Polymer Chemistry
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2024
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IF 4.1
Heng Wang,Weilu Ding,Zhencai Zhang,Yiwen Zhang,Zhao Yang,Mi Feng,Ming Jiang,Fei Xu
The synthesis of intraocular lenses (IOLs) with a high refractive index (RI) and good transparency to create patient-specific eye power is of primary importance, while the development of a novel IOL material, especially with outstanding optical characteristics and biocompatibility, is still an ongoing challenge. Herein, a bio-based poly(isosorbide thioether) (PITE) with excellent optical properties was developed as a novel IOL material and a new strategy for synthesizing high molecular weight PITE using ionic liquid catalysts was proposed. Compared to traditional IOLs (RI = 1.45–1.54), the synthesized bio-based PITEs showed the highest RI of 1.64 and an optical transparency of 93%, indicating that they were excellent optical materials. Furthermore, the resultant PITEs also exhibited ideal glass transition temperatures (Tg = 7.5–50.9 °C), good thermal stability (Td-5% > 312 °C) and excellent biocompatibility for L929 and HeLa cells. In order to achieve efficient synthesis of PITE, a series of functional ionic liquid catalysts were designed and synthesized. Among them, 1,8-diazabicyclo[5.4.0]-undec-7-en-8-ium lactate ([DBU][Lac]) in a trace amount (0.5 mol%) exhibited the highest catalytic performance, presenting a Mw value of up to 63.3 kg mol−1, higher than 7.4 kg mol−1 without an IL. Detailed mechanistic investigations using nuclear magnetic resonance spectroscopy and density functional theory calculations revealed that the “amphiphilic” character of ILs showed a cation–anion synergistic catalytic mechanism and then promoted nucleophilic hydrothiolation. The present study could provide enormous opportunities for the design and synthesis of bio-based optical polymers with high performance for IOLs, corneal contact lenses and other optical uses.
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INTERNATIONAL DAIRY JOURNAL
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2024
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IF 3.1
Yang Liu,Luyao Fan,Bingxin Zhang,Zhenbo Xu,Thanapop Soteyome,Lei Yuan
Biofilms formed by Bacillus licheniformis usually serve as a continuous bacterial contamination in the dairy industry. The purpose of this study was to explore how 1% organic acids (citric acid, phenyllactic acid, malic acid , and butyric acid) and their 1% organic peroxyacids (peroxycitric acid, peroxyphenyllactic acid, peroxymalic acid, and peroxybutyric acid) can inactive the planktonic and biofilm cells of B. licheniformis . Results demonstrated that the number of B. licheniformis planktonic cells was increased from 4 to 6.46 Log CFU mL −1 when treated with water. Organic peroxyacids, especially peroxyphenyllactic acid (PPA), obviously inactivated planktonic cells of B. licheniformis by a range of 3.32–4.14 Log CFU mL −1 . Moreover, organic peroxyacids could also decrease the cell surface hydrophobicity of bacteria, and effectively control the Ca 2+ -mediated biofilm formation by B. licheniformis in 96-well plates (reduction of OD values by 0.14–0.33) and on stainless steel (reduction of cell counts by 1.20–2.49 Log CFU cm −2 ). The low minimum biofilm eradication concentration of PPA (0.125%) also suggests its strong biofilm inactivation activity, which could serve as a novel and environmentally friendly biofilm control agent in the dairy industry.
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TALANTA
·
2024
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IF 5.6
Mengmeng Ji,Yi Chen,Yufei Hu,Gongke Li
The origin of coffee beans impacts the aroma, flavor, and consumer acceptance, resulting from volatile organic compounds (VOCs) such as ketones, aldehydes, alcohols, pyrazine, and esters. Among them, ketones are associated with the refreshing fruity flavor of coffee beans and can serve as key substances for identifying their origin. Herein, the novel method of cyclic cataluminescence (CCTL) was presented and proven to be feasible for differentiating the origins of coffee beans based on the ketones-involved multiple cataluminescence reactions. A series of exponential decay CCTL peaks were measured through nano Al 2 O 3 -catalyzed reactions. By fitting the variation of peak intensity I n with time t , the characteristic attenuation coefficient k was calculated, which can be used to successfully distinguish the origin of the selected coffee beans in combination with chemometrics. The method was validated in the tests of 82 coffee beans. Coffee from the same origin has similar k values, while coffee from different origins has different k values. The discrimination accuracy of linear discriminant analysis and hierarchical clustering analysis was 100 %. The established method was fast. We anticipate that the technique could also serve as a promising new tool for reliably, effectively, and swiftly identifying the origins of other plant products.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
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IF 7.7
Li Li,Mingjie Xia,Lina Yang,Yutang He,He Liu,Mengxi Xie,Miao Yu
Polysaccharides impact intestinal fermentation and regulate interfacial properties which affect absorption and transportation. Short-chain fatty acids (SCFAs), the main metabolites of soy hull polysaccharide lysate, are readily absorbed by the body and perform various physiological functions. We analysed the interfacial properties and transport of soy hull polysaccharide-derived SCFAs in the Caco-2 cell model to clarify the transmembrane transport mechanism. The results showed that the interfacial properties of the co-culture system were influenced by both transit time and concentration of SCFAs, the uptake and transit rates of SCFAs at 1–3 h increased significantly with time ( P < 0.05). With increasing transit time and concentration, the transit rates of SCFAs on the apical side (AP) → basolateral side (BL) and BL → AP sides increased and then stabilised, the transit rate of the AP → BL side was higher than that of the BL → AP side. Proteomic analysis showed that soy hull polysaccharide-derived SCFAs resulted in the differential expression of 285 upregulated and 501 downregulated after translocation across Caco-2 cells. The differentially expressed proteins were mainly enriched in ribosomes, oxidative phosphorylation, nuclear transport, and SNARE vesicular transport. This study lays the theoretical foundation for understanding the structure-activity relationship of soy hull polysaccharides in the intestine.
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MOLECULES
·
2025
·Vol. 30
·期 4
·933
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IF 4.6
Jialing Lu,Jia Zheng,Dong Zhao,Yan Xu,Shuang Chen
Strong-aroma type Baijiu and its diluted samples were characterized through descriptive analysis. Significant changes were observed in four (ethanol, Jiao-aroma, fruity, and grain) of the nine aroma attributes, primarily attributed to variations in ethanol concentration rather than other compounds. The thresholds of 40 compounds in aqueous solutions with alcohol concentrations of 20%, 30%, 40%, 50%, and 60% were measured using three-alternative forced-choice tests. The thresholds of 30 compounds were significantly positively correlated with ethanol concentration. The thresholds of 40 compounds were affected by ethanol concentration to varying degrees, with changes ranging from 2 to 692 times. Due to the varying degrees of alcohol influence on the compound threshold, the aroma profile of diluted Baijiu sample is different from the original Baijiu sample.
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MOLECULAR NUTRITION & FOOD RESEARCH
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2024
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IF 4.5
Yu-Ru Ren,Wen-Ting Cui,Kai-Li Jiang,Kai-Qi He,Yong-Ming Lu,Yan Chen,Wen-Juan Pan
Age-related cognitive decline is primarily attributed to the progressive weakening of synaptic function and loss of synapses, while age-related gut microbial dysbiosis is known to impair synaptic plasticity and cognitive behavior by metabolic alterations. To improve the health of the elderly, the protective mechanisms of Oudemansiella raphanipes polysaccharide (ORP-1) against age-related cognitive decline are investigated. The results demonstrate that ORP-1 and its gut microbiota-derived metabolites SCFAs restore a healthy gut microbial population to handle age-related gut microbiota dysbiosis mainly by increasing the abundance of beneficial bacteria Dubosiella , Clostridiales , and Prevotellaceae and reducing the abundance of harmful bacteria Desulfovibrio , strengthen intestinal barrier integrity by abolishing age-related alterations of tight junction (TJ) and mucin 2 (MUC2) proteins expression, diminish age-dependent increase in circulating inflammatory factors, ameliorate cognitive decline by reversing memory- and synaptic plasticity-related proteins levels, and restrain hyperactivation of microglia-mediated synapse engulfment and neuroinflammation. These findings expand the understanding of prebiotic–microbiota–host interactions.
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JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
·
2024
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IF 3.3
Min Zheng,Chen Xie,Dan Ye,Yong Chen,Ziyao Wang,Le Wang,Fang Xiong,Sheng Zhang,Qiang He,Hui Wu,Zhinong Wu,Hongfu Zhou,Ling Li,Jun Xing,Xiaolei Miao
BACKGROUND Qingzhuan dark tea polysaccharides (QDTP) have been complexed with Zinc (Zn) to form the Qingzhuan dark tea polysaccharides-Zinc (QDTP-Zn) complex. The present study investigated the protective effects of QDTP-Zn on ulcerative colitis (UC) in mice. The UC mouse model was induced using dextran sodium sulfate (DSS), followed by oral administration of QDTP-Zn (0.2 and 0.4 g kg −1 day −1 ). RESULTS QDTP-Zn demonstrated alleviation of UC symptoms in mice, as evidenced by a decrease in disease activity index scores. QDTP-Zn also regulated colon tissue injury by upregulating ZO-1 and occludin protein expression, at the same time as downregulating tumor necrosis factor-α and interleukin-6β levels. Furthermore, QDTP-Zn induced significant alterations in the abundance of bacteroidetes and firmicutes and notably increased levels of short-chain fatty acids (SCFAs), particularly acetic acid, propionic acid, and butyric acid. CONCLUSION In summary, QDTP-Zn exhibits therapeutic potential in alleviating enteritis by fortifying the colonic mucosal barrier, mitigating inflammation and modulating intestinal microbiota and SCFAs levels. Thus, QDTP-Zn holds promise as a functional food for both the prevention and treatment of UC. © 2024 Society of Chemical Industry.
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PHYTOMEDICINE
·
2025
·
IF 8.3
Zhe Song,Zhou Qiao,Jia Liu,Lingfei Han,Xi Chen,Yun Wang
Background The gut microbiota is firmly associated with the progression of ulcerative colitis (UC). Beneficial microbial metabolites, such as butyrate, exert vital roles in maintaining intestinal homeostasis. The Sea buckthorn berry is a traditional Chinese medicine homologous to food and medicine which is widely applied in the prevention and treatment of UC in clinic practice. Recent studies have exhibited the potential function of Sea buckthorn on regulating the gut microbiota, however, the mechanism underlying its anti-colitis effects and the key gut microbes mediating its efficacy are still unclear. Purpose This study is intended to explore the pharmacological mechanism of the efficacy of Sea buckthorn berries extract (SBE) in alleviating UC from the perspective of the gut microbial regulation. Methods The effect of SBE on UC was evaluated on dextran sulfate sodium (DSS)-induced murine model by assessing the body weight change, colon length, disease activity index (DAI), histopathological staining and the transcriptional expression of genes associated with inflammation and mucosal integrity. The dependence of the gut microbiota in the therapeutical effects of SBE on UC was confirmed by pseudo-germ-free mice and the co-housing experiment. The differential gut microbes altered by SBE were discovered by 16S rRNA sequencing and qPCR. The levels of short chain fatty acids (SCFAs) in bacterial medium and colonic contents were determined by GC–MS/MS. Bacterial colonization was conducted to estimate the effects of the bacteria on UC and to verify the involvement of the functional bacteria in the efficacy of SBE. A butyrate receptor G protein-coupled receptor (GPR)109A antagonist mepenzolate bromide (MPN) was used to validate the important role of butyrate and GPR109A in the anti-colitis effects of SBE and functional bacteria on UC. Two-way ANOVA was employed for multiple curve comparison and One-way ANOVA and Brown-Forsythe ANOVA test were used for multiple group comparison. Statistical significance was defined as p < 0.05 . Results SBE treatment significantly alleviated DSS-induced UC and its therapeutical effects was impaired in pseudo-germ-free mice. Moreover, the co-housing experiment exhibited that SBE-altered microbiota could effectively ameliorate UC. Further research demonstrated that Faecalibaculum rodentium was obviously increased by SBE and could be transferable by co-housing. Moreover, butyrate, a product of F. rodentium , dramatically decreased in UC mice while could be recovered by SBE administration. Abolishment of F. rodentium using vancomycin deprived the efficacy of SBE, but this could be reversed by recolonization of F. rodentium . Finally, blockage of the butyrate's receptor GPR109A weakened the effects of F. rodentium , indicating the indispensability of butyrate and GPR109A in the anti-colitis effects of F. rodentium . Conclusion SBE has potent therapeutical efficacy on UC including relieving inflammation and enhancing intestinal epithelial integrity, which is mediated by the gut F. rodentium -regulated butyrate−GPR109A axis.
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Foods
·
2025
·Vol. 14
·期 13
·2390
·
IF 5.1
Xi Peng,Yushi Wei,Deming Gong,Guowen Zhang
Background: Exploring new strategies to improve type 2 diabetes mellitus (T2DM) is one of the frontier hotspots in the field of healthy food. Flavonoid–metal complexes have become one of the research hotspots in the field of health foods due to their unique structural and functional properties. Methods: In this study, the effect of hesperetin–copper(II) complex [Hsp–Cu(II)] on the gut microbiota of mice with T2DM was investigated by the 16S rRNA high-throughput sequencing. Results: The analyses of α and β diversity indicated that the richness and diversity of gut microbiota in the T2DM mice decreased and the community structure was significantly different from the normal mice. Hsp–Cu(II) increased the abundances of the beneficial bacteria (Lactobacillus,Ligilactobacillus,Romboutsia,Faecalibaculum, andDubosiella), and decreased the amounts of the harmful bacteria (Desulfobacterota,Corynebacterium, andDesulfovibrio) and the ratio ofFirmicutes/Bacteroidetes(from 44.5 to 5.8) in the T2DM mice, which was beneficial for regulating the composition of intestinal microbiota. The linear discriminant analysis effect size analysis showed that the intervention of Hsp–Cu(II) made the short-chain fatty acid (SCFA) producers (o_Lachnospirales,f_Lachnospiraceae,g_Faecalibaculum,g_Romboutsia, andg_Turicibacter) and the lactic acid bacteria producers (f_Lactobacillaceaeando_Lactobacillales) highly enriched, and the production of its metabolite SCFAs (acetic acid, propionic acid, butyric acid, and valeric acid) were increased in a dose-dependent manner, promoting the SCFA metabolism. Conclusions: Hsp–Cu(II) may improve glucose metabolic disorders and alleviate T2DM by modulating gut microbiota composition, promoting probiotics proliferation and SCFAs production, restoring intestinal barrier integrity, and suppressing local inflammation. These research findings may provide a theoretical basis for developing Hsp–Cu(II) as a new hypoglycemic nutritional supplement, and offer new ideas for the dietary food nutritional regulation to alleviate T2DM.
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LANGMUIR
·
2025
·
IF 3.9
Xin Song,Chunfeng Li,Lei Le,Mingli Liu
Waterborne polyurethanes (WPUs) have become the preferred alternative for researchers aiming to replace solvent/emulsion-based resins in carbon fiber (CF) coatings, owing to their superior adhesion, eco-friendliness, and cost-effectiveness. However, conventional polyester-based WPUs have often exhibited inadequate mechanical properties, thermal stability, and solvent resistance. To tackle these limitations, modified WPUs were developed by incorporating alkyl long chains, benzene π–π bond stacking, aromatic ring ether bonds, and biphenyl groups into the molecular structure through the functionalization of the polymerization system with 1,7-hexanediol, ethoxylated bisphenol A, and 1,3/1,4-bis(2-hydroxyethoxy) benzene. The inclusion of these comonomers optimized the properties of the WPUs with significant increases in thermal weight loss temperature T5% and tensile strength of 23.4% and 53.1%, respectively. The utilization of WPUs as coatings proved to be highly effective in enhancing the chemical activity, wettability, and mechanical properties of CF. The application of the coating resulted in a substantial improvement, with a 58.2% increase in the fiber surface energy and a 21.5% enhancement in the filament tensile strength, reaching values of 54.1 mN/m and 6.053 GPa, respectively. Furthermore, the WPUs exhibited the capability of rectifying defects in CF and enhancing surface roughness. Importantly, the tensile properties of WPUs-CF exceeded those of numerous established counterparts globally, highlighting a broad spectrum of potential applications.
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BIOCHIMIE
·
2025
·
IF 3
Wenbo Cao,Jun Tan
Comprehensive characterization of fatty acid (FA) structures has important value, as they are important components of cells and are crucial for cell structure and function. However, in view of the different structural possibilities of unsaturated FAs due to the carbon–carbon double bond (C C) location and its chemical configuration, there are still certain difficulties in characterizing unsaturated FAs with high structural specificity. In this work, we present a method based on nuclear magnetic resonance (NMR) spectroscopy for comprehensive characterization of unsaturated FAs. Combining 1D and 2D-NMR spectroscopy, it could provide diagnostic information specific to C C locations and stereochemistry of unsaturated FAs, facilitating FA isomers identification. Structural characterization of unsaturated FAs at the isomeric level has been validated by examination of multiple sample types through our proposed approach. The capability of the proposed method for relative quantitation of FA isomers utilizing its specific diagnostic peaks was also demonstrated. Unlike conventional approaches requiring both reference standards and extensive sample processing, the current proposed method represents a potential alternative by resolving unsaturated lipid structures at high structural level directly.
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Food Frontiers
·
2025
·
IF 6.9
Xiaole Zhao,Bing Zheng,Tianxiang Ao,Jianhua Xie,Yi Chen,Hesham El-Seedi,Hairong Huang,Baoting Liu,Qiang Yu
Polygonatum cyrtonema polysaccharide (PCP-80%) is one of the major active ingredients in Polygonatum cyrtonema . By establishing the type 2 diabetes mellitus (T2DM) rat model and applying multi-omics analysis, the present study aimed to explore the potential mechanism of PCP-80% to alleviate T2DM in terms of the interactions between intestinal microbiota and their metabolites. The results suggested that PCP-80% effectively improve the blood glucose and lipids levels, enhance intestinal barrier function. In addition, PCP-80% restored gut microbiota disorders, increased the secretion of short-chain fatty acids (SCFAs), and enhanced bile acid (BA)-converting enzyme-rich microbiota abundance. Furthermore, PCP-80% intervention significantly ameliorated BA dysmetabolism while enhancing metabolic homeostasis in T2DM rats. These changes activated the G protein-coupled bile acid receptor 1 (TGR5) and farnesoid X receptor (FXR), triggering fibroblast growth factor 15 (FGF15) secretion to ameliorate T2DM-induced intestinal barrier dysfunction and glucose/lipid dysregulation. Mechanistically, PCP-80% exerted therapeutic effects through a microbiota-bile acid crosstalk axis, wherein gut microbiota remodeling enhanced bile acid metabolism and amplified TGR5/FXR-FGF15 signaling, ultimately restoring metabolic homeostasis in T2DM rats.
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