ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
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2024
·
IF 6.2
Rongfang Yang,Jiaxin Zhang,Xiumei Xing,Shiyuan Zhong,Wenxue Li,Lixian Wen,Yuwei Zhang,Hongwei Zhou,Shen Chen,Wen Chen,Yongmei Xiao,Liping Chen
Benzene exposure has been linked to various adverse health effects. However, the effective strategy for prevention or treatment of benzene-induced hematotoxicity remains unsolved. We previously administrated hepatocyte-specific deletion of Ppp2r1a gene (encoding PP2A Aα subunit) mice with benzene via inhalation for 28 days, and found homozygote (HO) mice exhibited alleviative hematotoxicity compared with wild type (WT) mice. Here, we integrate untargeted metabolomics and transcriptomics data to identify the key metabolic pathways and metabolites attenuating benzene-induced hematotoxicity. Metabolomics analysis revealed the perturbation of nicotinate and nicotinamide metabolism, as well as taurine and hypotaurine metabolism pathways, were implicated in regulating benzene-induced hematotoxicity. Meanwhile, transcriptome analysis showed that immune-, inflammation-, and metabolism-related pathways were obviously disturbed in WT mice groups upon benzene exposure, while sirtuin signaling pathway, associated with nicotinate and nicotinamide metabolism, was activated in HO mice groups. Notably, combined metabolomics and transcriptomics analysis further confirmed the involvement of nicotinate and nicotinamide metabolism, taurine and hypotaurine metabolism pathways in relieving benzene-induced hematotoxicity. Specific metabolites, including 1-methylnicotinamide (MNA), nicotinamide (NA), β-nicotinamide mononucleotides (NMN), and taurine were identified as the potential metabolites alleviating benzene-induced adverse effects. In vitro experiments demonstrated the protective effect of MNA and NA against 1,4-benzoquinone (1,4-BQ)-caused cytotoxicity in HL-60 cells. In vivo , MNA supplementation in drinking water could effectively restore the decline in white blood cell (WBC), lymphocyte (LYMPH), and reticulocyte (RET) counts, also mitigate oxidative damage and genotoxicity in response to benzene exposure. These observations highlight the potential of MNA supplementation as a strategy for preventing benzene-caused hematotoxicity.
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TOXICOLOGY
·
2024
·
IF 4.8
Jingyu Wang,Xiaoli Guo,Yujiao Chen,Wei Zhang,Jing Ren,Ai Gao
Benzene exposure leads to hematotoxicity, and epigenetic modification is considered to be a potential mechanism of benzene pathogenesis. As a newly discovered post-transcriptional modification, the roles of N6-methyladenosine (m6A) in benzene hematotoxicity are still unclear. m6A can only exert its gene regulatory function after being recognized by m6A reading proteins. In this study, we found that the expression of m6A reader IGF2BP1 decreased in benzene poisoning workers and in 20 μM benzene metabolite 1,4-BQ-treated AHH-1 cells. Further overexpression of IGF2BP1 in mice alleviated 50 ppm benzene-induced hematopoietic damage, suggesting that IGF2BP1 plays a critical role in benzene hematotoxicity. Next, we examined transcriptome-wide m6A methylation in vitro to search for target genes of IGF2BP1. We found that benzene metabolite 1,4-BQ treatment altered the m6A methylation levels of various genes. The comprehensive analysis of mRNA expression and m6A methylation uncovered that the hypomethylated Ribosomal Protein L36 (RPL36) and its consequent reduced expression impaired cell proliferation. Mechanically, m6A modification reduced RNA stability to down-regulate RPL36 expression. Moreover, overexpression of IGF2BP1 relieved RPL36 reduction and cell proliferation inhibition caused by benzene in vitro and in vivo by directly binding with RPL36 mRNA. In conclusion, the m6A reader IGF2BP1 attenuates the stability of RPL36 and cell proliferation to mediate benzene hematotoxicity by recognizing m6A modification. IGF2BP1 and RPL36 may be key molecules and potential therapeutic targets for benzene hematotoxicity.
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JOURNAL OF HAZARDOUS MATERIALS
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2025
·
IF 11.3
Jiaqing Huang,Xiaoyong Xia,Jiajia Li,Liang Liu,Chunyue Xu,Jinkai Qiu,Cheng Lian,Qingfeng Xu,Jianmei Lu
The extraction of TcO 4 - from nuclear wastewater via adsorption-based methods is recognized as a highly promising strategy but confronted with significant challenges due to the harsh conditions often encountered, such as highly acidic or alkaline environments, elevated ionic strengths, and intense radiation fields. In this work, we have designed and synthesized a triazine-tri-imidazole based cationic covalent organic polymer, CTFT, with covalent triazine frameworks (CTF) as the structural building blocks and tri-imidazole-based (TIB) units as the connecting motifs. This highly conjugated polymer successfully overcomes the aforementioned challenges and exhibits remarkable ReO 4 - (a non-radioactive substitute to TcO 4 - ) uptake capabilities across five critical performance metrics simultaneously: ultrafast adsorption kinetics (equilibrium reached within 0.5 min), exceptional resistance to strong acids and bases (4 M HNO 3 and 4 M NaOH), high selectivity towards ReO 4 - (80.5 %, 5000 × over SO 4 2- ), superior radiation resistance (400 kGy γ-rays), and outstanding recyclability (20 cycles, 95.6 % retention). Additionally, CTFT achieves a high ReO 4 - removal efficiency in simulated Hanford waste (85.3 %, 10 g/L). Experimental and theoretical calculation results demonstrate that strong electrostatic interactions and affinity exist between imidazolium cation and ReO 4 - . This finding provides a potential design strategy for developing polymers with high durability in the field of nuclear environmental remediation.
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WATER RESEARCH
·
2025
·
IF 12.4
Lingyou Meng,Zhuo Li,Binhong Qu,Peng Li,Jianhui Sun,Yang Qu,Ziqing Zhang,Liqiang Jing
The ultrasensitive, visual and intelligent identification of persistent chlorophenols (CPs) in complex drinking and environmental water matrices is highly desirable. In this study, we have established an interesting colorimetric dye eosin Y (EY)-molecular imprinted Bi 4 O 5 Br 2 nanosheet photosensitization sensing system for CPs detection, in which the key is the rapid EY photosensitization decolorization to be efficiently inhibited in the presence of CPs. It displays an ultrasensitive detection of CPs, especially for the typical 2,4,6-trichlorophenol (TCP) across from 10 ng·L −1 to 1 mg·L −1 , achieving a limit of detection of 7 ng·L −1 with remarkable selectivity. By means of in-situ Fourier transform infrared spectroscopy, time-resolved laser flash photolysis spectroscopy, and theoretical calculations, the outstanding performance is attributed to (i) the efficient transfer of triplet excited state electrons from EY to the ultrathin Bi 4 O 5 Br 2 (∼4 nm) nanosheets through energy band alignment and (ii) enhanced TCP selective adsorption resulting from a planar adsorption configuration induced by multiple Bi–Cl interactions, along with specific molecular imprinting recognition sites. Additionally, a real-time intelligent sensing platform was further engineered by integrating automatic sampling, an optical fiber source and a smartphone with color recognition software, enabling convenient and visual detection of TCP in challenging water environments. The sensing system exhibited excellent performance in detecting TCP across various actual water matrices, achieving acceptable recovery rates ranging from 93.33% to 113.33% with the relative standard deviations between 0.80% and 11.31%. It also demonstrated significant advantages over the ultra-performance liquid chromatography-tandem mass spectrometry, particularly regarding speed, simplicity and sensitivity, thus indicating substantial potential for practical applications in water quality monitoring.
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CHEMICAL ENGINEERING JOURNAL
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2025
·
IF 13.2
Yimeng Du,Jian Li,Mingfu Zhu,Pengcheng Lin,Ying Chen
State-of-the-art solar-driven evaporation systems plays an important role in generating clean freshwater with near zero energy consumption. There still remains pressing needs for innovative system design to enhance evaporation rates. Herein, synergistic enhancement of solar interface evaporation by oxidation engineering of photothermal materials, hybridization of water channels and energy supplement of waterwheel is proposed. Oxidation engineering is used to prepare a conjugated oxidized polybenzene, exhibiting high solar absorption capabilities of 87.5 %. Chitosan hydrogel is combined with poly (methacrylic acid) to acquire a self-supporting water transport structure. The obtained bilayer evaporator achieves an evaporation rate of 2.07 kg·m −2 ·h −1 and an energy efficiency of 93.0 %. Building upon these materials, a waterwheel system that utilizes the kinetic and potential energy of water is constructed. This system increases the evaporation rate to 4.13 kg·m −2 ·h −1 with minimal water flow. This system demonstrates the potential for efficient and sustainable clean water production, underscoring its significance in addressing water scarcity challenges.
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Processes
·
2025
·Vol. 13
·期 7
·2159
·
IF 2.8
Xue-Mei Zhang,Shi-Zhong Yang,Homely Isaya Mtui,Bo-Zhong Mu
Recently, vegetable oil-derived monounsaturated fatty acids (MUFAs) have predominantly been utilized in producing bio-based surfactants, resulting in low bioresource utilization and high separation costs. Although polyunsaturated fatty acids (PUFAs) are abundant and often co-exist with MUFAs, bio-based surfactants synthesized from PUFA-rich feedstocks have been less researched due to concerns regarding their interfacial performance. In this study, a novel series of PUFA-based zwitterionic surfactants with strong interfacial activity was synthesized from waste vegetable oils via an eco-friendly three-step process, optimized through an orthogonal experimental design. The structures and conversion rates of the surfactants were confirmed using GC-MS, LC-MS, and ESI-MS. At 0.5 g/L and 3.0 g/L (typical concentrations often used in most oil fields), the bio-based surfactants derived from waste soybean oil (PUFA-to-MUFA ratio ≈ 2.11, C18:2, and C18:1 in large contents) could reduce the interfacial tension between Daqing crude oil and simulated formation groundwater to an ultra-low level of ~10−3mN/m. These results confirm our hypothesis that bio-based zwitterionic surfactants derived from PUFA-rich feedstocks possess excellent interfacial activity, providing a potential sustainable option to be considered for chemically enhanced oil recovery.
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JOURNAL OF WUHAN UNIVERSITY OF TECHNOLOGY-MATERIALS SCIENCE EDITION
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2025
·Vol. 40
·期 4
·946-952
·
IF 1.1
Guo Jiahua,Wei Tao,Huagn Zhixiong,Deng Zongyi,Shi Minxian
We aimed to enhance the flame retardancy of epoxy resin (EP) by synthesizing a novel, halogen-free flame retardant through a one-pot method. The synthesis utilized 9,10-dihydro-9-oxa-10-phosphaphenanthrene-10-oxide (DOPO), furfurylamine (FA), and benzene propionaldehyde (BPA) as raw materials. We conducted differential scanning calorimetry (DSC) analysis to investigate the effects of FPD on the curing process and thermal properties of EP. Our findings reveal that incorporating FPD into EP can facilitate a faster curing process and increase the carbon residue post-combustion. Specifically, the FPD/EP-7 composite demonstrates a limiting oxygen index (LOI) of 34.9% and achieves a UL-94V-0 rating with a phosphorus content of 0.91wt%. These results indicate that FPD significantly enhances the thermal stability and charring rate of EP, thereby improving its flame retardancy. Although the addition of FPD slightly reduces the mechanical properties of EP, the composite material maintains excellent performance.
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Advanced Composites and Hybrid Materials
·
2025
·Vol. 8
·期 4
·1-23
·
IF 21.8
Yin Xiujuan,Xue Shuqin,Ji Jiaqi,Zhao Mingyu,Shao Min,Yin Likang,Zhang Saisai,Liu Lei,Li Bin,Zhang Lei,Li Yuan,Wang Xiao
Liver fibrosis (LF) is a leading cause of liver-related mortality worldwide. Although antifibrotic drugs are commonly used in clinical practice, their efficacy remains limited. Excessive reactive oxygen species (ROS) in the fibrotic liver microenvironment play a crucial role in LF progression. Nanozymes, owing to their enzyme-mimicking catalytic activity and antioxidant properties, offer a promising strategy for LF treatment. Vanadium-based nanozymes exhibit ROS-scavenging capabilities and promote fibrosis reversal, while zirconium (Zr)-based metal–organic frameworks (MOFs), such as UiO-66, possess excellent biocompatibility and catalytic activity. However, the therapeutic efficacy of nanozymes is hindered by their intrinsic catalytic limitations. Ultrasound (US), a non-invasive therapeutic modality, has been shown to enhance nanozyme activity and improve treatment outcomes. In this study, we developed a dual-nanozyme composite (UiO-66/V 2 C/L-Arg/pPB, UVLp) with targeted ROS-scavenging and L-arginine (L-Arg) delivery capabilities. Upon ultrasound exposure, UVLp releases L-Arg and nanozymes, facilitating nitric oxide (NO) generation, alleviating oxidative stress, and mitigating liver fibrosis. This work introduces a novel ultrasound-activated nanozyme platform for LF therapy, providing valuable insights for clinical translation.
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CHEMISTRY OF MATERIALS
·
2025
·
IF 7
Panpan Yang,Sheng Lu,Yuemiao Zhang,Xiaoting Lu,Pengfei Huang,Kun Wu,Jun Shi,Yi Fu
The production of degradable polymer materials with high thermal conductivity is urgently needed to reduce plastic pollution from electronic waste. This research prepared a series of intrinsically thermally conductive polyesters (L-LCPs) by the melt polycondensation reaction of biphenyl diol with three different dicarboxylic acids, which are dl-tartaric acid, dl-malic acid, and diethanolic acid. The thermal conductivity and hydrolysis behavior of these were investigated. Biphenyl group π–π stacking enhances the interchain interactions and endows the polyester with high thermal conductivity. The thermal conductivity of L-LCP3 reaches 0.716 W/(m·K), showing a significant improvement of 168.8% compared to L-LCP1, which is 3.5 times higher than polyethylene terephthalate (PET). The differential scanning calorimetry (DSC) results of the cooling process and the polarizing optical microscopy (POM) pictures showed that all of the L-LCPs are bidirectional thermotropic liquid crystal polymers. Meanwhile, the L-LCPs were efficiently hydrolyzed to valuable raw materials by using the mixed solvents tetrahydrofuran (THF) and H2O. The notable merits of the solvent system are the fragmentation effect of tetrahydrofuran and the enhancement of the catalyst NaOH activity by H2O. The L-LCPs are transformed into oligomers or monomers as the hydrolysis reaction proceeds. The residue weights of L-LCP3 were reduced to 67.2% in the THF–H2O solvent system. The T5%, Tmax, and residual carbon of L-LCP3 were 375.1 °C, 430.4 °C, and 6.2% at 800 °C, respectively, indicating that it has good thermal stability.
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ENERGY & FUELS
·
2025
·
IF 5.3
Haoyu Liu,Yanlin Wang,Hong Yuan
The introduction of mesopores to zeolite crystals via small organic templates has attracted widespread attention. In this study, we used cetylpyridinium bromide (CET–PyBr) to direct the synthesis of hierarchical meso-microporous ZSM-5 zeolite (HMM). By varying the CET–PyBr and sodium sulfate contents in the initial gel, the pore structure and acidity of the HMM were systematically modified. X-ray diffraction (XRD), Fourier-transform infrared (FTIR) spectroscopy, scanning electron microscopy (SEM), transmission electron microscopy (TEM), and N2 adsorption/desorption were utilized to investigate HMM’s mesoporous network. In HMM, mesopore formation was attributed to the assembly of nanocrystal clusters. By optimizing the organic templates, the HMM formation mechanism was elucidated. The acidities of the HMM catalysts were further characterized using temperature-programmed ammonia desorption, magic angle spinning nuclear magnetic resonance, and Py-IR spectroscopy. At 500 °C, the catalytic cracking of oleic acid over HMM yielded up to 54.0% light olefins, and HMM maintained its activity for up to 40 h. HMM’s homogeneous mesopores and moderate acidity contributed to its extended lifespan and enhanced its gaseous product yield.
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PEST MANAGEMENT SCIENCE
·
2025
·
IF 3.8
Haiyan Yu,Tao Zhang,Cunyu Wei,Juan Yang,Xinle Ma,Jingchao Chen,Hailan Cui,Feng Liu,Xiangju Li
BACKGROUND Mesosulfuron-methyl (MSM) is currently the only available selective herbicide for controlling Aegilops tauschii in wheat fields. Improving the control performance of MSM against Ae. tauschii is crucial for ensuring wheat yield. Herein, strategies to improve the bioactivity of MSM against Ae. tauschii and the underlying mechanism were investigated. RESULTS The efficacy of MSM oil dispersion (MSM-OD, GR 50 = 21.62 g a.i. ha −1 ) on Ae. tauschii was higher than emulsion in water (GR 50 = 59.96 g a.i. ha −1 ) and emulsifiable concentrate (GR 50 = 77.34 g a.i. ha −1 ). A greater retention on Ae. tauschii leaves was responsible for the increased MSM-OD bioactivity. As the particle size decreased from 13.58 to 1.20 μm, the herbicidal activity of MSM-OD towards Ae. tauschii increased 3.07-fold, which was attributed to the small particle size-enabled faster plant absorption of MSM. Polyvinyl alcohol (PVA, 3%) addition in MSM-OD with a small particle size (MSM-OD-S + PVA) increased MSM residue on Ae. tauschii leaves after washing, and thus herbicidal activity. The increased wettability on Ae. tauschii leaves was related to the PVA-induced rainfastness increase of MSM-OD-S. Importantly, MSM-OD-S + PVA at the recommended field rate did not show an adverse effect on wheat growth. CONCLUSION A suitable formulation, reduced particle size and PVA addition can increase the herbicidal activity of MSM against Ae. tauschii , particularly under rainy conditions. These results can provide guidance for the development and application of other herbicides. © 2025 Society of Chemical Industry.
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Advanced Healthcare Materials
·
2025
·
IF 9.6
Danying Yi,Tao Wang,Shuangshuang Xu,Yuying Liu,Zhonghao Wang,Ning Li,Ye Wu,Yiyan He
Conventional cancer treatments often result in tissue loss, incomplete tumor excision, infections, and systemic toxicity, severely impacting patient recovery. These complications frequently involve excessive reactive oxygen species (ROS) generation and persistent inflammation, pathological features also characteristic of burn wounds and postoperative tumor sites. To address this, an injectable ROS/pH-responsive hydrogel integrating localized tumor therapy and wound healing is developed. The hydrogel is fabricated via Schiff base crosslinking of a thioketal-based ROS-cleavable linker with aldehyde-functionalized hyaluronic acid, enabling degradation under oxidative and acidic conditions. The hydrogel demonstrates mechanical robustness, excellent biocompatibility, and stimulus-triggered, on-demand drug release. In a breast tumor model, the designed hydrogel facilitates controlled co-delivery of a chemotherapeutic agent 5-fluorouracil (5-FU) and a photosensitizer precursor 5-aminolevulinic acid (ALA), and ensures precise, sustained drug release, achieving synergistic chemo-photodynamic therapy and superior tumor inhibition. Given the pathological similarities between tumor resection wounds and burn injuries, a second-degree burn model is employed to assess the hydrogel's regenerative performance under ROS-rich, inflammation-prone conditions. The hydrogel enables localized antioxidant drug N-acetyl-L-cysteine (NAC) delivery and non-mechanical, on-demand removal. These findings highlight the potential of this multifunctional hydrogel as a minimally invasive, dual-purpose platform for managing cancer-associated tissue injuries and oxidative stress-mediated wound healing.
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