CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Zimin Cai,Fangqin Fu,Sifeng Zhu,Jibin Wu,Xu Han,Shuai Jiang,Zhiyong Qian,Cheng Wang
The pharmacokinetic behavior of nanocarrier in vivo has been confirmed to be greatly influenced by the dynamic protein corona covered its surface, which also affects the ultimate clinical efficacy. Herein, we explored one novel polymersomes based on Poly(2-methyl-2-oxazoline) polymers (PMOXA 5 -PDBH 13 -PMOXA 5 ) with excellent drug-carrying capacity and specific protein corona manipulation. Compared to PEGylated nanoparticle (NP), the polymersomes (PC-SOM) provided a considerable advancement in therapeutic efficiency, which can selectively accumulate in tumor tissues, enhancing cellular internalization via specific proteins covering its surface such as fibronectin and moesin. Notably, in vivo antitumor effect showed that doxorubicin-loaded PC-SOM exhibited superior inhibitory rate 75.5% than 48.24% of PEGylated NP. Furthermore, through protein corona analysis we found that PC-SOM enhanced the adsorption of apolipoprotein A-I while suppressed the adsorption of complement C3 and immunoglobulin in serum from healthy volunteers and human breast cancer volunteers. These elaborated the reasons of longer circulation times and superior tumor-targeting capabilities of PC-SOM. Our work provided a promising nanoagent with novel surface-design by the dynamic protein corona for excellent pharmacokinetic behavior and antitumor effect.
✓ 已验证
产品关联
DOI
高影响因子
MINERALS ENGINEERING
·
2025
·
IF 5
Jiaqiao Yuan,Xiang Gong,Hongyu Lu,Wei Jiang,Hao Lai,Shuming Wen,Shaojun Bai,Dandan Wu
To address the challenge of separating ilmenite from titanaugite, the feasibility of a novel collector (2-ethylhexyl) phosphonic acid mono-2-ethylhexyl ester (HEHEHP) was firstly investigated in this work. The flotation results indicated that HEHEHP possessed superior collecting performance over a broader pH range for ilmenite compared to benzohydroxamic acid and sodium oleate. Under conditions with a pH of 8.0±0.2, a high-quality concentrate with a TiO 2 grade of 40.74% and a recovery of 87.66% was achieved. Adsorption studies and AFM analysis implied that the adsorption density of HEHEHP on ilmenite was significantly higher than that on titanaugite. Zeta potential analysis implied that the negatively charged HEHEHP anion primarily acted on ilmenite through chemisorption. ToF-SIMS, XPS, and FTIR further corroborated that HEHEHP interacted with the Fe and Ti sites on the ilmenite surface primarily through the P=O and P-OH functional groups in the adsorption process, leading to the formation of PO-Fe or PO-Ti bonds, thereby chemically adsorbing onto the ilmenite. DFT calculations proved that the two O atoms in the PO(OH) group exhibited significant reactivity, serving as the main active sites during the adsorption of HEHEHP. In summary, the chemical interactions between the PO(OH) group in HEHEHP and the active Fe and Ti sites on the ilmenite surface are responsible for the primary mechanism for the selective adsorption of HEHEHP.
✓ 已验证
产品关联
DOI
高影响因子
Desalination and Water Treatment
·
2015
·
IF 1.173
Ben Zhang,Juan Li,Xiaogai Lv,Yuanchen Cui,Ying Xu
Polyaspartic acid/2-amino-2-methyl-1,3-propanediol graft copolymer, a novel non-phosphorus scale and corrosion inhibitor, was synthesized and characterized by infrared spectroscopy. Its performance was evaluated by static scale inhibition method and dynamic corrosion testing. It was found that the graft copolymer showed excellent inhibition ability against CaCO3, CaSO4, and Ca3(PO4)2 scales and a definite inhibition corrosion performance as well. The inhibition efficiency was close to 99.9% against CaCO3, CaSO4, and Ca3(PO4)2 when the inhibitor was at an appropriate concentration. The inhibitor had still possessed higher antiscale efficiency against CaCO3 with increasing concentration of Ca2+ and heating time. In addition, The graft copolymer could change the structure of crystals CaCO3, CaSO4, and Ca3(PO4)2 by observation of scanning electron microscopy.
✓ 已验证
DOI
高影响因子
POLYMER SCIENCE SERIES B
·
2015
·Vol. 57
·期 5
·460-472
·
IF 0.577
Sa Zongpeng,Li Yapeng,Zhao Haochen,Hu Qi,Wei Jia,Wang Jingyuan
Through H-shaped macroinitiator glycol-chlorine((Cl) 2 -PEG-(Cl) 2 ) to initiate the ATRP reaction of 2-Hydroxyethyl Methacrylate (HEMA) we synthesized H-shaped copolymer (PHEMA) 2 - b -PEG- b -(PHEMA) 2 . After we modified the copolymer with histidine (His), the self-assembling and drug release behavior was studied. The morphology of the copolymer micelles and drug loaded micelles were examined by transmission electron microscope (TEM). Spherical micelles and core-shell structure with a diameter of 165 nm were obtained (at pH = 7.0). Due to the presence of imidazole-ring in histidine the copolymer show commendable pH-sensitivity, which made the copolymer potential application as drug carrier exhibiting good control-released property.
✓ 已验证
DOI
高影响因子
Small
·
2026
·
IF 11.8
Xuemin Ma,Yajuan Hu,Peirong Zhou,Huiyue Wang,Yongcen Chen,Xiaoxuan Han,Zichen Yang,Jing He,Yun He,Gang Tao,Rui Cai
Diabetic wound healing remains challenging due to microenvironmental complexities, including infection, hypoxia, and impaired angiogenesis. In this study, we established a diabetic rat wound model and found that the diabetic microenvironment significantly impaired angiogenesis, thereby delaying wound healing. To address this, a composite microneedle patch (M-TCHb MN) enabling in situ oxygen release was designed. The M-TCHb MN integrates TA-Ce metal phenol networks-encapsulated Hb nanoparticles (TA-Ce@Hb NPs) encapsulated in silk fibroin (SF) at needle tips with MXene nanosheets encapsulated in PVA at the base layer. In vitro studies confirmed that the base layer inhibits bacterial infection via PTT. TA-Ce@Hb NPs released from needle tips reduced oxidative stress and regulated macrophage polarization for inflammation resolution, while simultaneously catalyzing H 2 O 2 decomposition to generate O 2 . It works synergistically with Hb's oxygen release to reverse a hypoxic environment and promote angiogenesis. In vivo, M+TCHb MN suppressed infection, controlled inflammation, and enhanced angiogenesis. RNA sequencing analysis revealed that the relief of hypoxia enhances angiogenesis (upregulating the expression of VEGF) by activating the MEK1/2-ERK1/2 pathway. Collectively, M-TCHb MN represents an integrated strategy that combines antimicrobial, antioxidant, anti-inflammatory, and pro-angiogenic functions to synergistically accelerate diabetic wound healing, offering a translatable platform for clinical management.
✓ 已验证
DOI
高影响因子
JOURNAL OF CHEMICAL AND ENGINEERING DATA
·
2019
·
IF 2.298
Xiaoda Wang,Yuan Gao,Chaoqun Li,Zhixian Huang,Ting Qiu
Liquid–liquid equilibrium data were determined for the two ternary systems of water + thioglycolic acid (TGA) + 2-ethyl-1-hexyl thioglycolate (ETE) and water + 2-ethyl-1-hexyl thioglycolate (ETE) + 2-ethyl-1-hexanol (EHL) at 293.15, 303.15, and 313.15 K under 101 kPa. The nonrandom two-liquid (NRTL) and universal quasi-chemical (UNIQUAC) activity coefficient models were used to correlate the experimental LLE data. The LLE data calculated by the NRTL and UNIQUAC models were in good agreement with the experimental ones.
研究领域:
化学工程
·
物理化学
✓ 已验证
DOI
高影响因子
ANALYTICAL CHEMISTRY
·
2018
·
IF 6.042
Mengzhe Guo,Liyan Zhang,Yan Du,Wencheng Du,Dantong Liu,Cheng Guo,Yuanjiang Pan,Daoquan Tang
5-(Hydroxymethyl)-2′-deoxycytidine (5-hmdC), 5-(formyl)-2′-deoxycytidine (5-fodC), and 5-(carboxyl)-2′-deoxycytidine (5-cadC) are crucial intermediate products of the DNA demethylation pathway, which can also act as potential biomarkers reflecting the diagnosis and prognosis in multiple tumors. Detecting 5-hmdC, 5-fodC, and 5-cadC in human urine has various advantages including readily available samples and being noninvasive to patients. However, few works have reported the detection of 5-fodC and 5-cadC due to their trace amounts. Here we developed a novel magnetic hyper-cross-linked microporous polymer (HMP) material based on polyionic liquid (PIL) for the enrichment of 5-hmdC, 5-fodC, and 5-cadC. These magnetic PIL-HMP materials provided specific enrichment superiority for three modified cytidines. After enrichment, the signal intensity of 5-hmdC, 5-fodC, and 5-cadC increased 10–75-fold with lower limits of quantitation (LLOQ) of 0.049, 0.781, and 0.781 ng/mL, respectively. The recoveries were approximately 86.5–95.2% for 5-hmdC, 95.2–107.8% for 5-fodC, and 99.4–102.4% for 5-cadC under the relative standard deviation (RSD) of 0.2–10.3%. Finally, we successfully applied magnetic PIL-HMP materials coupled with high-performance liquid chromatography–electrospray ionization tandem mass spectrometry (HPLC-ESI-MS/MS) in enrichment and quantitative determination of 5-hmdC, 5-fodC, and 5-cadC in human urine of 10 breast cancer patients and 10 healthy people. We found that the level of 5-hmdC decreased in breast cancer patients (p < 0.05), while the levels of 5-fodC and 5-cadC increased (p < 0.05, p < 0.01). Our results demonstrated that the levels of metabolic 5-hmdC, 5-fodC, and 5-cadC in human urine are closely related to breast cancer, which could contribute to the clinical diagnosis and investigation of breast cancer and its occurrence and development mechanisms.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF CHEMICAL AND ENGINEERING DATA
·
2010
·
IF 1.695
Yihe Wang,Weidong Yan
Densities of binary mixtures of 1,3-diethyl propanedioate with methanol, ethanol, propan-1-ol, propan-2-ol, butan-2-ol, 2-methyl-propan-1-ol, and pentan-1-ol have been measured at temperatures of (288.15, 298.15, 313.15, and 328.15) K using an Anton Paar model DMA 5000 M oscillating densimeter. Excess molar volumes were calculated from these densities. The experimental data were fitted to the Redlich−Kister equation.
✓ 已验证
产品关联
DOI
高影响因子
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
·
2019
·
IF 4.833
Wen-Jing Zhu,Ben-Wen Cui,Hui Min Wang,Ji-Xing Nan,Hu-Ri Piao,Li-Hua Lian,Cheng Hua Jin
Six series of 4-(benzo[ c ][1,2,5]thiadiazol-5-yl)-3(5)-(6-methylpyridin-2-yl)- pyrazoles 18a – d , 19a – d , 22a – d and 3(5)-(6-methylpyridin-2-yl)-4-(thieno[3,2,- c ]- pyridin-2-yl)pyrazoles 20a – d , 21a – d , 23c , 23d have been synthesized and evaluated for their activin receptor-like kinase 5 (ALK5) and p38α mitogen activated protein (MAP) kinase inhibitory activities in enzymatic assays. Among these compounds, the most active compound, 22c , inhibited ALK5 phosphorylation with an IC 50 value of 0.030 μM in the enzymatic assay. Compound 22c showed four-fold more potent activity against ALK5 kinase than the clinical candidate, compound LY-2157299 . The selectivity index of 22c against p38α MAP kinase is 235, which is much higher than that of LY-2157299 (4) and equally selective to that of EW-7197 (218). Compound 22c effectively suppressed protein and mRNA expression of collagen I and α-SMA in TGF-β-induced LX-2 human hepatic stellate cell (HSC), this result shows that compound 22c has the ability to inhibit the activation of HSC. Compound 22c is expected to be a preclinical candidate for the treatment of hepatic fibrosis .
✓ 已验证
DOI
PubMed
高影响因子
POLYMER COMPOSITES
·
2025
·
IF 4.7
Yifeng Lai,Jun Liu,Xiaowei Hu,Yiju Zhu,Yuting Yang,Xuan Yang,Guowen Peng,Songbo Tan
The development of efficient gamma-ray shielding materials is crucial for addressing increasingly complex radiation environments. In this study, (BiO) 4 CO 3 (OH) 2 (BCH) and (BiO) 4 CO 3 (OH) 2 @Gd 2 O(CO 3 ) 2 ·H 2 O (BG) fillers were synthesized via a hydrothermal method. After being dispersed into epoxy resin by mechanical stirring, the mixtures were molded using a vacuum-assisted thermal curing process. Under 59.5 keV gamma irradiation, the linear attenuation coefficient (LAC) of BG/EP-50 reached 5.8 cm −1 , representing an 84% increase compared to BCH/EP-50 (3.15 cm −1 ) and about 33 times that of pure EP (0.17 cm −1 ). In addition, the temperature at 50% weight loss (T 50% ) of BG/EP-50 increased to 637.9〬C, which is 60.9% higher than that of the epoxy matrix, indicating improved thermal stability. The BG filler, constructed through a simple two-step hydrothermal route, demonstrated a synergistic effect between Bi and Gd components, which not only compensated for the limitations of Bi in the low-energy region but also enhanced the gamma shielding capability of the epoxy resin at higher energies. Compared to several shielding materials reported in recent years, BG/EP-50 shows superior performance and offers a promising strategy for lightweight and environmentally friendly polymer-based gamma shielding materials.
✓ 已验证
产品关联
DOI
高影响因子
INORGANIC CHEMISTRY
·
2021
·
IF 5.165
Xiao-Bao Li,Chun-Li Hu,Fang Kong,Jiang-Gao Mao
Two new antimonous phosphates, namely Ba3Sb2(PO4)4 and Cd3Sb2(PO4)4(H2O)2, have been successfully prepared through mild hydrothermal reactions. Ba3Sb2(PO4)4 features a 1D [Sb(PO4)2]3– chain structure separated by Ba2+ cations while Cd3Sb2(PO4)4(H2O)2 presents a 2D [Sb(PO4)2]3– layered structure with Cd2+ located at the interlayer space. The [Sb(PO4)2]3– chain in Ba3Sb2(PO4)4 is the first example of 1D antimonous phosphate structure, and Cd3Sb2(PO4)4(H2O)2 represents the first d10 transition metal antimonous phosphate. Based on UV–vis–NIR spectra, both Ba3Sb2(PO4)4 and Cd3Sb2(PO4)4(H2O)2 can display large optical band gaps (4.30 and 4.36 eV, respectively). But their transparent ranges are quite different because of the coordination water of Cd3Sb2(PO4)4(H2O)2 (500–2000 and 500–1300 nm for Ba and Cd compounds). The anhydrous Ba3Sb2(PO4)4 shows high thermal stability in the nitrogen atmosphere (900 °C). Because of the incorporation of the lone pair cation of Sb(III), the birefringence of Ba3Sb2(PO4)4 and Cd3Sb2(PO4)4(H2O)2 has been enhanced to 0.086 and 0.053 at 532 nm, respectively.
研究领域:
无机化学
·
材料科学
·
光学材料
·
晶体学
✓ 已验证
DOI
高影响因子
JOURNAL OF ORGANIC CHEMISTRY
·
2023
·
IF 3.6
Yuhang Xue,Chengjun Wu,Haiwen Li,Cunde Wang
Acetic acid-catalyzed (3 + 2) cyclization reaction of substituted 2-aroyl-3-aryl-1,1-dicyanocyclopropanes with arylhydrazines was investigated for the efficient synthesis of 4-dicyanomethyl-1,3,5-triaryl-4,5-dihydropyrazoles in good yields, in which 4,5-double substituents are predominantly trans selective. This approach included the consecutive condensation, ring opening, and double nucleophilic cyclization reaction.
研究领域:
有机化学
·
合成方法学
·
杂环化学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）