JOURNAL OF MATERIALS SCIENCE
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2019
·Vol. 54
·期 11
·8262-8275
·
IF 3.442
He Zhenglong,Jiang Shuai,An Na,Li Xudong,Li Qifeng,Wang Junwei,Zhao Yuhua,Kang Maoqing
Isophorone diisocyanate-loaded microcapsules were synthesized with controllable size for self-healing of structural polymer materials. The obtained microcapsules showed good compatibility with polymer resins, e.g., one-component epoxy and multi-component polyurethane/water glass structural materials. During the processing of composite self-healing materials, the highly cross-linked composite capsule wall ensured the integrity of microcapsules and prevented the leakage and degradation of reactive liquid isocyanates effectively. A relatively larger amount of self-healing agent could be released to the local cracks with the increasing size and content of microcapsules in polymer matrix which improved the self-healing efficiency of the composites. Based on the microcapsules with a diameter of ~96 μm, the healing efficiency of epoxy composites containing 15 wt% of capsules and polyurethane/water glass composites containing 20 wt% of capsules could reach to 105 and 101% recovery of fracture toughness, respectively. The crack-healing effect was further verified by scanning electron microscopy. Meanwhile, a possible self-healing mechanism of microcapsules to the cracks of composite polymer materials was proposed.
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高影响因子
JOURNAL OF MATERIALS SCIENCE
·
2019
·Vol. 54
·期 11
·8515-8530
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IF 3.442
An Ran,Zhang Baoming,Han Linglin,Wang Xiangdong,Zhang Yulin,Shi Lingying,Ran Rong
Healable, flexible, near infrared sensitive and strain-sensitive for wearable device and healthcare monitoring are successfully formed from sensitive, conductive and biocompatible hydrogels. In this work, a sensitive, mechanically self-healing hydrogel was fabricated via the incorporation of multiwalled carbon nanotubes (MWCNTs) into the hydrophobically associated polyacrylamide hydrogels. As a result, the optimal tensile strength (0.91 MPa) and electrical conductivity (0.5 S m −1 ) were achieved for the PAM/MWCNTs composite hydrogels. Due to its various functions, the cross-linking hydrogel could be made as a strain sensor. The strain sensor achieved a gauge factor of 5.6, and its response time was 0.3 s. It could be stretched at least for 200 cycles, which was further applied to monitor human movement, including movement of the hands, elbow and even swallowing. With excellent mechanical properties, tensile sensitivity and biocompatibility, the prepared hydrogels could be used as a perfect material for electronic skin. At the same time, flexible and healable PAM/MWCNTs hydrogel had a sensitive near-infrared light response, and we create a new flexible and healable near-infrared light-sensitive photosensor because of the incorporation of MWCNTs, which is different from the traditional NIR photosensor. It could be used in NIR detector, medical instrument and health equipment.
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高影响因子
ENDOCRINE
·
2019
·Vol. 64
·期 3
·512-524
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IF 3.296
Liu Xiaohong,Zeng Xin,Chen Xuanming,Luo Ruixi,Li Linzhao,Wang Chengshi,Liu Jingping,Cheng Jingqiu,Lu Yanrong,Chen Younan
Purpose It is demonstrated that unsaturated fatty acids can counteract saturated fatty acids-induced lipotoxicity, but the molecular mechanisms are unclear. In this study, we investigated the protective effects of monounsaturated oleic acid (OA) against saturated palmitic acid (PA)-induced cytotoxicity in rat β cells as well as islets, and mechanistically focused on its regulation on endoplasmic reticulum (ER) stress. Methods Rat insulinoma cell line INS-1E cells and primary islets were treated with PA with or without OA for 24 h to determine the cell viability, apoptosis, and ER stress. SD rats were fed with high-fat diet (HFD) for 16 w, then, HFD was half replaced by olive oil to observe the protective effects of monounsaturated fatty acids rich diet. Results We demonstrated that PA impaired cell viability and insulin secretion of INS-1E cells and rat islets, but OA robustly rescued cells from cell death. OA substantially alleviated either PA or chemical ER stressors (thapsigargin or tunicamycin)-induced ER stress. Importantly, OA attenuated the activity of PERK-eIF2α-ATF4-CHOP pathway and regulated the ER Ca 2+ homeostasis. In vivo, only olive oil supplementation did not cause significant changes, while high-fat diet (HFD) for 32 w obviously induced islets ER stress and impaired insulin sensitivity in SD rats. Half replacement of HFD with olive oil (a mixed diet) has ameliorated this effect. Conclusion OA alleviated PA-induced lipotoxicity in INS-1E cells and improved insulin sensitivity in HFD rats. The amelioration of PA triggered ER stress may be responsible for its beneficial effects in β cells.
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PubMed
高影响因子
Journal of Natural Medicines
·
2019
·Vol. 73
·期 2
·388-396
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IF 1.966
Wang Lei,Cao Fei,Zhu Li-li,Liu Peng,Shang Yu-ru,Liu Wen-hui,Dong Xin,Bao Hai-dong,Gong Peng,Wang Zhong-yu
To investigate if andrographolide impairs cholestatic liver injury. All rats were randomly divided into six groups—(1) control ( n = 6), (2) control + 200 mg/kg andrographolide ( n = 6), (3) alpha-naphthylisothiocyanate (ANIT)-control ( n = 6), (4) ANIT + 50 mg/kg andrographolide ( n = 6), (5) ANIT + 100 mg/kg andrographolide ( n = 6), and (6) ANIT + 200 mg/kg andrographolide ( n = 6). We gavaged 50 mg/kg ANIT to mimic cholestatic liver injury in rats. Seven days after treatment, all the rats were killed. Serum biochemistry and hepatic histopathological assays were performed to evaluate liver injury. We observed that 200 mg/kg andrographolide significantly decreased the level of alanine transaminase, aspartate aminotransferase, alkaline phosphatase, γ-glutamyltranspeptidase, total bilirubin, and total bile acid in the blood. It also markedly decreased hepatic interleukin-6 and tumor necrosis factor α. Furthermore, 200 mg/kg andrographolide significantly decreased malondialdehyde but increased superoxide dismutase, glutathione, and erythrocyte glutathione peroxidase. Moreover, 200 mg/kg andrographolide effectively increased the accumulation of sirtuin 1 and nuclear erythroid 2-related factor-2. It also attenuated the level of nuclear factor kappa-light-chain-enhancer of activated B and cyclooxygenase-2. These data suggest that andrographolide may impair cholestatic liver injury via anti-inflammatory and anti-oxidative stress.
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PubMed
高影响因子
Natural Products and Bioprospecting
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2019
·Vol. 9
·期 3
·201-208
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IF 0
Liu Qi,Chi Quan,Fan Ru-Ting,Tian Hui-Dong,Wang Xian
Abstract A sensitive and rapid high performance liquid chromatography–mass spectrometry (HPLC–MS) method was developed and validated for simultaneous quantification of ten steroid hormones, including estrogens, androgens, progesterones, and corticosteroids four classes of steroids. The following ten steroid hormones were analyzed: progesterone, 21-deoxycortisol, estrone, 4-androstenedione, testosterone, dihydro-testosterone, androstenone, dehydroepiandrosterone, corticosterone and cortisone. Stable deuterated isotopes were used as internal standards for quantification. Sample preparation with and without derivatization were performed after liquid–liquid extraction, and the corresponding results were compared according to sensitivity and selectivity. Hydroxylamine derivatization was found to improve the ionization efficiency of the analytes for electrospray ionization MS analysis. The gradient of mobile phase and experimental parameters for HPLC separation were optimized. The lower limits of quantification were in the range of 0.05–5 ng mL −1 with wide linear range for the ten steroid hormones. The intra-day precision < 11.1% and recovery of 84.5–120% with negligible matrix effect were achieved, where within the acceptance limits of the FDA guideline. Total HPLC–MS analysis time was 6 min. This method enables simultaneous quantification of steroids in human serum. It will be helpful for the serum steroid profiling in order to understand various endocrinology diseases. Graphical Abstract
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PubMed
Nano-Micro Letters
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2019
·Vol. 11
·期 1
·1-13
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IF 9.043
Zhao Shuai,Sun Shan,Jiang Kai,Wang Yuhui,Liu Yu,Wu Song,Li Zhongjun,Shu Qinghai,Lin Hengwei
Multifunctional nanocarrier-based theranostics is supposed to overcome some key problems in cancer treatment. In this work, a novel method for the preparation of a fluorescent mesoporous silica–carbon dot nanohybrid was developed. Carbon dots (CDs), from folic acid as the raw material, were prepared in situ and anchored on the surface of amino-modified mesoporous silica nanoparticles (MSNs–NH 2 ) via a microwave-assisted solvothermal reaction. The as-prepared nanohybrid (designated MSNs–CDs) not only exhibited strong and stable yellow emission but also preserved the unique features of MSNs (e.g., mesoporous structure, large specific surface area, and good biocompatibility), demonstrating a potential capability for fluorescence imaging-guided drug delivery. More interestingly, the MSNs–CDs nanohybrid was able to selectively target folate receptor-overexpressing cancer cells (e.g., HeLa), indicating that folic acid still retained its function even after undergoing the solvothermal reaction. Benefited by these excellent properties, the fluorescent MSNs–CDs nanohybrid can be employed as a fluorescence-guided nanocarrier for the targeted delivery of anticancer drugs (e.g., doxorubicin), thereby enhancing chemotherapeutic efficacy and reducing side effects. Our studies may provide a facile strategy for the fabrication of multifunctional MSN-based theranostic platforms, which is beneficial in the diagnosis and therapy of cancers in future.
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PubMed
高影响因子
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
·
2019
·Vol. 26
·期 15
·15710-15723
·
IF 2.914
Wang Yuxiong,Rao Lei,Wang Peifang,Guo Yong,Guo Xiang,Zhang Lixin
In order to overcome photocatalytic technology application limitations in water due to weak light intensity, it is crucial to synthesize photocatalysts that respond to weak light. In this study, porous and oxygen-doped carbon nitride (CN-MC) was synthesized via supramolecular preassembly technology using melamine and cyanuric chloride. The carbon nitride catalyst produced via this technology has a relatively high surface area (63.2 m 2 g −1 ), irregular pores, and oxygen doping characteristics, which enhance the light capture capacity, increase the number of reactive sites, and accelerate electron–hole separation efficiency. Thus, the CN-MC exhibited excellent photocatalytic activity during the degradation of organic pollutants Rhodamine B (RhB, 95% removal within 6 h) and tetracycline hydrochloride (TC-HCl, 70% removal within 6 h) under low-intensity light (the light intensity = 0.8~1.8 mW cm −2 with a wavelength range of 300–700 nm). Mechanistic analysis showed that ·O 2 − and ·OH were the dominant active free radicals during RhB and TC-HCl photocatalytic degradation over CN-MC. The proposed synthesis strategy effectively improves the photocatalytic activity of graphite carbon nitride under weak light by producing a porous morphology and oxygen atom doping.
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高影响因子
SN Applied Sciences
·
2019
·Vol. 1
·期 5
·1-10
·
IF 0
Wang Longlong,Weng Yujing,Duan Peigao,Liu Xianyun,Wang Xiaolong,Zhang Yulong,Wang Chenguang,Liu Qiying,Ma Longlong
Sorbitol was reported as one promising platform compounds as a C6 sugar related derivative from biomass cellulose due to its high oxygen content with six hydroxyl groups. Our previous work has reported the selective hydrodeoxyenation (HDO) of sorbitol into long alkanes such as pentane and hexane (C5/C6) over carbon supported ruthenium-molybdenum catalysts. Here, the effect of acidic pretreatments of those carbon catalysts on the performance of HDO reaction was studied in detailed. The result indicated that carbon support pretreated by phosphoric acid presented much phosphorus groups, but the carbon support pretreated by nitric acid presented high graphitization degree. Moreover, the phosphoric acid pretreated catalyst (RuMo/C–P) obtained high HDO performance in the sorbitol conversion with 79.7% carbon yield of C5/C6 alkane (pentane and hexane). Finally, detailed characterizations (N 2 -adsorption, XRD, HRTEM, XPS, XRF, Raman, NH 3 -TPD, Py-IR spectrums, etc.) were performed over relevant catalysts for correlating their catalytic and physicochemical properties.
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RARE METALS
·
2019
·Vol. 38
·期 5
·379-389
·
IF 1.785
Ji Jia-Hui,Xiao Yi-Fei,Shen Bin,Yi Qiu-Ying,Zhang Jin-Long,Xing Ming-Yang
The recovery of heterogeneous catalysts can save costs and avoid secondary pollution, but its separation efficiency and recovery cost are limited by conventional separation methods such as precipitation–flocculation, centrifugation and filtration. In this paper, we found that surface-defective metal sulfides/oxides (WS 2 , CuS, ZnS, MoS 2 , CdS, TiO 2 , MoO 2 and ZnO) commonly used in advanced oxidation processes (AOPs) could be magnetically recovered at room temperature and atmospheric pressure by mechanically mixing with Fe 3 O 4 . Zeta potential, Raman, X-ray photoelectron spectroscopy (XPS) and electro-spin resonance (ESR) spectra were measured to explore the mechanism of the magnetic separation phenomenon. The exposed active metal sites on the surface of defective metal sulfides/oxides are beneficial for the formation of chemical bonds, which are combined with electrostatic force to be responsible for the magnetic separation. Moreover, other factors affecting the magnetic separation were also investigated, such as the addition of amount of Fe 3 O 4 , different solvents and particle sizes. Finally, WS 2 was chosen to be applied as a co-catalyst in Fenton reaction, which could be well separated by the magnetic Fe 3 O 4 to achieve the recycle of catalyst in Fenton reaction. Our research provides a general strategy for the recycle of metal sulfides/oxides in the catalytic applications.
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高影响因子
IONICS
·
2019
·Vol. 25
·期 7
·3107-3119
·
IF 2.289
Lu Qinghua,Zhu Qinglin,Guo Weimin,Li Xiaoman
Lithium–sulfur (Li–S) battery is one of the most promising next-generation energy storage devices due to its high-capacity density and low cost. However, lithium–sulfur batteries could not be widely used in a large range due to the “shuttle effect” and sulfur insulation. Herein, we proposed a novel composite cathode of carbon nanotubes@manganese dioxide@sulfur@polypyrrole (C@MnO 2 @S@PPy). X-ray diffraction (XRD), scanning electron microscope (SEM), and transmission electron microscopy (TEM) BET analysis show that sulfur filled into the pores of C@MnO 2 , and PPy was successfully coated on C@MnO 2 @S. TG indicated that the compound contained 60 wt% active sulfur. The prepared cathode of C@MnO 2 @S@PPy composites shows excellent rate performance and cycle stability. At a high rate of 1C, its maximum discharge capacity reached 1218 mA h g-1 and its average capacity decreasing rate was only 0.096%/cycle when running over 500 cycles. The interaction mechanism of MnO 2 with polysulfides was investigated by adsorption tests and XPS analysis. The excellent electrochemical performance might be due to a combination of adsorption or catalytic properties of MnO 2 and the conductivity of carbon materials and PPy.
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高影响因子
IONICS
·
2019
·Vol. 25
·期 7
·3189-3196
·
IF 2.289
Wang Ping,Zhou Yiyang,Xu Pei,Ding Yunsheng
Dielectric relaxation spectroscopy (DRS) was used to investigate the effect of morphological evolution on conductivity behavior of PLA/PCL blends containing P[MPEGMA-IL]. The morphology of blends changes from sea-island morphology into co-continuous morphology with increasing P[MPEGMA-IL] content. P[MEPGMA-IL] could mainly localize in PCL domains and expand to the interface layer between the PLA and PCL phase because of the low viscosity of PCL phase and the high affinity of MEPGMA groups for both polymer phases. The dielectric results were discussed in terms of α relaxation that corresponds to normal and segmental mode movement, interfacial polarization that corresponds to interfacial aggregation of charge carriers, and ac conductivity that originates from conductive network of mobile charge carriers. Co-continuous morphology and high ions concentration lead to the enhancement of segment movement and ion conductive channel in PCL phase, which correspond to high conductivity and low activation energy of PLA/PCL/8P[MEGMA-IL] blend.
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高影响因子
Journal of Inorganic and Organometallic Polymers and Materials
·
2019
·Vol. 29
·期 4
·1154-1159
·
IF 1.637
Tang Qingjie,Wu Wenrong,Zhang Huoli,Luo Junzhi,Zhang Bingyao,Guo Xiangkun,Jia Jianbo,Cao Jianliang
The cauliflower-like AgBr/Ag 3 PO 4 /sulfonated polystyrene sphere (SPS) heterojunction photocatalyst was prepared using wastewater containing silver ion and SPS as raw materials via in situ ion change method. The AgBr/Ag 3 PO 4 /SPS photocatalyst was characterized by field emission scanning electron microscopy, X-ray diffraction and UV–Vis diffuse reflectance spectra (UV–Vis DRS). The results showed that AgBr nanoparticles and Ag 3 PO 4 nanoparticles are highly dispersed on the surface of sulfonated polystyrene. And the heterogeneous junction structures are also formed between AgBr and Ag 3 PO 4 , which is benefit for the separation of photogenerated electrons and holes. Hence, the AgBr/Ag 3 PO 4 /SPS photocatalyst had an excellent activity for photocatalytic degradation of rhodamine B (RhB) in water under visible light irradiation. The cyclic test results showed that the AgBr/Ag 3 PO 4 /SPS photocatalyst also had a good stability.
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高影响因子
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