JOURNAL OF NANOBIOTECHNOLOGY
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2025
·Vol. 23
·期 1
·1-17
·
IF 12.6
Jiang Kai,Lin Zhenyi,Cheng Mingrui,Chen Yanmin,Jiang Yiru,Xu Changhua,Zhu Lijuan,Gong Bo,Zhang Chuan,Hong Jiaxu
Dry eye disease (DED) is a prevalent ocular surface disorder characterized by chronic inflammation and oxidative stress, significantly impacting vision and quality of life. Although reactive oxygen species (ROS) serve as a key upstream regulator that initiate and perpetuate inflammatory cascades in DED, current clinical therapies predominantly target downstream inflammatory pathways, leading to suboptimal treatment outcomes. To address this limitation, we developed a novel mucin-1 (MUC1)-targeted nanotherapeutic platform (tFNA-IM) by integrating the dual antioxidant and anti-inflammatory agent itaconate (ITA) with ROS-scavenging tetrahedral framework nucleic acids (tFNA) for efficient DED treatment. The engineered tFNA-IM exhibits uniform nanostructure and optimal size distribution, enabling deep penetration into ocular tissues, while the conjugated MUC1 aptamer significantly enhances cellular internalization in human corneal epithelial cells (HCECs), as demonstrated by confocal microscopy and flow cytometry analyses. Functionally, tFNA-IM effectively neutralizes ROS, reduces apoptosis, and downregulates pro-inflammatory cytokines in vitro, demonstrating potent anti-oxidative and anti-inflammatory capabilities. In a murine DED model, tFNA-IM exhibits prolonged ocular retention and superior therapeutic efficacy, markedly improving corneal epithelial integrity and suppressing inflammatory responses. These findings establish aptamer-functionalized tFNA as a precision nanoplatform for ocular drug delivery, offering a synergistic therapeutic strategy to disrupt the ROS-inflammatory vicious cycle in DED. Graphical MUC1-aptamer–guided tetrahedral DNA (tFNA-IM) delivers itaconate to the cornea, simultaneously scavenging ROS and suppressing cytokine cascades to break the ROS–inflammation loop and restore epithelial integrity.
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FOOD CHEMISTRY
·
2025
·
IF 9.8
Wenqian Zhu,Wenwen Cao,Rui Chen,Zhen Zhang,Chaohai Pang,Zhongsheng Yi,Shuhuai Li,Xionghui Ma,Jianping Li
Acrylamide (AAm), a carcinogenic by-product formed during food processing, presents significant health concerns. Here, we developed an innovative photoelectrochemical (PEC) sensor for ultra-sensitive AAm detection, based on a framework-targeted affinity strategy. Utilizing a metal-coordinated porphyrin-based covalent organic framework (TT-Por(Co)-COF) as the capture layer, the sensor leverages thiophene units to enhance charge transport and selectively adsorb AAm. Independent Gradient Model (IGMH) analysis confirmed two weak interaction regions, predominantly hydrogen bonding and van der Waals forces, between AAm and the TT units. Signal amplification is achieved using CdTe quantum dots functionalized with an AAm-specific aptamer. Upon AAm binding, the aptamer facilitates QD accumulation, significantly enhancing photocurrent for precise quantification. Under optimized conditions, the sensor exhibited excellent analytical performance with a linear range from 1 pM to 1000 nM and a detection limit of 0.19 pM (3σ/S, n = 11). offering a promising solution for real-time food safety monitoring.
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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2025
·
IF 6.2
Bin Ma,Jiafeng Niu,Hao Zhu,Huibing Chi,Zhaoxin Lu,Fengxia Lu,Ping Zhu
Aldo-keto reductase is responsible for the formation of nontoxic 3-epi-deoxynivalenol (3-epi-DON) from 3-keto-DON, which is an enzymatic detoxification manner to completely eliminate the toxicity of mycotoxin DON against health and environmental threats. Therefore, unlocking the facilitated substrate specificity of aldo-keto reductase for 3-keto-DON has become a critical challenge for advanced catalytic performance. In this endeavor, a loop-based engineering strategy was developed for aldo-keto reductase AKR13B3 from Devosia A6–243 to catalyze 3-keto-DON. A 31.9-fold switch from a disfavored substrate to the preferred one was produced along with a significant 37.9-fold increase in catalytic efficiency. Kinetic parameter determinations, structural analyses, and molecular simulations were employed to elucidate the molecular mechanisms underlying these enhancements in catalytic activity and substrate specificity. Overall, our work presents a feasible scheme for designing aldo-keto reductases with exceptional substrate specificity and catalytic activity, holding great promise for developing enzymatic detoxification agents.
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JOURNAL OF ALLOYS AND COMPOUNDS
·
2025
·
IF 6.3
Muhammad Shoaib,Shengyuan Xu,Haocheng Zhai,Qihui Sun,Shahab Ahmad,Maysam alsharawneh,Yifan Liu,Yang Guo,Xinyu Mu,Wei Tian,Xian Jian
An ideal and distinctive microwave-absorbing carbon-based material feature an eco-friendly, low-cost fabrication process combined with high loss efficiency and strong absorption potential. Here we design an innovative nanohybrids with carbon nano onion (CNO) from paraffin ultra-pure lamp oil by flame method awning unique structure to boost up the dielectric loss. And TiO 2 is introduced for efficient microwave absorption loss through an in-situ process using C 7 H 8 O and TiCl 4 , while SiO 2 plays a critical role in controlling the dielectric constant through the use of tetraethyl orthosilicate (TEOS). To boost up the nanohybrids effective loss mechanism the material is exposed to a carbon capsule (CC) utilizing acetylene (C 2 H 2 ) as a carbon source for 5 minutes under argon to prepare CNO/TiO 2 /SiO 2 /CC nanohybrids. The nearby dual-nanocarbon forms multi-level interfaces enhancing the multi-level rebound and microwave absorption of the microwave interfaces. The as-designed CNO/TiO 2 /SiO 2 /CC has effective minimum reflection loss (RL min ) value of -54.4 dB and the maximum effective absorption bandwidth (EAB max ) of 5.5 GHz at a thickness of 1.9 mm. It also has good thermal conductivity. Hence, this work confirms that high-performance nanohybrids derived from paraffin ultra-pure lamp oil are promising candidates, providing a novel approach for the design and development of carbon-based microwave absorbers.
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Food & Function
·
2020
·Vol. 12
·期 4
·1626-1638
·
IF 4.171
Xu-Hui Huang,Yu-Ying Zhang,Ming Zhu,Da-Yong Zhou,Ming Du,Bei-Wei Zhu,Xiu-Ping Dong,Ian Fisk,Lei Qin
Clam is a kind of nutritious, delicious and economical aquatic food around the world and is famous for its unique aroma. Instrumental analysis, sensory analysis, and comprehensive statistical analysis were performed to explain the relationship between aroma and odorants in clam soup. Six extraction methods combined with GC-MS and sniffing were utilized to obtain the aroma fingerprints of clam soup and to analyze the correlation with aroma perception. Solvent extraction methods were more effective than headspace extraction methods for the volatiles of clam soup. SAFE was the best method to obtain the most comprehensive information of volatiles of clam soup. The sequence of a combination of different extraction methods and SAFE would also affect the results of volatiles extracted from clam soup. Volatiles extracted via SDE, P&T, and SPME would add further information to the result of SAFE. A total of 119 volatile compounds were identified from clam soup by summarising the results of different extraction methods. The significant effect of 14 key odorants in clam soup on aroma perception was verified by aroma recombination and odorant omission tests. A neural network diagram of the aroma profile was designed to visualize the information of odor perception. Furthermore, the results would be beneficial for aroma research studies of aquatic food and the processing of clam products.
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JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
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2025
·
IF 4.7
Lican Wang,Weikun Zhu,Jie Li,Junyi Yue,Jiangyao Chen
H 2 O shows a significant contribution to form oxygen- and hydrogen-containing products during photocatalytic oxidation of aromatic hydrocarbons. However, it was unclear what the roles of atoms in H 2 O in subsequent oxidation of these products. In this study, the photocatalytic oxidation of two aromatic alcohols, benzyl alcohol and phenethyl alcohol, on TiO 2 (79 % anatase and 21 % rutile) were investigated in mixed H 2 O (or H 2 18 O, D 2 O) and O 2 system. Aromatic aldehydes, acids and esters were main aromatic products, while modified TiO 2 and isotope-containing H 2 O did not change the product species. Aromatic aldehydes showed ≤ 0.19 % and ≤ 1.58 % of 18 O- and D-labeling rates, suggesting hardly involvement of H 2 O in their formation. Aromatic acids exhibited a 18 O-labeling rate range of 28.12 %-40.33 % and the highest D-labeling rate of 0.76 %, while a maximum enhancement of 18 O-labeling rate was 0.11 % in the –C=O group of the acids, indicating that H 2 O selectively provided O atom in the formation of –OH group of aromatic acids. The 18 O- and D-labeling rates of aromatic esters were in the range of 9.01 % to 15.95 % and 1.73 % to 8.08 %, suggesting that both oxygen and hydrogen atoms from H 2 O contributed to aromatic ester formation. Further analyzing mass fragmentation confirmed that H 2 O separately contributed its hydrogen and oxygen atoms to the –C=O and R–O groups of the esters. Based on the isotope tracing results, the contribution roles of H 2 O’s hydrogen and oxygen atoms in oxidation of aromatic alcohols to corresponding aromatic products were proposed. The findings in this study help to clarify the role of H 2 O in the oxidation process of aromatic alcohols at the atomic level and comprehensively reveal the oxidation mechanism of the aromatics.
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Polymers
·
2025
·Vol. 17
·期 8
·1030
·
IF 4.9
Chaoqun Wang,Tong Wu,Yidi Li,Jie Liu,Yanshai Wang,Kefeng Wang,Yang Li,Xuefei Leng
Amphiphilic block copolymers with complex topologies (e.g., star and brush topologies) have attracted significant attention in drug delivery owing to their superior performance over linear micelles. However, their precise synthesis and structure–property relationships require further investigation. In this study, hydroxylated polybutadiene with adjustable topology and hydroxyl group density was employed as a macroinitiator to synthesize well-defined amphiphilic poly (ethylene oxide)- b -poly( ε -caprolactone- ran - δ -valerolactone) (PEO- b -P(CL- ran -VL)) copolymers via ring-opening polymerization (ROP). A series of linear, star, linear–comb, and star–comb copolymers were prepared as curcumin-loaded micellar carriers for the study. The self-assembly behavior, drug encapsulation efficiency, and in vitro release profiles of these copolymers in aqueous environments were systematically investigated. The results demonstrated that increasing the branch length of star–comb copolymers effectively reduced micelle size from 143 to 96 nm and enhanced drug encapsulation efficiency from 27.3% to 39.8%. Notably, the star–comb architecture exhibited 1.2-fold higher curcumin encapsulation efficiency than the linear counterparts. Furthermore, the optimized star–comb nanoparticles displayed sustained release kinetics (73.38% release over 15 days), outperforming conventional linear micelles. This study establishes a quantitative structure–property relationship between copolymer topology and drug delivery performance, providing a molecular design platform for programmable nanocarriers tailored to diverse therapeutic requirements of various diseases.
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Journal of Environmental Sciences
·
2025
·
IF 6.3
Jing Yang,Yongjie Fan,Jia Tang,Kunde Lin
Benzalkonium chlorides (BACs), a major class of quaternary ammonium compounds, are widely used disinfectants in hospital settings and commonly enter wastewater treatment systems. Although the role of tertiary amines in promoting disinfectant byproduct (DBP) formation has been well documented, the contribution of BACs to chlorination reactions has been largely overlooked. This study demonstrates that BACs significantly enhance the chlorination of phenol, promoting the formation of toxic chlorophenols and their downstream transformation products. The enhancing effect is attributed to the generation of highly reactive R 3 N⁺-Cl intermediates via BAC oxidation by chlorine. The strong electrophilic nature of R 3 N⁺-Cl facilitates chlorination, leading to the increased formation of 2,4-dichlorophenol and 2,4,6-trichlorophenol, with shorter-chain BACs (C12) exhibiting stronger effects than longer-chain counterparts (C14, C16). Further oxidation of 2,4,6-trichlorophenol leads to the formation of trichloro-hydroxy-cyclopentene-dione, a highly toxic DBP. Density functional theory calculations suggest that while the electronic properties of BAC-derived chloramine intermediates are similar, the reactivity of longer-chain BACs decreases due likely to lower aqueous solubility and diffusion rates. These findings highlight BACs as important contributors to chlorinated DBP formation in chlorination processes and underscore the need to assess their impact in wastewater treatment, particularly in hospital effluents with high BAC concentrations.
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CRYSTAL GROWTH & DESIGN
·
2025
·
IF 3.4
Ruoling Wu,Caixia Xu,Ke Ding,Jiarong Zhang,Haibin Sun,Long Xu
Herein, high-quality (006)-oriented and ultrawide bandgap near-stoichiometric lithium niobate quasi-single crystal thin films are prepared using the sol–gel method. The optimal growth condition is investigated by changing the drying and annealing temperatures. The (006)-diffraction pattern of the X-ray diffraction spectra implies the high purity phase of the quasi-single crystal thin films. The molar ratio of the Li and Nb elements is analyzed using X-ray photoelectron spectroscopy and inductively coupled plasma mass spectrometry, confirming that the ratios close to 1:1 are measured. The bandgap of the lithium niobate is approximately 4.4 eV using the Tauc-plot fitting of the absorption spectra, and high-performance solar-blind photodetector based on the ultrawide bandgap lithium niobate thin films is studied. This work paves the way for advancing cost-effective optoelectronic devices based on lithium niobate thin films for UV detection technology.
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JOURNAL OF CONTROLLED RELEASE
·
2025
·
IF 11.5
Kunpeng Liu,Binbin Jiao,Guan Zhang,Zhihua Gan,Shicong Lai,Zhenshan Ding,Qingsong Yu
Bladder cancer remains a significant clinical challenge, necessitating the development of innovative therapeutic strategies. Recent advancements have highlighted the potential of reactive oxygen species (ROS)-responsive drug delivery systems in cancer therapy. In this study, we introduce a novel treatment approach utilizing a ROS-responsive camptothecin (CPT) prodrug encapsulated within a chitosan nanocarrier, named CACPT. Cinnamaldehyde (CA), acting as a ROS generator, forms thioketal bonds with CPT to create a prodrug that responds selectively to the elevated ROS levels within the tumor microenvironment. Upon exposure to high ROS conditions, these thioketal bonds are cleaved, resulting in the simultaneous release of CPT and CA. The liberated CA further enhances ROS production, establishing a positive feedback loop that amplifies the therapeutic effect. The use of amphiphilic chitosan nanocarriers enhances the retention and penetration of the prodrug within bladder tissue, optimizing its therapeutic potential. Our experimental findings demonstrate that this self-enhanced ROS-responsive release promotes increased cellular uptake and significantly enhances the anticancer efficacy of CACPT. These results position CACPT as a promising candidate for intravesical therapy in bladder cancer, potentially overcoming current limitations in treatment options. The innovative combination of ROS-responsive mechanisms and chitosan nanocarriers represents a paradigm shift in bladder cancer therapeutics, offering a multifaceted approach with substantial promise for clinical translation.
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ELECTROCHIMICA ACTA
·
2025
·
IF 5.6
Yuda Lin,Kaihui Lin,Xiaohui Xu,Junjie Chen
In this paper, a new composites material Zn 3 V 3 O 8 /VO 2 @Nitrogen graphene (ZnVO/VO 2 @NG) was synthesized, and its structural features and electrochemical properties were systematically characterized. The electrochemical analysis reveals that the electrode exhibits fast electron/lithium ion transport kinetics, and its pseudocapacitive behavior storage characteristics can achieve ultra-fast dynamic response. The ZnVO/VO 2 @NG electrode maintains a high reversible specific capacity of 995 mAh g -1 after 700 cycles at 1 A g -1 , and an impressive rate capability of 540 mAh -1 at 5 A g -1 . In addition, first-principles calculation reveals that ZnVO/VO 2 @NG exhibits zero-bandgap metallic properties with excellent electrical conductivity. Meanwhile, differential charge density and adsorption energy calculations further demonstrates that Li-ions at the interface of ZnVO and NG have a charge transfer as high as 1.71 eV, and a corresponding adsorption energy of -5.46 eV, which suggests the existence of strong lithium interactions at this interface. These findings provide an important theoretical basis for a deeper understanding of the lithium ion storage properties at the heterogeneous interface.
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ENERGY & FUELS
·
2025
·
IF 5.3
Shengqi Lin,Hailong Huang,Jieyi Fan,Chunhe Li,Kuankuan Ren,Weidong Dou
Photocatalytic conversion of biomass-derived compounds into value-added chemicals coupled with hydrogen production presents a promising strategy to address energy and environmental challenges. In this study, a series of NiB/ZnIn2S4 nanocomposites were synthesized via a facile two-step hydrothermal approach. The designed system enables the simultaneous utilization of photoexcited electrons and holes in redox reactions, achieving efficient benzyl alcohol oxidation and hydrogen evolution. The optimized 3%-NiB/ZnIn2S4 nanocomposite demonstrates exceptional photocatalytic performance, exhibiting a hydrogen evolution rate of 7223.2 μmol g–1 h–1 in 1.50 vol % benzyl alcohol solution, representing 2889.3-fold and 4.8-fold enhancements over pristine NiB and ZnIn2S4, respectively. Furthermore, the system maintains robust stability over 14 photocatalytic cycles, achieving 71.7% conversion efficiency and 86.8% selectivity toward benzaldehyde production. The enhanced performance originates from the formation of Z-scheme heterojunctions between NiB and ZnIn2S4, which facilitates efficient charge carrier separation and transport, as evidenced by improved photocurrent response and reduced electrochemical impedance. This work provides valuable insights into the photocatalytic valorization of biomass-derived platform chemicals under visible light irradiation.
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