Cell Death & Disease
·
2018
·Vol. 9
·期 9
·1-11
·
IF 5.638
Wang Yunchuan,Zheng Jianping,Han Yue,Zhang Yijie,Su Linlin,Hu Dahai,Fu Xiaobing
Junctional adhesion molecule-A (JAM-A) belongs to the immunoglobulin superfamily, it predominantly exists at the tight junctions of epithelial and endothelial cells. JAM-A is known to regulate leukocyte trans-endothelial migration, however, how it affects the proliferation and migration of keratinocytes, the two essential steps during wound healing, has less been explored. In this study, we showed that JAM-A was significantly expressed in normal skin epidermis. RNAi-mediated JAM-A knockdown remarkably promoted the proliferation and migration of keratinocytes. We also found that loss of JAM-A increased the protein levels of p -FAK, p -Erk1/2, and p -JNK; however, FAK inhibitor PF-562271 restrained the expression of p -FAK and p -Erk1/2 elevated by JAM-A RNAi, but not p -JNK, and also slowed down keratinocyte proliferation and migration. Finally, in a rat wound model we showed that absence of JAM-A significantly promoted the wound healing process, while the use of PF-562271 or Erk1/2 inhibitor PD98059 repressed those effects. These data collectively demonstrate that suppressing JAM-A expression could promote the proliferation and migration of keratinocytes and accelerate the healing process of rat skin wounds, potentially via FAK/Erk pathway, indicating that JAM-A might serve as a potential therapeutic target for the treatment of chronic refractory wounds.
研究领域:
分子生物学
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细胞生物学
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伤口愈合研究
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信号通路
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PubMed
高影响因子
Nature Communications
·
2025
·Vol. 16
·期 1
·1-14
·
IF 15.7
Wang Peng,Zhao Danyang,Zhang Peng,Hui Xiaobin,Zhang Zhiwei,Wang Rutao,Wang Chengxiang,Ge Xiaoli,Liu Xiaojing,Li Yuguang C.,Yin Longwei
The metallic phase MoS 2 (1T-MoS 2 ) supported metal-nanocatalyst is an appealing material system for accelerating the redox kinetics of non-aqueous Li | |O 2 batteries. However, the drawbacks associated with the surface orbital steric effect and the internal electron coupling results in a detrimental effect for the stability of 1T-MoS 2 , especially for the interface charge transfer. This makes it difficult to incorporate guest metal nanoparticles without compromising the 1 T phase support. To circumvent these issues, here we propose a p-block element (In-O) doping strategy to stabilize the 1 T phase MoS 2 by moderating the surface orbital steric effect and strengthening the internal chemical bonding, and thus for the epitaxial Ru nanocatalyst graft on the stabilized 1T-MoS 2 for Li | |O 2 batteries. The experimental and theoretical analyzes indicate that the In-O-MoS 2 @Ru enhances the O 2 dissociation and facilitates the adsorption of LiO 2 intermediates. This effect promotes the growth of weakly crystalline Li 2 O 2 films during oxygen reduction reaction, which can be more easily decomposed during the oxygen evolution reaction, thereby enhancing the bifunctional-catalytic kinetics. When employed at the positive electrode for non-aqueous Li | |O 2 batteries, In-O-MoS 2 @Ru shows an overpotential of 0.37 V and a cycling life of 284 cycles at 200 mA g −1 with a final discharge specific capacity of 1000 mAh g −1 at 25 °C.
研究领域:
材料科学
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电化学
·
储能技术
·
纳米技术
·
催化
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高影响因子
Scientific Reports
·
2020
·Vol. 10
·期 1
·1-11
·
IF 3.998
Wang Yue,Xiao Han,Yang Lei,Jia Xiaojing,Guo Xuan,Zhang Zhaobin
p -Alkoxyphenols (AOPs) are a class of ethers that are widely used in industrial and agricultural productions and daily necessities. p -Phenoxyphenol (PhOP) and p -pentyloxyphenol (PeOP) belong to this class and have been reported to be estrogenic in vitro. However, their in vivo estrogenic activities have rarely been of concern. In this study, we performed an immature mouse uterotrophic assay and studied the estrogenic effects of these two compounds in mice. The results revealed that the uterine weights of the animals treated with PhOP significantly increased at doses of 30 and 300 mg kg -1 bw day -1 for 3 days ( P < 0.05), while no significant uterotrophic effects were observed in the mice treated with PeOP. Using next-generation transcriptome sequencing (RNA-seq), we also analyzed the gene expression in the uterine tissue of mice treated with PhOP and PeOP. The observed gene regulation patterns of the PhOP- and PeOP-treated specimens were similar to those of the 17 β -estradiol (E 2 )-treated specimens. In particular, some estrogen-responsive genes, such as the Sprr2 gene family, Apoa1 , Prap1 , and Ahsg , displayed a regulation trend similar to that of E 2 . In addition, molecule docking analysis revealed that both PhOP and PeOP could be well docked into the active site of hERα, with potential of mean force (PMF) values of − 58.68 and − 52.67 kcal mol -1 for PhOP and PeOP, respectively. The results of this study indicate that PhOP exhibits relatively strong in vivo estrogenic activity, which could be of future concern.
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高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2024
·
IF 9.4
Xiaofei Zhou,Guijuan Wei,Chang Liu,Qian Zhao,Hui Gao,Wenbo Wang,Xixia Zhao,Xin Zhao,Honglei Chen
The production of hydrogen through seawater electrolysis has recently garnered increasing concern. However, hydrogen evolution reaction (HER) by alkaline seawater electrocatalysis is severely impeded by the slow H 2 O adsorption and H* binding kinetics at industrial current densities . Herein, a face-centered cubic/hexagonal close packed (fcc/hcp) NiRu alloy heterojunction was fabricated on Ni foam (N doped NiRu-inf/NF) by a low-temperature nitrogen plasma activation. Simultaneously, nitrogen atoms are introduced into the alloy to facilitate d-p hybridization. When N doped NiRu-inf/NF is integrated into a dual-electrode cell for urea-assisted seawater electrolysis, it achieves 100 mA cm −2 with an ultra-low voltage of 1.36 V and excellent stability. Density functional theory (DFT) verifies that the robust d-p hybridization among Ni, Ru and N exhibits more energy level matching for H 2 O molecule adsorption at the Ru sites, while simultaneously reducing the interaction between H* and Ni sites in N -doped NiRu-inf.
研究领域:
材料科学
·
电化学
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能源材料
·
催化
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DOI
高影响因子
ACS Applied Materials & Interfaces
·
2020
·
IF 8.758
Bala Ismail Adamu,Attia Falak,Yi Tian,Xinghua Tan,Xiangmin Meng,Peipei Chen,Hanfu Wang,Weiguo Chu
High sensitivity, low limit of detection (LOD), and short response and recovery times at room temperature (RT) are critical for gas sensors. For NO2, different binary metal oxide-based sensors were developed to achieve superior performance at elevated temperatures instead of RT. Herein, we report on CuO@CuO and Cu3Mo2O9@CuO sensors with CuO and Cu3Mo2O9 micro/nanorods vertically aligned on the CuO layers, which were directly fabricated using a facile, low-cost, and catalyst-free chemical vapor deposition (CVD) technique. Their sensing performance tests revealed that the Cu3Mo2O9@CuO p–p heterojunction sensors exhibited a high response of 160% to 5 ppm NO2, an excellent sensitivity of 50% ppm–1, a low LOD of 2.30 ppb, a short response time of 49 s, and a rapid recovery of 241 s at RT, obviously better than those for CuO@CuO sensors. The superior performance of Cu3Mo2O9@CuO sensors could be attributed to the Schottky heterojunction formed between p-Cu3Mo2O9 micro/nanorods and p-CuO films, the catalytic effect, and the anisotropic nature of Cu3Mo2O9 micro/nanorods. This study not only provides a simple, low-cost, and batchable fabrication method of homo/heterojunction sensors with micro/nanorods vertically aligned on films but also opens an avenue for sensor design by tuning the Schottky barrier height to enhance RT performance.
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高影响因子
Chem
·
2026
·Vol. 12
·期 6
·
IF 19.1
Ying Wang,Yanqing Fu,Qiliang Wei,Dongjiang Yang,Qiao Liu,Weiyou Yang
Aqueous zinc-iodine batteries (AZIBs) are attractive for safe and low-cost energy storage yet are hindered by sluggish iodine redox kinetics and severe polyiodide shuttling. While single-atom catalysts (SACs) based on d -block transition metals have been extensively explored, their limited orbital directionality constrains performance. Herein, we propose an orbital-engineering strategy using p -block elements to enable effective p - p orbital hybridization and enhanced electronic coupling. Bi SACs anchored on N-doped porous carbons (Bi-NC) leverage their semi-metallic nature to induce effective Bi 6 p -I 5 p interactions, thereby accelerating iodine conversion and suppressing shuttling. The Bi-NC/I 2 cathode delivers 134.7 mAh g −1 with exceptional stability over 100,000 cycles at 16 A g −1 , exhibiting only 0.000141% decay per cycle. Furthermore, a Zn/Bi-NC/I 2 pouch cell achieves 1.07 mAh cm −2 and maintains 100% capacity retention after 200 cycles at 5 mA cm −2 . This work establishes p - p orbital hybridization as a powerful design principle for durable aqueous batteries.
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高影响因子
JOURNAL OF CATALYSIS
·
2022
·
IF 8.047
Xiuli Li,Yuan Tan,Zongyang Liu,Juan Su,Yan Xiao,Botao Qiao,Yunjie Ding
Chemoselective hydrogenation of aromatic nitro compounds to the corresponding anilines is an environmentally benign technology for the production of key intermediates in manufacturing of pharmaceuticals, agrochemicals, dyes and fine chemicals. Non-noble metal Cu-based catalysts have been reported as a low-cost alternative but suffer from poor activity. Herein, by fabricating nickel oxide promoted Cu catalysts, a promoted activity was obtained in supported Cu-Ni bimetal catalyst system. Characterizations such as H 2 -TPR and XPS indicate a strong interaction between Cu and Ni, which contributes to its high activity and selectivity in hydrogenation of p -chloronitrobenzene ( p -CNB) to p -chloroaniline ( p -CAN). Control experiments suggest that either monometallic copper or pure nickel oxide is less active for the reaction but the interaction of NiO x with Cu generates much more active species, resulting in significantly improved catalytic reactivity and selectivity. The activity was found to be highly dependent on the contents of Cu 0 & Cu + in Cu-Ni bimetal catalyst, as the specific reaction rates for hydrogenation of p -CNB grew linearly with the increment of Cu 0 & Cu + loadings. Kinetic studies and in-situ DRIFTS of p -CNB imply the 10Cu-5Ni/AlSBA-R catalyst possesses good capacity for the activation of hydrogen and nitro group, leading to high p -CNB conversion and p -CAN production. The present work provides a good example for understanding the interaction between Cu and nickel oxides, and helps to develop highly efficient non-noble metal catalysts for selective hydrogenation of aromatic nitro compounds to corresponding anilines.
研究领域:
催化化学
·
环境科学
·
材料科学
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DOI
高影响因子
Advanced Composites and Hybrid Materials
·
2022
·Vol. 5
·期 2
·1362-1375
·
IF 11.806
Wang Deng,Wang Rui,Huang Kai,Lei Ming,Tang Haolin
The Si-P nanohybrids, as an underlying candidate for the anode material of the next-generation lithium-ion batteries (LIBs), possess a high theoretical specific capacity of 2900 mAh g −1 but decays rapidly owing to the large volume change during lithiation/delithiation. Meanwhile, two-dimensional transition metal carbides (MXenes) with outstanding conductivity and specific crystal structure have been revealed with a relative low Li + diffusion barrier, which exhibits underlying application prospects in the area of energy storage and can be particularly utilized as the conductive matrix for realizing the outstanding performance of lithium storage. Herein, we employ an MXenes (Ti 3 C 2 T x )-buffer strategy to improve the electrochemical properties of the traditional Si-P anode by a relatively simple mechanical ball-milling method. Obvious chemical bonds between Si-P and Ti 3 C 2 T x have been confirmed for as-prepared Si-P/Ti 3 C 2 T x composites, where P nanolayer acts as an intermediate layer and guarantees the composite integrity and the tight contact between red phosphorus, Si, and Ti 3 C 2 T x matrix. Moreover, the Si-P/Ti 3 C 2 T x composite electrode, in comparison with Si-P composite and Si, exhibits an enhanced rate performance (632.4 mAh g −1 at 5A g −1 ) and a higher reversible capacity (980.8 mAh g −1 after 500 cycles at 500 mA g −1 ), indicating it’s a promising candidate for advanced LIBs anode. Graphical abstract The high-performance chemically bonded double-conductive protective layer lithium-ion battery anode was developed by mechanical ball-milling strategy.
研究领域:
材料科学
·
能源存储
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DOI
高影响因子
Advanced Science
·
2022
·Vol. 9
·期 22
·2201594
·
IF 17.521
Rui Yang,Xiaozhong Zheng,Minkai Qin,Binbin Lin,Xiaoyun Shi,Yong Wang
Recently, extensive research efforts have been devoted to drive electrocatalytic water-splitting for hydrogen generation by electricity or solar cells. However, electricity from power grid and the intermittent property of sunlight inevitably brings about environmental pollution and energy loss. Thus, a novelty energy system for simultaneous generating H 2 from solar energy and overcoming the intermittence of sunlight is highly desirable. Herein, a self-powered energy system with solar energy as the sole input energy is successfully assembled by integrated Zn–air batteries with stable output voltage, solar cells, and water splitting electrolyzer to efficient H 2 production. Specially, the Zn–air batteries are charged by the solar cell to store intermitted solar energy as electricity during light reaction. Under unassisted light reaction, the batteries could release electric energy to drive H 2 production. Therefore, the aim for simultaneous generating H 2 and eliminating the restrictions of intermittent sunlight are realized. The solar-to-hydrogen efficiency and solar-to-water splitting device efficiency of the self-powered energy system are up to 4.6% and 5.9%, respectively. This work provides the novel design systems for H 2 production and the usage of renewable energy.
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Materials
·
2020
·Vol. 13
·期 20
·4551
·
IF 3.057
Linglei Jin,Baikang Zhu,Xuesong Wang,Le Zhang,Debin Song,Jian Guo,Hengcong Tao
With the assistance of surfactant, Fe nanoparticles are supported ong-C3N4nanosheets by a simple one-step calcination strategy. Meanwhile, a layer of amorphous carbon is coated on the surface of Fe nanoparticles during calcination. Transmission electron microscopy (TEM), scanning electron microscope (SEM), X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), and inductively coupled plasma (ICP) were used to characterize the morphology, structure, and composition of the catalysts. By electrochemical evaluate methods, such as linear sweep voltammetry (LSV) and cyclic voltammetry (CV), it can be found that Fe25-N-C-800 (calcinated in 800 °C, Fe loading content is 5.35 wt.%) exhibits excellent oxygen reduction reaction (ORR) activity and selectivity. In 0.1 M KOH (potassium hydroxide solution), compared with the 20 wt.% Pt/C, Fe25-N-C-800 performs larger onset potential (0.925 V versus the reversible hydrogen electrode (RHE)) and half-wave potential (0.864 V vs. RHE) and limits current density (2.90 mA cm−2, at 400 rpm). In 0.1 M HClO4, it also exhibits comparable activity. Furthermore, the Fe25-N-C-800 displays more excellent stability and methanol tolerance than Pt/C. Therefore, due to convenience synthesis strategy and excellent catalytic activity, the Fe25-N-C-800 will adapt to a suitable candidate for non-noble metal ORR catalyst in fuel cells.Keywords:oxygen reduction reaction;iron;coating;P-123
研究领域:
材料科学
·
电化学
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DOI
高影响因子
APPLIED SURFACE SCIENCE
·
2025
·
IF 6.9
Ming Yang,Lihong Liu,Bo Li,Yannan Mu,Jiaming Chen,Shan Gao,Yingming Xu,Lihua Huo
At present, the effective detection of H 2 S is of indispensable significance for safeguarding human health and maintaining production safety. In this study, a simple ammonia volatile liquid phase deposition method was adopted to in-situ construct cross-linked porous NiO nanoflakes composites on the surface of graphene (Gr) layers under mild conditions from room temperature to calcination. Through regulating the deposition reaction time, the proportion of NiO to Gr components in the composite material can be flexibly controlled. Among them, the NiO nanoflakes/Gr-8 material prepared by deposition for 8 h shows the optimal H 2 S gas sensitivity performance. At the optimal operating temperature of 92℃, the detection limit of H 2 S of this sensor is as low as 10 ppb, and its performance is significantly better than that of most sensing materials. Its outstanding performance stems from multi-dimensional structural optimization: NiO serves as the gas-sensitive active center to dominate the sensing response. The introduction of Gr increases the specific surface area of the material and significantly enhances its electrical conductivity. Particularly crucial is that the p-p heterostructure formed at the NiO/Gr interface effectively promotes the ionization of adsorbed oxygen ions. This study provides a new idea for the development of high-performance H 2 S gas sensors through a collaborative optimization strategy of “active components-conductive substrates-heterostructure interfaces”.
研究领域:
材料科学
·
传感器技术
·
纳米材料
·
环境监测
·
气体传感
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产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2022
·
IF 10.383
Zhuoyao Li,Chengyu Zhang,Huixiang Sheng,Jin Wang,Yameng Zhu,Liuyingzi Yu,Junjie Wang,Qiming Peng,Gang Lu
Localized surface plasmon resonance (LSPR) has been demonstrated to be highly effective in the initialization or acceleration of chemical reactions because of its unique optical properties. However, because of the ultrashort lifetime (fs to ps) of plasmon-generated hot carriers, the potential of LSPR in photochemical reactions has not been fully exploited. Herein, we demonstrate an acceleration of the plasmon-mediated reduction of p-nitrothiophenol (PNTP) molecules on the surface of silver nanoparticles (AgNPs) with in situ Raman spectroscopy. p-Mercaptophenylboronic acid (PMPBA) molecules coadsorbed on AgNP surfaces act as a molecular cocatalyst in the plasmon-mediated reaction, resulting in a boosting of the PNTP reduction. This boosting is attributed to the improved transfer and separation of the plasmon-generated hot carriers at the interface of the AgNPs and coadsorbed PMPBA molecules. Our finding provides a highly simple, cost-effective, and highly effective strategy to promote plasmonic photochemistry by introducing a molecular cocatalyst, and this strategy can be extended to promote various plasmon-mediated reactions.
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高影响因子
危险品化学品经营许可证（带存储）