Cancer Nanotechnology
·
2026
·
IF 4.8
Wang Xin,Liu Purui,Cao Chuanxi,Yan Qinhan,Qin Ruoshan,He Dengqi
Multidrug resistance and the acidic tumor microenvironment (TME) of malignant melanoma significantly limit the efficacy of conventional therapies. In this study, we constructed a near-infrared (NIR)-responsive thermosensitive phase-transition core–shell nanosystem (CaO-DOX-IR820@DLTP). This nanosystem uses CaO as the core, co-loading the chemotherapeutic drug doxorubicin (DOX) and the photothermal agent IR820, with a thermosensitive DLTP polymer shell as the outer layer. Characterization results show that the nanosystem has a uniform particle size, good stability, and excellent biocompatibility. Under NIR irradiation, the hyperthermia generated by IR820 induces phase transition and melting of the DLTP shell, enabling controlled release of DOX. Meanwhile, CaO reacts with water in the TME to trigger a chain exothermic reaction, enhancing photothermal therapeutic efficacy. The resulting Ca (OH)₂ effectively neutralizes lactic acid in the TME, thereby inhibiting M2 polarization of tumor-associated macrophages (TAMs) and alleviating lactate-mediated immunosuppression. Both in vitro and in vivo experimental results demonstrate that the nanosystem exhibits favorable tumor cell-killing effects, providing a novel strategy for the treatment of malignant melanoma. Graphical
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DOI
高影响因子
JOURNAL OF MOLECULAR STRUCTURE
·
2026
·
IF 4.7
Da-zhong Ding,Ying Fan,Yan Zhang,Meng-meng Niu,Xing-tong Zhou,Zhong-hua Sun,Yang Li,Ping Gao,Lin Pei,Zhao Yang
Metronidazole (MNZ), a widely used clinical agent for anaerobic infections, requires light-protected handling during manufacturing, storage, and administration owing to its inherent photolability. Accordingly, co-crystallization offers a distinctive strategy to optimize pharmaceutical properties, while preserving the chemical integrity of pharmaceutical ingredients. To address these limitations, a novel cocrystal of MNZ with the food antioxidant butyl gallate (BG) was successfully synthesized using ultrasound-assisted solvent evaporation and liquid-assisted grinding (LAG). Fourier-transform near-infrared (FT-NIR) spectroscopy was employed for near-real-time and in-situ monitoring of the LAG synthesis process. Single-crystal X-ray diffraction confirmed a 2:1 MNZ:BG stoichiometry of the cocrystal, which was stabilized by hydrogen bonding and intermolecular interactions within the lattice. Comprehensive solid-state characterization, including powder X-ray diffraction, fourier transform infrared spectroscopy, FT-NIR, differential scanning calorimetry, thermogravimetric analysis, and scanning electron microscopy, revealed distinct spectral and thermal signatures relative to pure MNZ, BG, and their physical mixture, validating the new crystalline phase. The cocrystal demonstrated markedly improved critical attributes: a threefold increase in photostability (with an 81% reduction in photolytic impurities), excellent tabletability despite the poor compressibility of pure MNZ, and a 50% lower minimum inhibitory concentration against the clinically relevant anaerobic bacterium Clostridium sporogenes , compared to MNZ alone. In conclusion, this study demonstrated cocrystal engineering as an effective strategy for enhancing the key pharmaceutical properties of MNZ, with FT-NIR monitoring presenting a viable tool for process control.
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高影响因子
NEW JOURNAL OF CHEMISTRY
·
2019
·Vol. 43
·期 25
·10025-10029
·
IF 3.069
Xinrong Shi,Fangjun Huo,Jianbin Chao,Yongbin Zhang,Caixia Yin
The role of hydrazine in production is not to be underestimated due to its strong reducibility. However, every coin has two sides. Hydrazine represents a great hazard to the environment, which cannot be ignored. Aiming to prevent harm to people or the environment, a new near-infrared fluorescent probe is presented. This probe is specifically designed to sense hydrazine vapor accumulated in an enclosed space and detect excessive hydrazine in water samples. It shows good selectivity and a turn-on effect, as well as a remarkable color change that can be distinguished by the naked eye. This effect has been utilized for quantitative detection in real water samples. Moreover, the color change of the probe adsorbed on filter paper can be observed by the naked eye to monitor the presence of hydrazine in the air in real time; this property of the probe is expected to be used for hydrazine detection in industrial environments.
研究领域:
分析化学
·
环境科学
·
生物传感
·
分子诊断
·
工业安全监测
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高影响因子
Advanced Optical Materials
·
2024
·Vol. 12
·期 16
·2303144
·
IF 8
Mengdi Xu,Zhongyuan Li,Qiqi Li,Tinglin Mou,Xuesong Wang,Dong Yan,Ye Li,Xianju Zhou,Zhen Fang,Lixin Ning
Broadband near-infrared (NIR) emissions in the long wavelength region with simultaneous high efficiency and thermal stability are desirable for NIR phosphor-converted light-emitting diodes (NIR pc-LEDs) light sources. Herein, a novel broadband NIR-emitting phosphor is reported, Ba 5 La 3 MgAl 3 O 15 :Cr 3+ (BLMAO:Cr 3+ ), which exhibits a NIR emission band spanning 700–1300 nm with maximum peak wavelength ( λ max ) at 925 nm and full width at half maximum of 160 nm. The optimized phosphor achieves an internal quantum efficiency of 66%, and the integrated emission intensity at 423 K remains 61% of that at room temperature, which surpasses most Cr 3+ -activated phosphors emitting in the long-wavelength NIR region ( λ max > 900 nm). The NIR luminescence properties are elucidated on the basis of density functional calculations of the multiple Cr 3+ local structures as generated by the Ba/La occupation disorder in the host material. The applications of the NIR phosphor in pc-LED devices are demonstrated, showing potential in night-vision and nondestructive examination. The results indicate that BLMAO:Cr 3+ is a promising phosphor with highly efficient and thermally stable broadband NIR emission for NIR LED light sources.
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高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2019
·Vol. 29
·期 38
·1904416
·
IF 15.621
Huai Yang,Longfei Pan,Xiaoting Wang,Hui-Xiong Deng,Mianzeng Zhong,Ziqi Zhou,Zheng Lou,Guozhen Shen,Zhongming Wei
Mixed-valence states can bring unexpected unique phenomena, especially novel anisotropic physics, due to structural asymmetry, which originate from the discrepant distribution of atoms with different valence. This study reports an unexploited mixed-valence-driven quasi-1D Sn II Sn IV S 3 crystal, which exhibits widely and distinctively anisotropic polarized-light absorption reaching ≈3.4 from the deep ultraviolet to near-infrared region (250–850 nm). The fabricated polarization-sensitive photodetectors based on highly air-stable Sn II Sn IV S 3 nanowires display strong linear dichroism among the UV–vis–NIR spectrum with responsivity exceeding ≈150 A W −1 . Furthermore, the devices are further constructed onto a flexible polyethylene terephthalate (PET) substrate and the photoresponse remains roughly unchanged after repeated bending. This work based on novel mixed-valence-driven quasi-1D ternary sulfide Sn II Sn IV S 3 excites interest in low-symmetry semiconductors for developing broadly spectral polarization-sensitive photodetectors with environmental stability and mechanical flexibility.
研究领域:
材料科学
·
半导体物理
·
纳米光学
·
光电子学
·
凝聚态物理
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高影响因子
Journal of Materials Chemistry C
·
2019
·Vol. 7
·期 13
·3751-3755
·
IF 6.641
Jiao Ma,Hao Wu,Jianbei Qiu,Jing Wang,Qi Wang,Yong Yang,Dacheng Zhou,Jin Han
All-inorganic CsPbX3 (X = Cl, Br, and I) perovskite quantum dots have great potential in the field of white light emission owing to their excellent optical properties. However, to date the research on white light based on perovskite quantum dots has focused on downconversion luminescence, while the up-conversion luminescence properties of quantum dots have received less attention due to lacking the anti-Stokes luminescence properties of the material itself, resulting in limitations in upconversion white light emission to some extent. In this paper, upconversion lanthanide ion-doped fluoride nanoparticles and perovskite quantum dots are combined; the luminescence of the quantum dots is excited successfully by the upconversion luminescence of the nanoparticles and then composite samples with white emission are obtained with regulators of concentration.
研究领域:
光电子学
·
纳米材料
·
光子学
·
发光材料
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高影响因子
Journal of Materials Chemistry C
·
2023
·Vol. 11
·期 31
·10483-10491
·
IF 6.4
Lei Wang,Xiaohong Ji,Qinyuan Zhang
Enhancing the near-infrared (NIR) photoresponse of molybdenum disulfide (MoS2) is essential for its photoelectric applications including photo communication. Herein, continuous Er-doped MoS2 (MoS2:Er) films were synthesized via a multi-step process. The enhanced NIR response of MoS2:Er at 808 nm and 980 nm is attributed to the characteristic absorption of Er3+ at both wavelengths and the increased traps introduced by Er-doping. The developed MoS2:Er/SiO2/p-Si heterojunction device possesses a rapid response time of ∼1.4 μs, a high detectivity of ∼3.67 × 1010 Jones, and a wide 3 dB bandwidth of 7.9 kHz at −0.5 V under 980 nm laser irradiation. The dark current of the heterojunction photodetector can be suppressed under 980 nm laser illumination for a period longer than 8 ms because of an extra light-generated field in the dark induced by the residual charges in the traps. Meanwhile, a NIR light communication system is demonstrated by employing the heterojunction detectors as the receiver. This work provides an alternative method to synthesize homogeneous metal-doped MoS2 films and an effective strategy to modulate the photoelectric performance of MoS2-based devices.
研究领域:
材料科学
·
光电子学
·
纳米技术
·
光电探测器
·
半导体物理
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高影响因子
CERAMICS INTERNATIONAL
·
2024
·
IF 5.1
Yixin Sun,Yining Wang,Minliang Deng,Xiaole Xing,Yiying Zhu,Mengmeng Shang
The swift progress in portable spectrometer technology has fostered a widespread need for compact light sources. Concurrently, near-infrared phosphor-converted light-emitting diodes (NIR pc-LEDs), characterized by their low cost and compact structure, emerge as an optimal choice. Inspired by phase optimization through fluxes, we successfully synthesized pure phase Lu 3 Mg 2 GaSi 2 O 12 (LMGS):Cr 3+ , 3 wt%MgF 2 luminescent materials by incorporating various fluxes including LiF, NaF, MgF 2 , CaF 2 , SrF 2 and BaF 2 . These materials emit broadband NIR light ranging from 620 nm to 1150 nm, with full width at half-maximums (FWHMs) exceeding 125 nm. By employing a dual-fluxes strategy to further enhance the luminescence intensity of Cr 3+ , the LMGS:3%Cr 3+ , 1 wt%NaF, 2 wt%MgF 2 sample exhibits a 2.45 times increase in emission intensity compared to the LMGS:3%Cr 3+ , 3 wt%MgF 2 sample. Concurrently, the quantum efficiency rises from 24 % to 46 %. Moreover, the integrated emission intensity of LMGS:3%Cr 3+ , 1 wt%NaF, 2 wt%MgF 2 retains at 75 %@425 K of its value at RT. Upon coupled with a 430 nm LED chip, the luminescent material exhibits an NIR output power of 43.8 mW@300 mA, indicating promising applications in rapid night identification, night vision and non-destructive testing.
研究领域:
材料科学
·
光学材料
·
固态照明
·
光子学
·
无机化学
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高影响因子
Journal of Innovative Optical Health Sciences
·
2024
·
IF 2.3
Zhenghao Liu,Ziyue Ju,Hanyu Liu,Zhan Wang,Ruichan Lv
Rare earth luminescent materials have attracted extensive attention in the biomedical field as noncontact temperature monitoring devices with microscopic resolution due to their properties in the visible and near-infrared regions. At the application level, it is required to have a certain temperature monitoring capability in the near-infrared region II window to enhance the tissue penetration depth. Here, two kinds of YOFs: Er 3 + , Yb 3 + were prepared by co-precipitation and hydrothermal method, and the luminescence was enhanced by ion doping. An Er 3 + -based ratiometric nanothermometer of 4 F 9 ∕ 2 → 4 I 1 5 ∕ 2 (672 nm, upconversion luminescence) to 4 I 1 3 ∕ 2 → 4 I 1 5 ∕ 2 (1580 nm/1566 nm, NIR II downshifting luminescence) were designed with the Stark energy level. When doped with 2% Zn 2 + , the relative temperature sensitivity of YOF prepared by co-precipitation method was improved from 0.30% ∘ C − 1 (30 ∘ C) to 0.59% ∘ C − 1 (30 ∘ C), expanding its use as a temperature monitoring device possibility. The temperature sensitivity of YOF prepared by hydrothermal method was 1.01% ∘ C − 1 (30 ∘ C). Finally, the NIR II luminescence of the prepared nanothermometer was used as a control for temperature monitoring of heating sites in mice. The results showed that it can distinguish heating site from control site and no significant cytotoxicity or damage to the tissues was revealed, indicating its broad prospects in the biomedical field and other temperature monitoring scenarios in the future.
研究领域:
生物医学
·
材料科学
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高影响因子
CERAMICS INTERNATIONAL
·
2022
·
IF 5.532
Yaqi Zhu,Jian Yang,Mingwei Wang,Yangqi Meng,Rongyun Jiang,Hancheng Zhu,Duanting Yan,Chunguang Liu,Changshan Xu,Yuxue Liu
In this study, spinel-phase Zn 2 Ga 3- x Fe 3+ x Ge 0.75 O 8 ( x = 0, 0.002, 0.004, 0.02, 0.04, 0.08, 0.2) and Zn 2 Ga 2.98- x Fe 3+ x Cr 0.02 Ge 0.75 O 8 ( x = 0, 0.0004, 0.001, 0.002 0.003, 0.004) nanoparticles were prepared by one-step hydrothermal method in combination with vacuum annealing. For ZGGO: Fe 3+ nanoparticles , the near infrared (NIR) emissions (∼725 nm) originate from the 4 T 1 ( 4 G)→ 6 A 1 ( 6 S) transition of Fe 3+ occupying octahedral and tetrahedral sites of Ga 3+ . Furthermore, their afterglow time is more than 15 min and Fe 3+ doping will influence the generation of antisite defects pair ( Ga Zn 0 − Zn Ga ′ ). For Cr 3+ and Fe 3+ co-doped ZGGO nanoparticles with average size of ∼46 nm, the NIR persistent luminescence around ∼700 nm, originating from the 2 E→ 4 A 2 and 4 T 2 → 4 A 2 transitions of Cr 3+ , can be observed and the afterglow time exceeds 850 min. With the increase of Fe 3+ concentration, the afterglow intensity decreases due to the decreased number of ( Ga Zn 0 − Zn Ga ′ ) defects and deeper traps. In particular, autofluorescence-free imaging and MR imaging were successfully realized by using ZGGO: Cr 3+ , Fe 3+ 0.002 nanoparticles dispersed in the simulated biological fluid environments (H 2 O, SLS and HSA). Their clear afterglow images can be acquired within 3 min after the stoppage of the UV irradiation and their transversal relaxivity (r 2 ) is in the range of 227–140 mM −1 s −1 , which is close to the conventional Feridex T 2 agent (108 mM −1 s −1 ). Our results suggest that ZGGO: Cr 3+ , Fe 3+ nanoprobes have potential applications in the diagnosis and therapy of disease.
研究领域:
材料科学
·
医学影像学
·
生物医学工程
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高影响因子
MACROMOLECULAR RAPID COMMUNICATIONS
·
2024
·Vol. 45
·期 13
·2300737
·
IF 4.2
Ruyue Wang,Xingxing Chen,Yilong Cheng,Zicheng Ding,Xiaoqing Ming,Yanfeng Zhang
Near-infrared (NIR)-triggered shape memory hydrogels with promising mechanical strength hold immense potential in the field of biomedical applications and soft actuators. However, the optical and mechanical properties of currently reported hydrogels usually suffer from limited solubility and dispersion of commonly used photothermal additives in hydrogels, thus restricting their practical implementations. Here,, a set of NIR-responsive shape memory hydrogels synthesized by polyaddition of diisocyanate-terminated poly(ethylene glycol), imidazolidinyl urea (IU), and p -benzoquinone dioxime (BQDO) is reported. The introduction of IU, a hydrogen bond reinforcing factor, significantly enhances the mechanical properties of the hydrogels, allowing for their tunable ranges of the ultimate tensile strength (0.4–2.5 MPa), elongation at break (210–450%), and Young's modulus (190–850 kPa). The unique hydrogels exhibit an intrinsic photothermal effect because of the covalently incorporated photothermal moiety (BQDO), and the photothermal supramolecular hydrogel shows controllable shape memory capabilities characterized by rapid recovery speed and high recovery ratio (>90%). This design provides new possibilities for applying shape memory hydrogels in the field of soft actuators.
研究领域:
生物材料学
·
高分子化学
·
生物医药工程
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高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2026
·
IF 5.4
Guoyi Yan,Mengyu Li,Dongyan Yan,Kaibin Zhou,Jingbo Han,Jiaxin Yuan,Can Yang,Shuyi Yan,Yange Xing,Mengyao Luo,Ruoling Jia,Kaikai Wang,Mingyuan Wu
A NIR-responsive nanosystem enabled on-demand release of Ag + . • The synergistic PTT/Ag⁺ therapy enhanced antibacterial and antibiofilm performance. • The nanosystem demonstrated high catalytic performance toward organic pollutants. The bacterial resistance induced by antibiotic abuse and bacterial biofilm barriers has constituted a major challenge in the field of global public health. To address this issue, a near-infrared (NIR)-responsive polydopamine-functionalized silver nanoparticle (PDA@Ag) antibacterial system was developed to achieve dual-function antibacterial and catalytic performance. Under NIR irradiation, polydopamine exhibited excellent photothermal conversion performance, enabling direct antibacterial through a mild photothermal therapy (PTT) while simultaneously triggering the precisely controlled release of Ag⁺ via NIR-responsive, thus achieving synergistic PTT/Ag⁺ antibacterial activity. In vitro experimental results demonstrated that the system exhibited significant antibacterial efficacy against S. aureus (97.4%) and E. coli (98.6%), and effectively disrupted bacterial biofilms. Furthermore, the strong adhesion property of the polydopamine matrix effectively prevented the aggregation of Ag NPs, ensuring catalytic stability and endowing PDA@Ag with a high capability of reducing 4-nitrophenol (4-NP), with a reaction rate constant of 0.029 min⁻¹ . Given that the systemic in vivo safety requires further comprehensive evaluation, the current NIR-responsive intelligent on-demand release nanoplatform developed in this study is primarily suited for localized/superficial bacterial infection therapy. Download: Download high-res image (156KB) Download: Download full-size image
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