JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
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2014
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IF 1.357
Zhang Jianping,Guo Jianfeng,Zhang Yao,Yang Jiao
The graft polymer Dex-g-PSSS was obtained through poly(sodium 4-styrene sulfonate) (PSSS) grafted on dextran(Dex) by using the cerium salt–hydroxyl group redox initiation system. The cross-linked microspheres C(Dex-g-PSSS) were synthesized by suspension polymerization with epichlorohydrin as the cross-linking agent. The chemical structure and physicochemical characteristics of C(Dex-g-PSSS) microspheres were represented by infrared spectroscopy (FTIR), optical microscope, and zeta potential analysis. The aim of the study is to constitute a colon-specific drug delivery system via molecular design, using C(Dex-g-PSSS) microspheres as the drug-carrying material and taking 5-fluorouracil (5-FU) as the model drug. The drug-carrying ability and mechanism of the cross-linked microspheres C(Dex-g-PSSS) for 5-FU were investigated. Finally, in vitro release tests for the drug-carrying microspheres were conducted. The experimental results show that in the medium with pH 2, the cross-linked microspheres C(Dex-g-PSSS) exhibit a strong adsorption ability for 5-FU because of strong electrostatic interactions and have an adsorption capacity of 154 ± 7.5 mg/g, displaying high drug-carrying efficiency. The in vitro release behavior of the drug-carrying microspheres is highly dependent on pH and dextranase. In the medium with pH 2, the drug-carrying microspheres do not release the drug and in the medium with pH 1, they release a little, whereas in the medium with pH 7.4, a sudden delivery phenomenon of the drug will occur, and in the presence of dextranase, a more sudden delivery phenomenon of the drug will occur, displaying an excellent colon-specific drug delivery behavior.
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CHEMISTRY-A EUROPEAN JOURNAL
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2017
·Vol. 23
·期 41
·9831-9837
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IF 5.317
Qiang Cao,Qing Yin,Qi Chen,Zhi-Bing Dong,Bao-Hang Han
Graphical Removed from the mix : The synthesis of fluorinated iron–porphyrin conjugated porous polymers through direct C−H arylation polymerization is described (see scheme). The application of these polymers as heterogeneous catalysts for Baeyer–Villiger oxidation is also discussed. By considering the high reactivity of fluorinated iron–porphyrin and good stability of porphyrin-based porous polymers, fluorinated iron–porphyrin conjugated porous polymers ( FPOP-3 – 6 ) were synthesized through direct C−H arylation polymerization. The obtained materials are chemically and thermally stable, of which FPOP-3 exhibits the highest Brunauer–Emmett–Teller specific surface area (about 840 m 2 g −1 ). For functional studies of the obtained polymers as heterogeneous catalysts, catalytic transformation of cycloketones into lactones by oxygen through Baeyer–Villiger oxidation was used as a model reaction. Fluorinated phenyl substituents of the iron–porphyrin not only are beneficial to the conversion, but also can stabilize the porphyrin to resist catalyst breakdown. The polymer FPOP-3 , with high porosity, exhibits the best catalytic efficiency and recycling effect. The recovered catalyst also shows good catalytic activities after recycling three times with a small loss in yield.
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APPLIED CATALYSIS B-ENVIRONMENTAL
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2024
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IF 20.2
Jianxin Zhu,Haiyang Liu,Haijun Chen,Xiuyi Hua,Deming Dong,Dapeng Liang,Zhiyong Guo,Na Zheng
Low degradation efficiency and significant transition metal leaching are two challenges in persulfate activation systems based on metal-organic frameworks (MOFs) for organic pollutant degradation. Here, the challenges were solved by designing and synthesizing a micron-sized core-shell material, γ-Al 2 O 3 -C-MIL-100(Fe) (γACM), by coating the γ-Al 2 O 3 core with carbon (γ-Al 2 O 3 -C) and futher modifying with MIL-100(Fe). Testing γACM with sulfamethazine (SMZ) demonstrated its outstanding peroxydisulfate (PDS) activation, achieving 92.5 % SMZ removal within 20 min at a low oxidant/pollutant ratio. Fe leaching from γACM was effectively inhibited, with only 3.59 % Fe lost after three recycles. The system showed adaptability across a wide pH range, and usability in sewage effluent, indicating promise for practical application. The hydrophobicity of γ-Al 2 O 3 -C, the coordinatively unsaturated sites in MIL-100(Fe), and the strong bounding of MIL-100(Fe) on γ-Al 2 O 3 -C ensured the effective SMZ gather, PDS activation, and Fe stability respectively, which led to the excellent performances of γACM.
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CHEMICAL ENGINEERING SCIENCE
·
2024
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IF 4.1
Shuang Wei,Mengyue Li,Kexin Li,Sheng Zhong,Yatao Su,Ruirui Zhang,Ruixia Liu
The oxidation of cyclohexane to produce adipic acid suffered from the inefficient and polluting two-step process. We introduce the CuCo Prussian blue analogues derived in situ C, N doped CuCo composite catalysts in the selective oxidation of cyclohexane. Due to the in-situ doping of C and N elements in the form of active graphite carbon and pyridine nitrogen, the oxygen vacancy content and the ability to activate oxygen are improved. The one-step efficient catalytic oxidation of cyclohexane to adipic acid was realized due to the excellent electron transfer performance between C, N elements and metals.
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CHEMICAL ENGINEERING SCIENCE
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2024
·
IF 4.1
Shandi Zhong,Cai Xu,Quanfu Long,Hang Zhou,Jianhai Yang,Jia Guo,Xiaozhong Wang,Liyan Dai
Using O 2 as an oxidant, developing a non-noble metal catalyst for the selective catalytic C–H bond oxidation of p-chlorotoluene is desirable and challenging. In this work, a series of Co, Cr co-doped OMS-2 (Octahedral Molecular Sieve-2) catalysts were prepared by a conventional refluxing method. It was found that the incorporation of Co and Cr improved the catalytic activity for the selective oxidation of p-chlorotoluene to p-chlorobenzaldehyde. Among these catalysts, CoCr/OMS-2 (Co: Cr = 1: 1, mass ratio), the best catalyst, shows that the conversion and the selectivity of p-chlorobenzaldehyde is 94.8 % and 94.3 %, respectively. The enhanced catalytic activity was due to the larger specific surface area and even dispersion of active components. The characterization results also disclosed that the co-doping of Co and Cr increased the oxygen vacancy and enhanced the ability to activate the surface lattice oxygen. Additionally, density functional theory calculations demonstrated that co-doping of Co and Cr promoted the adsorption of p-chlorotoluene and O 2 , and decreased the energy barrier of rate-determining step (the conversion of p-chlorobenzyl alcohol to p-chlorobenzaldehyde). Besides, when H 2 O was added to the reaction system as the second solvent, the activation and dissociation of O 2 , and the formation of p-chlorobenzaldehyde were facilitated, in agreement with the experimental results. This work demonstrated the promotional effect of Co, Cr co-doped into OMS-2 catalyst and the role of H 2 O for the selective oxidation of p-chlorotoluene.
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JOURNAL OF ALLOYS AND COMPOUNDS
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2024
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IF 5.8
Yuqing Dong,Chengsen Li,Shuting Zhang,Xiangwei Meng,Meijie Yu
Porous structure design and magnetic-dielectric composite are effective ways to develop electromagnetic wave (EMW) absorbing materials with light-weight, thin-thickness, large effective absorption bandwidth (EAB), and strong reflection loss (RL). This article presents a simple one-step nitridation method for synthesizing Fe 4 N@C compounds with sea-island like and core-shell structures. The optimal RL value of Fe 4 N@C is up to −60.01 dB, and the EAB (frequency range for RL< −10 dB) is 5 GHz (11.1–16.1 GHz) with a thickness of 1.9 mm. The EAB reaches 5.5 GHz (12.5–18 GHz) when the matching thickness is 1.7 mm. The multi-component design achieved excellent impedance matching properties. The carbon frame connects the core-shell particles to form a three-dimensional porous structure, providing multiple reflection losses. Therefore, this work provides a convenient way to design efficient and lightweight EMW absorbers with special structures.
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FOOD CHEMISTRY
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2025
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IF 9.8
Cailin Qiao,Xinrou Wang,Huibo Luo,Yi Ma,Ping Yang,Danqun Huo,Suyi Zhang,Changjun Hou
The direct and rapid detection of high-concentration tannic acid (TA) was crucial for food quality monitoring. In this study, a TA detection system was developed based on a binary metal V and Co-enclosed carbon substrate (VCo-N-C) nanozyme with laccase-like activity, which innovatively shifted the conventional detection approach from the 3,3′,5,5′-tetramethylbenzidine (TMB) discoloration principle to the 4-aminoantipyrine(4-AP) color enhancement principle. In the presence of VCo-N-C, 4-AP specifically bound to the oxidation products of TA, resulting in a brown-red compound. The sensing platform reduced the reaction time to 10 min and extended the detection range to 0.1–3000 mg/L (R 2 > 0.99). Ultimately, the VCo-N-C&4-AP system was successfully applied to detect TA content in high-concentration actual samples such as brandy, white liquor, and tea beverages without the need of pretreatment. This study provided a new and powerful strategy for food quality control and monitoring.
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APPLIED SURFACE SCIENCE
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2024
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IF 6.3
Junhao Cai,Yaru Peng,Po Hu,Yuan Zhou,Qiaoge Yao,Hao Lyu,Youtang Gao
The light absorption, active sites, and charge carriers separation of photocatalysts are extremely important factors in the field of photocatalysis. Near-perfect lattice-matched homojunction constructed using disorder engineering and doping strategies is an effective strategy to improve photocatalytic activity. Herein, we developed crystalline TiO 2 nanoparticles (NPs) and Ti 3 C 2 T x MXene-derived C-doped amorphous TiO x homojunction (TCT) at room temperature. In this homojunction, TiO 2 NPs are evenly distributed on the surface of the C-TiO x nanosheet to form a type-II structure, which promotes the separation of photogenerated carriers. The light absorption range of TCT extends to 550 nm due to the presence of intermediate energy levels in C-TiO x , which increases its photon absorption capacity. Moreover, TCT possesses a large number of oxygen vacancies, which are beneficial for improving the adsorption and degradation of pollutants. These characteristics of TCT could significantly improve its photodegradation performance for tetracycline. Interestingly, the precursor mass ratio of TCT with the best degradation efficiency is different under different illumination conditions, which is attributed to the different band gaps of C-TiO x and TiO 2 NPs resulting in different light absorption ranges. This work provides a new approach to rationally designing crystalline and amorphous homojunction for photocatalytic applications.
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CHEMICAL ENGINEERING JOURNAL
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2024
·
IF 13.3
Xue Liu,Wei Yan,Jie Song,Hao Song,Wenmiao Chen,Yuexing Zhang,Yanli Chen
Enhancing the exposure of active sites and optimizing the electronic structure of the catalysts are indispensable for efficient catalyst design, yet remains challenging in the renewable energy field. Herein, a sequential pyrolyzing and phosphating approach for a well-designed GO/CoTPP gel precursor has been explored to prepare a Co-based carbon catalyst containing single-atom Co-N x and hollow Co 2 P active species (Co 2 P/Co-N-C) for multifunctional electrocatalytic reactions. Kirkendall effect occurring during the template-free one-pot phosphating approach induced the formation of the hollow Co 2 P structure in the catalyst, simultaneously optimizing the electron structure and allowing the active sites to be exposed to a greater extent. DFT calculations demonstrated that the Co 2 P and Co-N x structures enable Co 2 P/Co-N-C to have a suitable d-band center depending on the electron transfer from Co 2 P to Co-N x , which enhances the adsorption of O* and the dissociation of OH* in oxygen electrode reactions, thereby facilitates catalytic reactions. As a result, the Co 2 P/Co-N-C exhibits excellent trifunctional activity with a half-wave potential of 0.89 V in alkaline for oxygen reduction reaction (ORR), overpotentials of 330 mV for oxygen evolution reaction (OER) and 190 mV for hydrogen evolution reaction (HER), respectively, which are among the best results reported to date for Co-containing carbon-based catalysts. Furthermore, the flexible Zinc-air battery with Co 2 P/Co-N-C electrodes also demonstrates a high open circuit voltage of 1.35 V, which is applied to build the self-powered device for water splitting continuously. Our work provides a facile strategy to prepare high-performance trifunctional catalysts by morphology/structure control of metal-based NPs on carbon-based materials.
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CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Daibing Hou,Xuedan Cui,Yiming Tang,Meng Liu,Hantong Qie,Pengjie Zhao,Wenpeng Leng,Nan Luo,Huilong Luo,Wenxia Wei,Aijun Lin,Tianwen Zheng
Rebounding and lagging during the process of remediating contaminated sites are challenging problems. A potential solution is developing slow-release materials that could assist in the long-term remediation of contaminated sites. This study synthesised a slow-release Fe-C composite (CSBC-nZVI@β-CD), which exhibits a synergistic effect of encapsulated layers and nanocracks, using a liquid-phase reduction method. Furthermore, the reduction and dechlorination mechanism of trichloroethene (TCE) was systematically investigated. The introduction of β-cyclodextrin (β-CD) intensified the Kirkendall effect, forming nano zero-valent iron (nZVI) with abundant radial nanocracks and a litchi-like appearance on the biochar surface. Additionally, β-CD created an encapsulation layer measuring 5–7 nm on the surface of nZVI, improving its electron transport capacity and hydrophobic properties. The CSBC-nZVI@β-CD nanocomposite successfully removed 99 % of TCE in solution within 2 h and accomplished a degradation efficiency of 98.9 % within 15 d. The synergistic effect of the β-CD encapsulating layer and nanocracks facilitated the reactivity and electron-retarding capacity, resulting in a broad pH tolerance and anti-interference ability. Density-functional theory (DFT) calculations and experimental methods were used to study the mechanism of TCE reduction dechlorination; the unique structure of β-CD tended to bind with Fe as well as adsorb TCE, thereby facilitating electron transfer and the enrichment of TCE at the reaction interface. In addition, the sustained-release Fe-C composites reduced the bonding energy required during the TCE degradation reaction and promoted the complete reaction of the product. Overall, CSBC-nZVI@β-CD exhibited significant potential for the long-term remediation of groundwater.
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PHYTOMEDICINE
·
2024
·
IF 6.7
Huizhen Tian,Qigang Pan,Jianfeng Wu,Juanjuan Liao,Yuwei Wan,Ke Pei,Qiong Liu,Lingbing Zeng,Yanli Cao,Qiaofa shi,Nanzhen Kuang,LiJuan Sun,Xiaomin Yu,Xiaotian Huang
Background Coxsackievirus B3 (CVB3) is a leading cause of viral myocarditis and is currently lacking specific pharmacological treatments, highlighting the critical need for therapeutic development. Icariin (ICA), a prenylated flavonol glycoside, was previously found to exhibit several pharmacological effects, but its potential to combat CVB3 remains uninvestigated. Purpose This study aimed to elucidate the anti-CVB3 efficacy of ICA and elucidate its molecular mechanisms. Methods CVB3-infected HeLa cells, H9C2 cells and neonate rat ventricular cardiomyocytes (NRVCs) were selected as in vitro models, and were treated with ICA at 1 and 10 μM. Additionally, BALB/c mice that were infected with CVB3 via intraperitoneal injection were chosen as in vivo model and were treated with ICA or ribavirin over 3 days. The effect of ICA against CVB3 was determined by Cell Counting Kit-8 (CCK-8) assay, western blot, real-time fluorescence quantitative PCR (RT–qPCR), terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay, hematoxylin and eosin (H&E) staining, immunohistochemistry (IHC) and flow cytometry. Results In this study, it was found that ICA is capable of reducing CVB3 viral load both in vitro and in vivo . Mechanistic studies suggested that ICA prevents cardiomyocyte apoptosis by attenuating the S100 calcium binding protein A6 (S100A6)/β-catenin/c-Myc signaling pathway. Additionally, ICA inhibits the secretion of proinflammatory cytokines tumor necrosis factor alpha (TNF-α), interleukin-1beta (IL-1β) and CXC motif chemokine ligand 2 (CXCL2) in heart tissue, thereby mitigating CVB3-induced myocarditis. Moreover, ICA also regulates the immune response of CD4 + T, CD8 + T and Treg cells by changing the cells numbers in spleen tissue. Lastly, ICA can reduce the load of other enteroviruses (such as CVA6, CVA16 and EV71) in rhabdomyosarcoma (RD) cells as well. Conclusion Our findings indicate that ICA provides significant protection against CVB3 infection by modulating the S100A6/β-catenin/c-Myc signaling pathway, suggesting its potential use as a novel drug against CVB3 infection in clinical application.
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CARBOHYDRATE POLYMERS
·
2025
·
IF 12.5
Jinping Peng,Rongwei Fu,Yihui Huang,Jinqing Lu,Xiaofeng Xie,Zhenkun Xue,Mingjie Chen,Xingrou Wu,Hangbo Yue,Haiyan Mai
Alkaline aqueous solutions facilitate the rapid extraction of high-performance cellulose nanofiber (CNF) at 15 °C. However, the role and mechanism of NaOH in this process remain unclear. This study investigated the dissolution process of cellulose by controlling the NaOH concentration (1–7 wt%) at 15 °C and explored the effect and underlying mechanism of the NaOH concentration on cellulose dissolution in alkaline solvents. The results showed that the addition of NaOH strengthened the hydrogen bonding network of the solvent, whereas the addition of urea and thiourea promoted the dissolution of cellulose. The higher the concentration of NaOH is, the smaller the volume of hydrate molecules formed; smaller molecules more readily enter the cellulose molecules and form new hydrogen bonds with cellulose molecular chains, thereby destroying the original hydrogen bonds between cellulose molecules and their crystal structure. During dissolution, cellulose decomposes into microfibrils, and nanosized cellulose separates; moreover, the diameter and length of the CNF decrease with increasing NaOH concentration. When the concentration of NaOH reaches 7 %, the cellulose is completely broken down into CNF, and the yield is >60 %. As dissolution progresses, the crystallinity of cellulose first increases and then decreases (75.95 %–81.00 %–77.02 %), but its crystal size remains unchanged.
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危险品化学品经营许可证（带存储）