MOLECULAR DIVERSITY
·
2024
·
IF 3.9
Ou Yuqin,Guo Xue,Zhang Qi,Zhang Wei,Gan Xiuhai
Plant-parasitic nematodes are seriously affecting agricultural production worldwide and there are few highly effective and low-risk nematicides to control nematode diseases. In order to discover new nematicides, a series of 1,2,4-oxadiazole derivatives containing amide fragments have been designed and synthesized with the principle of active substructure splicing. The nematicidal activity of the target compounds was evaluated in vitro and it indicated that compound C3 exhibited the most nematicidal activity against Bursaphelenchus xylophilus , Aphelenchoides bessey i, and Ditylenchus destructor with the LC 50 values of 37.2, 36.6, and 43.4 μg/mL, respectively, which were superior to positive agent tioxazafen. The preliminary mechanism results revealed that compound C3 not only inhibited the reproduction of B. xylophilus populations, but also affected the production of ROS and the accumulation of lipofuscin and lipids. Furthermore, compound C3 showed good inhibition of succinate dehydrogenase (SDH) with the IC 50 value of 45.5 µmol/L. Molecular docking indicated that compound C3 had excellent binding to amino acids around the SDH active pocket. This work indicated that 1,2,4-oxadiazole derivative containing amide fragment is a promising template for the discovery of new nematicides and compound C3 can be used as a potential nematicide candidate. Graphical abstract
研究领域:
农业化学
·
农药科学
·
分子生物学
✓ 已验证
DOI
PubMed
高影响因子
ACTA PHARMACOLOGICA SINICA
·
2024
·
IF 6.9
Yang Qin,He Wen-hao,Xie Li,Chen Tao,Liu Ruo-fan,Hu Jia-jia,Guo Jia-yin,Tan Guo-zhu,Wu Fu-ling,Gu Peng,Chen Peng,Chen Yu
Acetaminophen (APAP) overdose-induced acute liver injury (ALI) is characterized by extensive oxidative stress, and the clinical interventions for this adverse effect remain limited. Astilbin is an active compound found in the rhizome of Smilax glabra Roxb . with anti-inflammatory and antioxidant activities. Due to its low oral bioavailability, astilbin can accumulate in the intestine, which provides a basis for the interaction between astilbin and gut microbiota (GM). In the present study we investigated the protective effects of astilbin against APAP-induced ALI by focusing on the interaction between astilbin and GM. Mice were treated with astilbin (50 mg·kg −1 ·d −1 , i.g.) for 7 days. After the last administration of astilbin for 2 h, the mice received APAP (300 mg/kg, i.g.) to induce ALI. We showed that oral administration of astilbin significantly alleviated APAP-induced ALI by altering the composition of GM and enriching beneficial metabolites including hydroxytyrosol (HT). GM depletion using an “antibiotics cocktail” or paraoral administration of astilbin abolished the hepatoprotective effects of astilbin. On the other hand, administration of HT (10 mg/kg, i.g.) caused similar protective effects in APAP-induced ALI mice. Transcriptomic analysis of the liver tissue revealed that HT inhibited reactive oxygen species and inflammation-related signaling in APAP-induced ALI; HT promoted activation of the Nrf2 signaling pathway to combat oxidative stress following APAP challenge in a sirtuin-6-dependent manner. These results highlight that oral astilbin ameliorates APAP-induced ALI by manipulating the GM and metabolites towards a more favorable profile, and provide an alternative therapeutic strategy for alleviating APAP-induced ALI.
研究领域:
药理学
·
肝病学
·
微生物学
·
分子生物学
✓ 已验证
DOI
高影响因子
Nature Communications
·
2024
·Vol. 15
·期 1
·1-18
·
IF 14.7
Zhang Yan,Shen Jiayi,Xie Famin,Liu Zhiwei,Yin Fangfang,Cheng Mingxiu,Wang Liang,Cai Meiting,Herzog Herbert,Wu Ping,Zhang Zhi,Zhan Cheng,Liu Tiemin
Resistance to stress is a key determinant for mammalian functioning. While many studies have revealed neural circuits and substrates responsible for initiating and mediating stress responses, little is known about how the brain resists to stress and prevents overreactions. Here, we identified a previously uncharacterized neuropeptide Y (NPY) neuronal population in the dorsal raphe nucleus and ventrolateral periaqueductal gray region (DRN/vlPAG) with anxiolytic effects in male mice. NPY DRN/vlPAG neurons are rapidly activated by various stressful stimuli. Inhibiting these neurons exacerbated hypophagic and anxiety responses during stress, while activation significantly ameliorates acute stress-induced hypophagia and anxiety levels and transmits positive valence. Furthermore, NPY DRN/vlPAG neurons exert differential but synergic anxiolytic effects via inhibitory projections to the paraventricular thalamic nucleus (PVT) and the lateral hypothalamic area (LH). Together, our findings reveal a feedforward inhibition neural mechanism underlying stress resistance and suggest NPY DRN/vlPAG neurons as a potential therapeutic target for stress-related disorders.
研究领域:
神经科学
·
应激生物学
·
行为神经科学
✓ 已验证
DOI
PubMed
高影响因子
Journal of Sustainable Metallurgy
·
2024
·
IF 2.5
Peng Miaomiao,Xi Chen,Shen Keyu,Tan Yangjing,Li Fei
A novel greenness and low-cost biosorbent was prepared by polyethylene polyamine-modified waste biomass of sugarcane bagasse in this study, which was used to remove molybdenum(VI) from aqueous solution. The structural properties and adsorption mechanism of this amine-functionalized sugarcane bagasse adsorbent (SCB-A) on Mo(VI) were investigated by SEM–EDS, BET, TG, FTIR, XPS, and batch adsorption experiments. The results show that the adsorption reaction between SCB-A and Mo(VI) was a spontaneous endothermic process, and its theoretical maximum adsorption capacity was about 231.48 mg/g. The adsorption capacity was 8.93-fold compared to that of pristine sugarcane bagasse. This adsorption process was more consistent with the Langmuir model and pseudo-second-order kinetics model, indicating that this process was monolayer adsorption on a homogeneous surface and the adsorption rate was controlled by the chemisorption process. SCB-A possessed great reusability, maintaining a stable adsorption capacity after five recycles. For the adsorption toward Mo(VI), SCB-A also exhibited superior selectivity in a multi-ion coexistence solution. Therefore, SCB-A has tremendous potential in the economically and feasible removal of Mo(VI) from wastewater. Graphical Abstract
研究领域:
环境科学
·
材料科学
✓ 已验证
DOI
高影响因子
Frontiers of Materials Science
·
2023
·Vol. 17
·期 4
·1-11
·
IF 2.7
Chen Pin,Di Siyuan,Xie Weixin,Li Zihan,Zhu Shukui
Herein, a novel visible-light-responsive photocatalyst with high efficiency was firstly synthesized at room temperature. The mild synthetic method resulted in a uniform spherical triazine-based covalent organic framework (TrCOF2) with ultra-high specific surface area as well as chemical stability. Due to the synergistic effect between the self-assembled uniform spherical structure and the abundant triazine-based structure, photoelectron–hole pairs were efficiently separated and migrated on the catalysts. On this basis, TrCOF2 was successfully applied to efficiently degrade bisphenol A (BPA). More than 98% of BPA was deraded after 60 min of visible light treatment, where the active specie of •O
− 2
played a vital role during the degradation of BPA. The holes of TrCOF2 could produce O 2 by direct reaction with water or hydroxide ions. Simultaneously, photoelectrons can be captured by O 2 to generate •O
− 2
. Moreover, density functional theory (DFT) calculations proved the outstanding ability of the exciting electronic conductivity. Remarkably, a reasonable photocatalytic mechanism for TrCOF2 catalysts was proposed. This research can provide a facile strategy for the synthesis of TrCOFs catalysts at room temperature, which unfolds broad application prospects in the environmental field.
研究领域:
环境科学
·
材料科学
✓ 已验证
DOI
高影响因子
IRANIAN POLYMER JOURNAL
·
2014
·Vol. 23
·期 11
·899-906
·
IF 1.469
Lai Jianbin,Yang Fafu,Guo Hongyu,Jiao Ziyu
By introducing 1,2,3-triazole-ester groups on thiacalix[4]arene based on click chemistry and then ammonolysis with ethylenediamine, diethylenetriamine or triethylenetetramine, three novel 1,2,3-triazole-modified thiacalix[4]arene polymers were conveniently prepared in “4+2” condensation mode in ideal yields. The structures of polymers 4a–4c were confirmed by elemental analysis, FTIR and 1 H NMR spectra. The surface morphologies of polymers 4a–4c were investigated by SEM micrographs. The M
n
of novel polymers 4a–4c indicated approximately 18–20 calixarene units in each polymer molecule. The dye adsorption abilities of polymers 4a–4c for series of organic dyes (alizarin green, orange I, neutral red (NR), Congo red (CR), orange G (OG), crystal violet, Victoria blue B and methylene blue) were studied by solid–liquid adsorption experiments. The adsorption experimental results implied that they had excellent adsorption abilities for tested organic dyes. The highest adsorption percentage reached 97 % for OG. The best saturation adsorption capacities for NR and CR were as high as 1.282 and 1.407 mmol/g, respectively. These novel polymers possessed stable adsorption abilities in the scopes of pH 5–9 and had good reused properties after desorption. The adsorption mechanism proposed that not only dipole interaction, electrostatic interaction and hydrogen bonding interaction, but also the π–π stacking interaction plays important role in binding dyes.
✓ 已验证
DOI
高影响因子
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
·
2012
·Vol. 23
·期 8
·1913-1919
·
IF 2.316
Li Ning,Yu Meihua,Deng Liandong,Yang Jun,Dong Anjie
Hydrogels with the advantages of prolonging drug release and administration convenience are necessary for intravaginal drug delivery to prevent sexual transmission of human immunodeficiency virus and other vaginal infections. In this study, the thermosensitive hydrogel of methylcellulose modified by stearic acid (MCS) were evaluated in the presence of NaCl and phosphates, which exhibited sol-to-gel transition performance at body temperature or even lower. The in vitro cytotoxicity and in vivo mucosal irritation were investigated and the results showed that MCS hydrogel possessed good biocompatibility similar with hydroxyethyl cellulose (HEC) gel. Significantly, the release studies revealed that MCS hydrogel could control tenofovir sustained release for 10 h without burst release, longer than that from HEC gel or poloxamer 407 hydrogel. Therefore, MCS thermosensitive hydrogel would be a promising carrier for intravaginal delivery of antiviral drugs for long time controlled release.
研究领域:
药剂学
·
生物材料学
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
·
2018
·Vol. 315
·期 2
·119-126
·
IF 1.181
Tan Juan,Wang Yanfei,Liu Na,Liu Mouwu
The adsorption of uranium (VI) using tetraphenylimidodiphosphinate (Htpip) was studied. Factors of affecting sorption efficiency have been investigated and results showed the adsorption of uranium (VI) was equilibrium at pH 4.5, time 20 min, adsorbent dosage 0.005 g and initial concentration 50 mg L −1 reaching 99.86 mg g −1 of adsorption capacity and 99.86% of removal efficiency. Additionally, the interfering ions studies showed that the adsorbent possessed excellent adsorption selectivity of uranium (VI). The surface morphology of Htpip was investigated by SEM. The adsorption process of uranium (VI) onto Htpip fit the pseudo-second-order kinetic model and the Freundlich isotherm model very well.
研究领域:
环境科学
·
化学工程
✓ 已验证
DOI
高影响因子
Electrocatalysis
·
2022
·Vol. 14
·期 2
·247-258
·
IF 2.933
Zhao Zhipeng,Liu Yinmeng,Yi Wenjing,Wang Haiyang,Liu Zhongyi,Yang Jing-he,Zhang Meng
Binder-free nickel–cobalt phosphate (NiCoPO) micro flakes are evenly grown on the nickel foam (NF) by a simple hydrothermal method, which can act as a highly efficient bifunctional electrocatalyst (NiCoPO/NF) for both oxygen evolution reaction (OER) and urea oxidation reaction (UOR). NiCoPO/NF presents the relatively prominent OER and UOR activities with ultralow potentials of 1.51 V and 1.34 V (vs. reversible hydrogen electrode) to reach the current density of 100 mA cm −2 , respectively. The outstanding UOR and OER performance of NiCoPO/NF might be attributed to the fact that the successful incorporation of oxygen atoms into Ni/Co phosphate is beneficial for the oxidation of metal atoms at high overpotential. In addition, NF can improve the electrical conductivity to accelerate the electron transfer from the electrode to the catalyst. Additionally, in the alkaline solution (1 M KOH), NiCoPO/NF shows excellent durability and stability after the consecutive OER and UOR tests for 48 h. The design of NiCoPO/NF would pave the way to construct more efficient bifunctional electrodes for electrocatalytic water splitting with or without urea in alkaline solution, which provides a novel technological platform for the conversion of human waste into the sustainable energy. Graphical Abstract
研究领域:
材料科学
·
电化学
·
可再生能源
✓ 已验证
DOI
高影响因子
Frontiers of Chemical Science and Engineering
·
2011
·Vol. 5
·期 4
·409-415
·
IF 0
Cao Hongfei,Feng Yakai,Wang Heyun,Zhang Li,Khan Musammir,Guo Jintang
By using the corresponding L -amino acid sodium as initiator, ɛ -caprolactone-depsipeptides CL-Ala and CL-Leu were prepared by the reactions of ɛ -caprolactone (CL) with L -alanine and L -leucine, respectively, and p -dioxanone-depsipeptide (PDO-Leu) was prepared by the reaction of p -dioxanone (PDO) with L leucine. Two poly( ɛ -caprolactone) oligomers (PCL-Ala and PCL-Leu) of different molecular weights with depsipeptide unit were synthesized by controlling the feed ratio of L -amino acid sodium and CL. The presence of the depsipeptide structure in these obtained products was confirmed by 1 H NMR spectra and the molecular weight of the poly( ɛ -caprolactone) oligomers was measured by gel permeation chromatography (GPC). These products contain a hydroxyl group and a carboxyl group in one molecule, which means they could act as bifunctional monomers for further polymerization to prepare high molecular weight polymers. By this way, the depsipeptide unit could be introduced into the polymers and the biodegradation rates of the novel polymers could be well controlled in vivo by the tailored molecular structures.
研究领域:
有机化学
·
高分子化学
·
生物材料学
✓ 已验证
DOI
Frontiers of Materials Science
·
2023
·Vol. 17
·期 3
·1-9
·
IF 2.7
Li Wenjing,Wu Ni,Che Sai,Sun Li,Liu Hongchen,Ma Guang,Wang Ye,Xu Chong,Li Yongfeng
Polyurethane (PU) foams are widely used in thermal management materials due to their good flexibility. However, their low thermal conductivity limits the efficiency. To address this issue, we developed a new method to produce tannic acid (TA)-modified graphene nanosheets (GTs)-encapsulated PU (PU@GT) foams using the soft template microstructure and a facile layer-by-layer (L-B-L) assembly method. The resulting PU@GT scaffolds have ordered and tightly stacked GTs layers that act as three-dimensional (3D) highly interconnected thermal networks. These networks are further infiltrated with polydimethylsiloxane (PDMS). The through-plane thermal conductivity of the polymer composite reaches 1.58 W·m −1 ·K −1 at a low filler loading of 7.9 wt.%, which is 1115% higher than that of the polymer matrix. Moreover, the mechanical property of the composite is ∼2 times higher than that of the polymer matrix while preserving good flexibility of the polymer matrix owing to the retention of the PU foam template and the construction of a stable 3D graphene network. This work presents a facile and scalable production approach to fabricate lightweight PU@GT/PDMS polymer composites with excellent thermal and mechanical performance, which implies a promising future in thermal management systems of electronic devices.
研究领域:
材料科学
·
热管理技术
✓ 已验证
DOI
高影响因子
BULLETIN OF MATHEMATICAL BIOLOGY
·
2023
·Vol. 85
·期 10
·1-27
·
IF 3.5
Wang Mengshou,Li Gao,Peng Liangrong,Hong Liu
Epigallocatechin-3-gallate, as a representative amyloid inhibitors, has shown a promising ability against A \(\beta \) fibrillation by directly degradating the mature fibrils. Most previous studies have been focusing on its functional mechanisms, meanwhile its optimal dosage has been seldom considered. To solve this critical issue, we refer to the generalized Logistic model for amyloid fibrillation and inhibition and adopt the optimal control theory to balance the effectiveness and cost (or toxicity) of inhibitors. The optimal control trajectory of inhibitors is analytically solved, based on which the influence of model parameters, the difference between the optimal control strategy and several other traditional drug dosing strategies are systematically compared and validated through experiments. It is found that the strategy of multiple-times adding is more suitable for a long-term disease treatment, while single high-dose therapy is preferred for a short-term treatment. We hope our findings can shed light on the rational usage of amyloid inhibitors in clinic.
研究领域:
生物物理学
·
医学工程
·
药理学
✓ 已验证
DOI
PubMed
高影响因子
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