Journal of Water Process Engineering
·
2020
·
IF 3.465
Wanhe Qi,Songming Zhu,Abubakar Shitu,Zhangying Ye,Dezhao Liu
Under Minamata Convention restrictions, mercury-free UV source was in need for ultraviolet disinfection in recirculating aquaculture systems (RAS). Ultraviolet emitting diodes (UV-LEDs) seemed a potential mercury-free UV source and had gained increasing attention in water disinfection. In this study, a mercury-free UVA-LED and low concentration peroxymonosulfate (PMS) combination was proposed for E. coli (CGMCC 1.3373) inactivation and real RAS wastewater disinfection. Results showed that UVA-LED and low concentration PMS combination enhanced E. coli inactivation over UVA-LED alone. A synergistic effect on E. coli inactivation with synergy factor of 58.7 % was found when combining UVA-LED irradiation with 1 mg/L PMS. Kinetic rate constant increased by up to 139 % by UVA-LED and 1 mg/L PMS combination, which implied the required UV fluence to 2-log E. coli inactivation was saved up to 42 %. Also, UVA-LED and 1 mg/L PMS combination showed disinfection potential for real RAS wastewater treatment. Mechanism study revealed that the Cl − , · OH and SO 4 ·- played important roles and · OH was dominant radical in saline solution by UVA-LED/PMS process compared to that in phosphate buffered solution(PBS). The E. coli inactivation was caused by UVA-LED irradiation and reactive species generated in UVA-LED/PMS system. Our study provided a potential strategy to introduce the mercury-free UV-LED into RAS and a better understanding of UVA-LED/PMS disinfection process.
研究领域:
环境科学
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水处理
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水产养殖
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微生物学
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高影响因子
Chemical Engineering Journal Advances
·
2021
·
IF 0
Chao Liu,Cao Fang,Changsheng Shao,Xinxin Zheng,Hangbo Xu,Qing Huang
Currently, there is a huge demand for medical biomaterials aimed to improve antibacterial effect and promote wound healing. In this work, a facile and single-step approach of synthesizing silver nanoparticles (AgNPs) and reduced graphene oxide (rGO) composite material (namely, AgNPs@rGO) using high-voltage direct-current (DC) non-thermal plasma was proposed. Electron-beam (e-beam) from the DC-plasma discharge zone was implanted into the solution of AgNO 3 and graphene oxide (GO), leading to the reduction of both GO and silver ions. As a result, AgNPs were formed and distributed homogeneously on the reduced graphene sheets. This composite material exhibits excellent antibacterial performance, being able to kill both Gram-positive bacteria Staphylococcus aureus ( S. aureus ) and Gram-negative bacteria Escherichia coli ( E. coli ) effectively. Furthermore, this composite material was utilized to prepare wound-healing band-aids. The in vitro assay on mice confirmed the satisfactory curing effect. The cytotoxicity for bio-compatibility and the mechanism for sterilization were also examined and clarified. As such, this work puts forward a facile and new route of preparing antibacterial biomaterial and demonstrates its promising prospect in wound-healing application.
研究领域:
材料科学
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生物医学工程
·
纳米医学
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DOI
INDUSTRIAL CROPS AND PRODUCTS
·
2017
·
IF 3.181
Weibin Ma,Luling Zhao,Yanli Xie
The efficacy of eight kinds of green leaf volatiles (GLVs) was investigated as potential natural antifungal agents against Aspergillus flavus in this study. Based on the in vitro assay, volatile phase inhibitory effects of the selected eight GLVs were consistently more effective on A. flavus growth than contact phase inhibitory effects, and ( E )-2-hexenal exhibited the highest efficacy as it could totally inhibited growth of A. flavus at concentrations of 0.032 μL/mL air and 1.6 μL/mL under vapor and contact conditions, respectively. Furthermore, results obtained from the in vivo assay demonstrated that ( E )-2-hexenal possessed potent fumigant activity in reducing A. flavus infection in stored peanut seeds, as it could completely inhibit colonization of A. flavus at 0.32 μL/mL air. Both in vitro and in vivo assay results provided convincing evidence that ( E )-2-hexenal, one of the GLVs that is naturally present in many plants, can potentially be used as a highly efficient and eco-friendly antifungal fumigant to protect peanut seeds from contamination of A. flavus during storage.
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Nano Select
·
2021
·Vol. 3
·期 5
·956-964
·
IF 0
Mengjia Li,Lihua Zhu,Xian Zhang,Chen Wang,Deyu Gao,Jiaheng Han,Chunlei Chen,Hongwei Song,Sai Xu,Cong Chen
Owing to the significant roles in balancing carrier transport, bandgap alignment, and perovskite crystallization, realizing high-quality electron transport layers (ETLs) and their effective electronic contact with the perovskite photoactive layer is crucial for future commercialization of perovskite solar cells (PSCs). Here, a high-quality SnO 2 ETL is firstly deposited at room temperature via the low-cost electron beam evaporation (E-beam) technology to help achieve an impressive PCE of 18.88% for rigid PSCs and a PCE of 15.73% for flexible devices. Then we introduced a novel passivating ligand molecule, 11 Maleimidoundecanoic acids (11MA), to help induce functional defects passivation at the interface of SnO 2 /Perovskite to coordinate with Pb 2+ in perovskite and Sn 4+ in SnO 2 via the functional groups (-C = O, -COOH). As a result, 11MA could help achieve the best PCE of 20.94% with negligible hysteresis for rigid devices. Also, doping 11MA in the perovskite photoactive layer further enhanced the PCE to 22.08% with much improved 2000 hours ambient stabilities. Finally, we fabricated different large-area rigid devices (10, 40, 100, and 600 mm 2 ) toward speeding up the commercialization of PSCs by industrial E-beam technology and rational defects passivation strategies.
研究领域:
材料科学
·
能源技术
·
纳米技术
·
光电工程
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CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Xuan Huang,Ming Yi,Kewen Tang
To address resources shortage and environmental degradation, noble metal recovery from e-waste is in desperate need. Herein, to achieve selective extraction of gold (Au) and palladium (Pd) from practical e-waste, a series of tridentate thioether extractants are designed with ester functional groups at both ends of the thioether. By varying the chain length of the ester alkyl, the relationship between extractant structure and performance is further explored. The results indicate that the as-introduced tridentate structure facilitate the Au(III) and Pd(II) extraction, demonstrating a complex mechanism involving both coordination substitution and ion association. Notably, the extractant with the shortest carbon chain length and smallest molecular weight delivers outstanding extraction capacities of 920.2 mg/g for Au(III) and 280.7 mg/g for Pd(II). More importantly, it exhibits superior selectivity (∼100 %) for Au(III) and Pd(II) in complex metal solutions. This work guides the design of thioether-based extractants for sustainable recovery of noble metal from practical e-waste.
研究领域:
化学工程
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环境科学
·
材料科学
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Food Chemistry-X
·
2026
·
IF 9.2
Guili Huang,Yu Shi,Xinyao Quan,Qianshuo Shao,Su Yan,Siyao Sui,Jiajia Ma,Jiayu Qian,Weiming Chai,Yuning Wang
Volatile Organic Compounds (VOCs) are critical determinants of loquat flavor quality and cultivar differentiation, but comprehensive characterization and rapid detection remain challenging. This study aimed to establish a robust approach for discriminating three loquat cultivars and evaluating their flavor quality by integrating electronic nose (E-nose) technology and Comprehensive Two-Dimensional Gas Chromatography–Time-of-Flight Mass Spectrometry (GC × GC-TOF-MS). GC × GC-TOF-MS was used for VOC profiling, while E-nose was applied for rapid fragrance characterization, with orthogonal partial least squares-discriminant analysis (OPLS-DA) and correlation analysis performed to identify discriminatory compounds and sensor-VOC relationships. GC × GC-TOF-MS identified over 2000 volatile compounds across three loquat cultivars. OPLS-DA further screened 22 discriminatory VOCs with variable importance in projection (VIP) values >1, which contributed to aroma hierarchy shifts among cultivars. E-nose sensors W1W and W1S showed high sensitivity to floral-scent-related VOCs, serving as key factors for distinguishing fragrance quality. Notably, E-nose detection results exhibited good consistency with GC × GC-TOF-MS data, and W1W/W1S sensors were significantly positively correlated with key VOCs. These findings demonstrate that the integration of E-nose and GC × GC-TOF-MS offers complementary advantages for comprehensive VOC characterization and cultivar discrimination. The established approach provides a scientific basis for optimizing loquat quality standards by incorporating VOC-driven biochemical authenticity and a potential efficient method for rapid, non-destructive assessment of postharvest flavor quality in loquat cultivars. These results facilitate quality control and cultivar authentication in the fruit industry.
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF THE AMERICAN OIL CHEMISTS SOCIETY
·
2026
·
IF 2.4
Ning Zhang,Huihui Zhang,Fengqin Tu,Xinghe Zhang,Jiaojiao Yin,Pan Gao
Beef tallow is valued in the food industry for its unique flavor but remains susceptible to oxidative deterioration during storage and processing, leading to rancidity and quality loss. This study evaluated the effects of four antioxidants (propyl gallate, PG; tert-butylhydroquinone, TBHQ; butylated hydroxytoluene, BHT; and vitamin E, VE) within regulatory limits on beef tallow during 15 days of oven-accelerated oxidation. A multi-index assessment (oxidation indices, antioxidant capacity, tocopherol retention) combined with principal component analysis (PCA) was used. The antioxidants did not alter the fatty acid composition. PCA ranked TBHQ first in overall performance, followed closely by PG. At 0.1 g/kg, PG limited the acid value to 1.49 mg/g and the p-anisidine value to 1.97 after 15 days, although TBHQ at 0.2 g/kg showed a slightly lower acid value (1.28 mg/g). Notably, PG retained 16.06 mg/kg of endogenous tocopherols after 3 days of oxidation, whereas tocopherols were undetectable in TBHQ-treated groups. The FRAP value of the PG group reached 511.95 μmol TE/100 g. Although TBHQ showed strong efficacy, its use has attracted increasing regulatory scrutiny and consumer concern in some regions. PG offers a favorable safety profile while providing comparable protection in several indices, delaying early tocopherol depletion under accelerated oxidation and exhibiting superior FRAP values. Therefore, PG at 0.1 g/kg can serve as a favorable alternative to TBHQ in beef tallow systems.
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产品关联
DOI
高影响因子
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2026
·
IF 6.7
Feng Hao,Chenzhe Li,Yan Luo,Tingcai Dong,Chengyao Wang,Ziruo He,Jiting Li,Huaizhang Yang,Kun Wei,Yabin Yang,Le Cai
Rising environmental and health risks of synthetic pesticides have fueled the search for eco-friendly alternatives. Taiwania flousiana Gaussen, a rare evergreen, is a valuable source of bioactive compounds, with the lignan Taiwanin E (from its discarded bark in Yunnan, China) showing potential insecticidal activity. Herein, we chemically modified Taiwanin E to improve its solubility and insecticidal activity, and the resultant derivative E13 exhibited potent larvicidal activity against Armigeres subalbatus larvae. Enzyme assays, molecular docking, and dynamics simulations validated this activity, while DFT calculations clarified the structural basis for E13’s superior performance. Bee toxicity tests further confirmed its environmental safety. This study identifies Taiwanin E derivatives as promising sustainable alternatives to conventional insecticides, advancing eco-friendly pest control and enabling resource utilization of the endangered T. flousiana.
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PubMed
高影响因子
FOOD AND CHEMICAL TOXICOLOGY
·
2026
·
IF 3.2
Yang Yan,Yongfei Gu
Gastric cancer (GC) is a primary epithelial malignancy originating in the stomach. This research explored the influence and mechanism of Orientin on cellular senescence in GC. Orientin was predicted to regulate multiple cell cycle-related pathways, including cyclin-dependent protein kinase activity. Orientin docked with cyclin dependent kinase 2 (CDK2), cyclin A2 (CCNA2), cyclin E1 (CCNE1), and cyclin E2 (CCNE2) with binding energies of -9.1, -7.5, -7.2, and -8.3 kcal/mol, respectively. The IC 50 values of Orientin for AGS and HGC-27 cells were 24.33 μM and 39.28 μM, respectively. Orientin dose-dependently inhibited GC cell proliferation, promoted G0/G1 phase arrest, as well as downregulated CDK2, CCNA2, CCNE1, and CCNE2 expression. It enhanced senescence-associated β-galactosidase staining intensity, upregulated p16 and p21, and downregulated phosphorylated retinoblastoma (p-Rb). In vivo , Orientin also suppressed tumor progression, promoted p16 and p21 expression, and inhibited CCNE/CCNA-CDK2 signaling. Orientin exerts anti-cancer effects in GC through triggering cellular senescence and cell cycle arrest, likely via activating p16/p21-Rb signaling axis and inhibiting the CCNE/CCNA-CDK2 pathway. Download: Download high-res image (282KB) Download: Download full-size image
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BIORESOURCE TECHNOLOGY
·
2026
·
IF 8.2
Zihan Zhang,Yu Zhang,Qingqing Liu,Wanqing Song,Yi Hu,Binbin Nian
A novel triple evolution strategy overcame the lipase activity-stability trade-off. • CM5 showed 2.3-fold higher activity and 4.8-fold solvent tolerance than WT. • MD simulations link CM5 stability to rigidity and stable hydration shell. • The VES synthesis strategy achieved the highest yield and reusability to date. • A complete chain from computational design to practical production was validated. Biocatalysts exhibit broad application prospects in industrial production. However, the inherent instability of natural enzymes in non-aqueous media severely limits their practical utilization. Using Candida rugosa lipase as a model, a synergistic evolution strategy integrating ancestral sequence reconstruction, free energy optimization and surface hydration shell modulation was developed in this study. The optimal mutant CM5 exhibited simultaneously enhanced stability and activity, showing a 4.78-fold increase in tolerance to 65% (v/v) dimethyl sulfoxide, a 1.67-fold extension in half-life at 50 ℃ and a 2.30-fold increase in activity compared to the wild type. Molecular dynamics simulations indicated that the enhanced stability of CM5 originates from improved structural rigidity and the stabilized hydration shell. Meanwhile, its increased activity is attributed to a reduced energy barrier for the lid conformational transition and an optimal enzyme substrate affinity that significantly boosts substrate turnover efficiency. Moreover, a volumetric activity of 142.71 U/mL in a 5 L bioreactor was obtained via optimization of the chassis cells, and the resulting culture was then used for the immobilization. The lipase CM5 immobilized on amino octadecyl bifunctional macroporous resin (CM5@AOMR) achieved a vitamin E succinate yield of > 99.9% and maintained an outstanding yield of 98.2% even after ten consecutive batch reactions. Overall, this study developed a comprehensive workflow from computational design and efficient fermentation to immobilization and practical applications of lipase, providing a promising new approach for developing next generation biocatalysts suited for extreme industrial environments. Download: Download high-res image (234KB) Download: Download full-size image
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SEPARATION AND PURIFICATION TECHNOLOGY
·
2026
·
IF 9.1
Qian Du,Qingshan Li,Hao Li,Jianming Pan
With the fast pace of technological advancement and the accelerating replacement cycle of electronic devices, the process of extracting gold from electronic waste ( E -waste) has emerged as a pivotal challenge for resource recycling and environmental sustainability. In this work, a series of thiourea-functionalized polyhedral oligomeric silsesquioxane (POSS)-based polymers (POSS@ATU-X) abundant in sulfur (S) and nitrogen (N) active sites was synthesized through a facile one-step functionalization strategy, and its performance and underlying mechanism for Au(III) adsorption were systematically investigated. POSS@ATU-4 delivered a rapid adsorption kinetic profile, with 90% of its maximum adsorption capacity attained within 3 h and equilibrium reached at 6 h. Isothermal adsorption tests revealed an ultra-high maximum adsorption capacity of 2643.64 mg g −1 at 318 K. Notably, POSS@ATU-4 exhibited outstanding selectivity for Au(III) in both multi-metal coexisting systems and actual printed circuit board (PCB) leachate, with its removal rate far exceeding those of other coexisting metal ions. After six consecutive adsorption-desorption cycles, the material retained 99% of its initial adsorption efficiency, demonstrating exceptional structural stability and reusability. Mechanistic studies elucidated that Au(III) removal was governed by the synergistic effects of electrostatic attraction and surface coordination interactions. This work provides a feasible and effective strategy for achieving highly selective and stable gold recovery from acidic E -waste streams, which holds great promise for practical industrial applications.
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NUCLEIC ACIDS RESEARCH
·
2026
·Vol. 54
·期 5
·
IF 15
Liu Wuzhen,Hu Kefan,Nie Shiqi,Feng Zhang,Li Qiongfang,Zhang Hailei,Liang Shumin,Peng Jialin,Zhang Shoudong,Cai Zongwei,Xia Yiji
Recently, nicotinamide adenine dinucleotide (NAD+) and other nucleotide analogs have been identified as non-canonical RNA caps in both prokaryotes and eukaryotes. In Escherichia coli, NAD capping has been shown to be influenced by environmental conditions in a gene-specific manner, yet its regulatory mechanisms remain poorly understood. We previously reported that most transcripts produced by sibD are NAD-capped during the stationary phase. In this study, we found that the 35-bp minimal promoter of sibD is sufficient for its NAD capping. When this minimal promoter was applied to express genes not typically producing NAD-RNAs, their transcripts could also be NAD-capped. These findings strongly support that NAD capping in E. coli occurs during transcription initiation mediated by the promoter and RNA polymerase. Additionally, the bacterial alarmone ppGpp and the small protein DksA, both transcription initiation regulators, synergistically enhance transcription of both NAD-capped and uncapped RNAs from sibD and its homologous genes, sibC and sibE, in vitro. In contrast, the ppGpp⁰ mutant, deficient in ppGpp synthesis, showed a significant reduction in NAD-RNA production from these genes. Our findings elucidate the cis-elements and trans-acting factors mediating NAD capping during transcription initiation, offering novel insight into this regulatory process.
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PubMed
高影响因子
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