JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2020
·
IF 4.192
Renjie Zhou,Jiahao Yu,Shuo Li,Jian Zhang,Chenqiang Wang,Lianfu Zhang
Amadori compounds (ACs; N-(1-deoxy-d-fructos-1-yl)-amino acid) are superior flavor precursors and potential functional ingredients in food processing. In this study, vacuum dehydration as an excellent and universal method for the formation of ACs in both simulation systems and food processing was revealed. In total, 12 amino acids referring to all six categories were selected to conduct simulated reactions with glucose in aqueous models. At 90 °C, yields of 11 ACs were significantly increased by vacuum dehydration, reaching 4–198 times compared to a heat sealing reaction in aqueous systems, and formation of 5-hydroxymethyl-2-furaldehyde (5-HMF) and browning were slower than that by a dry powder reaction. In particular, the yields of Fru-Arg, Fru-His, and Fru-Glu reached 87.03, 90.73, and 89.88 mol %, respectively. The order of promotion effect was acid ACs > basic ACs > unique ACs > polar neutral ACs > aliphatic ACs > aromatic ACs. The excellent effect was mainly attributed to the control of water activity (Aw) and pH, which enabled the models to reach the optimal reaction state quickly by adjusting the vacuum degree at mild temperatures. The method was also applied to AC enrichment in tomato sauce processing; the AC content could rise to 30.72 mg/g, which was more than 17 times than those in samples without vacuum dehydration and two commercial tomato sauces.
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International Journal of Electrochemical Science
·
2023
·
IF 1.5
Jia Qiao,Juan Du,ZhongshengLiu,Haitao Zhou,Hejing Wen,Chao Liu,Jianhong Yang
Graphene-based materials are cathodes of Al-ion batteries and have attracted the attention of researchers worldwide. However, reasons for self-discharge in Al/graphene batteries have not been studied in depth. In the present work, a pseudo-capacitive reaction is proposed to be a probable cause of the self-discharge. Quantitative analysis of the capacitance process and diffusion-control process is critical for the pseudo-capacitive behavior in Al/graphene batteries. Two self-supported graphene cathodes (R h -GOP and R n -GOP) were successfully produced from graphene oxides (GO) reduced with hydriodic acid and hydrazine vapor, respectively. R h -GOP and R n -GOP cathodes enabled the delivery of considerably high specific capacities of 81.5 mAh g -1 and 92.8 mAh g -1 , at the current density of 2 A g -1 . In addition, the activation processes of both materials were observed during 200 cycles of the charge-discharge process. From a quantitative perspective, the ratios of faradaic pseudo-capacitance to the total capacity of the R h -GOP and R n -GOP cathode were 48.6% and 38.5%, respectively, at a scanning rate of 5.0 mV s -1 . It is found that the proportion of faradaic pseudo-capacitance will increase as cyclic voltammetry scanning increases, which indicates the existence of pseudo-capacitance being the reason why it an Al/graphene battery has to be charged-discharged at high current densities to maintain normal operation.
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Current Protocols
·
2023
·Vol. 3
·期 5
·e741
·
IF 0
Wen-Wu Sun,Yi-Bing Xie,Ting-Ting Deng,Jie Huang,Ji-Kai Liu,Bin Wu
Despite the importance of nucleosides and nucleotides for drug discovery, only a few practical methods to prepare tricyclic nucleosides have been reported. Here, we describe a synthetic strategy for late-stage functionalization of nucleosides and nucleotides via chemo- and site-selective acid-promoted intermolecular cyclization. The nucleoside analogs with an additional ring were obtained in moderate-to-high yields, including some antiviral drugs (acyclovir, ganciclovir, and penciclovir) derivatives, endogenous fused ring nucleoside (M 1 dG) and its derivatives, and nucleotide derivatives. © 2023 Wiley Periodicals LLC. Basic Protocol 1 : Synthesis of tricyclic acyclovir analogs ( 3a-3c ) Basic Protocol 2 : Synthesis of tricyclic nucleosides M 1 dG ( 6 ) and M 1 G ( 9 ) Basic Protocol 3 : Synthesis of tricyclic nucleotide ( 12 )
研究领域:
药物化学
·
有机合成
·
核酸化学
·
分子生物学
·
化学生物学
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抗病毒药物研发
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APPLIED CATALYSIS B-ENVIRONMENTAL
·
2026
·
IF 21.1
Xingyu Han,FangFang Liu,Hanxiao Wang,Yangjing Liu,Shuhui Huo,Min Wang,Jianwei Ren,Xuyun Wang,Hongbing Song,Jian Liu,Rongfang Wang
Ni(OH) 2 /NF demonstrates strong electrocatalytic performance in the oxidation of 1-methoxy-2-propanol (MOP) to 1-methoxy-2-propanone (MOA). However, its catalytic efficiency is restricted by two sluggish dehydrogenation stages: the oxidation of Ni 2 + –OH to generate the active Ni 3+ –O intermediate, and the abstraction of the α-hydrogen from the MOP molecule. To address these limitations, the present study introduces a strategy centered on tuning the electronic structure. By incorporating manganese (Mn) into the coordination structure of Ni(OH) 2 /NF nanosheets in a controlled manner, both reaction steps are effectively enhanced through synergistic effects. X-ray photoelectron spectroscopy (XPS) and synchrotron-based X-ray absorption fine structure (XAFS) analyses reveal that Mn incorporation modifies the local electronic environment of Ni through electronic interactions. This adjustment decreases the d -orbital electron density of Ni, thereby facilitating the oxidation of Ni 2+ to the catalytically active Ni 3+ species during MOP conversion. Electrochemical measurements combined with density functional theory (DFT) calculations indicate that Mn incorporation markedly enhances the adsorption of MOP molecules on the catalyst surface, which thereby promotes more efficient reaction kinetics. This synergistic regulation effectively lowers the energy barrier associated with the dual dehydrogenation steps, resulting in markedly improved catalytic performance of Mn–Ni(OH) 2 /NF for MOP oxidation, with the product Faradaic efficiency reaching around 90 %.
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高影响因子
Journal of Traditional Chinese Medicine
·
2023
·Vol. 43
·期 5
·887-896
·
IF 2.6
Yiding ZHAO,Xiaoning YAN,Shanshan JIANG,Yong LIU,Chun DONG,Huiyan CHI,Chaoyi MAO
Objective To investigate the efficacy of Zhenxin Anshen formula (, ZXAS) on atopic dermatitis (AD) by transient receptor potential vanilloid 1 (TRPV1) and transient receptor potential ankyrin 1 (TRPA1) signalling pathway in mice and . Methods AD-like lesions were induced by 1-chloro-2,4-dinitrobenzene (DNCB) to the shaved dorsal skin of BALB/c mice. BALB/c mice were divided into five groups: normal control, model control, cetirizine, low-, medium-, and high-dose of ZXAS. After ZXAS in-tervention, the skin lesions and blood samples were collected for hematoxylin and eosin-stained and measuring the concentrations of inflammatory cytokines. Immun-oglobulin E (IgE), interleukin (IL)-4, IL-5, IL-13, and thymic stromal lymphopoietin (TSLP) were de-tected by Enzyme-linked immunosorbent assay (ELISA). The spinal cords were collected for measuring the expression of gastrin-releasing peptide receptor (GRPR), TRPV1, and TRPA1 by using immunohistochemistry, western blotting, and quantitative real-time polymerase chain reaction (qRT-PCR) analyses. In addition, 3-(4,5-dimethylthiazolyl-2)-2, 5-diphenyltetrazolium bromide (MTT) assay, flow cytometry, ELISA, and Western blotting were conducted for analysis of primary dorsal root ganglia (DRG) neurons . Results ZXAS treatment improved DNCB-induced AD-like lesions through reducing dermatitis score, number of scratching and epidermal thickness, accompanied by the de-creased IgE and Th2 inflammatory cytokines. ZXAS also supressed the mRNA and protein expression of GRPR, TRPV1, and TRPA1 in the spinal cord. The medicated sera of ZXAS decreased capsaicin-induced Ca influx and downregulated the expression of TRPV1, TRPA1, and phospholipase C in DRG neurons. Conclusions The therapeutic effect of ZXAS on AD may be related to the regulation of TRPV1 and TRPA1 and inhibition of Ca2+ signals in neurons.
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DOI
PubMed
高影响因子
JOURNAL OF CHEMICAL THERMODYNAMICS
·
2015
·
IF 2.679
Xiaowei Sun,Qiuxiang Yin,Suping Ding,Zhiming Shen,Ying Bao,Junbo Gong,Baohong Hou,Hongxun Hao,Yongli Wang,Jingkang Wang,Chuang Xie
(Solid + liquid) equilibrium data for indomethacin (IMC) and nicotinamide (NCT) in both methanol (MeOH) and methanol/ethyl acetate (EA) mixture were determined using a static method at T = (298.15 and 313.15) K under atmospheric pressure. The 1:1 (IMC + NCT) co-crystal and IMC·MeOH were found in both systems under conditions investigated. The solubility of the 1:1 (IMC + NCT) co-crystal was correlated using a mathematical model consisting of both solubility product and a complexation process. Solubility of (IMC + NCT) co-crystals as a function of co-former (NCT) concentration was evaluated. It was found that temperature has a significant effect on the formation of methanol solvate in the systems investigated. Solvate formation could be suppressed either by increasing temperature or using solvent mixtures. Additionally, the solvent mixture could level out the solubility differences between IMC and NCT , resulting in larger and more symmetric regions for the (IMC + NCT) co-crystal, which would be helpful to the development of the co-crystallization process for the 1:1 (IMC + NCT) co-crystal.
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高影响因子
JOURNAL OF VOICE
·
2024
·
IF 2.5
Zhe Chen,Ke-Da Li,Min Gao,Shui-Hong Zhou,Hong-Tian Yao,Jiang-Tao Zhong,Yang-Yang Bao,Zi-Ming Fu,Zai-Zai Cao
Summary Objective We assessed the expression of glucose transporter (GLUT)-1 and hexokinase (HK)-Ⅱ in vocal cord leukoplakia (VCL) and investigated its clinical significance. Methods We collected 127 archival pathological specimens from patients with VCL, 29 from vocal cord polyps, and 31 with laryngeal carcinoma at our hospital between December 2018 and December 2022. GLUT-1 and HK-II expression was detected using immunohistochemistry. Results Significant differences were observed between the VCL and vocal cord polyp groups according to sex ( P < 0.0001), smoking status ( P = 0.001), and alcohol consumption ( P = 0.007). GLUT-1 expression was observed in 36.2%, 20.7%, and 90.3% of patients with VCL, vocal cord polyps, and laryngeal carcinoma, respectively. GLUT-1 was highly expressed in severe dysplasia or carcinoma in situ (CIS) compared with vocal cord polyps ( P < 0.001). GLUT-1 expression was lower in the VCL group than in the laryngeal carcinoma group ( P < 0.001). HK-II expression was observed in 42.5%, 34.5%, and 80.6% of patients with VCL, vocal cord polyps, and laryngeal carcinoma, respectively. HK-II expression was significantly higher in severe dysplasia or CIS compared with vocal cord polyps ( P = 0.004). HK-II expression was lower in the VCL group than in the laryngeal carcinoma group ( P < 0.001). Both GLUT-1 expression ( P < 0.001) and HK-II expression ( P = 0.03) increased significantly with the degree of dysplasia. A significant correlation was observed between GLUT-1 and HK-II expression (r = 0.313, P < 0.001). Conclusion GLUT-1 and HK-II are significantly overexpressed in VCL patients. In VCL patients, GLUT-1 and HK-II expression levels increase proportionally with the degree of dysplasia.
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DOI
PubMed
高影响因子
MOLECULES
·
2026
·Vol. 31
·期 4
·753
·
IF 5.1
Yabing Xin,Qian Wu,Yitong Gao,Can Xiao,Qidong You,Zhengyu Jiang,Mengchen Lu
PIM kinases, as members of the serine/threonine kinase family, regulate key cellular processes such as proliferation, apoptosis, and metabolism by phosphorylating multiple substrates, making them important therapeutic targets for cancer treatment. In this study, we reported a series of structurally novel PIM-1 kinase inhibitors based on a scaffold-hopping strategy. After multiple rounds of structural optimization, the highly active compoundC2was obtained, exhibiting an IC50of 33.02 ± 1.31 nM against PIM-1 kinase. Molecular docking results revealed that compoundC2stably bound to the hydrophobic cavity of the PIM-1 protein and formed hydrogen bond interactions with polar residues in the hinge region, thereby effectively inhibiting kinase activity. In vitro antitumor assessment demonstrated significant proliferation inhibition of the hematological tumor cell line MM.1S (IC50= 1.87 μM), comparable to the positive controlSGI-1776(IC50= 1.71 μM). In addition, compoundC2possessed favorable drug-like properties and excellent stability in simulated gastrointestinal fluids and rat plasma. This study provides promising lead compounds for the development of novel PIM-1-targeted anticancer drugs, which can be further optimized.
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高影响因子
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
·
2014
·Vol. 39
·期 7
·3313-3319
·
IF 2.93
Jing Lin,Fei Liang,Yaoming Wu,Wanqiang Liu,Limin Wang
We prepared Ti 1.4 V 0.6 Ni ribbons by arc-melting and subsequent melt-spinning techniques. Ti 1.4 V 0.6 Ni + x Mg ( x = 1, 1.5, 2, 2.5 and 3, wt.%) composite alloys were obtained by the mechanical ball-milling method. The structures and hydrogen storage properties of alloys were investigated. Ti 1.4 V 0.6 Ni + x Mg composite alloys contained icosahedral quasicrystalline phase, Ti 2 Ni-type phase, β-Ti solid-solution phase and metallic Mg. The electrochemical and gaseous hydrogen storage properties of alloys were improved with Mg addition. Ti 1.4 V 0.6 Ni + 2 Mg alloy showed maximum electrochemical discharge capacity of 282.5 mAh g −1 as well as copacetic high-rate discharge ability of 82.3% at the discharge current density of 240 mA g −1 compared with that of 30 mA g −1 , and the cycling life achieved above 200 mAh g −1 after 50 consecutive cycles of charging and discharging. The hydrogen absorption/desorption properties of Ti 1.4 V 0.6 Ni + x Mg ( x = 1, 2 and 3, wt.%) alloys were better than Ti 1.4 V 0.6 Ni. Ti 1.4 V 0.6 Ni + 3 Mg alloy also exhibited a favorable hydrogen absorption capacity of 1.53 wt.%. The improvement in the hydrogen storage characteristics caused by adding Mg may be ascribed to better hydrogen diffusion and anti-corrosion ability.
研究领域:
材料科学
·
金属功能材料
·
储能材料
·
物理化学
·
电化学
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高影响因子
MICROPOROUS AND MESOPOROUS MATERIALS
·
2013
·
IF 3.365
Xue Jiang,Zhuang Zhuang,Feng Xin
Highly b-oriented Titanium Silicalite-1 (TS-1) zeolite films were synthesized on polyvinyl acetate (PVAc) modified glasses by hydrothermal crystallization. The prepared samples were characterized by X-ray diffraction (XRD), field-emission scanning electron microscope (FE-SEM), atomic force microscopy (AFM), Fourier transform infrared spectroscopy (FT-IR) and a contact-angle instrument. The results showed that the mass of PVAc on the glasses would influence the process of superficial nucleation and oriented growth of TS-1 films profoundly. A favorable amount of PVAc on smooth surface of glassy substrate was determined to form a highly b-oriented and fully covered TS-1 film by attracting appropriate precursor and template, then making TS-1 nucleate and grow orientedly. Based on the obtained results, a scheme of fabricating b-oriented TS-1 films was proposed.
研究领域:
材料科学
·
无机化学
·
薄膜制备
·
沸石化学
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高影响因子
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS
·
2017
·
IF 0.809
Shaohua Zhu,Yan Zhang,Peipei Li,Wenzhu Bi,Xiaolan Chen,Yufen Zhao
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高影响因子
MOLECULAR REPRODUCTION AND DEVELOPMENT
·
2026
·Vol. 93
·期 7
·e70135
·
IF 2.6
Yang Sun,Haipeng Pei,Xing Zhang,Yi Jing,Ziheng Zhang,Xinghao Zhang,Huaying Qian,Fengjuan Chang,Yuhang Geng,Ziyang Han,Yun Chen
Pyroptosis, a proinflammatory form of programmed cell death mediated by the NLRP3 inflammasome, has recently been implicated in Sertoli cell inflammatory injury. Crocin, a water-soluble carotenoid glycoside derived from Crocus sativus L. and Gardenia jasminoides Ellis, exhibits anti-inflammatory, antioxidant, and anti-apoptotic properties, yet its role in Sertoli cell pyroptosis remains unclear. Here, we investigated the pharmacological effects and mechanisms of crocin in regulating TM4 Sertoli cell viability and pyroptosis. Network pharmacology based on oligoasthenospermia (OA)-related candidate targets, together with molecular docking, identified HSP90AA1 as a candidate molecular target associated with crocin-mediated regulation of Sertoli cell pyroptosis. MST analysis further provided target-engagement evidence supporting a direct interaction between crocin and HSP90AA1. In TM4 Sertoli cells, crocin improved cell viability, enhanced Ki-67 expression, and protected against lipopolysaccharide/nigericin-induced pyroptosis, as evidenced by reduced lactate dehydrogenase release, decreased PI-positive cells, and downregulated expression of IL-1β, IL-18, NLRP3, Caspase-1, and GSDMD. Moreover, under HSP90AA1-overexpressing conditions, crocin partially reduced pyroptosis-related injury and inflammatory mediator expression, supporting the involvement of HSP90AA1 in crocin-mediated regulation of Sertoli cell pyroptosis. Collectively, these findings indicate that crocin enhances Sertoli cell proliferation and mitigates inflammasome-driven pyroptosis through an HSP90AA1-associated mechanism. These findings should be interpreted as preliminary in vitro evidence for crocin-mediated regulation of Sertoli cell proliferation and pyroptosis, and further validation in animal models and clinical samples is required.
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