Alexandria Engineering Journal
·
2024
·
IF 6.2
Xiangkun Li,Zhenhua Guo
This study presents a photo sensor for caffeine (CA) detection, employing gold nanoparticles (Au NPs) immobilized on bismuth vanadate on indium tin oxide substrate (Au-BiVO 4 /ITO). The characterization of the Au-BiVO 4 /ITO electrode was investigated by surface analysis, crystallography and electrochemical methods. The incorporation of Au NPs into the BiVO 4 structure has significantly increased the photocatalytic performance of the material, especially its photocurrent response. This modification has increased the photocurrent from the initial value of 200 µA to more than 300 µA. The Au-BiVO 4 /ITO PEC sensor demonstrated enhanced photocurrent responses to CA under visible light, compared to BiVO 4 /ITO. Under optimized conditions, the PEC sensor showed a linear correlation between analytical signal and CA concentration from 0.3 to 270 μM, with obtained detection limit of 0.08 μM. Using the standard addition way, it measured CA in serum and urine samples from athletes, achieving average recovery rates of 99.4 % in serum and 97.8 % in urine, which indicates high accuracy. Moreover, the results showing strong agreement with standard HPLC analysis and demonstrating high recovery efficiency. Furthermore, the sensor demonstrated excellent performance with acceptable figure of merit for CA measurement, making it suitable for reliable analytical applications in biological samples.
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ADVANCED ENGINEERING MATERIALS
·
2024
·Vol. 26
·期 15
·2400249
·
IF 3.4
Yuanli Shen,Yu Xiang,Dhandapani Kuzhandaivel,Luyao Wang,Zixiang Weng,Longhui Zheng,Jianlei Wang,Qia Zhang,Lixin Wu
Carbon-based composite materials have garnered widespread attention in the field of personal thermal management (PTM). In these applications, constructing conductive fillers with a highly cross-linked network is key to achieving the rapid electrothermal conversion of materials. Herein, a novel carbon-based composite material is successfully developed using screen printing technology, with a waterborne polyurethane (WPU) matrix embedded with carbon nanotubes (CNTs) and calcein-modified graphene nanosheets (CAG). Due to the strong π–π conjugation interactions present in the highly cross-linked carbon-based network, the resulting CAG-CNTs/WPU composite forms a 3D conductive network, which not only demonstrates a significant synergistic effect but also facilitates efficient transport of electrons and phonons. Experimental results show that the CAG-CNTs/WPU composite possesses excellent electrothermal conversion properties and an upper high thermal conductivity (3.10 W m −1 K −1 ). At a low voltage of 5 V, the composite exhibits a rapid response, increasing to 50 °C in 20 s. This research not only highlights the importance of adopting environmentally friendly preparation methods but also emphasizes the synergistic role played by 2D graphene nanosheets and 1D CNTs in building an efficient 3D electrothermal network, which has significant scientific and application value in advancing PTM applications.
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MICROCHIMICA ACTA
·
2025
·Vol. 192
·期 9
·1-10
·
IF 5.3
Wang Feifei,Wang Xinling,Wang Yu,Zhang Yin,Liu Tianxiang,Sun Jian
A novel and facile fluorescence turn-on assay for detecting α-glucosidase (α-Glu) activity and screening inhibitors is reported. This assay exploits α-Glu-catalyzed hydrolysis of L-ascorbic acid-2-O-α-D-glucopyranosyl (AA2G) to release ascorbic acid (AA), triggering an in situ fluorogenic reaction with N-methylethylenediamine (N-MEDA) that generates non-conjugated polymer dots (NCPDs). These NCPDs emit blue fluorescence at 425 nm upon excitation at 350 nm, and the fluorescence intensity increases proportionally with the concentration of α-Glu, enabling quantitative detection of enzymatic activity. The fluorescent assay demonstrates a linear response ranging from 0.01 to 10 U/mL and achieves a low detection limit of 0.0034 U/mL, surpassing most existing methods in sensitivity and width of linear range. In addition, the proposed method has been successfully applied to screen α-Glu inhibitors (AGIs) and determine α-Glu activity in real samples, yielding satisfying results. This work introduces a robust analytical framework and promising approach for clinical diagnosis and anti-diabetic drug discovery. Graphical
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RSC Advances
·
2025
·Vol. 15
·期 37
·30456-30465
·
IF 4.6
Jiangpeng Tang,Chang-ye Hui,Shunyu Hu,Wanyan Wu,Peishuo Cao,Jingwen Ling,Xueqin Yang,Zhenlie Huang,Yan Guo
Rapid, low-cost trace inorganic Hg(II) detection in environmental waters remains a critical public-health challenge. Here, we engineered Escherichia coli into a naked-eye whole-cell biosensor by coupling a redesigned MerR-Pmer element to the pyomelanin biosynthetic pathway. Three 4-hydroxyphenylpyruvate dioxygenase (HppD) homologs from Aeromonas media WS, Aeromonas hydrophila 4AK4, and Pseudomonas aeruginosa PAO1 were codon-optimized and functionally screened. The sensor strain of TOP10/pHg-PAO1 exhibited the broadest quantitative range (4.9–1250 nM) and the lowest detection limit (1.2 nM), outperforming most fluorescent counterparts. The water-soluble red-brown pyomelanin product was measured directly in the culture supernatants by absorbance at 400 nm, without requiring extraction. It remained chromogenically stable for at least 14 hours. The biosensor demonstrated absolute selectivity for Hg(II) in the presence of other ions, including Mg(II), Ca(II), Cd(II), Mn(II), Cu(II), Pb(II), and Zn(II), all at a concentration of 5 μM. It retained quantitative accuracy in tap, lake, and coastal seawater matrices. These features enable on-site, equipment-free screening of environmental waters and establish pyomelanin as a robust, user-friendly chromogenic reporter for next-generation whole-cell sensors.
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DESALINATION
·
2025
·
IF 9.8
Minfu Mo,Yaling Lin,Danni Lin,Xiaojuan Ma,Yubin Hong,Lihui Chen,Dong Wang,Liulian Huang
Cellulose acetate (CA) has attracted much attention in the preparation of ultrafiltration membranes due to its green and sustainable characteristics. However, its poor performance (separation and antifouling performance, etc.) limits the application of CA-based membranes in water treatment. In this work, we prepared a cellulose acetate ultrafiltration membrane with enhanced separation performance by enhancing the dissolution process of CA. The dissolution process of CA was controlled by adjusting the ratio of mixed solvent ( N , N -dimethylacetamide (DMAC) and N -methyl pyrrolidone (NMP)), which could tune the phase conversion rate, optimizing the pore structures of the membranes. Compared to the single solvent (M0, M8), the optimal membrane (M4) exhibited a finger-like pore structure and the lowest surface roughness, which was favorable for achieving high water flux. As a result, the M4 possessed a comparable pure water flux (335.8 L·m −2 h −1 ) which was higher than M0 (1.8 times) and M8 (1.7 times), while the BSA rejection rate reached 96.4 %. Besides, the M4 showed a stable separation performance in different operation pressures, BSA concentration, and long-term experiments. This work provided a new method for the preparation of cellulose acetate ultrafiltration membrane with good separation performance and anti-fouling performance and also provides a new way for water treatment.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2024
·
IF 9.4
Changyong Zhao,Hanyan Wu,Xuejie Gao,Chen Cheng,Shuiping Cai,Xiaofei Yang,Runcang Sun
Challenges associated with lithium dendrite growth and the formation of dead lithium significantly limit the achievable energy density of lithium metal batteries (LMBs), particularly under high operating current densities. Our innovative design employs a state-of-the-art 2500 separator featuring a meticulously engineered cellulose acetate (CA) coating (CA@2500) to suppress dendrite nucleation and propagation. The C O functional groups in CA enhances charge transfer kinetics and triggering the decomposition of lithium bis(trifluoromethanesulfonyl)imide (LiTFSI), which leads to the formation of a more robust solid electrolyte interphase (SEI) composed primarily of LiF. Moreover, the introduction of polar functional groups in the CA enhances the separator’s hydrophilic properties, facilitating the uniform Li + flux and creating a conductive pathway for efficient lithium migration. As a result, the CA@2500 separator exhibits a high lithium-ion transfer number (0.88) and conductivity. The lithium symmetric cell assembles with the CA@2500 separator displays a stable cycling performance over 5500 h at a current density and capacity of 10 mA cm −2 and 10 mAh cm −2 , respectively. Additionally, LPF battery with CA@2500 separator shows an excellent capacity retention at 0.2 C with an average decay of 0.055 % per cycle. Moreover, a high capacity of 105 mAh g −1 is maintained after 500 cycles at 5 C with an average decay of only 0.027 % per cycle. This work achieved high stability of LMBs through simplified engineering.
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PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY
·
2024
·
IF 2.6
Yun Meng,Ye Cai,Mengyao Cui,Yuhang Xu,Long Wu,Xiang Li,Xiaoqin Chu
The aim of this study was to prepare a solid self-microemulsifying drug delivery system (S-SMEDDS) of cinnamaldehyde (CA) by spray drying technique to improve the oral bioavailability of CA. The preparation of CA S-SMEDDS with maltodextrin as the solid carrier, a core-wall material mass ratio of 1:1, a solid content of 20% (w/v), an inlet air temperature of 150 °C, an injection speed of 5.2 mL/min, and an atomization pressure of 0.1 MPa was determined by using the encapsulation rate as the index of investigation. Differential scanning calorimetry (DSC) revealed the possibility of CA being encapsulated in S-SMEDDS in an amorphous form. The in-vitro release showed that the total amount of CA released by S-SMEDDS was approximately 1.3 times higher than that of the CA suspension. Pharmacokinetic results showed that the relative oral bioavailability of CA S-SMEDDS was also increased to 1.6-fold compared to CA suspension. Additionally, we explored the mechanism of CA uptake and transport of lipid-soluble drugs CA by S-SMEDDS in a Caco-2/HT29 cell co-culture system for the first time. The results showed that CA S-SMEDDS uptake on the co-culture model was mainly an energy-dependent endocytosis mechanism, including lattice protein-mediated endocytosis and vesicle-mediated endocytosis. Transport experiments showed that CA S-SMEDDS significantly increased the permeability of CA in this model. These findings suggested that CA S-SMEDDS is an effective oral solid dosage form for increasing the oral bioavailability of lipid-soluble drug CA.
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FOOD CHEMISTRY
·
2025
·
IF 9.8
Ya Yu,Mengting Yuan,Ling Zhou,Yanan Liu,Ya Chen,Dongxu Wu,Zhihong Chen,Qingqing Yuan,Yang Han,Juhua Wang,Xiuheng Xue
Cinnamaldehyde (CA), P-Anisaldehyde (PAA), N-heptanal (NHA) and Citronellal (CNA) were used to modify sodium caseinate (SC) as emulsifiers to stabilize β-carotene emulsion, and the binding mechanism of SC and spice aldehyde (SA) was discussed. The results showed that the binding of SA and SC was mainly driven by non-covalent interaction, especially hydrogen bonding. It was also found that CA may form covalent bond with SC through Schiff base reaction. Moreover, the combination of SA altered the structure of SC, enhanced its surface hydrophobicity, and improved its emulsifying property. The β-carotene has been better embedded by using CA-SC composite as surface stabilizer, and the droplets dispersed uniformly and with a droplet size of 222.65 nm, Emulsifying activity index (EAI) was 58.52 m 2 /g, emulsion stability index (ESI) was 42.22 min when the pH was 8.0. Thus, CA was better to be used to improve the emulsification stability of β-carotene by combining with SC as surface stabilizer.
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FOOD HYDROCOLLOIDS
·
2024
·
IF 11
Ruican Wang,Richard W. Hartel,Xinyu Zhai,Wenhui Fu,Yi Sun,Shuo Wang
Phase separation is a prevalent phenomenon in gummy confections, often arising from potential molecular incompatibility between gelatin and long-chain polysaccharides in glucose syrups (GS). This study focuses on analyzing the phase separation and gelling behaviors of gelatin-GS mixtures, elucidating the roles played by water content and small molecular weight (MW) additional ingredients. Mixtures with 6% gelatin, 40% GS, and varying portions of water, sucrose/allulose, citric acid (CA), and citrates (soluble/insoluble) were prepared. Phase separation behaviors were observed using inverted fluorescent microscopy, with the gel properties characterized using rheology, texture profile analysis (TPA), and water-holding capacity (WHC) analysis. The results highlight the significant impacts of these small MW components on biopolymer compatibility (cosolubility). In gelatin-GS-water mixtures, reducing the water ratio without the addition of sugars promoted phase separation towards the polysaccharide-rich morphologies, while enhancing the sol-gel transition and gel strength due to increased gelatin/water ratio. The incorporation of sucrose or allulose into gelatin-GS-water mixtures, without altering the gelatin/GS/water ratio, generally improved the protein-polysaccharide co-solubility during mixing but had an adverse overall effect on gel formation. Acidification with CA increased the surface charges of the proteins, enhancing the biopolymer miscibility and gelling performance. Soluble citrates, e.g., sodium citrate (SC) and potassium citrate (PC), promoted protein-polysaccharide miscibility and gelation at low concentrations (1–5%), but led to severe phase separation and weakened gelation at higher dosage levels (7.5–10%). In contrast, insoluble citrate, i.e., calcium citrate (CC), marginally enhanced the protein-polysaccharide miscibility while facilitating gummy gelation as an active filler.
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Journal of Energy Storage
·
2025
·
IF 9.8
Chang Chen,Litong Fang,Shaowu Jiu,Yanxin Chen,Yan Liu
A robust natural adhesive force is inherently present between the surface waxes and the plant straw. Utilizing this inherent property, the current investigation represents the pioneering development of straw-based shape-stabilized phase change materials (PCMs), achieved by incorporating capric acid (CA) PCMs to densify the matrix. The phase change gypsum composite was formulated by integrating the straw-based shape-stabilized PCMs within the gypsum matrix. The straw-based shape-stabilized PCMs not only enhanced the mechanical characteristics of the gypsum-based matrices through their biomass fiber attributes but also augmented the thermal storage capacity by functioning as PCMs. An exhaustive assessment was conducted on the physical, chemical, and thermal properties of the synthesized shape-stabilized PCMs and phase change gypsum composites. The phase change temperature and latent heat of the straw-based shape-stabilized PCMs were determined to be 26.25 °C and 133.36 J/g, respectively, with demonstrated thermal stability. Optimal mechanical properties were observed in the phase change gypsum composites when the straw-based shape-stabilized PCMs were 15 mm in length and 30 vol% in content, with flexural and compressive strengths reaching 4.52 and 12.07 MPa, respectively. The incorporation of straw-based shape-stabilized PCMs markedly diminished the thermal conductivity of the gypsum-based composites, with a thermal conductivity value of 0.4165 W/(m·K) recorded for a 40 vol% loading. The characteristics of the phase change gypsum composites fabricated in the present study render them ideally suited for deployment within the construction industry, facilitating both cleaner production methodologies and enhanced energy efficiency in buildings.
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ACTA MATERIALIA
·
2025
·
IF 9.3
Xiang Wei,Minhui Yuan,Meng Jiang,Huang Gong,Jing Shuai,Jiayi Ye,Lianjun Wang,Qihao Zhang,Wan Jiang
Zintl-phase thermoelectrics with CaAl 2 Si 2 -type structures exhibit desirable “phonon-glass electron-crystal” behavior. However, the development of environmentally friendly p-type counterparts remains challenging. While n-type Mg 3 Sb 2 -based compounds have achieved high figures of merit ( zT > 2.0), their integration with non-Zintl systems is hindered by thermal and chemical mismatches. Moreover, many existing p-type Zintl compounds rely on toxic (Cd, Pb) or scarce (Yb, Ge) elements, restricting their scalability and sustainability. Here, we report a scalable, rare-earth- and toxicity-free p-type Zintl compound, Ca 0.5 Mg 1.297 Ag 0.003 Zn 1.2 Sb 2 , developed via targeted Mg-site substitution. First-principles calculations reveal that Ca substitution at Mg1 sites induces beneficial electronic structure modifications, including bandgap widening, valence band sharpening, and an indirect-to-direct bandgap transition, collectively enhancing carrier mobility (50 cm 2 ·V -1 ·s -1 ) and strengthening carrier-phonon scattering at elevated temperature. Simultaneously, trace Ag doping at Mg2 sites precisely tunes the carrier concentration by nearly one order of magnitude, achieving improved electrical conductivity while maintaining ultralow thermal conductivity. As a result, the optimized compound achieves a peak zT of 0.81 at 773 K and an average zT of 0.50 over 300–773 K. These results demonstrate a chemically stable, sustainable, and high-performing Zintl platform, offering a promising strategy for advancing eco-friendly thermoelectric technologies.
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Nature Nanotechnology
·
2019
·Vol. 14
·期 4
·379-387
·
IF 33.407
Gong Ningqiang,Ma Xiaowei,Ye Xiaoxia,Zhou Qunfang,Chen Xiaoai,Tan Xiaoli,Yao Shengkun,Huo Shuaidong,Zhang Tingbin,Chen Shizhu,Teng Xucong,Hu Xixue,Yu Jie,Gan Yaling,Jiang Huaidong,Li Jinghong,Liang Xing-Jie
Mitochondrial redox homeostasis, the balance between reactive oxygen species and antioxidants such as glutathione, plays critical roles in many biological processes, including biosynthesis and apoptosis, and thus is a potential target for cancer treatment. Here, we report a mitochondrial oxidative stress amplifier, MitoCAT-g, which consists of carbon-dot-supported atomically dispersed gold (CAT-g) with further surface modifications of triphenylphosphine and cinnamaldehyde. We find that the MitoCAT-g particles specifically target mitochondria and deplete mitochondrial glutathione with atomic economy, thus amplifying the reactive oxygen species damage caused by cinnamaldehyde and finally leading to apoptosis in cancer cells. We show that imaging-guided interventional injection of these particles potently inhibits tumour growth in subcutaneous and orthotopic patient-derived xenograft hepatocellular carcinoma models without adverse effects. Our study demonstrates that MitoCAT-g amplifies the oxidative stress in mitochondria and suppresses tumour growth in vivo, representing a promising agent for anticancer applications.
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