SEPARATION AND PURIFICATION TECHNOLOGY
·
2025
·
IF 9
Xiaolei Cui,Yuchen Cui,Ziang Li,Zixi Kang,Soryong Ryan Chae,Lubomira Tosheva,Hailing Guo
Under industrially conditions (pressures ≥10 bar), polymer membranes usually exhibit poor CO 2 /CH 4 separation performance and limited stability, severely restricting their practical application. Here, we present a materials engineering strategy, in which phenolic resin is in-situ polymerized on the surface of NH 2 -UiO-66 to engineer the MOF-polymer interface, thereby enabling high CO 2 /CH 4 separation performance and excellent structural stability for mixed matrix membranes. The phenolic resin forms a uniform coating (∼10 nm thick) on the porous MOF surface, providing a high-density CO 2 active sites that accelerate CO 2 transport. In addition, due to favorable interfacial interactions between the phenolic resin shell and the polyetherimide matrix, the resulting MMMs exhibit excellent stability under high pressures. Compared to the pristine PEI membranes, the CO 2 permeability and CO 2 /CH 4 selectivity of the optimized 30-RF@NH 2 -UiO-66-PEI membranes are enhanced by 8550% and 1500%, respectively. Under simulated industrial conditions (10/90 CO 2 /CH 4 mixture at 10 bar and 50 °C), the engineered membranes maintain a CO 2 permeability of 6105 Barrer and a CO 2 /CH 4 selectivity of 30.5, demonstrating excellent separation performance. More importantly, the 30-RF@NH 2 -UiO-66-PEI membrane exhibits both scalability (readily extendable to the square-meter level) and cost-effectiveness (∼55 USD per square meter). This work highlights the potential of phenolic resin-modified MOF fillers to enable efficient CO 2 /CH 4 separation under realistic industrial conditions.
✓ 已验证
产品关联
DOI
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2023
·
IF 8.6
Dandan Xu,Bing Zhao,Qinglong Luo,Xiao Du,Xiaogang Hao,Zhong Liu
It is a meaningful study to develop adsorbents with high adsorption capacity and fast adsorption rate for the removal of specific ions in aqueous solution. This paper mainly studies the removal of boron in aqueous solution by UiO-66. Regular octahedral structured UiO-66(HAC) via acetic acid-promoted was synthesized by a hydrothermal method. The boron adsorption kinetics, isotherms, thermodynamics, mechanism, and recycling on UiO-66(HAC) were further investigated in batch adsorption process, which found that adsorption capacity of UiO-66(HAC) is enhanced by 40% compared with UiO-66. UiO-66(HAC) exhibits great adsorption performance of 79.43 mg·g −1 at 25 °C and the adsorption process reaches equilibrium rapidly in 2 h. The selective adsorption of boron by UiO-66(HAC) is due to the presence of a large amount of Zr-OH which can chemically adsorb with boron. Compared with traditional boron removal adsorbents, UiO-66(HAC) has higher boron adsorption capacity and is easy to regenerate. It is a promising boron removal adsorbent in aqueous solution.
✓ 已验证
DOI
高影响因子
ACS Nano
·
2025
·
IF 16
Zhihua Wang,Mingda Han,Yiqiao Wang,Ning Wang,Yilin Yang,Bingru Shao,Qiannan Miao,Zhan Shi,Fei Yan,Shouhua Feng
B-cell lymphoma (BCL) is a hematological malignancy with high heterogeneity and represents an aggressive proliferation of mature B-cells. Despite the initial success of traditional treatments for BCL in clinical trials, a majority of patients eventually develop resistance to therapy and have poor clinical outcomes. Epigenetic dysregulation is a major contributor to the pathogenesis of BCL, and therapies targeting epigenetic pathways is a promising alternative strategy for treating BCL. Herein, we developed a metal–organic framework (MOF)-based nano-sonosensitizer for ultrasound-driven cascade immunotherapy against BCL. The nano-sonosensitizer was synthesized by encapsulating copper complex of the m6A-mRNA demethylase inhibitor into UiO-66-NH2, which possesses a Z-scheme heterostructure and allows efficient electron–hole pair separation for generating reactive oxygen species (ROS) under ultrasound activation. These CuR@UiO66 sonosensitizers were functionalized with mPEG-PO3 and anti-CD19 antibody, and the resulting CRUPPA19 particles could specifically accumulate in the BCL tissue and also target lymphoma cells that infiltrated into the bone marrow. Once internalized, CRUPPA19 could induce intracellular ROS production and apoptosis under ultrasound irradiation. Subsequently, ultrasonic stimulation triggered autophagy-mediated release of Cu and Rhein from CRUPPA19, thereby increasing protein lipoylation and global mRNA methylation, which led to cuproptosis and the transcriptional repression PDL1, respectively. These cascades synergistically induced immunogenic cell death in the tumors and promoted activation of CD8+ T cells, eventually leading to an antilymphoma immune response. CRUPPA19-mediated sono-immunotherapy not only eliminated the primary and metastatic lymphomas but also cleared lymphoma cells from the bone marrow. This study provided an insight into a MOF-based nanoepigenetic therapy platform with ultrasound-triggered cascade amplification for enhanced antihematological tumor immunity.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ANALYTICA CHIMICA ACTA
·
2025
·
IF 6
Jiaqi Niu,Jinhui Liu,Ping Guo,Min Du,Wanqing Wu,Ziyang Zhang,Ye Ning,Dedi Zhou,Haidong Cao
As a common contaminating bacterium, Escherichia coli (E. coli) has caused severe harm in various fields such as food, healthcare, and the environment. Traditional detection methods for Escherichia coli, owing to factors like high cost and low efficiency, are unable to meet the detection requirements at the present stage. Therefore, the development of a simple, rapid, and highly efficient detection method for Escherichia coli represents an urgent issue that needs to be addressed promptly. This study focused on the development of a highly selective molecularly imprinted electrochemical sensor for E. coli. Molecularly imprinted polymers (MIPs) were prepared by electropolymerization on the surface of glassy carbon electrode using o-phenylenediamine as the functional monomer, aminated metal-organic frameworks (MOFs) and carbon nanotubes (CNTs) as the composites, and bovine serum albumin (BSA) was added into the polymer film to attenuate the non-imprinting effect. The linear range of the sensor was 10-10 7 CFU/mL and the detection limit was 5.2 CFU/mL. Good recovery rates were shown in real samples of drinking water, milk and orange juice. In addition, the good binding ability of the E. coli template molecule to the functional monomer o-phenylenediamine was verified by molecular docking and molecular dynamics (MD) simulations. This study was able to detect E. coli in 20 min, which provides a more open idea for the application of rapid detection of E. coli on-site, as well as the construction of molecularly imprinted electrochemical sensors and the analysis of the binding mechanism between template molecules and functional monomers.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING SCIENCE
·
2025
·
IF 4.3
Chengyu Sun,Yihao Ji,Wenyan Huang,Fuli Deng,Yi Zhang
The recovery of rare earth elements from mineral wastes is extremely critical for the soaring global demand due to their unique roles and resource scarcity. In this work, the defective phosphoric acid functionalized UiO-66-COOH (UiO-66-COOH-OP-ST2) was prepared via the successive phosphoric acid functionalization and defect modulation procedures towards UiO-66-COOH. The adsorption results disclosed that maximal adsorption capacities of UiO-66-COOH-OP-ST2 and phosphoric acid functionalized UiO-66-COOH (UiO-66-COOH-OP) were found to be 132.76 and 83.11 mg/g at pH = 6, respectively. Adsorption kinetics curves and isotherms revealed that the adsorption process was consistent with pseudo second order kinetic model and Langmuir isothermal model. Furthermore, UiO-66-COOH-OP-ST2 can maintain 91.74 % of initial adsorption capacity after five consecutive adsorption–desorption cycles, and exhibit no significant changes in the XRD patterns, demonstrating an excellent recycling stability. In addition, the adsorption mechanism elucidated that the elevated adsorption performance was mainly attributed to the electrostatic attraction and complex interaction between the O sites and Yb(III) based on EDS and XPS analysis. This work efficiently improved adsorption performance of metal organic frameworks after simultaneously grafting functional groups and creating defective sites without affecting their stabilities.
✓ 已验证
产品关联
DOI
高影响因子
Chemosensors
·
2025
·Vol. 13
·期 9
·340
·
IF 3.7
Hongmei Gao,Yourong Zhao,Yuhong Xie,Yiying Wang,Jie Che,Daojiang Gao,Zhanglei Ning
In this study, a novel carbon quantum dots-functionalized UiO-66 composite was successfully prepared via the post-synthetic modification method and further developed into a ratiometric fluorescent probe for detecting uric acid. The composite demonstrates excellent structural and luminescent stability under challenging environmental conditions. As a ratiometric fluorescent probe, its recognition principle relies on the ratio of response signals from two different fluorescent emission centers in the composite. In the presence of uric acid, the fluorescence emission intensity at 430 nm from CDs did not change significantly. However, the fluorescence intensity at 545 nm from Tb3+ions decreased remarkably. This material was evaluated for its capacity to sense urinary components and was shown to specifically recognize uric acid over a wide concentration range (0~5 × 10−3M). Moreover, it exhibited strong resistance to interference and high sensitivity in uric acid detection. The detection limit (LOD) was determined to be 0.102 μM through quantitative analysis. The sensing mechanism was validated through spectral overlap and fluorescence lifetime analysis, which can be attributed to the fluorescence resonance energy transfer (FRET) process. This ratiometric fluorescent probe provides an efficient and reliable strategy for detecting the biomarker uric acid.
✓ 已验证
产品关联
DOI
高影响因子
Food and Bioprocess Technology
·
2026
·Vol. 19
·期 11
·532
·
IF 5.6
Li Qiwen,Ding Fuya,Gao Shisong,Jiang Xingyi,Gao Rui,Cui Xiuming,Ge Feng,Li Na
β-Glucosidases are important biocatalysts for upgrading glycosylated phytochemicals into high-value functional ingredients, but practical bioprocessing is often constrained by insufficient stability and poor substrate selectivity. Herein, a thermostable β-glucosidase (CB-glu) from Caldicellulosiruptor bescii was immobilized on zirconium-based metal–organic frameworks (MOFs) bearing tunable surface functionalities (–H, –NH 2 , –OH, and –2OH). In addition to catalytic characterization, N 2 adsorption–desorption, water-contact-angle, zeta-potential, X-ray photoelectron spectroscopy (XPS), and fluorescence emission analyses were introduced to clarify how carrier physicochemical properties and interfacial microenvironments influence immobilized-enzyme performance. Interfacial analyses showed that CB-glu adsorption reduced the accessible BET area of UiO-66-OH from 1026.4 to 796.7 m 2 g −1 , introduced 11.78 at.% surface N, and occurred despite net-negative zeta potentials of both components, supporting adsorption dominated by interfacial rather than long-range electrostatic interactions. Among the tested supports, UiO-66-OH showed the best compatibility with CB-glu, broadening pH adaptability, improving activity at elevated temperatures, and enhancing tolerance to metal ions and organic solvents. Most importantly, CB-glu@UiO-66-OH selectively hydrolyzed the outer C20-linked glucose of PPD-type ginsenosides and completely converted ginsenosides Rb 1 , Rb 2 , and Rb 3 into ginsenoside Rd without further formation of F 2 or CK. The immobilized biocatalyst maintained 100% conversion over eight consecutive cycles. These findings establish surface-functionalized UiO-66 as a practical microenvironment-engineering platform for regulating β-glucosidase robustness and substrate selectivity, providing a reusable bioprocess for the targeted production of ginsenoside Rd as a high-value functional ingredient.
✓ 已验证
DOI
高影响因子
Sustainable Materials and Technologies
·
2026
·
IF 9.7
Hong Chen,Wei Ou,Hongchang Huang,Junlan Li,Juncheng Liu
Both the 2D titanium carbide (Ti 3 C 2 T x ) MXene and the 3D rare earth doped zirconium-based metal organic framework (Ln 3+ @UiO-66, MOF) were constructed on the colorless transparent polyimide (CPI) film to form the heterojunction multifunctional nano-coating via a one-pot immersion method in order to improve the UV resistance of CPI. Firstly, the S/CPI film was obtained via the CPI being modified with silica (SiO 2 ) sol, and then the Ti 3 C 2 T x MXene was loaded onto the surface of the S/CPI film via the hydrogen bond, finally the Ln 3+ @UiO-66 was loaded onto the ultra-thin Ti 3 C 2 T x MXene nanosheets to obtain optimal sample (MXene/Ln 3+ @UiO-66-S/CPI). The transmittance of MXene/Ln 3+ @UiO-66-S/CPI is 93.33%, which is only 0.94% lower than that of S/CPI. The tensile strength and elongation of MXene/Ln 3+ @UiO-66-S/CPI are basically the same as those of S/CPI. The attenuation values of transmittance, tensile strength, and elongation for MXene/Ln 3+ @UiO-66-S/CPI film after 5000 equivalent sun hours (ESHs) UV irradiation are 2.44%, 10%, and 18%, respectively, i.e., this film gets both a high transparency and a super ultraviolet resistance. This may be attributed to the fact that the MXene/Ln 3+ @UiO-66 multifunctional nano-coating can absorb the UV light and undergo the down-conversion, weakening the UV irradiation intensity.
✓ 已验证
产品关联
DOI
高影响因子
MICROCHEMICAL JOURNAL
·
2026
·
IF 5.2
Guixia Wang,Yao Lei,Liqiang Yang,Zhuo Yang,Ruting Zheng,Xianming Liu,Min Wang
The phosphatase-like activity of UiO-66 was improved by introducing OMS. • UiO-66-OMS exhibited twice the catalytic activity of pristine UiO-66. • This enhanced activity results from enlarged pores and boosted Lewis acidity. • A sensitive colorimetric immunoassay was developed for the detection of CEA. UiO-66 with open metal sites (UiO-66-OMS) nanozymes were synthesized via defect engineering through the introduction of benzoic acid as a modulator during UiO-66 synthesis. As a monocarboxylic acid analogous to the organic ligand 1,4-benzenedicarboxylic acid (BDC), benzoic acid competes with BDC for coordination to Zr O clusters, thereby creating abundant coordinatively unsaturated open metal sites while preserving the crystal structure of UiO-66. Using 4-nitrophenyl phosphate ( p -NPP) as the model colorimetric substrate, UiO-66-OMS exhibited enhanced phosphatase-like catalytic activity, which was twice that of pristine UiO-66. Mechanistic investigations revealed that the increased activity stems from the enlarged pore size and specific surface area of the nanozyme, as well as its enhanced Lewis acidity. By employing UiO-66-OMS as an antibody label, a sensitive colorimetric immunoassay was developed for the detection of carcinoembryonic antigen (CEA), with a linear range of 10–400 ng/mL and a limit of detection of 1.17 ng/mL. This study offers a new strategy for the development of highly active MOF-based nanozymes. Download: Download high-res image (111KB) Download: Download full-size image
✓ 已验证
产品关联
DOI
高影响因子
BIOELECTROCHEMISTRY
·
2026
·
IF 4.9
Mingzhu Yang,Dujuan Li,Ao Wang,Yifan Zhang,Jiale Ouyang,Xinyi Wang,Liang Hong,Dingyi Tong,Minghua Wang,Jianhan Lin,Qiong Luo,Gaofeng Wang
Breast cancer, a globally prevalent malignancy in women, requires early diagnosis to improve patient outcomes, where ctDNA serves as a key biomarker. In the present study, an electrochemical biosensor based on CRISPR/Cas12a and Au@UiO-66 nanozyme synergistic dual amplification was developed to achieve ultrasensitive detection of breast cancer marker ctDNA. Au@UiO-66-modified ssDNA probes were anchored to the gold electrode via thiol groups. The intact ssDNA probe anchors Au@UiO-66 nanozyme to the electrode, where its peroxidase-like activity efficiently catalyzes H 2 O 2 reduction to generate amplified reduction peak currents. Target ctDNA activates Cas12a's trans-cleavage capacity by binding specifically to crRNA. Under the presence of the target, Au@UiO-66 nanozymes are released, resulting in a discernible drop in the peak current linked to H 2 O 2 reduction. Benefiting from the optimized experimental conditions, the biosensor demonstrates a broad linear detection range (from 10 fM to 10 nM) for the target ctDNA, along with an exceptionally low detection limit of 6.14 fM. Successful detection in human serum samples demonstrates its practicality. The platform's high specificity is attributed to the programmable crRNA design, enabling detection of specified DNA sequences and showcasing significant adaptability for diagnosing multiple genetic targets, highlighting its potential in clinical cancer diagnosis.
✓ 已验证
DOI
PubMed
高影响因子
Journal of Environmental Chemical Engineering
·
2026
·
IF 7.5
Shuangshuang Long,Jingwen Wang,Shuqian Meng,Yaxin Liu,Jing Zhang,Zihao Ren,Jiadi Li,Yangyang Xin,Zheng Dong,Baolu Cui,Libing Qian,Wenwu Zhou,Kai Hu,Luyao Wang,Peipei Li,Yaping Zheng,Zhiyuan Yang,Dechao Wang
Porous liquids (PLs), combine the high adsorption capacity of porous solids with the fluidity of liquids, show great promise in selective CO 2 capture. However, current studies on Type I PLs lacks systematic investigations into the regulatory role of porous host particle size and its impact on in-depth analysis of the gas sorption-separation process. Herein, we successfully fabricated PLs by grafting polyether amine oligomer chains onto the surface of size-tailored UiO-66-OH as the porous host, which endow the PLs with good thermal stability, transparency, low viscosity, and promising CO 2 /N 2 separation. UiO-66-OH-PLs were fabricated by grafting polyether amine oligomer steric solvent onto UiO-66-OH via dehydrative condensation. The effect of porous host size on CO 2 separation behavior of UiO-66-OH-PLs and the selective sorption-separation mechanism were systematically investigated using sorption isotherm and kinetic models. UiO-66-OH-PLs exhibit markedly enhanced CO 2 sorption capacity relative to the pure steric solvent, confirming the preservation of accessible cavities in porous hosts. The PLs further exhibit distinct size-dependent physicochemical and sorption properties as decreasing the particle size of UiO-66-OH porous hosts increases oligomer grafting density, reduces bulk viscosity and enhances both CO 2 sorption capacity and CO 2 /N 2 separation selectivity. CO 2 adsorption isotherms are best fitted by the SS-Langmuir-Freundlich model, indicating that CO 2 sorption by UiO-66-OH-PLs is single-component sorption on heterogeneous surfaces, integrating Langmuir monolayer sorption and Freundlich non-ideal sorption characteristics. Kinetic analysis reveals that the optimal pseudo-first-order kinetic model, demonstrating that CO 2 sorption rate is dominated by the sorption-desorption process between adsorbate molecules and adsorbent surface-active sites, rather than intraparticle or liquid film diffusion. This work opens up a promising avenue for the rational design of high-performance PLs that can be tailored to meet the demands of practical industrial chemical separation processes.
✓ 已验证
产品关联
DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2026
·
IF 5.4
ZhenXiang Xu,Yuan Gao,JingLiang Wang,YunHuan Li,YiPeng Zhao,Xin Meng,Xia Feng,Li Chen,YiPing Zhao
Bio-based porous adsorbents for multicomponent air purification are often constrained by limited active-site density, insufficient control over hierarchical pore architectures, and inadequate mechanical robustness. Herein, chitosan was functionalized with poly(amidoamine) (PAMAM) dendrimers of different generations and combined with carboxymethyl cellulose (CMC) and UiO-66-NH 2 to construct nitrogen-enriched composite aerogels. The effects of PAMAM generation and UiO-66-NH 2 loading on the pore architecture, surface chemistry, mechanical response, and pollutant-capture performance of the aerogels were systematically evaluated. The optimized CG 2 MUNA-2 aerogel exhibited a well-connected porous network and sustained a compressive stress of 13.62 MPa at 80% strain. It achieved a CO 2 uptake of 0.64 mmol·g −1 at 273.15 K and a formaldehyde adsorption capacity of 1.57 mmol g −1 , while retaining 92.4% of its initial formaldehyde adsorption capacity after five adsorption-desorption cycles. When incorporated into cigarette filter rods, CG 2 MUNA-2 reduced CO, CO 2 , and total particulate matter by 30.87%, 14.01%, and 62.58%, respectively. Its superior overall performance was associated with a favorable balance among accessible amine functionalities, pore connectivity, and UiO-66-NH 2 dispersion. These results indicate that the coordinated regulation of PAMAM generation and MOF loading offers a rational materials-design strategy for developing biopolymer-based aerogels for multicomponent air-pollutant capture and cigarette-smoke purification. Download: Download high-res image (278KB) Download: Download full-size image
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）