MICROCHIMICA ACTA
·
2019
·Vol. 186
·期 6
·1-8
·
IF 5.479
Li Chunmei,Zheng Youkun,Ding Hongwei,Jiang Hui,Wang Xuemei
We report on the synthesis of chromium(III)-doped carbon dots (Cr-CDs) by one-pot hydrothermal pathway using tris(2, 4-pentanedionato) chromium(III) and polyethyleneimine as precursors. The Cr-CDs have a graphene-analogous structure and display blue-green fluorescence with excitation/emission maxima at 350/466 nm, a 20% quantum yield, and excitation-independent emissions. Their cytotoxicity is low. The Cr-CDs were used as a fluorescence probe for p -nitrophenol ( p -NP). The assay has a linear working range that extends from 0.8~150 μM and a 0.27 μM lower detection limit. The assay was applied to the detecting of p -NP in spiked human urine, and conceivably may be extended to a method for the determination of parathion.
Schematic presentation for the synthesis of Cr-CDs (chromium(III)-doped carbon dots) and their application to the fluorometric determination of p -NP ( p -nitrophenol) based on an inner filter effect.
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IONICS
·
2019
·Vol. 25
·期 8
·3859-3866
·
IF 2.289
Bao Wentao,Tian Hua,Jiang Yang,Zhu Kaixin,Zhang Runa,Tan Yu,Li Wang,Yu Zhifeng,Wang Lin
Ni–Al layered double hydroxide with nitrate anions as interlayer building blocks was synthesized by a dual-anion intercalating strategy of hydroxyl and nitrate anions during a facile co-precipitation process. In this case, nitrate anions with low charge densities are capable to expand the interplanar spacing between host layers of Ni–Al layered double hydroxide in the replacement of pristine carbonate anions, benefiting to the diffusion of electrolyte ions to active sites within electrodes. Moreover, the optimization for packed arrangement of Ni–Al layered double hydroxide with nitrate anions nanosheets can be effectively realized by modulating reactant concentrations, leading to the formation of nanolayered structure in favor of increasing electrolyte accessible active sites within electrodes. The optimized Ni–Al layered double hydroxide with nitrate anions achieves a high specific capacitance of 1616 F g −1 at 1 A g −1 together with a capacitance retention of 82% at 10 A g −1 and good cycling stability.
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MICROCHIMICA ACTA
·
2019
·Vol. 186
·期 9
·1-8
·
IF 5.479
Zou Bin,Cheng Hongying,Tu Yifeng
An electrochemiluminescence (ECL) immunosensor was fabricated to detect myoglobin in human serum. Specifically, gold nanoparticles and platinum nanowires were deposited onto indium tin oxide-coated glass with 3-aminopropyl-trimethoxysilane as the linker to fabricate a basal electrode. The gold nanoparticles had a diameter of approximately 5 nm, and the platinum nanowires had diameters of approximately 2–3 nm and lengths on the order of dozens of nanometers. The nanomaterials effectively enhanced the ECL of luminol and enabled it to emit strong light, even in a weakly basic environment. A myoglobin antibody was then covalently immobilized on the electrode. Upon formation of the immunocomplex, the intensity of the luminol ECL was reduced. Under the optimized experimental conditions, the intensity of the ECL linearly decreased with the logarithm of the myoglobin concentration over the range of 3.0 ng·mL −1 to 0.32 μg·mL −1 , and the detection limit was 0.11 ng·mL −1 .
Schematic of an electrochemiluminescent immunosensor for myoglobin using gold nanoparticles and platinum nanowires as supporting matrix on indium tin oxide coated glass. It can detect myoglobin in human serum with a detection limit of 0.11 ng·mL −1 and high selectivity.
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MICROCHIMICA ACTA
·
2019
·Vol. 186
·期 8
·1-8
·
IF 5.479
Chen Ya-Shun,Xiao Hua-Ming,Wang Tian-Qi,Yu Lei,Feng Yu-Qi
A MALDI-TOF mass spectrometric method is described for the determination
of small molecule compounds with cis-diol. It is based on the use of a binary matrix
consisting of boron nitride (BN) and α-cyano-4-hydroxycinnamic acid that was
modified with the derivatization reagent of (3-(acridin-9-ylamino)phenyl)boronic
acid which can recognize cis-diols. The binary matrix is used for
desorption/ionization (DI) in the positive ion mode. The mechanism leading to DI
enhancement was investigated. The results imply that BN is beneficial for the DI
because it induces an enhancement in the positive ion mode. The boronic
acid-functionalized binary matrix was successfully applied to capture the glucose,
shikimic acid and quinic acid. The method was applied to the determination of
3-chloro-1,2-propanediol in plant oil.
Schematic representation of a method for detecting the
cis-diol compounds on matrix assisted laser desorption/ionization
time-of-flight mass spectrometry (MALDI-TOF MS) using the binary
matrix of boron nitride (BN)/α-cyano-4-hydroxycinnamic acid (CHCA)
that was modified with (3-(acridin-9-ylamino)phenyl) boronic acid
(AYPBA).
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MICROCHIMICA ACTA
·
2019
·Vol. 186
·期 8
·1-8
·
IF 5.479
Qin Zucheng,Jiang Yanxiao,Piao Huilan,Tao Shuo,Sun Ying,Wang Xinghua,Ma Pinyi,Song Daqian
Halloysite nanotubes (HNTs) were functionalized with gold nanoparticles. The morphology and structures of this composite were characterized by Fourier transform infrared spectroscopy, scanning electron microscopy, powder X-ray diffraction, and surface area and pore-size analyses. The material was employed, in conjunction with a syringe pump and an organic filter head, to the enrichment of five triazines (atrazine, desmetryn, prometorn, tebumeton, ametryn) in spiked rice samples. Several parameters that may affect the extraction efficiencies, including type and volume of extraction solvent, amount of sorbent, times of ultrasonic extraction and adsorption, volume and flow rate of elution solvent, were optimized. Following elution with acetonitrile, the herbicides were quantified by using HPLC. Under the optimum conditions, the LODs of the method, when applied to spiked rice samples, are the range from 0.06 to 1.32 ng g −1 (LODs = 3SD/k). The relative intra-day and inter-day recoveries ranged from 80.6 to 106.5% and 80.4–107.3%, respectively, and relative standard deviations ranged from 0.8 to 8.7% and 3.6–9.6%, respectively.
Packed hybrids of gold nanoparticles and halloysite nanotubes (Au/HNTs) were prepared and applied to the dispersive solid-phase extraction by packed sorbent of five triazine herbicides from rice.
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Cell Death & Disease
·
2019
·Vol. 10
·期 6
·1-19
·
IF 5.959
Zhou Wenjuan,Ma Liying,Yang Jing,Qiao Hui,Li Lingyu,Guo Qian,Ma Jinlian,Zhao Lijuan,Wang Junwei,Jiang Guozhong,Wan Xiangbin,Adam Goscinski Mariusz,Ding Lina,Zheng Yichao,Li Wencai,Liu Hongmin,Suo Zhenhe,Zhao Wen
Human mutT homolog 1(MTH1), the oxidized dNTP pool sanitizer enzyme, has been reported to be highly expressed in various malignant tumors. However, the oncogenic role of MTH1 in gastric cancer remains to be determined. In the current study, we found that MTH1 was overexpressed in human gastric cancer tissues and cells. Using an in vitro MTH1 inhibitor screening system, the compounds available in our laboratory were screened and the small molecules containing 5-cyano-6-phenylpyrimidine structure were firstly found to show potently and specifically inhibitory effect on MTH1, especially compound MI-743 with IC 50 = 91.44 ± 1.45 nM. Both molecular docking and target engagement experiments proved that MI-743 can directly bind to MTH1. Moreover, MI-743 could not only inhibit cell proliferation in up to 16 cancer cell lines, especially gastric cancer cells HGC-27 and MGC-803, but also significantly induce MTH1-related 8-oxo-dG accumulation and DNA damage. Furthermore, the growth of xenograft tumours derived by injection of MGC-803 cells in nude mice was also significantly inhibited by MI-743 treatment. Importantly, MTH1 knockdown by siRNA in those two gastric cancer cells exhibited the similar findings. Our findings indicate that MTH1 is highly expressed in human gastric cancer tissues and cell lines. Small molecule MI-743 with 5-cyano-6-phenylpyrimidine structure may serve as a novel lead compound targeting the overexpressed MTH1 for gastric cancer treatment.
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高影响因子
Nano Research
·
2019
·Vol. 12
·期 12
·2971-2981
·
IF 8.515
Ding Xianguang,Zhao Haitao,Li Chunyan,Wang Qiangbin,Jiang Jiang
Real-time tracking drug release behavior is fundamentally important for avoiding adverse effects or unsuccessful treatment in personalize medical treatment. However, the development of a non-invasive drug reporting platform still remains challenging. Herein the design of a novel synthetic magnetic resonance imaging (MRI) agent for drug release tracking (SMART) is reported, which integrates photothermal core and paramagnetic ion/drug loading shell with a thermal valve in a hybrid structure. Through near-infrared (NIR)-II photothermal effect originating from inner Au-Cu 9 S 5 nanohybrid core, burst release of drugs loaded in the mesoporous silica shell is achieved. The concomitant use of a phase change material not only prevents premature drug release, but also regulates heating effect, keeping local temperature below 45 °C, enabling synergistic chemotherapy and mild hyperthermia in vitro and in vivo. Furthermore, the drug release from SMART facilitates proton accessibility to the paramagnetic ions anchored inside mesopores channels, enhancing longitudinal T 1 relaxation rate and displaying positive signal correlation to the amount of released drug, thus allowing non-invasive real-time monitoring of drug release event. The current study highlights the potential of designed MRI nanophores such as SMART for real-time and in-situ monitoring of drug delivery for precision theranostic applications.
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Scientific Reports
·
2019
·Vol. 9
·期 1
·1-10
·
IF 4.011
Ren Liufen,Lin Daohui,Yang Kun
The debate on whether the nonlinear sorption of nonionic organic compounds (NOCs) by soil organic matter (SOM) is captured by nonlinear partition or adsorption has been going on for decades because the used SOM samples are complex mixtures from various precursors with varied humification degrees in natural environment. Therefore, in this study, hydrothermal method was employed to prepare humus-like substances from a sole precursor (i.e., rice straw) with various humification degrees for nonlinear sorption of 25 aromatic compounds, then to have an insight into the underlying mechanisms of the nonlinear sorption of NOCs by SOM. It was observed that the increasing humification degree of humus-like substances, i.e., decreasing in the polarity ((O + N)/C) and increasing in the aromaticity, result in the increase of isotherm nonlinearity and sorption capacity/affinity of NOCs. Sorption capacity of NOCs, obtained by isotherm fitting using Dubinin-Astakhov (DA) model and Dual-Mode (DM) model, are positively correlated with their solubility in water and octanol, indicating the nonlinear sorption could be captured by nonlinear partition mechanism. Specific interactions including hydrogen-bonding interaction and π - π interaction between aromatic structures of humus-like substances and organic molecules could be responsible for the nonlinear partition and the increase of sorption affinity with the enhancement of humification degree. These obtained correlations are valuable for understanding the underlying mechanisms of nonlinear sorption and elucidating the transport of NOCs in the environment.
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高影响因子
Food and Bioprocess Technology
·
2019
·Vol. 12
·期 11
·1907-1916
·
IF 3.032
Zhou Lei,Liao Tao,Liu Junping,Zou Liqiang,Liu Chengmei,Liu Wei
The activity of polyphenoloxidase (PPO) treated by acidic pH and mild thermal processing was found to be closely related to the conformational changes. Weakly acidic environment (pH 4.0–6.0) resulted in reversible inhibition of activity and slight changes in the conformation, and refolding of PPO was observed after readjusting pH to 6.8. At pH lower than 4.0, PPO activity was strongly inhibited with great unfolding in conformation and all changes were irreversible. Acidic environment increased the susceptibility of PPO to thermal treatment, and greater changes in activity and conformation of PPO were observed under the combined treatment of acidic pH and mild thermal treatment. Besides, the inactivation of PPO induced by thermal treatment followed a biphasic kinetic model, and acidic pH increased the inactivation rate of labile and stable PPO. The combination of acidic pH and mild thermal processing expected to avoid the nutritional loss and sensory damage in fruits and vegetables caused by severe acid or temperature.
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高影响因子
MONATSHEFTE FUR CHEMIE
·
2019
·Vol. 150
·期 11
·1903-1910
·
IF 1.501
Li Zhongqiu,Yang Kunhao,Lv Yueguang,Wang Qingnan,Li Chang,Wu Li,He Yujian
Abstract A novel method, based on modified silver nanoparticles, for high-throughput visual detection of heavy metal ions in polyvinyl chloride (PVC) products was developed including a key pretreatment process in which tetrahydrofuran was used to dissolve PVC powder samples quickly. Heavy metal ions were successfully transferred from THF to the aqueous phase by the liquid–liquid extraction method during the pretreatment procedures. Then, enriched Cu 2+ , Mn 2+ , and Cr 3+ were detected by three kinds of silver nanoparticles (4-MBA-AgNPs, 4-MBA-MA-AgNPs, and 4-NBT/4-MBA-AgNPs) using naked eyes and microplate reader, respectively. The visual detection limits of Cu 2+ , Mn 2+ , and Cr 3+ were 1.0 × 10 −6 M, 1.0 × 10 −7 M, and 1.0 × 10 −6 M, while the detection limits of Cu 2+ , Mn 2+ , and Cr 3+ were 2.5 × 10 −8 M, 5.0 × 10 −8 M, and 5.0 × 10 −8 M using microplate reader, respectively. Apparently, the proposed method could provide a potent means in the practical detection of heavy metal ions in PVC products with advantages of low-cost, rapid, high-throughput, and on-site detection. Graphic abstract
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JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2019
·Vol. 31
·期 3
·2231-2239
·
IF 2.195
Zhao Gao-yu,Le Meng-ting,Zeng Gui-ju,Zhang Yu,Li Jin-hai
A new and rapid synthetic method toward polymer phenylethnylcopper (PPECu) nanowires is developed. PPECu nanowires have been firstly fabricated through using ascorbic acid instead of methanol as reducing agent. The preparation time of PPECu can be decreased from 48 to 2 h, even at a lower temperature. Ag/PPECu nanocomposites were prepared by the in situ reaction of PPECu and Ag (NH 3 ) + 2 ions with different concentrations. Ag/PPECu photocatalysts showed high visible-light H 2 production activity, which originated from the combined action of electrons transfer, sacrificing reagent and SPR effect of Ag nanoparticles.
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MICROCHIMICA ACTA
·
2019
·Vol. 186
·期 12
·1-9
·
IF 5.479
Liang Wenting,Rong Yanqin,Fan Lifang,Zhang Caihong,Dong Wenjuan,Li Jing,Niu Jianping,Yang Cheng,Shuang Shaomin,Dong Chuan,Wong Wai-Yeung
Reduced graphene oxide containing Fe 3 O 4 nanoparticles was decorated with hydroxypropyl-β-cyclodextrin (HP-β-CD) to construct a novel nanocomposite (3D-rGO/Fe 3 O 4 /HP-β-CD). The composite was placed on a glassy carbon electrode (GCE) to design an electrochemical sensor for detecting simultaneously serotonin (5-HT), dopamine (DA), and ascorbic acid (AA). The interconnected porous reduced graphene oxide framework tightly anchored to the Fe 3 O 4 magnetic nanoparticles warrants good electrical conductivity and efficient catalytic activity. The HP-β-CD acts as a supramolecular host with high recognition ability for 5-HT, DA and AA. Well-separated oxidation peaks and increased peak currents were observed for 5-HT, DA, and AA individually and in mixtures by differential pulse voltammetry (DPV). The following figures of merit were found for simultaneous electrochemical determination of 5-HT, DA, and AA: (a) Well separated peaks at around 0.316, 0.16 and − 0.044 V; (b) linear responses in the 0.01 – 25 μM, 0.02 – 25 μM and 10 – 350 μM; (c) detection limits of 3.3 nM, 6.7 nM and 3.3 μM (S/ N = 3), and (d) recoveries of 96.9-103%, 97.3%-102% and 96.3-105% from spiked serum samples, respectively. All relative standard deviation (RSD) are less than 4%.
Schematic representation of simultaneous detecting serotonin (5-HT), dopamine (DA) and ascorbic acid (AA) for three-dimensional reduced-graphene oxide/Fe 3 O 4 /hydroxypropyl-β-cyclodextrin (3D-rGO/Fe 3 O 4 /HP-β-CD) by differential pulse voltammetry (DPV) approach.
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危险品化学品经营许可证（带存储）