LANGMUIR
·
2025
·
IF 3.9
Haojie Sun,Chunfeng Mao,Jingxuan Xu,Qinyi Li,Yuanhao Mao,Lanjing Zhao,Shengyan Li
Maximizing the mass transfer rate and enhancing the effective spread of active sites and recovery of catalysts between various stages of reaction could help to realize catalytic oxidative performance. Colloidal catalysts can break through the bottleneck problems between solid and liquid catalysts. In this work, colloid Zr-MOFs materials were prepared for the first time as support, and CDUT-Colloid catalysts were prepared by combination with liquid active components. Catalysts exhibit efficient mass transfer characteristics and high dispersion of active sites characteristic of ILs, while possessing the advantages of easy recovery and high stability. The oxidative desulfurization performance approaches 100% under mild reaction conditions (m(CDUT-Colloid-2) = 0.5 g, t = 90 min, n(O)/n(S) = 10, 30 °C). This catalyst exhibits excellent recycling performance, stability of structure, absorbability, and suitable viscosity. The proper viscosity of the colloidal catalyst facilitates phase transfer at the interface, accelerating the transfer of sulfide from the oil phase to the colloidal phase. The phase interface after the reaction is easy to separate, ensuring purity of the final oil. Based on structural analysis, desulfurization performance, and the capture experiment of the transition state (•OH), the oxidative desulfurization reaction mechanism of the colloidal catalytic system can be obtained. The catalytic reaction mechanism can be divided into two steps of collaborative catalysis, which can reveal the uniqueness of the colloidal catalyst in the reaction process. This unique colloidal catalyst provides a research approach for catalysts and lays the foundation for the study of functional materials.
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Analytical Methods
·
2025
·Vol. 17
·期 25
·5298-5307
·
IF 2.6
Yang Cao,Chun Huang,Kui Li,Xi Zhang,Mengfei Tong,Jiale Tu,Kun Yang,Shuai Yuan,Hong Zhang
To sensitively detect ochratoxin A (OTA), a CRISPR/Cas12a-assisted electrochemiluminescence (ECL) aptasensor based on COF@Ru coupled with a DNA tetrahedral scaffold (DTS) was successfully fabricated. The covalent organic framework (COF) acted as a confined micro-reactor for the tris(2,2′-bipyridyl)ruthenium(II)/tri-n-propylamine (Ru(bpy)32+/TPrA) system and hence, evidently enhanced ECL signals. Au nanoparticles (AuNPs) coupled with DTS caused more ferrocene (Fc)-modified quenching DNA probe molecules to be attached to the surface of the sensing electrode, which could reduce the detection background. Activated CRISPR/Cas12a could effectively amplify the ECL signal since it could cut off a considerable amount of quenching DNA probe molecules and make them move away from the electrode. Owing to these strategies, the fabricated ECL aptasensor could detect OTA as low as 3.5 fg mL−1 in a linear detection range of 10−5–100 ng mL−1. Furthermore, the CRISPR/Cas12a and COF@Ru coupled with DTS-based ECL biosensor possessed high stability and specificity. More importantly, the ECL biosensor could effectively detect OTA in food samples, indicating that it can play a role in monitoring OTA levels in the field of food safety.
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PLANT BIOTECHNOLOGY JOURNAL
·
2025
·
IF 10.5
Xuefeng Wei,Guangjin Fan,Song Yang,Xianchao Sun,Lin Cai
Summary Delivery of exogenous nucleic acid to intact plants is a desirable but challenging technology due to the dominant transport barrier posed by the plant cell wall. Here, we found that three different morphologies of g-C 3 N 4 nanomaterials synthesized from urea can assist in the delivery of exogenous nucleic acids into mature leaf cells of Nicotiana benthamiana . Among these, g-C 3 N 4 carbon dots (CDs) showed a higher ability to deliver exogenous nucleic acid compared to nanoporous and g-C 3 N 4 nanosheets. The delivery ability of exogenous dsRNA and plasmid DNA by g-C 3 N 4 could also be restrained by stomatal closure and the endocytosis pathways in plant cells. Furthermore, the coupling of g-C 3 N 4 CDs with dsCP (CDs@dsCP), which is the dsRNA matching a specific fragment of the Coat protein -encoding gene of TMV, resulted in a superior antiviral effect compared with other morphologies of g-C 3 N 4 @dsRNAs and other loaded dsRNAs, which match Replicase , RNA-dependent Replicase or Movement protein of TMV. Significantly, a single spray of CDs@dsCP provided virus protection for at least 5 days. In addition, the g-C 3 N 4 CDs and g-C 3 N 4 CDs@dsRNA had no adverse effects on plant growth and development. Overall, our study presents a novel biocompatible and convenient tool for gene expression or gene silencing in intact plant leaves by spraying g-C 3 N 4 nanomaterials encapsulated with DNA or dsRNA, the efficiency of which is affected by the morphology of the g-C 3 N 4 nanomaterial, stomatal state and plant endocytosis pathway, and a highly promising solution for plant virus disease, which is an unsolved problem in plant disease control.
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Microsystems & Nanoengineering
·
2025
·Vol. 11
·期 1
·1-12
·
IF 9.9
Wang Fang,Zhou Liangyu,Guo Wei,Lin Haisong,Zhang Ruotong,Kuang Shaolong,Liu Yuan,Fan Xiaoxue,Chan Yau Kei,Deng Hui,Shum Ho Cheung
The plasma-derived reactive oxygen and nitrogen species (RONS) enable cold atmospheric plasma (CAP) to combat cancer and infectious wounds. Achieving therapeutic outcomes with CAP necessitates precise treatment doses. Current CAP devices are constrained by their capability of delivering a single dose to a single sample, limiting dose optimization. We propose a novel “one exposure, multiple-dose delivery” strategy by programming gas flows. This approach facilitates efficient screening of optimal CAP dose by distributing feed gas through boundary-conditioned transport channels to generate multiple, flux-varied gas streams, which ignite plasmas with diverse chemical compositions and dose gradients across samples. Our developed demonstration device, capable of administering three doses to sixteen samples, significantly reduces experimental complexity, particularly when handling large candidate doses or samples for treatment. Leveraging multiplexed treatment, we capably optimize the CAP dose to effectively eradicate the liver cancer cell line of Huh7 and bacteria of S. aureus within one exposure. Furthermore, we find manipulating gas flow velocities allows targeted generation of short-lived species. This approach disentangles the roles of short-lived and long-lived RONS in therapeutic applications, offering critical insights into their bio-functional mechanisms. The concept of multiplexed dose treatment with fluidic manipulation promises to catalyze the development of high-efficiency CAP devices and advance research in CAP-based therapies.
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Advanced Science
·
2025
·
IF 14.1
Tao Qin,Lian Qin,Yang Zhao,Yin Chen,Qianyue Liu,Xiaoguang Lin,Yongfeng Lan,Yaohui Huang,Yan Liu,Ke Zhang,Lifan Pan,Jiaxiao Li,Kunpeng Duan,Hao Liang,Mingjing Yin,Guiyang Fan,Lian Liu,Yu Deng,Lin Liao,Danke Su,Ming Gao,Junyu Lu
Sepsis induced acute liver injury (SALI), is a type of acute and severe disease that is generally characterized by producing significant amounts of reactive oxygen species (ROS) in liver tissue, and in response to excessive ROS, producing huge amounts of inflammatory factors by hepatocytes. Considering the crucial role of ROS in SALI, a Pd doped CeO 2 (CP) nano-heterojunction with enhanced ROS scavenging capacity is developed to act as a catalytic nanomedicine for the treatment of SALI. Combining with near infrared (NIR) irradiation, it exhibits excellent scavenging capacity of ROS including hydroxyl radical (•OH), superoxide anion (•O 2 − ), as well as singlet oxygen ( 1 O 2 ) for CP. Significantly, it also demonstrates the excellent antioxidant and anti-inflammatory activities for lipopolysaccharides (LPS) stimulated macrophages (RAW264.7), and cecum ligation and puncture (CLP) treated C57BL/6J mice via reducing intracellular ROS levels, decreasing inflammatory factors expression levels, as well as activating Keap1/Nrf-2/HO-1 pathway to reprogram redox homeostasis, induce cellular autophagy, reduce systemic inflammation and promote liver tissue repair, finally achieving the alleviation of SALI. It provides a promising therapeutic strategy of CP+NIR with high efficacy and biosafety for the management of SALI.
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Small Methods
·
2025
·
IF 9.1
Zheng Chen,Qiyue Wang,Sirui Cui,Xi Hu,Peihua Lin,Bo Zhang,Daishun Ling,Fangyuan Li
Piezoelectric materials have emerged as versatile tools for ultrasound-triggered cancer therapy, yet their clinical application is constrained by inefficient charge separation and the limited availability of catalytic substrates in the tumor microenvironment. Here, an electronegativity-modulated piezoelectric metal–organic framework (CapMOF@HA) is reported through controlled heteroepitaxial growth of CaO 2 on pMOFs, followed by surface functionalization with hyaluronic acid (HA) for tumor-targeting capability for enhanced piezocatalytic therapy. Of note, the electronegativity-modulated heterogeneous interfaces between CaO 2 and pMOF promote the separation of electron–hole pairs while suppressing recombination through the electronegativity effect, significantly amplifying piezocatalytic reactive oxygen species (ROS) generation (•OH, 1 O 2 , and •O 2 ⁻) under ultrasound stimulation. Furthermore, the controlled decomposition of calcium peroxide provides a continuous supply of H 2 O 2 and O 2 as catalytic substrates, while releasing Ca 2+ to induce calcium overload, triggering mitochondrial dysfunction and glutathione peroxidase 4 inhibition for ferroptosis induction. This strategy integrates enhanced piezoelectric catalysis with ferroptosis induction, overcoming long-standing limitations in piezocatalytic systems to achieve precise and robust tumor ablation. By combining substrate self-sufficiency with multifunctional therapeutic mechanisms, this work establishes tumor piezocatalytic ferroptosis as a transformative platform for next-generation piezoelectric cancer therapy.
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TALANTA
·
2025
·
IF 6.1
Qing Peng,Chenxin Qiu,Pengcheng Huang,Fang-Ying Wu
As highly toxic organophosphates, nerve agents can lead to the dysfunction of the nervous system, so the detection of nerve agents has become an important topic. Herein, a MOF-on-MOF heterostructure, Eu-BTC@UiO-66-NH 2 , was simply prepared via the interfacial growth approach to construct an integrated ratiometric fluorescent probe for the detection of nerve agent simulant diethyl chlorophosphate (DCP) both in the liquid and gas phases. In this detection system, the binding of DCP to the Zr–O clusters in UiO-66-NH 2 blocked a ligand-metal charge transfer (LMCT) process and restored the blue fluorescence of ligand (BDC-NH 2 ). On the other hand, the affinity of DCP with Eu 3+ in Eu-BTC hindered a ligand-metal energy transfer (LMET) process, and destroyed the antenna effect, thereby resulting in the weakening of the red fluorescence of Eu 3+ . Using the dual-emission response, this probe enabled ratiometric fluorescence detection of DCP with high accuracy and visualization capability. In addition, the probe was introduced into portable sodium alginate hydrogel to realize direct and sensitive detection of DCP vapor. This work is thus expected to hold great potential for on-site monitoring of nerve agents in a simple yet efficient way.
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JOURNAL OF MEMBRANE SCIENCE
·
2025
·
IF 9
Zhiyuan Huang,Ye Yuan,Weifan Wang,Hao Zheng,Zhi Wang
Mixed matrix membranes (MMMs) have demonstrated remarkable advantages in gas separation applications through the synergistic integration of polymeric matrices and nanostructured reinforcements. While these advanced composite thin-film materials exhibit substantial potential for CO 2 separation, their industrial-scale implementation confronts threefold challenges: elevated manufacturing costs, interfacial compatibility optimization between nanofillers and polymer matrices, and performance enhancement requirements for achieving superior separation efficiency. In this study, the green and economical nanofiller UIO-66-(COOH) 2 (denoted as UC) was strategically selected. A novel strategy involving synergistic modification using Zn 2+ and polyvinylamine (PVAm) was developed to address the critical challenge of severe particle agglomeration and sedimentation. This phenomenon, caused by intense electrostatic interactions between the strongly negatively charged UC and the cationic polymer PVAm during surface modification, was effectively mitigated through the proposed cooperative modification mechanism, resulting in the successful synthesis of P@UC-Zn exhibiting exceptional dispersibility and enhanced compatibility with the polymeric matrix. The fabricated P@UC-Zn-PVAm/mPSf MMMs containing 35 wt% filler exhibited remarkable CO 2 permeance (3250 GPU) and selectivity (166) under feed gas conditions (CO 2 /N 2 = 15/85 vol%, feed pressure: 2 bar). Furthermore, the optimized MMMs demonstrated robust operational stability in simulated flue gas tests and showed potential for applications in carbon dioxide-methane and carbon dioxide-hydrogen separations.
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FOOD CHEMISTRY
·
2025
·
IF 9.8
Chencheng Wei,Jiheng Zhang,Gaozheng Li,Yi Zhong,Zhaoting Ye,Handong Wang,Kezhi Li,Yuanzi Wu,Yuezhong Wu,Heng Luo,Qi Sun,Zuquan Weng
Formaldehyde (FA), a known carcinogen, is occasionally used illegally as a preservative in seafood, while traditional detection methods for FA residues often fail to meet the practical needs for nondestructive detection. In this study, a approach was developed by combining a portable Raman spectrometer with the InceptionTime deep learning model without sample pretreatment. Model were trained by FA-negative and FA-positive Raman spectral data from the shrimp surface and achieved accuracies of 84.40 % and 85.17 % at detection thresholds of 5 mg/kg (the primary safety detection threshold) and 100 mg/kg (the abuse-level contamination threshold), respectively. Metabolomic analysis and weight visualization indicated that the model particularly focused on Raman peaks associated with specific amino acids and astaxanthin-binding proteins. Two amino acid metabolites, timonacic and spinacine, were also identified as direct indicators of FA addition. Our model offers a field-deployable and practical approach for real-time and on-site FA detection scenario.
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DESALINATION
·
2025
·
IF 9.8
Changting Chen,Yu Liu,Jianguo Ma,Shujuan Liu,Jianqiang Luo,Xiaolan Tong,Xuejiao Peng
The effective separation and recovery of uranium holds significant strategic importance for the sustainable management of radioactive wastewater. In view of the limitations of traditional adsorption techniques, a novel uranium extraction system was constructed in this study using a coupled electrochemical-adsorption approach. An innovative glyphosate-functionalized chitosan composite electrode (GP-CS@CF) was developed and integrated with a galvanic cell-assisted (GCA) electrochemical system to achieve high-efficiency uranium removal. Experimental results demonstrated that GP-CS@CF exhibited an excellent adsorption capacity, and the GCA method achieved a uranium extraction rate nearly seven times that of traditional physicochemical adsorption methods, with a maximum adsorption capacity of 4860 mg/g. Moreover, GP-CS@CF exhibited excellent anti-interference properties and regeneration ability. Mechanistic analysis suggested that the enhanced uranium removal was attributed to synergistic effects of three pathways: adsorption by GP-CS@CF, electrochemical reduction via the GCA, and O 2 -mediated oxidation. This study offers a cost-effective and environmentally sustainable strategy for uranium extraction, which has significant potential for practical application.
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JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2025
·Vol. 36
·期 18
·1-11
·
IF 2.8
Liu KunLei,Liu Xumin,Dong Qingchen,Song Lijun,Liang Xinhui,Hu Dianfang,Yu Shihui
Flexible transparent conductive films based on copper nanowires (Cu NWs) are used in a variety of optoelectronic devices. However, their use is limited due to poor stability and adhesion. Herein, highly reliable flexible transparent conductive thin films consisting of SrSnO 3 (STO) and Cu NWs are fabricated using a combination of spin-coating and radio frequency magnetron sputtering techniques. The optical and electrical properties can be modified by changing the number of spin-coating cycle of Cu NWs. The STO thin films can effectively improve optical–electric performance of Cu NWs (before coating STO: 22.1 Ω/sq. at 81.5%, after coating STO: 18.7 Ω/sq. at 82.8%). Furthermore, after 20 tape tests and 2000 bending cycles (with a bending radius of 5.0 mm), the resistance of STO/Cu NW composites remains unchanged, demonstrating exceptional mechanical flexibility and adhesion retention. In addition, the composites show higher stability to high-temperature and high-humidity conditions, oxidation, corrosion, and sulfidation compared with that of Cu NW networks, which is due to the effective covering of STO layer. The combination of these characteristics makes the composite thin films an excellent candidate for substrates of novel flexible optoelectronic devices.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Yuanzhu Long,Wei Xu,Fengxiang Huang,Lu Peng,Yingqian Duan,Diansan Su,Zhaoqiong Zhu
Chitosan hydrogels are widely recognized as promising wound dressings. However, traditional preparation methods often rely on crosslinkers, which pose challenges in terms of biocompatibility and cost. This study introduces a new approach for the spontaneous formation of chitosan hydrogels via carbonic acid modulation, which is crosslinker-free, rapid, simple, and economical. By adding ammonium bicarbonate to acetic acid-solubilized chitosan, an unstable solution is formed. This solution spontaneously releases CO 2 and transforms into a gel within 30 min at 40 °C. Subsequent purification yields a pure chitosan hydrogel composed solely of chitosan and water. The prepared hydrogel demonstrates excellent biocompatibility and significantly promotes wound healing, achieving over 90 % closure of a 1 cm diameter full-thickness skin defect within 10 days. Key performance metrics include a compressive strength of 55.26 kPa, a water retention capacity of 7880.5 %, and a water vapor transmission rate of 496.2 g/(cm 2 ·day). This methodology not only circumvents the limitations of crosslinker-dependent methods but also establishes new possibilities for the biomedical applications of chitosan hydrogels, particularly in advanced wound care and other therapeutic contexts.
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