Journal of Animal Science and Biotechnology
·
2021
·Vol. 12
·期 1
·1-12
·
IF 5.032
Li Zongjun,Lei Xinjian,Chen Xiaoxu,Yin Qingyan,Shen Jing,Yao Junhu
Background In recent years, nitrooxy compounds have been identified as promising inhibitors of methanogenesis in ruminants. However, when animals receive a nitrooxy compound, a high portion of the spared hydrogen is eructated as gas, which partly offsets the energy savings of CH 4 mitigation. The objective of the present study was to evaluate the long-term and combined effects of supplementation with N-[2-(nitrooxy)ethyl]-3-pyridinecarboxamide (NPD), a methanogenesis inhibitor, and fumaric acid (FUM), a hydrogen sink, on enteric CH 4 production, rumen fermentation, bacterial populations, apparent nutrient digestibility, and lactation performance of dairy goats. Results Twenty-four primiparous dairy goats were used in a randomized complete block design with a 2 × 2 factorial arrangement of treatments: supplementation without or with FUM (32 g/d) or NPD (0.5 g/d). All samples were collected every 3 weeks during a 12-week feeding experiment. Both FUM and NPD supplementation persistently inhibited CH 4 yield (L/kg DMI, by 18.8% and 18.1%, respectively) without negative influence on DMI or apparent nutrient digestibility. When supplemented in combination, no additive CH 4 suppression was observed. FUM showed greater responses in increasing the molar proportion of propionate when supplemented with NPD than supplemented alone (by 10.2% vs. 4.4%). The rumen microbiota structure in the animals receiving FUM was different from that of the other animals, particularly changed the structure of phylum Firmicutes. Daily milk production and serum total antioxidant capacity were improved by NPD, but the contents of milk fat and protein were decreased, probably due to the bioactivity of absorbed NPD on body metabolism. Conclusions Supplementing NPD and FUM in combination is a promising way to persistently inhibit CH 4 emissions with a higher rumen propionate proportion. However, the side effects of this nitrooxy compound on animals and its residues in animal products need further evaluation before it can be used as an animal feed additive.
研究领域:
动物营养学
·
微生物学
✓ 已验证
DOI
PubMed
高影响因子
Foods
·
2025
·Vol. 14
·期 10
·1670
·
IF 5.1
Xi Wang,Siyi Wang,Shibing Zhang,Jiping Yin,Qi Zhao
As one kind of ‘probable human carcinogen’ (Group 2B) compound classified by the International Agency for Research on Cancer, 3-MCPD is mainly formed during the thermal processing of food. Tedious pretreatment techniques are needed for the existing analytical methods to quantify 3-MCPD. Hence, a nondestructive sensing technique that offers low noise interference and high quantitative precision must be developed to address this problem. Following this, Fourier transform infrared spectroscopy association with an convolutional neural network (CNN) model was employed in this investigation for the nondestructive quantitative measurement of 3-MCPD in oil samples. Before building the CNN model, NL-SGS-D2was utilized to enhance the feature extraction capability of model by eliminating the background noise. Under the optimal hyperparameter settings, calibration model achieved a determination coefficient (R2C) of 0.9982 and root mean square error (RMSEC) of 0.0181 during validation, along with a 16% performance enhancement enabled by the stepwise hybrid preprocessing strategy. The LODs (0.36 μg/g) and LOQs (1.10 μg/g) of the proposed method met the requirements for 3-MCPD detection in oil samples by the Commission Regulation issued of EU. The method proposed by CNN model with hybrid preprocessing was superior to the traditional model, and contributed to the quality monitoring of edible oil processing industry.
研究领域:
食品科学
·
分析化学
·
人工智能
✓ 已验证
DOI
PubMed
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2022
·
IF 9.136
Xinqian Li,Bo Li,Shuqi Li,Yaping Dong,Dandan Gao,Zhengrong Niu,Wu Li,Haitao Feng
Removing impurities from hexavalent chromium system without secondary pollution is the key to the successful development of green chromate production technology. Here, hydrated chromium oxide CrO x (OH) 3-2x with lamellar cluster microsphere structure was prepared by in-situ hydrothermal method and used to simultaneously adsorb Si (IV) and V (V) in high concentration Cr (VI) solution. In the in-situ hydrothermal process of pH 7, 160 ℃ for 8 h, the Si (IV) and V (V) removal rates of the actual chromate production Na 2 Cr 2 O 7 -Na 2 SiO 3 -NaVO 3 -H 2 O solution can reach 92.27 % and 94.81 %, respectively, which is higher than the ex-situ removal efficiency of Si (IV) (62.88 %) and V (V) (63.16 %) under the same conditions. Further characterization of STEM-elemental mapping, XPS and FT-IR results indicate that during in-situ adsorption, Si (IV) and V (V) are mainly adsorbed on the surface of CrO x (OH) 3-2X adsorbent by interacting with surface hydroxyl groups. More importantly, the simultaneous formation and adsorption of the adsorbent are more conducive to the full utilization of active adsorption sites on the adsorbent surface. After that, CrO x (OH) 3-2x was converted into nano Cr 2 O 3 with a purity of 97.87 % by simple desorption and calcination processes. In addition, the results of UV–vis DRS and SEM show that the residual Si and V elements in Cr 2 O 3 unexpectedly increase the size of the particles to about 300 nm, which redshifts the absorption band of the blue region by 3.3 nm. This results in more red absorption and makes Cr 2 O 3 more yellowish-green and exhibits excellent pigment properties. Thus, the in-situ synthesis, synergistic adsorption and green conversion of trivalent chromium adsorbent provide a promising and sustainable technology for the purification of high concentration Cr (VI) solution that avoids the discharge of Cr (VI) containing slag.
研究领域:
环境科学
·
材料科学
·
化学工程
✓ 已验证
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2020
·
IF 8.758
Qianyu Zhao,Hua Zhang,Haitian Zhao,Jia Liu,Jingyi Liu,Zilong Chen,Bin Li,Xiaojun Liao,Joe Mac Regenstein,Jing Wang,Xin Yang
Seven magnetic covalent organic framework molecularly imprinted polymers with magnetic responsiveness, large specific surface area, and molecular recognition ability were successfully synthesized, suitable for the separation of cyanidin-3-O-glucoside from complex samples. Using a room-temperature synthesis strategy, covalent organic frameworks accompanied by imprinted sites were formed in one step on the functionalized magnetic nanoparticles with 1,6-hexanediamine. The composite materials were easy to prepare and showed high adsorption capacity (127 mg g–1) together with favorable adsorption selectivity for cyanidin-3-O-glucoside over other flavonoids and phenolic acids. Magnetic covalent organic framework molecularly imprinted polymers exhibited good stability in 10 adsorption–desorption cycles. This work established a new method of extracting and separating high-purity anthocyanins and even unstable natural compounds.
研究领域:
材料科学
·
分析化学
·
天然产物研究
✓ 已验证
DOI
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2025
·
IF 9.7
Haolong Tan,Tongwei Gao,Wensheng Yang,Yue Gao,Quan Xie,Yunjun Ruan,Qian Chen,Tinghong Gao
The rapid development of microelectronic devices has increased the demand for miniature energy storage systems that are highly safe and exhibit long cycling life and excellent energy density. However, the lack of low-cost and high-performance fabrication methods presents a significant challenge to thin-film electrode fabrication. This study reports a strategy combining controllable pre-curing treatment with rapid thermal annealing (RTA), which enables in situ fabrication of high-quality sodium vanadium phosphate [Na 3 V 2 (PO 4 ) 3 ] thin films. RTA facilitates the cleavage of weak metal–O bonds in the precursor film, whereas optimisation of the pre-curing duration (0–100 s) effectively eliminates organic residues and strengthens the carbon framework, suppressing particle agglomeration. This synergistic control substantially improves crystallization uniformity and film densification, resulting in a refined grain structure and highly oriented crystal facets. Under optimal conditions, the thin film demonstrates a high specific capacity of 85.6 mAh g −1 at a current density of 1 A g −1 , retains 72.5 mAh g −1 even at 20 A g −1 , and demonstrates 90.3 % capacity retention after 200 cycles. Moreover, the assembled full sodium-ion cell exhibits an average operating voltage of 1.3 V while maintaining 94.2 % capacity retention after 500 cycles. This study elucidates for the first time the synergistic regulation pathway of the pre-curing–RTA coupling mechanism in Na 3 V 2 (PO 4 ) 3 thin-film fabrication and proposes an advanced preparation strategy for cost-effective, highly integrated, high-power sodium-ion thin-film devices, providing critical theoretical foundations and robust technical support for next-generation all–solid state sodium microbattery design and development.
研究领域:
材料科学
·
电化学
·
能源存储
·
薄膜制备
·
固态电池
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHINESE JOURNAL OF CHEMISTRY
·
2022
·Vol. 40
·期 17
·2054-2060
·
IF 5.56
Mengping Chen,Lang Lang,Lei Chen,Xiaomei Wang,Cen Shi,Qiwen Sun,Yigong Xu,Juan Diwu,Shuao Wang
Comprehensive Summary The environmental contamination of uranium will occur in scenarios such as nuclear accidents and leakage from nuclear waste storage sites, which eventually leads to the internal uranium exposure of people, causing consequential injuries of renal failure, osteosarcoma, etc . The development of uranyl specific chelating agents that could sequester uranium in vivo is in urgent need and is important for the safe and efficient development of nuclear industry. Metal organic frameworks (MOFs) already serve as efficient uranium depletion materials in solutions of a wide range of pH and ionic strength for nuclear fuel recycling, uranium extraction from seawater, as well as environmental decontamination. Herein, a chromium-based nano-metal organic framework (nano-MOF) functionalized interiorly with 3,2-HOPO ligands, MIL-101-HOPO, is rationally synthesized. In vitro adsorption experiments show that MIL-101-HOPO exhibits high adsorption selectivity and fast adsorption kinetics for uranyl. The results of in vivo uranyl decorporation assays reveal that MIL-101-HOPO with the decoration of HOPO ligands on the interior wall exhibits significantly increased uranyl removal ratio in kidneys comparing to the pristine nMOFs, and is more effective than the clinically used ZnNa 3 -DTPA. All those results corroborate the interior functionalization of MOFs as an efficient strategy to develop promising uranyl decorporation agents.
研究领域:
环境科学
·
材料科学
·
核工程
·
毒理学
✓ 已验证
DOI
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2025
·
IF 2.5
Tiantian Wang,Jianhong Wei,Furong Shi,Hejie Wang,Jinye He,Xudong Lv,Yuan Zhou,Pengzhi Guo,Chenglong Wang,Yangjun Xia
In recent years, polymerized small molecule acceptors (PSMAs) have emerged as a promising strategy that combines the strong absorption of small molecules with the film-forming ability and stability of polymers, thereby greatly boosting the performance of all-polymer solar cells (all-PSCs). We designed a non-fused acceptor, DTBT-IC, and its polymeric counterpart, PDTBT-Br-T, by selecting DTBT as the core, bithiophene as the π-bridge, and IC as the terminal group. PDTBT-Br-T was synthesized via Stille coupling and used with PM6 as the donor to fabricate organic solar cells. The PDTBT-Br-T-based device delivered superior performance, with a VOC of 1.050 V, JSC of 9.32 mA cm−2, FF of 45.33%, and a PCE of 4.44%, outperforming the DTBT-IC-based counterpart. Morphological and structural analyses revealed that PDTBT-Br-T exhibits more ordered backbone stacking and defined phase separation, enhancing exciton dissociation and charge transport, and suppressing energy loss. The study highlights that polymerization of DTBT-IC enhances intermolecular packing and microstructure, offering critical design insights for efficient all-PSCs.
研究领域:
材料科学
·
高分子化学
·
有机电子学
·
光伏技术
✓ 已验证
DOI
高影响因子
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
·
2024
·
IF 4.8
Yanqing Wang,Huanying Zhang,Feng Ding,Jianhua Li,Lianyu Li,Zhong Xu,Yan Zhao
Alzheimer's disease (AD) is a common neurodegenerative disease that causes progressive cognitive decline. A major pathological characteristic of AD brain is the presence of senile plaques composed of β-amyloid (Aβ), the accumulation of which induces toxic cascades leading to synaptic dysfunction, neuronal apoptosis, and eventually cognitive decline. Dietary n-3 polyunsaturated fatty acids (PUFAs), such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), are beneficial for patients with early-stage AD; however, the mechanisms are not completely understood. In this study, we investigated the effects of n-3 PUFAs on Aβ-induced toxicity in a transgenic AD Caenorhabditis elegans (C. elegans) model. The results showed that EPA and DHA significantly inhibited Aβ-induced paralytic phenotype and decreased the production of reactive oxygen species while reducing the levels of Aβ in the AD worms. Further studies revealed that EPA and DHA might reduce the accumulation of Aβ by restoring the activity of proteasome. Moreover, treating worms with peroxisome proliferator-activated receptor (PPAR)-γ inhibitor GW9662 prevented the inhibitory effects of n-3 PUFAs on Aβ-induced paralytic phenotype and diminished the elevation of proteasomal activity by n-3 PUFAs, suggesting that PPARγ-mediated signals play important role in the protective effects of n-3 PUFAs against Aβ-induced toxicity.
研究领域:
神经生物学
·
分子生物学
·
营养学
✓ 已验证
DOI
PubMed
高影响因子
Nature Catalysis
·
2023
·
IF 37.8
Sun Kai,Dong Juncai,Sun Hao,Wang Xingdong,Fang Jinjie,Zhuang Zhongbin,Tian Shubo,Sun Xiaoming
Metal-nitrogen-doped carbon (M-N-C) catalysts are promising platinum group metals alternatives for fuel cell cathodes; however, their randomly formed, unpredictable coordinations complicate any structure–property investigation and lead to low active site density. Here we achieve dense and well-defined cobalt sites on the surfaces of Co(CN) 3 microcrystals, which are identified by single-crystal X-ray diffraction and X-ray absorption spectroscopy. In situ infrared spectroscopy and density functional theory calculations elucidate that the high oxygen reduction reaction performance (half-wave potential is 0.90 V versus RHE) of the cubic Co(CN) 3 is due to its tailored coordination environment that optimizes *OH desorption. The cyanide linkage with minimized spacing between cobalt atoms maximizes active sites’ spatial density, which boosts the anion-exchange membrane fuel cell peak power density to 1.67 W cm −2 . The microcrystals with well-defined coordination structures can be used as Co-N-C analogues for their structure–property relationship investigations.
研究领域:
材料科学
·
电化学
·
催化
·
燃料电池技术
✓ 已验证
DOI
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2024
·
IF 8.1
Yao Huang,Xuefeng Hu,Chuanyi Wang,Detlef Bahnemann
Donor-acceptor (D-A) structure has gained momentous attention due to its controllable optical band gap and impressive carrier separation performance. The intramolecular charge transfer within photocatalysts could be modulated by constructing a D-A structure, thereby enhancing their performance in degrading pollutants. In our recent research, using poly(3-bromothiophene) (PTh-Br) and dicyandiamide (DCD) as precursors, a series of D-A structures (CN-PTh-Br(x)) based on polythiophene donors and carbon nitride acceptors were obtained by one-pot synthesis for first-time. The density functional theory calculations further demonstrate that PTh-Br segment (an electron donor) donates electrons to tri-s-triazine rings (an electron acceptor). The introduction of electron-rich polythiophene groups and electron-withdrawing Br atoms on carbon nitride skeleton can propel the transfer and separation of holes and electrons. Moreover, the polythiophene groups with high conjugation length can optimize the optical absorption of CN-PTh-Br(x) at 450–600 nm, thus markedly heightening the visible-light utilization efficiency of the materials. The photocatalytic performance of CN-PTh-Br(x) was assessed through the photodegradation of 2-mercaptobenzothiazole (MBT) under visible-light illumination. The photodegradation performance of CN-PTh-Br(0.5) stood out among all the samples, demonstrating a remarkable ability to remove 99.8% of MBT within 45 min.
研究领域:
材料科学
·
环境科学
·
光化学
✓ 已验证
DOI
高影响因子
Journal of Biomedical Nanotechnology
·
2021
·Vol. 17
·期 12
·2444-2454
·
IF 4.099
Li Guiyin,Li HaiMei,Chen Wei,Chen Huijiang,Wu Guanxiong,Tan Mingxiong,Liang Jintao,Zhou Zhide
An electrochemical aptasensor for quantitatively detecting glypican-3 (GPC3) was constructed by combining hemin-reduced graphene oxide-platinum (H-rGO-Pt) nanoparticles (NPs) with reduced graphene oxide-gold (rGO-Au) nanoparticles (NPs). Herein, the rGO-Au NPs deposited onto screen-printed
electrodes resulted in signal amplification due to their large surface areas. Meanwhile, highly conductive H-rGO-Pt NPs acted as a sensing medium that improved electrical conductivity and as an indicator for monitoring peak current for determination. A GPC3 aptamer (GPC3apt) with a low equilibrium
dissociation constant was used as a bio-recognition molecule. GPC3apt specifically captured GPC3 proteins and formed aptamer-GPC3 complexes, which impeded electron transfer and thus hampered the redox signal of hemin in H-rGO-Pt NPs. This developed electrochemical aptasensor showed a linear
response to GPC3 (from 0.001 μg/mL to 10 μg/mL) and had a detection limit of 0.001 μg/mL. This work provides a low-cost and highly sensitive detection with and good recovery for GPC3 and holds great promise for the clinical diagnosis of hepatocellular carcinoma.
研究领域:
生物医学工程
·
肿瘤学
·
纳米技术
✓ 已验证
DOI
PubMed
高影响因子
Drug Design Development and Therapy
·
2017
·
IF 2.822
Jingrun Chen,Junjie Liu,Dongxiao Cui,Chaoqun Yan,Liqiang Meng,Liqian Sun,Shurong Ban,Rui Ge,Taigang Liang,Qingshan Li
This study deals with the design and synthesis of a series of novel 4-methoxy-substituted and 5-methyl-substituted (3′S,4′S)-(−)-cis-khellactones. The newly synthesized compounds were characterized by 1H nuclear magnetic resonance (NMR), 13C-NMR, mass spectrometry, and elemental analysis. All the derivatives were subjected to in vitro cytotoxicity screening against HEPG-2 (human liver carcinoma), SGC-7901 (human gastric carcinoma), and LS174T (human colon carcinoma), by using the MTT assay. The results revealed that several of the 4-methoxy-substituted compounds exhibited potent cytotoxicity. Among these, compound 12e showed the highest activity against cancer cells which 50% inhibitory concentration (IC50) values were in the range of 6.1–9.2 μM with low toxicity on normal human hepatocyte. Preliminary investigation of possible mechanisms of action of compound 12e against HEPG-2 cells indicated possible induction of apoptosis, as determined by morphological observations and Annexin V/propidium iodide (PI) double staining, in addition to apparent dissipation of mitochondrial membrane potential (MMP), as measured by 5,5′,6,6′-tetrachloro-1,1′,3,3′-tetraethyl-imidacarbocyanine iodide (JC-1) staining in combination with the activation of caspase-9 and caspase-3 by Western blot analysis. Overall, the data suggest that compound 12e may be a promising potential anti-cancer agent that could act primarily by inducing apoptosis through the mitochondria-mediated intrinsic pathway in human hepatoma cells.
研究领域:
药理学
·
肿瘤学
·
药物化学
✓ 已验证
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）