INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2021
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IF 6.953
Aiping Zhang,Yucheng Zou,Yuhang Xi,Peng Wang,Yue Zhang,Liangru Wu,Hui Zhang
The feasibility of using unmodified bamboo shoot cellulose (BSC) to produce composite aerogels with sodium alginate (SA) in a fast and green way for sustained release of curcumin was explored for the first time, in which calcium ion-induced SA cross-linking could effectively retain the structural stability of aerogel skeleton. The aerogels were characterized by scanning electron microscopy, Fourier transform infrared spectroscopy and differential scanning calorimetry . The encapsulation and release of curcumin from aerogels were studied while the antioxidant activity of encapsulated curcumin was investigated. Curcumin was evenly encapsulated in the composite aerogels and showed a sustained release behavior, followed the first-order rate expression. Interpenetrating network structures were built between BSC and SA mainly through hydrogen bonding, which could be further reinforced by the cross-linking of CaCO 3 on the SA matrix. The original characteristics of BSC in the composite aerogels were well retained. The thermal stability and mechanical properties of the composite aerogels were improved by Ca 2+ -induced cross-linking, while the uncross-linked composite aerogels exhibited better encapsulation efficiency and in vitro antioxidant activity. Overall, this study was the first to use cellulose from bamboo shoot to develop aerogels for drug delivery purposes. The cellulose/alginate composite aerogels were promising to be used as biocompatible carriers for drug and nutraceutical delivery.
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Journal of Environmental Chemical Engineering
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2021
·
IF 5.909
Yangjinghua Yu,Runjun Sun,Zhong Wang,Mu Yao,Guohe Wang
Graphene oxide (GO) composite materials as adsorbent have been widely researched in the adsorption various heavy metal contaminated water . In order to improve its structural stability and adsorption properties, self-support GO/Sodium Alginate (SA)/1, 2-Propanediamine (PDA) composite membrane was prepared by vacuum filtration. The performance of amino functional groups in composite membranes was observed using X-ray photoelectron spectrum (XPS). The X-ray diffraction (XRD) was used to characterize the interlayer spacing. The Pb 2+ adsorption properties of composite membranes were discussed by intermittent adsorption experiments. Intermittent adsorption experiments include the subject of the pH, contact time, adsorption film weight, concentration of metal ion and temperature change. The Pb 2+ adsorption on the composite membrane strongly depends on pH. After 20 min of adsorption, the membrane reached the adsorption equilibrium, and the adsorption rate was fast. The maximum adsorption capacity of the composite membrane to Pb 2+ was 189.25 mg g −1 . The adsorption process of the membrane was consistent with the chemisorption process and mono-layer adsorption process. The GO/SA/PDA membranes can be used to the adsorption of Pb 2+ , which might give contribution to environmental protection.
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Journal of Analytical Methods in Chemistry
·
2021
·
IF 2.193
Hongchuan Li,Rui Jin,Hongxiang Hu,Yusef Kianpoor Kalkhajeh,Yingying Zhao,Yue Gao,Borui Zhang
Sodium alginate (SA), polyvinyl oxide (PEO), and ceramic nanomaterials were used to prepare alginate composite gel. The present study examined the removal rate and adsorption capacity of alginate composite gel for removal of wastewater As(III), Pb(II), and Zn(II). Batch experiments were conducted to study the influence of experimental parameters such as pH and temperature, as well as the mechanism of As(III), Pb(II), and Zn(II) adsorption with the new adsorbent. The results showed the high efficiency of sodium alginate composite gel for removal of wastewater As(III), Pb(II), and Zn(II). Under the condition of the best liquid-solid ratio and the contact time, the removal rates of As(III), Pb(II), and Zn(II) were 67.42%, 95.31%, and 93.96%, respectively. The pseudo-second-order kinetic equation was superior to fit the adsorption kinetics process. The isothermal adsorption models of As(III) and Pb(II) fitted well with the Freundlich model, and Zn(II) fitted well with the Langmuir model. The results of SEM, EDS, XPS, and FTIR analyses revealed that the adsorption process occurred mainly via chemisorption. The results of the present study suggest that new adsorbents can be effectively utilized for As(III), Pb(II), and Zn(II) removal from water.
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CARBOHYDRATE POLYMERS
·
2021
·
IF 9.381
Penghui Wang,Yajie Pu,Yanhan Ren,Rong Yang,Wenjie Zhang,Xiaoyan Tan,Wenliang Xue,Shuai Liu,Shuang Li,Bo Chi
Traditional hydrogels often fail to match the dynamic interactions between mechanical and cellular behaviors exhibited by the natural cartilage extracellular matrix. In this research, we constructed a novel hybrid hydrogels system based on sodium alginate and polyglutamic acid. By controlling the grafting rate and concentration of polymer, the gelation time and mechanical strength can be adjusted between range of 8–28 s and 60–144 kPa. By adding microcrystalline cellulose into the system, so that the degradation time was prolonged (125%) and the swelling rate was reduced (470%). Additionally, the presence of hydrazone bonds gives the system some dynamic response characteristics, and the hydrogel exhibits excellent self healing and injectable ability. It was found that the system had positive cytocompatibility (80%), which accelerated regulatory gene expression in cartilage tissue. In conclusion, this injectable hydrogel with self-healing and customizable mechanical strength will have broad application prospects in future biomedical engineering.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2021
·
IF 6.953
Wenqi Li,Liping Zhang,Die Hu,Ran Yang,Jie Zhang,Ying Guan,Fanxun Lv,Hui Gao
In this study, a novel mesoporous nanocellulose/sodium alginate (SA)/carboxymethyl-chitosan (CMC) aerogel was fabricated using a simple method. The adsorption of Cu 2+ and Pb 2+ on the aerogel in aqueous solutions was investigated. The obtained aerogel was characterized using scanning electron microscopy, fourier-transform infrared spectroscopy, transmission microscope, atomic force microscopy and N 2 adsorption–desorption. Furthermore, the fundamental Cu 2+ and Pb 2+c adsorption behaviours of the mesoporous aerogel, including the effect of pH, adsorption equilibrium and kinetics were investigated. The adsorption isotherms and kinetics of aerogel closely followed the Langmuir model and pseudo-second-order model, respectively, indicating that the adsorption behaviours can be classified as monolayer chemical adsorption. The aerogel exhibited high efficiency for the adsorption of Cu 2+ (169.94 mg/g) and Pb 2+ (472.59 mg/g). The aerogel maintained a high adsorption capacity for Cu 2+ (56 mg/g) and Pb 2+ (245 mg/g) after five adsorption–desorption cycles. Therefore, the as-prepared mesoporous aerogel has great potential in wastewater treatment.
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Journal of Environmental Sciences
·
2021
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IF 5.565
Siqi Zhang,Furui He,Xiuqin Fang,Xinyu Zhao,Yuanyuan Liu,Gaobo Yu,Yang Zhou,Yuhong Feng,Jiacheng Li
Soil aggregation plays an important role in agricultural production activities. However, the structure of soil aggregation is destroyed by the natural environment and unreasonable farming management, resulting in the loss of water, fertilizers and pesticides in soil. At present, hydrogels have been widely reported to promote the formation of soil aggregation. In this paper, amphiphilic calcium alginate (ASA/Ca 2+ ) was applied to promote the formation of soil aggregation and enhance pesticide retention. Initially, an ASA was obtained through the one-pot Ugi condensation (a four-component green chemical reaction). Then, ASA/Ca 2+ hydrogel is prepared by Ca 2+ cross-linking. The formation of soil aggregation was determined through the Turbiscan Lab Expert stability analyzer, Confocal Laser Scanning Microscope (CLSM), and Transmission Electron Microscope (TEM). And the effect of soil aggregation on acetamiprid environmental behavior was investigated by adsorption kinetics, adsorption isotherms, and leaching. The results shown that the three-dimensional network structure of ASA/Ca 2+ hydrogel can promote the formation of soil aggregation. Aggregate durability index (ADI) was 0.55 in the presence of ASA/Ca 2+ hydrogel, indicating that amphiphilic hydrogel can enhance the stability of soil aggregation. The adsorbing capacity of acetamiprid was 1.58 times higher than pure soil, and the release of acetamiprid only about 20% in the presence of ASA/Ca 2+ hydrogel. These results would be helpful for the formation of soil aggregation and pesticides adsorption on soil aggregation. Thus, ASA/Ca 2+ hydrogel is likely to improve soil quality, simultaneously it can minimize the mobility of pesticides in the agricultural system.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2021
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IF 6.953
Daojiu Zhang,Shaoyu Wang,Mingchun Wang,Zijian Wu,Steve W. Cui,Hao Wang,Biao Wang
This study attempted to prepare ternary conjugate emulsion from bovine serum albumin (BSA), dextran (DEX) and gallic acid (GA) to improve the stability of conjugate emulsion and the bioaccessibility of capsorubin. The release of capsorubin was further delayed by sodium alginate capsules in the intestinal phase. First, protein formed new functional groups and covalent bonds was analyzed by Fourier transform infrared (FTIR) and sodium dodecyl sulphate polyacrylamide gel electrophoresis (SDS-PAGE). Next, the stability of the ternary conjugate showed distinct pH correlation and the higher stability near the isoelectric point . Finally, the bioaccessibility of capsorubin embedded in sodium alginate emulsion was higher than that of ternary conjugate emulsion (65% and 34%).
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JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
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2021
·Vol. 109
·期 9
·1303-1312
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IF 3.368
Ji Ji,Guang Chen,Zitong Liu,Lili Li,Jiugang Yuan,Ping Wang,Bo Xu,Xuerong Fan
To improve mechanical properties of keratin (KR) porous scaffolds, we prepared a PEGylated keratin through thiol-ene click reaction. Several porous scaffolds were prepared by blending PEGylated keratin with sodium alginate (SA). The surface morphology, mechanical properties, and porosity of scaffolds were detailed studied at different KR/SA proportions. The results showed the content of SA had an effect on pore formation and mechanical properties. When the mass ratio of KR to SA was 2:1, the stress of yield point of the keratin porous scaffold reached 1.24 MPa, and also showed good deformation recovery ability. The PEGylated keratin porous scaffold had a high porosity and great cytocompatibility. Its' porosity is up to 81.7% and the cell viability is about 117.78%. This allows it to absorb the simulated plasma quickly (9.20 ± 0.37 g/g). In addition, the structural stability and acid–base stability of the keratin porous scaffold were also improved after PEGylation. Overall, the PEGylated keratin porous scaffold will be promising in tissue materials due to its great physical, chemical, and biological properties.
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EUROPEAN POLYMER JOURNAL
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2020
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IF 3.862
Xue Gao,Zhe Yu,Bingxin Liu,Jixu Yang,Xiaoyan Yang,Yueqin Yu
A biocompatible dual-stimuli responsive drug delivery for hydrophobic drugs based on self-assembled polymeric micelles was presented. Hydrophobic modified alginate (HMA), used dodecyl glycidyl ether as a hydrophobic group, could form self-assembled micelles in aqueous solution above the critical micelle concentration. Doxorubicin (DOX) was chosen as a model drug and successfully loaded in HMA micelles. The percentage of drug loading efficiency of the HMA was determined as 65.4% by using fluorescence measurement. The pH-triggered and enzyme-triggered release behavior of DOX from DOX-HMA micelles indicated that the release of DOX was accelerated in acidic medium and that the release rate was dramatically enhanced in the presence of Alpha-L-fucosidase. It was found that almost 80% DOX was released from the DOX-HMA micelles in the presence of AFU at pH 5.5. Moreover, in vitro drug release studies exhibited that the DOX-HMA was effectively taken up by the cancer cells, and the blank micelles showed low toxicity toward the cancer cells, while the drug loaded micelles had high toxicity, even than the free drugs. These results demonstrate that HMA may serve as a general platform for therapeutic delivery.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2019
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IF 4.784
Guobao Chen,Runan Wei,Xiang Huang,Fuping Wang,Zhongmin Chen
Transcatheter arterial chemoembolization (TACE) is well known as an effective treatment for hepatocellular carcinoma (HCC). In the present study, a novel embolic agent of sodium alginate (SA)-modified silk fibroin (SF) microspheres was successfully prepared by emulsifying cross-linking method. The SA-modified SF microspheres were evaluated for the ability of embolization by investigating the morphology, particle size, swelling ratio, degradation, cytotoxicity, blood compatibility, and in vivo embolization. The results found that SA-modified SF microspheres had smooth surfaces and good sphericity. Swelling ratio of the microspheres can meet the requirements of arterial embolic agent and have pH and temperature sensitivity. Furthermore, hemolytic and anticoagulant studies have proved that the microspheres have good blood compatibility. Cytotoxicity tests indicated that the microspheres could promote the proliferation of fibroblasts and HUVEC. In vivo embolization evaluation of microspheres revealed that the arteries could be embolized by SA-modified SF microspheres in 3 weeks. The ability of drug loading and releasing of microspheres was proved by the controlled release profile of Adriamycin hydrochloride. The findings indicated that the SA-modified SF microspheres can be used as a potentially biodegradable arterial embolic agent for liver cancer therapy.
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SENSORS AND ACTUATORS B-CHEMICAL
·
2019
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IF 6.393
Rui Liu,Bin Kong,Yun Chen,Xueping Liu,Shengli Mi
The helical structure is one of the most intriguing structures in nature; such an ingenious structure can be found from macromolecules to macroscopic areas, and the fabrication of helical structures has attracted research interest from mechanisms to applications. However, the fabrication of helical microfiber still remains a big challenge. In this study, a coaxial microfluidic device was made to continuously and controllably fabricate helical hydrogel microfibers with flexible shape by simply adjusting the flowrates. Various experimental conditions that can influence the diameter (d), pitch (p) and amplitude (A) of these formed coiled fibers were discussed. For the first time, the effects of G/M ratio of the alginates on the microfiber coiling phenomenon were examined. Additionally, magnetically responsive helical fibers were synthesized, and it is envisioned that hydrogel helical structure microfibers are highly versatile in different area, such as micro sensors, soft actuators and medical applications.
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CARBOHYDRATE POLYMERS
·
2022
·
IF 10.723
Rong Cai,Ying Chen,Jiawei Hu,Jinli Xiong,Jiawei Lu,Jiating Liu,Xiaobo Tan,Wenyong Liu,Yueyun Zhou,Yi Chen
A novel self-supported polysaccharide based hydrogel membrane was prepared by adding cellulose nanofiber (CNF) and micron-sized biochar (BC) into sodium alginate (SA) hydrogel with in-situ free water evaporation (“cooking”) process and ionic crosslinking, in which the polyethylene glycol (PEG) was used as a pore-forming agent. Herein, CNF can not only enhance the mechanical property of the matrix, but also assist the homogeneous dispersion of BC. As a result, the prepared membrane had a maximum tensile strength of up to 5.69 MPa, which was more than 2–3 times higher than the previously reported self-supported hydrogel membranes. The flux reached 61.5 Lm −2 h −1 under 0.35 MPa pressure, and the anti-fouling property was also excellent due to its hydrophilicity . In filtration tests, the rejection of Cr (III) and Cr (VI) of 50 mg/l could reach 96.8 % and 91.4 %, respectively. Moreover, the mechanism behind the exceptional high rejection for both cationic and anionic heavy metal was delineated.
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