JOURNAL OF ALLOYS AND COMPOUNDS
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2022
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IF 6.371
Xilei Xie,Peng Xiao,Liang Pang,Peng Zhou,Yangjie Li,Jian Luo,Jiangzhi Xiong,Yang Li
The low cost and high performance via a simple way of fabrication are considerable challenges for Si-based anode in the application of lithium-ion batteries. In this study, we synthesize a novel free-standing Si/C anode, consisting of yolk (Si)-shell (amorphous carbon) nanoparticles and carbon nanofibers (denoted as Si@void@C/CNFs), via a facile route of template removal and electrospun. The designed yolk-shell structure help buffer the volume expansion of silicon during the discharge/charge cycles, and the intertwined CNFs are conducive to electron fast transmission and guarantee structural integrity. As expected, with a low Si content (∼23 wt%), the self-supporting electrode of Si@void@C/CNFs exhibits a high specific capacity of ∼627.5 mAh g −1 as well as 69.3% capacity retention at 0.1 A g −1 after 100 cycles, better than Si@C/CNFs (20%) and Si/CNFs (9.5%) electrodes. The superior performance of Si@void@C/CNFs indicates that it is an attractive anode material for the practical application of Lithium-ion batteries.
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INDUSTRIAL CROPS AND PRODUCTS
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2022
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IF 6.449
Dongxue Cao,Enwei Wei,Zeyu Wang,Zhengyu Hu,Ling Qi,Hongli Zhou,Jingli Zhao
This paper aimed to elaborate the chemical characteristics of ginseng polysaccharide via chemical methods and instrumental analyses; additionally, the anti-glioma activity and immunostimulatory capacity were also evaluated via biological experiments. Ginseng polysaccharide by microwave-assisted extraction (MEGP) method was purified by spongiform diethylaminoethyl cellulose (DEAE) and further separated by DEAE-52 column chromatography to obtain four MEGP fractions (MEGP-0, MEGP-1, MEGP-2, MEGP-3). Utilizing Zeta potential analyzer and X-ray photoelectron spectroscopy (XPS), MEGPs were, for the first time, confirmed the valence state of C and O with the binding mode of elements, and all MEGP fractions contained triple-helix structure. MEGP-2 and MEGP-3 significantly reduced the cell growth rate of TJ905 and U87 , showing an inhibitory effect on glioma. Among four fractions, MEGP-2 markedly elevated the immunostimulatory capacity via the activation of MAPK signaling route, with an increasing the expression levels of p-p38, p-ERK and p-JNK. In summary, this paper laid a solid foundation for the development of ginseng, as a promising drug or tonic, in the fields of anti-glioma and immunoregulation.
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Science Bulletin
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2026
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IF 20.7
Mengxiao Li,Haiping Yu,Lingli Chen,Yu Li,Xinyu Wang,Huijie Wang,Qi Zhou,Xiangxu Cheng,Mingjun Hu,Jun Yang
Developing high-performance aqueous alkaline batteries for extreme environments remains a formidable challenge. Herein, we report a triamino-substituted hexaazatrinaphthalene (HATN-3NH 2 ) as a tailor-made anode for alkaline systems. Unlike hydroxyl-functionalized analogues that suffer from rapid dissolution in alkaline electrolytes, the amino group ensures exceptional chemical stability while its electron-donating nature effectively lowers the redox potential to −1.12 vs. Hg/HgO. Crucially, the introduced amino groups construct a robust intermolecular hydrogen-bond network that significantly enhances reaction kinetics and preserves ionic conductivity at ultra-low temperatures, a feature absent in unmodified hexaazatrinaphthalene (HATN), which exhibits rapid performance decay in cold conditions. Consequently, the HATN-3NH 2 //Ni(OH) 2 full cell delivers a specific capacity of 254.8 mAh g −1 at 0.5 A g −1 , a high discharge plateau (1.24 V), and outstanding cycling stability (39,000 cycles). Most notably, the battery demonstrates record-breaking low-temperature adaptability, delivering a high specific capacity of 185 mAh g −1 at −80 °C and 0.1 A g −1 , with stable cycling for over 1500 cycles, which represents the best reported performance for aqueous alkaline batteries to date. This work elucidates the irreplaceable role of amino functionalization in simultaneously achieving low potential, high stability, and cold tolerance, providing a precise molecular design strategy for extreme-environment energy storage. Amino-functionalized HATN forms robust hydrogen-bonding networks, enabling fast ion transport at ultra-low temperatures. Paired with an antifreeze KOH electrolyte, the full cell achieves record −80 °C performance, delivering 185 mAh g −1 at 0.1 A g −1 and stable cycling over 1500 cycles. Download: Download high-res image (151KB) Download: Download full-size image
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NEW CARBON MATERIALS
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2026
·Vol. 41
·期 4
·1054-1067
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IF 7.2
Sheng Wang,Zhijia Chen,Xiao Wang,Chunhua Yuan,Songbo Li,Huimin Yang
Adipic acid is widely used in fine chemical synthesis, biomedicine and other industrial fields, and is a key monomer for the synthesis of nylon-6,6 and nylon-6. Industrially, it is produced by the efficient catalytic oxidation of cyclohexane. However, the activation of the inert C―H bonds in cyclohexane remains a major challenge in the highly selective synthesis of acid products. Using a composite catalyst of copper on a carbon support produced from wood chip biomass, a green catalytic system was established for the one-pot oxidative synthesis of adipic acid from cyclohexane. Wood chips has two functions during pyrolysis: it acts as a carbon support precursor and an in-situ reducing agent, which reduces Cu 2+ into Cu/Cu 2 O active species to obtain Cu/Cu 2 O@C composite catalysts. The abundant defects in biomass carbon form strong coordination interactions with the copper active components, which effectively regulate the electronic distribution of active sites and improve the catalytic performance. Under optimized conditions (100 °C, 12 h), the Cu/Cu 2 O@C-0.1 catalyst achieves a cyclohexane conversion of 19.36% and an adipic acid selectivity of 73.28%. Mechanistic investigations show that the electronic interaction between the biomass carbon support and the copper species strengthens the adsorption of cyclohexanone, which is critical for promoting the selective formation of adipic acid. This study provides a viable strategy for developing eco-friendly, low-cost and high-efficiency advanced catalytic materials. Download: Download high-res image (138KB) Download: Download full-size image
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EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
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2012
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IF 3.346
Lianbao Ye,Yuanxin Tian,Zhonghuang Li,Hong Jin,Zhengguang Zhu,Shanhe Wan,Junyan Zhang,Pengjiu Yu,Jiajie Zhang,Shuguang Wu
Deregulation of receptor tyrosine kinase c-Met has been reported in human cancers and is considered as an attractive target for small molecule drug discovery . In this study, a series of spiro[indoline-3, 4′-piperidine]-2-ones were designed, synthesized and evaluated as novel c-Met inhibitors. The results showed that the majority of the compounds exhibited significant inhibitory effect on c-Met with IC 50 values of 0.0147–17 μM in TR-FRET-based assay and IC 50 values of 1.56–1400 μM in cell-based assay. Furthermore, our docking experiments verified the results and explained the molecular mechanism of eminent activities to c-Met.
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EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
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2016
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IF 3.902
Hong-Jin Tang,Xiao-Wei Zhang,Lin Yang,Wei Li,Jia-Huang Li,Jin-Xin Wang,Jun Chen
Xanthine oxidase (XO) is the key enzyme in humans which is related to a variety of diseases such as gout, hyperuricemia and cardiovascular diseases. In this work, a series of 2-arylbenzo[ b ]furan derivatives were synthesized based on salvianolic acid C, and they were evaluated for xanthine oxidase inhibitory and antioxidant activities. Compounds 5b , 6a , 6e and 6f showed potent xanthine oxidase inhibitory activities with IC 50 values ranging from 3.99 to 6.36 μM, which were comparable with that of allopurinol . Lineweaver-Burk plots analysis revealed that the representative derivative 6e could bind to either xanthine oxidase or the xanthine oxidase-xanthine complex, which exhibited a mixed-type competitive mechanism. A DPPH radical scavenging assay showed most of the hydroxyl-functionalized 2-arylbenzo[ b ]furan derivatives possessed the potent antioxidant activity, which was further validated on LPS-stimulated RAW 264.7 macrophages model. The structure-activity relationships were preliminary analyzed and indicated that the structural skeleton of 2-arylbenzo[ b ]furan and phenolic hydroxyl groups played an important role in maintaining xanthine oxidase inhibitory effect and antioxidant property for the series of derivatives. Meanwhile, molecular docking studies were performed to further confirm the structure-activity relationships and investigate the proposed binding mechanisms of compounds 5d , 6d and 10d binding to the protein.
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INTERNATIONAL JOURNAL OF PHOTOENERGY
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2012
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IF 1.769
Quan Gu,Huaqiang Zhuang,Jinlin Long,Xiaohan An,Huan Lin,Huaxiang Lin,Xuxu Wang
The C-doped CdO photocatalysts were simply prepared by high-temperature solid-state process. The as-prepared photocatalysts were characterized by X-ray powder diffraction (XRD), diffuse reflectance spectroscopy (UV-Vis DRS), scanning electron microscopy (SEM) and X-ray photoelectron spectroscopy (XPS). The results demonstrated that the carbon was doped into CdO, resulting in the red-shift of the optical absorption of CdO. The photocatalytic behavior of CdO and C-doped CdO was evaluated under the visible light irradiation by using the photocatalytic hydrogen evolution as a model reaction. The C-doped CdO photocatalysts had higher photocatalytic activity over parent CdO under visible light irradiation. The results indicated that the H2 production was due to the existence of CdS and the enhancement of visible light photocatalytic activity of H2 production was originated from the doping of carbon into the CdO lattice. The probably reaction mechanism was also discussed and proposed.
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APPLIED SURFACE SCIENCE
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2023
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IF 6.7
Lei Zhuang,Mingyuan Jian,Ruifang Xue,Nan Li,Jie Chen,Yanghe Fu,De–Li Chen,Weidong Zhu,Fumin Zhang
Developing efficient heterogeneous catalysts for the aerobic oxidation of C–H bonds using oxygen molecule as an oxidant to produce value–added aryl ketones is a challenging task. In this study, a series of cementite–iron–carbon composites (referred to as Fe–C–T, where T represents the pyrolysis temperature) were synthesized using a metal–organic–framework–mediated sacrificial template strategy. The Fe–C–T composites consist of highly dispersed Fe/(Fe 3 C or Fe 2 O 3 ) nanoparticles surrounded by graphitic carbon on porous carbon supports. Under mild reaction conditions (1 atm of O 2 pressure, 353 K, 12 h), with tert–butyl hydroperoxide (0.25 equiv.) as the initiator in a green solvent water, the prepared Fe–C–973 achieved a high conversion of 98.4 % for ethylbenzene and a selectivity of 98.7 % for acetophenone . This performance was markedly superior to the comparable Fe–C–873 and Fe–C–1073, as well as the commercially available Fe–based catalysts. Kinetic studies revealed that the catalytic system followed first–order kinetics for the substrate ethylbenzene, and the activation energy over Fe–C–973 was remarkably low of 40.4 kJ/mol. The highly distributed Fe 3 C nanoparticles embedded in the porous carbon framework were identified as the most active sites for the reaction.
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APPLIED SURFACE SCIENCE
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2023
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IF 6.7
Jun Cong,Shao-hua Luo,Peng-yu Li,Xin Yan,Li-xiong Qian,Sheng-xue Yan
Na 3 V 2 (PO 4 ) 3 (NVP) has become a hot material in the research field of sodium-ion batteries (SIBs) as a result of its unique structural advantages. Unfortunately, the poor electronic conductivity and ion diffusion ability fundamentally limit the practical development of NVP. Considering the above defects, a series of Li + doped Na 3−x Li x V 2 (PO 4 ) 3 /C cathode materials for SIBs are synthesized through hydrothermal assisted sol–gel method. The cell volume steadily decline with the raise of Li + doping amount, which is consistent with the usual doping effect. Moreover, with the increase of lithium doping amount, Li + preferentially occupies Na (2) site and then occupies Na (1) site. Through the first principles calculation, it is clear that the introduction of Li + can significantly reinforce the conductivity of the material system and diminish the electron localization phenomenon. The analysis of (1 1 6) crystal plane by TEM shows that Li doping will reduce the interplanar spacing. The change of V valence during the charge–discharge process of Na 2.8 Li 0.2 V 2 (PO 4 ) 3 /C is consistent with that of NVP by V element XANES characterization. There is no conventional phase transition phenomenon in the ex-situ XRD high-voltage charging state. The above facts indicate that lithium doping obtains a stable solid solution NVP. The electrochemical test results show that Na 2.8 Li 0.2 V 2 (PO 4 ) 3 /C can provide an amazing reversible capacity of 116.9 mAh/g (theoretical capacity of 117 mAh/g) and capacity retention rate of 99.82 % after 500 cycles. GITT results show that Li + can significantly increase the Na + diffusion coefficient of the material. Such excellent electrochemical performance is attributed to the fact that the doping of Li + activates the activity of Na + in Na (2) site and improves the reaction efficiency.
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SOLVENT EXTRACTION AND ION EXCHANGE
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2023
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IF 2
Dong Cao,Shuai Wang,Xin Ma,Jia Yang,Hong Zhong
Herein, a novel C=O–NOH-contained compound was synthesized and used in the extraction and recovery of copper from sulfate solution. Dodecyl phenyl ethyl hydroxamic acid (DPEHA) exhibited high selectivity to Cu(II) over the competing ions, and the separation factors (β) obtained were βCu/Zn = 227.370, βCu/Co = 199.094, βCu/Ni = 188.889, respectively. The separation effect was stronger than that of 2-hydroxy-5-nonyl acetophenone oxime. Meanwhile, extraction capacity of 0.10 g Cu(II) per gram DPEHA was reached, and the extracted Cu(II) can be stripped effectively. The investigation of extraction mechanism revealed that O atoms in C=O and O-H groups of DPEHA operate as active sites, which could powerfully chelate with Cu(II) by forming stable five-membered rings. The high copper extraction efficiency and selectivity associated with a simple synthesis of DPEHA make it to serve as the potential selective Cu(II) extractant, which also provide a novel insight for the research and development of economical Cu(II) extractants.
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PHYTOMEDICINE
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2023
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IF 7.9
Qi-Rui Hu,Qing-Xin Huang,Huan Hong,Yao Pan,Ting Luo,Jing Li,Ze-Yuan Deng,Fang Chen
s Background Liver cancer is a topical global health issue. The treatment of liver cancer meets significant challenges in the high recurrence rate and invasive incidence. Therefore, the treatment strategies that target epithelial-mesenchymal transition (EMT) induced by cyclooxygenase 2 (COX2)/ prostaglandin E2 (PGE2) pathway have become epidemic. Ginsenoside Rh2 has been proved to inhibit the EMT. However, the underlying mechanisms remain unclear. Moreover, the octyl ester derivative of Rh2 (Rh2-O) exhibited superior anti-proliferative and immunomodulatory effects than Rh2 in our previous researches, which indicated that Rh2-O might also exert inhibitory effects on invasion and metastasis . Purpose The aim of current study is to explore the inhibitory effects of Rh2 and Rh2-O on invasion and metastasis of hepatocellular carcinoma , and to investigate whether these effects are dependent on the c-Jun/COX2/PGE2 pathway. Study Design The Huh-7 liver cancer cells and the H22 tumor-bearing mice were treated with Rh2 and Rh2-O. Method In this paper, the inhibitory effects of Rh2 and Rh2-O on invasion and metastasis were tested by wound healing, trans-well assay and tumor-bearing mice, and the involvement of c-Jun/COX2/PGE2 pathway were verified by exogenous PGE2, activation of COX2 and overexpression of c-Jun. Results The results showed that Rh2 and Rh2-O could efficiently inhibit the invasion and metastasis in a dose-dependent manner ( p < 0.05). And the Rh2-O showed stronger effects than Rh2. Moreover, the exogenous PGE2, activation of COX2 by exogenous LPS and the overexpression of c-Jun by transfection all reversed the inhibitory effects of Rh2 and Rh2-O on metastasis or EMT ( p < 0.05). Conclusion Rh2 and Rh2-O could inhibit the invasion and metastasis of hepatocellular carcinoma via restraining the EMT, which was mediated by c-Jun/COX2/PGE2 pathway.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2023
·
IF 9.9
Dehong Huang,Shanglan Wu,Yi Wang,Zhenbao Zhang,Dengjie Chen
Lowering the operating temperatures of solid-oxide fuel cells (SOFCs) is critical, although achieving success in this endeavor has proven challenging. Herein, Bi 0.15 Sr 0.85 Co 0.8 Fe 0.2 O 3−δ (BiSCF) is systematically evaluated as a carbon dioxide (CO 2 )-tolerant and highly active cathode for SOFCs. BiSCF, which features Bi 3+ with an ionic radius similar to Ba 2+ , exhibits activity (e.g., 0.062 Ω cm 2 at 700 °C) comparable to that of Ba 0.5 Sr 0.5 Co 0.8 Fe 0.2 O 3−δ and PrBaCo 2 O 5+δ , while demonstrating a considerable advantage over Bi-doped cathodes. Moreover, BiSCF exhibits long-term stability over a period of 500 h, and an anode-supported cell with BiSCF achieves a power density of 912 mW cm −2 at 650 °C. The CO 2 -poisoned BiSCF exhibits quick reversibility or slight activation after returning to normal conditions. The exceptional CO 2 tolerance of BiSCF can be attributed to its reduced basicity and high electronegativity , which effectively restrict surface Sr diffusion and hinder subsequent carbonate formation. These findings highlight the substantial potential of BiSCF for SOFCs operating below 700 °C.
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