu,Weixing Huang,Fang Li,Deying Chen,Björn Berglund,Hang Xiao,Lanjuan Li,Mingfei Yao
Currently approved therapeutical strategies for inflammatory bowel diseases (IBD) suffer from variable efficacy and association with risk of serious side effects. Therefore, efforts have been made in searching for alternative therapeutics strategies utilizing gut microbiota manipulation. In this study, we show that the probiotic strain Ligilactobacillus salivarius Li01 (Li01) and the phytochemical prebiotic resveratrol (RSV) have synergistic effect in ameliorating colitis in mice. Oral coadministration of Li01 (10 9 CFU/d) and RSV (1.5 g/kg/d) promoted restoration of various inflammatory injuries and gut microbiota composition, exhibiting a favorable anti-inflammatory effect in DSS-induced colitis mice. The combination treatment was associated with reductions in the levels of proinflammatory cytokines IL-1 β and IL-6 and increases in the levels of the anti-inflammatory cytokine IL-17A in mouse serum. Moreover, the combination treatment was found to alter the composition and metabolism of the gut microbiota, especially influencing the production of short chain fatty acids and anti-inflammatory related molecules. The mechanism underlying the improved anti-inflammatory effect from the RSV and Li01 combination treatment was found to be associated with the environmental sensor mammalian aryl hydrocarbon receptor (AHR) and tryptophan metabolism pathway. Administration of RSV in combination with Li01 in different mouse model led to enhanced conversion of RSV into metabolites, including dihydroresveratrol (DHR), resveratrol-sulfate, and resveratrol-glucuronide. DHR was found to be the dominant metabolite of RSV in conventional and colitis mice. An increased DHR/RSV ratio was confirmed to activate AHR and contribute to an enhanced anti-inflammatory effect. DHR is considered as a potential AHR ligand. The DHR/RSV ratio also affected the serotonin pathway by controlling the expression of Tph1, SERT, and 5-HT 7 R leading to amelioration of colitis in mice. Our data suggest that treatment with a combination of Li01 and RSV has potential as a therapeutic strategy for IBD; further investigation of this combination in clinical settings is warranted.
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BIOMACROMOLECULES
·
2021
·
IF 6.988
Xiang Li,Xian-Xin Chen,Yu Xu,Xian-Bing Xu,Wen-Fei Wu,Qi Zhao,Jiang-Ning Hu
The purpose of this study was to construct a glycogen (Gly)-based nanoparticle (NP) with liver-targeted and redox response to effectively deliver resveratrol (Res) for improving nonalcoholic fatty liver disease (NAFLD). Herein, Gly was modified using α-lipoic acid (α-LA) and lactobionic acid (Lac) to obtain an amphiphilic polymer (Gly–LA–Lac), which was self-assembled in water and then encapsulated in Res to form Res NPs with excellent stability. As expected, the Res NPs exhibited liver-targeted and redox response release behavior. In vitro cell studies demonstrated that the nanocarrier treatment enhanced the cellular uptake of Res and reduced oxidative stress and inflammatory factor levels. Meanwhile, the in vivo tests proved that the nanocarriers effectively reduced hepatic lipid accumulation and oxidative stress levels via regulating the TLR4/NF-κB signal pathway to improve liver damage in NAFLD mice. In conclusion, this study provides a promising strategy through the construction of Gly-based nanocarriers for the encapsulation of Res to effectively alleviate the process of NAFLD.
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Foods
·
2025
·Vol. 14
·期 9
·1610
·
IF 5.1
Jianan Liu,Jinle Ma,Yingrui Wang,Hongshun Hao,Jingran Bi,Hongman Hou,Gongliang Zhang
This study aims to elucidate the synergistic antibacterial mechanism of benzyl isothiocyanate (BITC) and resveratrol (RES) on Staphylococcus aureus ( S. aureus ) at the transcriptional level. Compared with the individuals, the combination of BITC and RES (BITC_RES) reduced S. aureus growth, inhibited biofilm formation, and increased cell membrane disruption. The transcriptomic results showed that the BITC_RES group presented 245 and 1150 more DEGs than the BITC group and the RES group, respectively. In addition, some other key genes in the BITC_RES group, including serine protease ( splA , splE ), Sae regulatory system ( saeR , saeS , tsaE , sau300 ), accessory gene regulator protein C ( agrC ), cysteine protease ( sspB ), glutamyl endopeptidase ( sspA ), and hemolysin toxin family-related genes ( hly , lukDv , lukEv ), and the relative expression of these 12 genes was downregulated by 2.2–259.8-fold, 0.8–259.8-fold and 1.2–158.2-fold greater than those in the BITC group and the RES group, respectively. Finally, a synergistic antimicrobial effect of this combination was also observed in fresh lean beef at 4 °C and 25 °C. These findings provide information for future studies on the synergistic antimicrobial effects of BITC and RES on S. aureus .
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COMPOSITES PART B-ENGINEERING
·
2024
·
IF 12.7
Qiyuan Dai,Maocai Li,Xiyuan Han,Zetao Wang,Yilin Ding,Qi Feng,XiaoYing Wang,Qingtao Li,Xiaodong Cao
Postoperative bone regeneration repair for primary or metastatic bone tumors is often impeded by the adverse effects of chemotherapy treatment. As a low-toxicity therapeutic ion, the efficacy of Zn ions in promoting anti-tumor and bone regeneration outcomes has been demonstrated. However, the potential benefits are limited due to inadequate zinc intake in malignant cells and its anti-tumor mechanism remain unclear. Overcoming these difficulties, we report a new strategy for improving the delivery of Zn ions and antitumor drug by fabricating chitosan (CS) cryogel microspheres to synchronize the loading of resveratrol (Res) and Zn-BG. The Zn ions released from Zn-BG were combined with Res, then transported and enriched intracellularly, inducing apoptosis of tumor cells via multiple pathways. Moreover, the Zn-BG@Res-CS cryogel microspheres exhibited antibacterial and osteogenic effects. In particular, we found that this delivery system significantly inhibited tumor development and metastasis in vivo. Our founding suggests that the combination of Zn ions with Res could enhance cell uptake of Zn ions then induce apoptosis of tumor cells selectively. This study indicates that the combination chemotherapy and biomaterial construction could be a potential therapeutic approach for postoperative regeneration of bone tumor defects.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Jingtao Mei,Xianai Shi,Mingmao Chen,Yanan Cui,Chaoping Fang,Licong Yang
Resveratrol (Res) is a natural polyphenol exhibiting anti-oxidant and anti-inflammatory activity. However, the applications of Res have been limited due to its low stability and water solubility. To enhance the bioaccessibility of Res, unfolding bovine serum albumin-modified selenium nanoparticles (UBSA@SeNPs) encapsulated within chitosan (CS)-coated Pickering emulsions (CS-UBSA@SeNPs-PE) were used to load Res. The results showed that Res-loaded CS(0.06 %)-UBSA@SeNPs-PE has small droplet size (16.13 μm), high gel properties and excellent antioxidant properties. During the simulated digestion process, CS reduced the release rate of Res from Res-loaded CS(0.06 %)-UBSA@SeNPs-PE (42.27 %) to reach a slow release effect. Importantly, Res could quickly release from CS-UBSA@SeNPs-PE within intestinal fluid or in the presence of chitosanase. In simulated absorption experiments, the intestinal permeability of Res in Res-loaded CS(0.06 %)-UBSA@SeNPs-PE were enhanced by 292.31 % compare to Res-loaded CS(0 %)-UBSA@SeNPs-PE. In pharmacokinetic studies, Res-loaded CS(0.06 %)-UBSA@SeNPs-PE had an area under the curve (AUC) up to 3467.99 ± 127.43 ng*h/mL. Furthermore, CS also improved the mucoadhesive nature of UBSA@SeNPs-PE, resulting in a gut-retention time of Res-loaded CS(0.06 %)-UBSA@SeNPs-PE that reached up to 60 h. In conclusion, CS-UBSA@SeNPs-PE can serve as an effective oral delivery system for improving the bioaccessibility of Res.
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