Frontiers of Chemical Science and Engineering
·
2021
·Vol. 16
·期 4
·498-510
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IF 4.204
Bo Jinxiao,Li Mei,Zhu Xinli,Ge Qingfeng,Han Jinyu,Wang Hua
The electrochemical conversion of CO 2 -H 2 O into CO-H 2 using renewable energy is a promising technique for clean syngas production. Low-cost electrocatalysts to produce tunable syngas with a potential-independent CO/H 2 ratio are highly desired. Herein, a series of N -doped carbon nanotubes encapsulating binary alloy nanoparticles (M x Ni-NCNT, M= Fe, Co) were successfully fabricated through the co-pyrolysis of mela-mine and metal precursors. The M x Ni-NCNT samples exhibited bamboo-like nanotubular structures with a large specific surface area and high degree of graphitization. Their electrocatalytic performance for syngas production can be tuned by changing the alloy compositions and modifying the electronic structure of the carbon nanotube through the encapsulated metal nanoparticles. Consequently, syngas with a wide range of CO/H 2 ratios, from 0.5:1 to 3.4:1, can be produced on M x Ni-NCNT. More importantly, stable CO/H 2 ratios of 2:1 and 1.5:1, corresponding to the ratio to produce biofuels by syngas fermentation, could be realized on Co 1 Ni-NCNT and Co 2 Ni-NCNT, respectively, over a potential window of −0.8 to −1.2 V versus the reversible hydrogen electrode. Our work provides an approach to develop low-cost and potential-independent electrocatalysts to effectively produce syngas with an adjustable CO/H 2 ratio from electrochemical CO 2 reduction.
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INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
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2021
·Vol. 22
·期 2
·928
·
IF 5.924
Muhammad Inam,Lu Liu,Jian-Wei Wang,Ka-Xi Yu,Chi-Uyen Phan,Jie Shen,Wen-Hua Zhang,Guping Tang,Xiurong Hu
Puerarin (PUE) is a Chinese traditional medicine known to enhance glucose uptake into the insulin cells to downregulate the blood glucose levels in the treatment of type II diabetes. Nevertheless, the bioavailability of pristine PUE is limited due to its poor solubility and low intestinal permeability. In this work, we demonstrate that the solubility of PUE can be significantly enhanced via its co-crystallization with L-Proline (PRO). Two crystalline phases, namely, the solvate-free form [PUE][PRO] (I) and the solvated form [PUE]2[PRO]∙EtOH∙(H2O)2(II) are isolated. These two phases are characterized by single-crystal X-ray diffraction (SCXRD), powder X-ray diffraction (PXRD), Fourier-transformed infrared (FT-IR) spectra, nuclear magnetic resonance (NMR), and thermogravimetric analysis in association with differential scanning calorimetry (TGA-DSC). The solubility and dissolution rate of bothIandIIin water, gastrointestinal tract at pH 1.2, and phosphate buffer at pH 6.8 indicates a nearly doubled increase as compared to the pristine PUE. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay of pristine PUE,IandIIagainst murine colon cancer cell lines CT-26 and human kidney cell lines HEK-293 indicated that neither compound exhibits obvious cytotoxicity after 24 h. This work showcases that the readily available and biocompatible PRO can be a promising adjuvant to enhance the physicochemical properties of PUE toward orally administered drug formulation with improved pharmacokinetics.Keywords:puerarin;L-proline;pharmaceutical co-crystal;crystal structure;solubility and dissolution rate;Chinese traditional medicine;Hirschfeld analysis;hydrogen-bonding
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Journal of the Taiwan Institute of Chemical Engineers
·
2025
·
IF 6.3
Xin Liu,Ruixue Hu,Shiran Zhu,Xiangyu Liu,Yu Fang,Yihang Li,Wei Wei
Background The demand for adsorption technologies that facilitate the recovery and upcycling of the valuable metallic element, Co, has been increasing. The recovery of Co from wastewater using metal–organic frameworks (MOFs), which are promising adsorbents, is considerably limited because of the lack of selective adsorption sites. Furthermore, research on the upcycling of Co remains inadequate. Methods Herein, we develop an integrated strategy combining ion imprinting modification and photodeposition for the selective recovery and upcycling of divalent Co ions (Co(II)) using MOF adsorbents. Significant findings First, Co ion–imprinted sites are constructed on a typical MOF adsorbent, MIL-125 (labeled CoIP-ML), via molecular engineering using glycylglycine. Compared with the original aminated MIL-125, CoIP-ML exhibits a superior performance, achieving the maximum adsorption capacity ( q m = 218.6 mg/g) and selectivity (selective coefficient k Co(II)/Ni(II) = 3.61) for Co(II) via the chelation of Schiff base groups and adsorption at terminal carboxyl groups. The Co(II) adsorbed on CoIP-ML is upcycled through a facile photodeposition process into Co oxides, which function as a Fenton-like catalyst. The optimal catalyst effectively activates peroxymonosulfate for the removal of chloroquine diphosphate and chlortetracycline hydrochloride, achieving the upcycling of Co(II). This study presents a unique MOF-functionalization paradigm.
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Nanoscale
·
2019
·Vol. 11
·期 18
·8950-8958
·
IF 6.97
Hui Yang,Shunxing Li,Huiwu Yu,Fengying Zheng,Luxiu Lin,Jie Chen,Yuehai Li,Ye Lin
Control of the active sites/centers plays an important role in the design of novel electrode materials with unusual properties and achievement of sensors with high performance. In this study, three-dimensional (3D) freestanding multi-doped hollow carbon spheres (N–Co–Fe–HCS) with a layer thickness of 30 nm, which contained multiple active sites of the heteroatom N and transition metals (Co and Fe), were synthesized via a simple template method (with SiO2 as the template) and cost-efficient in situ self-polymerization, self-adsorption/reduction and carbonization strategies. Moreover, a series of hollow carbon sphere composites of the same family (N–HCS, N–Co–HCS and N–Fe–HCS) were prepared by this sensible process using the same method and precursors but different doping elements. These differences lead to different active sites/centers from hollow carbon spheres and improved electrocatalytic activities for dihydroxybenzene isomers. Furthermore, N–Co–Fe–HCS as an electrochemical sensor exhibited excellent simultaneous qualitative and quantitative determination performance for catechol (CC) and hydroquinone (HQ). The detection limit and the linear range were 75 nmol L−1 and 0.5–500 μmol L−1 for CC and 80 nmol L−1 and 0.5–1500 μmol L−1 for HQ, respectively. The interference from the components coexisting in river water on the detection of CC and HQ was not observed. These results indicate that high-performance electrochemical sensors can be constructed by in situ multi-element doping into electrode materials to achieve multi-active sites.
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CHEMICAL ENGINEERING JOURNAL
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2021
·
IF 13.273
Jiahuan He,Ziwei Huang,Wenzheng Chen,Xuezhang Xiao,Zhendong Yao,Zhaoqing Liang,Liujun Zhan,Ling Lv,Jiacheng Qi,Xiulin Fan,Lixin Chen
Recently, hydrolysis of ammonia borane (AB) is a promising way of producing and employing hydrogen in mild conditions. Nonetheless, the failure to develop inexpensive and high-performance catalyst impedes the further scale hydrogen energy application of AB. Given the fact that ex-situ formed nanocatalysts could be prone to abscission and agglomeration for insufficient dispersion and support, 1D composite microrods with 0D/1D/2D spatial structure constructed by mutual-supported 2D single-crystal Co 2 Mo 3 O 8 nanosheets and 0D Co nanoparticles (denoted as Co@Co 2 Mo 3 O 8 ) have been in-situ synthesized and introduced into the hydrolysis of AB for the first time. Excitingly, the novel Co@Co 2 Mo 3 O 8 exhibits one of the best catalytic performances in the hydrolysis of AB for non-noble metal/metal oxide heterojunction catalysts with TOF value reaching 17.28 m o l H 2 m o l ca t - 1 m i n - 1 at 25 °C, which is 3.95 and 24.0 times that of the single Co 2 Mo 3 O 8 and Co. Meanwhile, two kinds of catalytic components with high intrinsic activity (Co 2 Mo 3 O 8 and Co) and supporting each other in the 0D/1D/2D spatial structure (nanoparticles, microrods, and nanosheets) along with plentiful O vacancies induce the outstanding catalytic activity of Co@Co 2 Mo 3 O 8 . The large-scale controllable preparation method for in-situ fabrication of non-noble metal 0D/1D/2D composite catalysts with high performances would be an accelerator for great potential application for hydrolysis of AB.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2024
·
IF 7.7
Dai-Xu Wei,Duanfang Cai,Youguo Tan,Kezhi Liu,Jin-Wei Dao,Xiang Li,Aikeremujiang Muheremu
Huperzine A (HupA) is used in Alzheimer's disease (AD) therapy for its effective inhibition of acetylcholinesterase (AChE) and enhancement of cholinergic neuronal function. However, direct oral administration and injection of HupA cause side effects like nausea, anorexia, and rapid metabolism. Using a tripolymer, poly(3-hydroxybutyrate- co -3-hydroxyvalerate-co-3-hydroxyhexanoate (PBVHx), from the polyhydroxyalkanoate (PHA) family synthesized via synthetic biology, we present a novel AD therapy strategy with peritoneally administered PBVHx microspheres loaded with HupA (HupA-PBVHxMs). This approach extends HupA's metabolic duration in the blood and brain, enhancing AChE inhibition efficacy. Uniformly sized HupA-PBVHxMs, created using microfluidics and rotary evaporation, show up to 70.4 % drug encapsulation efficiency, sustained HupA release for 40 days, reduced neurotoxicity from Aβ25–35, and maintained in vivo HupA supply and AChE inhibition for over 20 days. In cognitive tests, HupA-PBVHxMs improved function in AD mice. Thus, PBVHx microspheres with slower HupA release and lower biotoxicity offer a superior platform for sustained AChE inhibitor release, outperforming commercial PLGA microspheres.
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高影响因子
ACS Applied Nano Materials
·
2026
·
IF 5.8
Hengchao Zhang,Rushun Xue,Mengke Li,Zhihao Wang,Lei Cao,Shanglin Yang,Xuefeng Xiao,Xiaojuan Li,Xiaozhou Feng,Xinhui Fan,Lingmin Yu
In situ grown 3D CuO nanoarray structures with an ordered architecture have emerged as promising materials for advanced CO gas sensing platforms owing to their intimate anchoring on a substrate, large surface area, and abundant exposed active sites. However, 3D CuO nanoarrays encounter high working temperature, slow response time, and inferior response value, impeding their practical use for CO gas detection. Herein, an Ag electronic sensitization strategy is proposed by a facile in situ deposition method. By innovatively constructing Ag nanoparticle coatings on the surface of CuO nanocone arrays, a high response (Rg/Ra) of 4.95 to 100 ppm of CO was achieved at a lower temperature of 180 °C, which is more than three times higher than that of pure CuO (240 °C, Rg/Ra = 1.53). At the same time, Ag/CuO has a fast response time (tres) of 49 s and a recovery time (trec) of 56 s, which is at least 19 s shorter than pure CuO. In addition, the sensor has good CO selectivity for other gases such as CO, NH3, C3H6O, and CH4O, as well as long-term stability for 8 weeks (relative error 4.03%), which is better than pure CuO (relative error 6.45%). This excellent performance is mainly attributed to the synergistic effect of the unique nanoarray structure of Ag/CuO and the strong sensitization effect of Ag. Therefore, this study provides a novel and promising strategy for developing high-performance chemical sensors using interfacial engineering.
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Crystals
·
2026
·Vol. 16
·期 2
·126
·
IF 2.9
Yuhang Liu,Ziqing Wu,Fenghua Chen,Yongming Liu,Rongrong Xue
In the organic biomineralization of guanine (GUA), amorphous GUA is utilized to enhance its solubility, facilitating its transport for the formation of biominerals, and GUA nanocrystals are employed to protect tissues from ultraviolet damage. These principles of GUA biomineralization inspire us to improve the solubility and photostability of trans-resveratrol (RES) using bio-purines, which limits its bioavailability. Bio-purines, such as GUA, hypoxanthine (HYP), and adenine (ADE), were used as co-formers in the amorphous systems of RES. Amorphous RES-2Purines with a 1:2 molar ratio were prepared via the neat ball-milling method and confirmed by powder X-ray diffraction, Raman spectroscopy, and diffuse reflectance spectroscopy. The stability, dissolution profiles, and photostability of RES-2Purines were comprehensively compared. RES-2Purines show high amorphous-to-crystalline transformation temperatures (>100 °C), confirmed by the differential scanning calorimetry-thermogravimetric analysis. Both RES-2HYP and RES-2ADE show an enhanced RES solubility (about 1.6-fold that of raw RES) in water and the simulated gastric fluid (pH 1.2). RES-2Purines can recrystallize quickly after being dispersed in water, which limits the solubility enhancements of RES-2Purines. RES-2Purines have better photostability than raw RES. Bio-purines are promising co-formers for amorphous systems to enhance the solubility and photostability of poorly water-soluble compounds.
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CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 12.5
Linyan Gu,Yangtao Qian,Yiting Liu,Miao Cheng,Tao Wei,Qianqian Liu,Ruirui Wang,Wanfei Li,Zhenxiao Fu,Haiyang Jiang,Zibo Li,Bo Liu,Jing Hu
The In–doped CuSnO 3 with a perovskite framework was facilely synthesized. • The Cu 1-x In x SnO 3 sensor show high response of R a /R g = 8.5 to 100 ppm CO at 250 °C. • The LOD of the CuSnO 3 with vs without In-doping is 16.1 ppb vs 30.1 ppb. • The sensitivity enhanced ∼2 times, and the response/recovery time significantly reduced. Metal oxide semiconductor (MOS) gas sensors for carbon monoxide (CO) detection still face challenges including slow research progress, insufficient stability, and unsatisfactory sensitivity. To address these issues, In-doped perovskite-type CuSnO 3 (Cu 1-x In x SnO 3 ) hybrids were synthesized via a one-step co-precipitation method and firstly used for CO detection in this work. The multi-level characterization analysis has confirmed the uniform elemental distribution of In, Cu, Sn, and O in Cu 1-x In x SnO 3 nanostructures (nanospheres and nanorods) with a well-defined perovskite framework. Gas-sensing evaluation revealed that the n-type Cu 1-x In x SnO 3 sensor exhibits excellent CO detection capability at 250 °C, demonstrating a high response (S = 8.5 to 100 ppm), outstanding linearity across various concentration ranges, fast response/recovery kinetics (18 s/73 s) and superior selectivity against interfering gases. The sensor also shows good reproducibility and retains ∼60% of its initial response after 35 days of storage under ambient conditions. Compared with pure CuSnO 3 , the sensitivity of In-doped CuSnO 3 is enhanced by ∼2 times, and the response/recovery time is accelerated from 30/118 s to 18/73 s, which can be attributed to the increasing of specific surface area, oxygen vacancies concentration and the formed Cu 2+ /Cu + redox couple induced by In-doping. The results presented here show a pioneering exploration of perovskite Cu 1-x In x SnO 3 for CO sensing, showcasing its potential as a high-performance sensing material. A perovskite-structured Cu 1-x In x SnO 3 hybrid was facilely synthesized via a one-step co-precipitation method and firstly used for high-sensitivity CO detection. Download: Download high-res image (166KB) Download: Download full-size image
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JOURNAL OF SOLID STATE CHEMISTRY
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2026
·
IF 3.2
Tianle Ge,Jiangfeng Mou,Rui Chen,Yuping Li,Kaizhao Wang,Yafei Wang,Kaijun Wang,Jin Hu,Tianyou Chen
Developing efficient and low-cost electrocatalysts is important for sustainable CO 2 utilization. Here, spherical Cu 11 In 9 alloy nanoparticles were synthesized on an MWCNT network via an impregnation-assisted reduction method. Electrochemical measurements in an H-type cell showed that Cu 11 In 9 @MWCNTs promoted CO 2 -to-CO conversion in 0.3 mol L −1 tetrabutylammonium chloride/acetonitrile (Bu 4 NCl/AN) electrolyte. At −2.4 V vs SHE, the Faradaic efficiency for CO (FE CO ) reached 95.8%, and the CO partial current density ( j CO ) approached 40 mA cm −2 . During 20 h of continuous electrolysis, the catalyst maintained approximately 95% CO selectivity and a stable current density. XPS and PDOS analyses indicated that Cu-In alloying modified the local electronic structures of Cu and In and shifted the d-band center of Cu away from the Fermi level. DFT calculations further showed more favorable CO 2 -to-CO energetics and less favorable H adsorption on Cu 11 In 9 than on Cu and In, consistent with the experimentally observed high CO selectivity and low H 2 formation. The MWCNT network maintained the dispersion and structural stability of the alloy nanoparticles, thereby increasing the exposure of accessible active sites and facilitating electrolyte contact and charge transport.
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ANALYST
·
2025
·
IF 3.3
Xu-Fei Sun,Yuqi Luo,Xunan Dong,Hu Luo,Ke-Jing Huang
The rapid and reliable quantitative detection of biological targets encounters challenges such as limited driving forces in reactions, low overall strand utilization, and the synthetic complexity of multi-modal materials. To address these issues, the design concept “entropy–enthalpy coupling with dual-mode decoupling” is introduced for the first time. Using miRNA-21 as a model analyte, an entropy–enthalpy co-driven decoupled dual-mode biosensor was developed by integrating independent photoelectrochemical (PEC) and fluorescent (FL) modules to assess its feasibility. Specifically, an output strand was designed within a three-stranded substrate/output complex, in which the terminal bases form hairpin structures through complementary pairing. This configuration enables the establishment of an entropy–enthalpy coupling driving force—increased entropy for the substrate strand and decreased enthalpy for the output strand—during cyclic amplification reactions. Additionally, by conjugating the substrate, fuel and output strands separately to magnetic beads, photosensitive materials, and fluorophores, complete decoupling of the PEC and FL modes was achieved, allowing independent PEC and FL signal outputs. In the developed biosensor, the device demonstrated well-defined linear correlation for PEC and FL within the 10 aM to 10 nM range, and the detection limits for miRNA-21 were established at 4.2 aM (PEC) and 5.3 aM (FL). Experimental results demonstrated the substantial potential of the “entropy–enthalpy coupling with dual-mode decoupling” framework for rapid and reliable quantitative detection of biological targets, while also providing new design paradigms for sensors in fields such as food safety and agriculture.
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高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 12.5
Peng Bai,Wenli Bao,Xuanyu Yue,Haiyan Wang,Xinwen Guo,Karen Wilson,Donghai Mei,Zhenglong Li
H 2 activates at Co sites; isolated Rh rather than Rh particles enables C2-O bond hydrogenolysis. • Reverse hydrogen spillover promoting C2-O hydrogenolysis with a 60.3% 1,5-pentanediol yield. • Reverse hydrogen spillover prevents precious metal poisoning by active H species during hydrogenation. The selective activation and cleavage of C O bonds through directional hydrogenation play a critical role in numerous industrial catalytic applications. Traditional noble metal catalysts often face challenges due to their strong propensity for active H₂ dissociation, leading to active site occupation by hydrogen atoms and subsequently hindering the efficiency of selective C O bond cleavage. Furthermore, achieving selective cleavage of high-bond-energy C O bonds while preserving lower-energy ones remains a significant challenge requiring further exploration. Herein, we present the design of a Rh single-atom catalyst anchored on Co for the selective cleavage of the high-bond-energy C2 O bond in furfural, serving as a model reaction. Through combined experimental investigations and density functional theory calculations, we demonstrate that Rh 1 Co single-atom alloys effectively lower the activation barrier for furfural hydrogenation, converting the C O bond cleavage process from an endothermic reaction to an exothermic one. This catalytic behavior is notably absent in conventional Rh catalysts. The strong interactions within the Rh 1 Co alloy significantly promotes the hydrogenolysis of the C2 O bond and achieving a 1,5-pentanediol yield of 60.3%, surpassing most previously reported catalysts. Most importantly, Co sites facilitate H 2 activation, while isolated Rh sites serve as the centers for C O bond cleavage, introducing a reverse hydrogen spillover mechanism distinct from traditional hydrogenation processes. This reverse hydrogen spillover mechanism addresses the issue of hydrogen-induced deactivation of precious metal active sites, offering a promising pathway for broader application across diverse catalytic hydrogenation systems. Download: Download high-res image (138KB) Download: Download full-size image
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危险品化学品经营许可证（带存储）