INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2025
·
IF 3.9
Yufei Ling,Yuxuan Wang,Yuanpeng Cai,Shizhen Zhao,Hui Liu
Considering the dynamic changes in the wound microenvironment and the risk of bacterial infection during healing, the synergistic design of antibacterial hydrogel dressings has become an effective treatment strategy. A multifunctional hydrogel Cur-F127/CMCs/PDA was prepared through the cross-linking of carboxymethyl chitosan (CMCs) with genipin (GP), followed by the loading of curcumin-F127 (Cur-F127) micelles and polydopamine (PDA) nanoparticles. Successful synthesis of the hydrogel was confirmed by Fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), and X-ray photoelectron spectroscopy (XPS). Results showed that the introduction of PDA endowed the hydrogel with excellent photothermal capability, achieving a temperature increase to 54.3 °C within 10 min under near-infrared (NIR) irradiation. Meanwhile, rapid Cur release was observed under NIR irradiation, exhibiting distinct “on/off” switching characteristics. The drug-controlled releasing behavior of the hydrogel was evaluated in physiological environments, and relatively high cumulative Cur release was obtained under simulated wound microenvironmental conditions (acid region and high temperature) due to the shrinking of polymer chains and micelle structure. The synergistic effect of Cur release and PDA photothermal therapy enabled the hydrogel to exhibit excellent antibacterial effects, and the survival rates of E. coli and S. aureus were reduced to 6.25% and 1.31%, respectively. Furthermore, in vitro biological studies demonstrated that the hydrogel possessed a good antioxidant property, hemostatic performance, blood compatibility, cell compatibility, and cell migration ability. In summary, the multifunctional wound dressing Cur-F127/CMCs/PDA provided a synergistic antibacterial strategy combining natural active compound release with photothermal effects, which accelerated the wound-healing process and holds significant clinical translational potential.
研究领域:
生物材料
·
组织工程
·
药剂学
·
创伤修复
·
纳米医学
·
感染控制
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产品关联
DOI
高影响因子
FASEB JOURNAL
·
2025
·Vol. 39
·期 17
·e70979
·
IF 4.2
Jinhong Wang,Xiaowei Xu,Yangfeng Wen,Benliang Wei,Junke Chen,Sihang Cai,Mengmeng Wang,Zhinan Wu,Yanhong Liu,Haifeng Zhang,Yiyi Zhong,Yuanqiang Zou
Probiotics and postbiotics are recognized for their potential to benefit skin health, and complete genome analysis serves as a pivotal tool to accelerate the exploration of probiotic functionalities. To investigate this relationship, this study aimed to elucidate the skin-promoting potential of Lactiplantibacillus plantarum BGI-N6 (BGI-N6) through integrated genomic analysis and phenotypic analysis. Results indicated that the high-precision complete genome of BGI-N6 comprises 3 257 641 bases with a 45% GC content and 3030 CDSs, involving multiple genes related to carbon source fermentation, gastrointestinal tolerance, and environmental adaptability. Notably, BGI-N6 possessed several bacteriostatic, antioxidant, and enzyme activity inhibition-related genes, which could encode the biosynthetic pathways of bacteriocins, glutathione/thioredoxin antioxidant systems, NADH peroxidase, catalase, and various organic acids. Supporting these genomic insights, in vitro experiments comparative evaluation revealed that BGI-N6 exhibited superior capabilities relative to Lactiplantibacillus plantarum 299v (299v) in antioxidant activity, inhibition of cutaneous pathogens growth, and suppression of skin-damaging enzyme (e.g., collagenase and elastase) activity. These effects were correlated with the production of lactic acid, 6-hydroxyhexanoate, coumarins, and other bioactive compounds by BGI-N6. The evidence from integrated genomic analysis and in vitro experiments established a critical theoretical foundation for the development of BGI-N6 as a candidate for probiotic and postbiotic applications targeting skin health. Graphical Integrated genomic analysis and phenotypic profiling accelerate functional characterization of L. plantarum BGI-N6, elucidating its skin-promoting potential through topical application or oral administration.
研究领域:
微生物学
·
皮肤科学
·
分子生物学
·
功能基因组学
·
转化医学
·
生物工程
·
营养与代谢
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
·
2025
·
IF 4.9
Qingfeng Luo,Yuyi Deng,Qiyuan Yang,Nanxin Zhao,Can Wang,Xingsheng Li
Osteopontin (OPN), highly expressed in foam cells, serves as a hallmark of atherosclerotic plaques and a potential target for site-specific drug delivery. In this study, we developed OPN-targeted liposomes (OPN LIP) co-loaded with curcumin and perfluoro-n-pentane (PFP) to enhance therapeutic efficacy against atherosclerosis. The liposomes exhibited uniform particle size, colloidal stability, favorable biocompatibility, and minimal cytotoxicity. In vitro experiments demonstrated efficient and time-dependent cellular uptake by ox-LDL–stimulated RAW264.7 foam cells. Upon exposure to low-intensity focused ultrasound (LIFU), the nanocarriers underwent acoustic cavitation-induced rupture, leading to rapid curcumin release and significant induction of apoptosis. OPN LIP treatment notably reduced IL-1α and TNF-α levels and aggravated apoptosis in foam cells. Transcriptomic analysis revealed modulation of inflammatory and apoptotic pathways, including TLR, NF-κB, and Mapk3 signaling. These findings highlight the potential of OPN LIP as an ultrasound-responsive, targeted nanoplatform capable of suppressing inflammation and foam cell viability, providing a promising approach for the treatment of atherosclerosis through combined physical and pharmacological strategies.
研究领域:
纳米医学
·
心血管疾病
·
药物递送
·
超声治疗
·
炎症生物学
·
细胞凋亡研究
✓ 已验证
产品关联
DOI
高影响因子
REACTIVE & FUNCTIONAL POLYMERS
·
2025
·
IF 5.1
Meixue Cao,Fei Zhou,Shuan Cheng,Xinyue Wang,Ziyu Yuan,Xiuwen Huang,Zuju Shu
To explore the effects of preparation methods on the release kinetics of curcumin (Cur)-loaded sustained-release composites, three fabrication techniques—solvent casting, uniaxial electrospinning, and coaxial electrospinning—were employed to develop Cur-loaded composites using Cur as the model drug, soluble starch (St) and polyvinyl alcohol (PVA) as the matrices. The microstructure and chemical composition of three composite groups were characterized, and their functional properties were evaluated, including swelling capacity, degradation behavior, Cur loading capacity (LC), Cur encapsulation efficiency (EE), and 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity. Additionally, the in vitro Cur release behavior of the composites was analyzed, and release kinetics were fitted using mathematical models. Results indicated that the preparation methods had no significant impact on the chemical composition of the Cur-loaded composites. However, the nanofibers fabricated by the coaxial electrospinning technique exhibited a unique core-shell microstructure, which distinguished them from the cast films and uniaxial electrospun membranes. Compared with the other two groups, the coaxial membrane showed higher Cur LC and EE, a higher swelling ratio, a lower degradation rate, and a stronger DPPH radical scavenging ability. Kinetic fitting revealed that the Cur release profiles of all three composite groups conformed to the First-order model, but their release performances differed significantly. The coaxial electrospun membrane outperformed the cast film and uniaxial electrospun membrane, with a Cur cumulative release rate of 51.73 % at 96 h and retained significant potential for sustained release. In conclusion, the preparation method directly regulated the antioxidant activity and sustained-release behavior of Cur in the composites. This study provides theoretical basis and technical reference for the design and development of novel drug-loaded sustained-release composite materials.
研究领域:
药物递送
·
生物材料
·
药剂学
·
高分子科学
·
抗氧化研究
✓ 已验证
产品关联
DOI
高影响因子
Gels
·
2025
·Vol. 11
·期 9
·732
·
IF 5.3
Peng Ding,Yanfang Sun,Guohua Jiang,Lei Nie
Immunoregulation is an emerging treatment strategy to promote wound healing by modulating the local immune system at the wound site. In this study, an extracellular matrix biomimetic and polysaccharide-based hydrogel was engineered to regulate the wound immune environment through Michael-type addition between maleimidyl pullulan and chitosan modified with hydroxyproline. The proposed hydrogel exhibited favorable injectable and self-healing properties, which facilitated the full coverage of irregularly shaped wounds. A natural polyphenol, epigallocatechin-3-gallate (EGCG), was incorporated into hydrogels, which thereby exhibited excellent biocompatibility, good reactive oxygen species (ROS) scavenging ability, anti-inflammatory activity, and antibacterial properties against S. aureus and E. coli . Furthermore, evaluations of a full-thickness skin defect mice model showed that the hydrogel with EGCG effectively alleviated the inflammatory response by reducing pro-inflammatory cellular infiltration and down-regulating the inflammatory cytokine TNF-α, while up-regulating anti-inflammatory cytokine IL-10. Notably, a faster wound healing rate was also achieved by the better promotion effect of the hydrogel on increasing the formation of re-epithelialization, granulation tissue generation, collagen deposition, and angiogenesis. Therefore, our immunoregulatory strategy showed great potential in the design of biomaterials for wound management.
研究领域:
生物材料
·
伤口愈合
·
免疫调节
·
高分子化学
·
组织工程
·
纳米医学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2025
·
IF 5.4
Yuxi Xiao,Zhi Li,Yanping Yu,Yuchen Xie,Li Xu,Heng Zheng
Multidrug resistance in bacteria, especially in Gram-negative bacteria, has been an emerging issue for public health. The antibacterial agent with high antibacterial activity but avoiding drug resistance is highly desired. Carbon dots (CDs), as a new type of nano-antimicrobial agent, has attracted heightened attention due to their tunable physicochemical properties and high biocompatibility. In this study, we developed one kind of CDs, i.e., Kana-CDs, which was prepared based on the ternary carbon sources, including kanamycin, phenylboronic acid and citric acid. Kanamycin provided the antibacterial activity, while citric acid assisted the carbonization of kanamycin and stabilized the CDs, and phenylboronic acid endowed Kana-CDs with antibacterial selectivity. Kana-CDs behaved a good inhibitory effect on Gram-negative bacteria but not on Gram-positive ones. As well, Kana-CDs could inhibit/eradicate the biofilm formation, and eliminate excessive reactive oxygen species (ROS). Kana-CDs succeeded in treating E. coli -infected wound animal without significant toxicity on major organs. Compared to kanamycin, Kana-CDs was more stable with selective antibacterial activity towards Gram-negative bacteria, along with extra ROS scavenging activity and better wound healing efficiency. This study provided a new strategy for nano-derivatization of antibiotics for reducing drug resistance and improving antibacterial efficacy.
研究领域:
纳米医学
·
微生物学
·
药剂学
·
感染性疾病
·
生物材料
·
自由基生物学
·
伤口愈合
✓ 已验证
产品关联
DOI
高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
·
2025
·
IF 5.6
Reyihanguli Alimu,Lanlan Dong,Patiguli Aihemaiti,Houfeng Jiang,Wurikaixi Aiyiti,Cijun Shuai
High-performance hydrogel biomaterials hold considerable promise for advanced wound care. However, the suboptimal mechanical properties of conventional hydrogel materials limit their practical application. In this study, Hyaluronic acid sodium salt (HA), xanthan gum (XG), and N-acryloyl-glycinamide (NAGA) hydrogels with porous structures were successfully fabricated using in-situ extrusion 3D printing technology, and a functionalization strategy involving tea polyphenol (TP) immersion was proposed to enhance material properties through additional hydrogen bonding. Systematic optimization of TP concentration and immersion time led to significant improvements in the resulting hydrogel: tensile strain increased from 95 % to 266 %, tensile stress improved 6.8-fold, and compressive stress increased 10-fold, with an elastic modulus of 0.68 MPa and toughness of 1.2 MJ/m³ . Furthermore, TP-treated hydrogels exhibited excellent biocompatibility and strong antioxidant activity and antibacterial activity. This study provides a simple yet effective secondary functionalization approach for enhancing the performance of 3D-printed hydrogels, offering a promising approach for multifunctional hydrogel biomaterials with integrated mechanical strength and biocompatibility. These findings open new avenues for advanced wound care systems and personalized medicine applications.
研究领域:
生物材料
·
组织工程
·
3D打印
·
高分子科学
·
伤口愈合
·
纳米技术
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2025
·
IF 6.2
Qianwei Liang,Qing Tian,Yifei Tan,Tianzhen Jiang,Zhen Li,Jianguo Feng
Drought stress causes a significant accumulation of reactive oxygen species (ROS) in crops, inhibiting their growth and development and threatening food security. This study constructs cerium-based metal–organic frameworks (CeMs) encapsulated with polydopamine (PDA), effectively eliminating ROS (O2•–, H2O2, ·OH, DPPH·, and ABTS·+). Experiments showed that CeMs@PDA exhibits superior wettability and outstanding translocation capabilities in wheat and rice. Under drought conditions, CeMs@PDA (12.5 mg L–1, 100 mg L–1) significantly increased the vigor index (71.84%, 224.83%) of seeds (wheat, rice). The application of 25 and 100 mg L–1 CeMs@PDA significantly alleviated drought-induced growth inhibition in wheat and rice seedlings, respectively. The inhibition of stem and root growth decreased from 28.07% and 38.15% to 3.72% and 4.43% in wheat seedlings, and the inhibition declined from 25.33% and 30.83% to 2.89% and 5.30% in rice seedlings, respectively. In addition, CeMs@PDA significantly increased the level of antioxidant enzyme activities in wheat and rice and showed better biosafety. This study opens valuable pathways for sustainable agriculture under water-limited conditions.
研究领域:
植物生理学
·
纳米农业
·
环境胁迫生物学
·
作物科学
·
分子生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INDUSTRIAL CROPS AND PRODUCTS
·
2025
·
IF 6.2
Jun Li,Xianling Yang,Pingcong Lv,Yuwei Zheng,Hongli Ou,Wanxia Wu,Xianggui Chen,Xiaoqi Yu
The high-value utilization of rice straw can not only unlock its potential economic and environmental benefits but also reduce greenhouse gas emissions, significantly enhancing resource efficiency and promoting sustainable agricultural development. In this study, rice straw was used as a biomass-derived carbon source to synthesize biocompatible rice straw-derived carbon dots (H 2 O-CDs) via a green hydrothermal method. The fluorescent sensor constructed based on H 2 O-CDs offered the advantages of wide range (8–100 μM), high sensitivity (2.27 μM), and wide pH stability (2.0–8.0), making it suitable for detecting ferric ions within cells. Additionally, H 2 O-CDs were innovatively studied the antioxidant properties and had been proven excellent antioxidant enhancement potential by 2 times, suggesting their future practical application as a cigarette filter additive for the efficient removal over 40 % of harmful oxidizing free radicals in cigarette smoke. With their low cost and outstanding biocompatibility, H 2 O-CDs not only enable the high-value utilization of rice straw but also provide new insights and technical support for sustainable agricultural development.
研究领域:
环境科学
·
材料科学
·
分析化学
·
农业科学
·
纳米技术
✓ 已验证
产品关联
DOI
高影响因子
FOOD CONTROL
·
2025
·
IF 6.3
Xianrui Chen,Lin Wang,Lihong Lin,Nitong Bu,Di Zhang,Zhenzhen Wu,Wei Liu,Jie Pang
The development of advanced antimicrobial packaging is crucial for ensuring food safety. This paper reports a novel photodynamic antibacterial film (PVA-CM@TFQ) that effectively combats microbial contamination, delays food spoilage and minimizes the risk of foodborne diseases transmission. Quercetin (Que) was encapsulated within a tannic acid-ferric ion (TA–Fe 3+ ) coordination network and embedded into a biodegradable polymer matrix composed of polyvinyl alcohol (PVA) and carboxymethyl chitosan (CM). The TA-Fe 3+ network significantly improved the stability of Que, while the resulting PVA-CM@TFQ demonstrated excellent mechanical properties, barrier performance, and biocompatibility. Upon light irradiation, the film produced reactive oxygen species (ROS), exhibiting potent photodynamic antibacterial activity, with inhibition rates of 99.83%, 99.42%, 100%, and 100% against Escherichia . coli, Staphylococcus . aureus , Candida. albicans , and Saccharomyces cerevisiae , respectively. When applied to raspberries, hawthorn, goldenberries, and lime, the film effectively prolonged shelf life by suppressing microbial proliferation, minimizing weight loss, and maintaining fruit firmness. These findings highlight a sustainable, light-responsive strategy for fruit preservation with significant potential in enhancing food safety.
研究领域:
食品科学与技术
·
高分子材料
·
光动力疗法
·
活性包装
·
采后生物学
·
抗菌技术
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2025
·
IF 8.2
Yafei Wang,Xiaowei Huang,Jiayi Jiang,Qi Meng,Yiran Li,Wenwen Zhao,Shaojuan Chen,Shaohua Wu
The healing of diabetic wounds is a complex process involving multiple physiological mechanisms, which necessitates an appropriate microenvironment to effectively facilitate the healing process. Recently, advanced wound dressings constructed by functionalizing cotton nonwovens with appropriate structures and biological properties have aroused intensive interest in chronic wound treatment and care. The present study fabricated composite dressings by coating cotton nonwoven webs with UV-cross-linked methacrylated gelatin (Megel) hydrogels containing Salvia miltiorrhiza–Radix Puerariae/polyhydroxyalkanoate-loaded short nanofibers (SP: 632 ± 191 nm diameter, 2.9 ± 2.7 μm length). The composite dressings exhibited a uniform microporous structure (pore size: 24.2 ± 9.2 μm), superior water retention (85.8 ± 0.3% after 2 h), and markedly improved mechanical properties (Young’s modulus: 6.8 ± 1.3 MPa; elongation at break: 153.8 ± 10.4%). Additionally, they demonstrated excellent performance in swelling, biodegradation, and free radical scavenging. All composite dressings demonstrated excellent biosafety and rapid hemostasis in liver bleeding models. Critically, the Cotton&Megel + SP-3% dressing accelerated diabetic mouse wound closure to ∼98% within 18 days, which also reduced early inflammation and markedly improved regenerated tissue quality by promoting collagen deposition, angiogenesis, and hair follicle formation. These results indicate that our composite dressings made from SP, Megel hydrogel, and cotton nonwoven hold significant potential as advanced dressing candidates for diabetic wound treatment.
研究领域:
生物材料学
·
伤口修复
·
糖尿病并发症
·
药物递送系统
·
组织工程
·
纳米医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Yilan Xie,Xiangdong Geng,Xuejing Zheng,Jie Liu,Keyong Tang
Carbon quantum dots (CQDs) were synthesized via a one-step hydrothermal route using soluble soybean polysaccharide (SSPS) as a green and renewable precursor. The resulting SSPS-derived CQDs (SCQDs) were uniform nanodots with average diameters ranging from 2.66 ± 0.69 nm to 2.81 ± 0.57 nm, exhibiting strong blue fluorescence and excellent water dispersibility. Structural characterization by TEM, XRD, FTIR, and XPS confirmed the amorphous carbon structure and the presence of abundant hydroxyl, carboxyl, and carbonyl groups on SCQDs, which contribute to their distinctive optical and functional properties. The SCQDs exhibited excitation-dependent photoluminescence with a quantum yield of 12.0 %. They also demonstrated potent radical scavenging activities of 91.3 % for ABTS and 79.4 % for DPPH, along with notable antibacterial properties. Furthermore, the SCQDs showed good biocompatibility within the concentration range of 50–500 μg/mL, maintaining cell viability above 70 % after 7 days of exposure. The SCQDs were successfully utilized for cellular imaging, Fe 3+ and Pb 2+ ion sensing, and preservation of strawberries and bananas. These results demonstrate the suitability of SSPS for serving as an effective precursor in the sustainable synthesis of multifunctional CQDs with significant potential for applications in biomedical imaging, environmental sensing, and active food packaging.
研究领域:
纳米材料学
·
生物医学工程
·
分析化学
·
食品科学
·
环境科学
·
分子影像学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）