Chemical Science
·
2024
·
IF 7.6
Wei-Xing Chen,Zi-Sheng Li,Harry W. T. Morgan,Cong-Cong Shu,Zhong-Ming Sun,John E. McGrady
We report here the synthesis and characterization of two endohedral Zintl-ion clusters, [Fe4Sn18]4− and [Fe4Pb18]4−, which contain rhombic Fe4 cores. The Fe–Fe bond lengths are all below 2.5 Å, distinctly shorter than in the corresponding Cu clusters, indicating the presence of Fe–Fe bonding. Subtle differences in the structure of the Fe4 core between the two clusters suggest that the change in tetrel element causes a change in electronic ground state, with a very short Fe–Fe bond length of 2.328 Å present across the diagonal of the rhombus in the lead case.
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JOURNAL OF MOLECULAR LIQUIDS
·
2024
·
IF 5.3
Huixiang Zhang,Yang Zhang,Fumin Xue,Hui Chen,Zhenguo Gao,Shichao Du,Yan Wang
Valsartan is an angiotensin II receptor antagonist used to treat hypertension. Crystals of valsartan were prepared and the stability of the valsartan (form E) at different solvents and temperatures was investigated. The solid-liquid equilibrium solubility of valsartan (form E) in twelve pure solvents was determined by a dynamic method at the temperature from 278.15 K to 323.15 K. Among the solvents used in the experiment, the solubility of valsartan (form E) was found to be highest in methanol and lowest in acetonitrile. In straight-chain alcohols, the solubility decreases with the increase of carbon chain length. The modified Apelblat model, λh model and NRTL model were used to correlate the solubility data. The thermodynamic properties of the mixing process such as Gibbs free energy, enthalpy and entropy were estimated by applying the NRTL model. The KAT-LSER model was adopted to explore solvent effects. Hirshfeld surface analysis and molecular electrostatic potential (ESP) were employed to visualize close contacts and charge distribution of valsartan and solvents. In addition, molecular dynamics (MD) simulation was performed to calculate intermolecular interactions between solute and solvent. Radial distribution function (RDF) and the mean square displacement (MSD) analyses were also carried out to explore molecular association and molecular diffusion.
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CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Yudong Song,Yang Zou,Qingquan Zhao,Xinjian Shi,Shengyan Yin,Zhenning Liu,Hang Sun
Continuous and dependable underwater motion monitoring and communication are crucial for ensuring the safety of swimming, divers and underwater workers. We have developed a coral-inspired piezoresistive electronic skin (Melamine sponge-poly(pyrrole)-polydimethylsiloxane, MS-ppy-PDMS e-skin) for motion monitoring and underwater communication. The microstructure of the coral-like poly(pyrrole) and the PDMS acting as “limestone” make MS-ppy-PDMS e-skin superhydrophobic, stable (up to 80,000 cycles and acid and alkali resistance), and sensitive over a wide pressure sensing range (1–2,000 kPa). Moreover, MS-ppy-PDMS e-skin exhibits remarkable breathability, photothermal antibacterial efficacy, and biocompatibility, thereby increasing the comfort of wear while maintaining its outstanding sensing functionality. MS-ppy-PDMS e-skin exhibited dependable electrical signals output in motion monitoring tests on land and underwater. Most crucially, the combination of underwater communication commands captured by MS-ppy-PDMS e-skin with a multilayer perceptron (MLP) neural network allows for rapid and precise analysis and recognition, achieving a 99.38% accuracy rate in identifying underwater communication commands. This enables the realization of intelligent perception function, and is expected to further advance the development of human brain-like cognitive systems. Overall, the coral bionic MS-ppy-PDMS e-skin demonstrates tremendous application potential in the fields of motion monitoring and underwater communication.
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CARBOHYDRATE POLYMERS
·
2024
·
IF 10.7
Shouyu Wu,Jiemei Ou,Shuyi Wang,Aiping Zheng,Fan Yang,Zidan Zhou,Xuanxuan Lu
The use of Pickering emulsions for biocatalysis is gaining increased attention. However, the extensive application is greatly limited due to the enzyme inactivation . Herein, a biocatalytic Pickering emulsion with high-performance utilizing cellulose nanocrystals immobilized lipases (CNCs-Lps) particles as stabilizer is advanced and applied for the synthesis of Vitamin E nicotinate . CNCs-Lps display high activity and reusability due to the construction of biocatalytic microreactor in the O/W emulsion system . The yield of vitamin E nicotinate ester reached up to 83 %. More importantly, the CNCs-Lps can be reused due to the similar principles to microreactors in Pickering emulsions . Reusability test showed that the CNCs-Lps could be recovered from the emulsion system by centrifugation and the yield of vitamin E nicotinate retains 78 % of initial value after five cycles, demonstrating overwhelming advantage than the fair counterpart with free lipases .
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RSC Advances
·
2024
·Vol. 14
·期 21
·15106-15111
·
IF 3.9
Weiyun Guo,Chaoyun Wu,Guanghui Li,Yonghui Wang,Shenghua He,Jihong Huang,Xueli Gao,Xiaoyue Yue
Glutathione (GSH) as an antioxidant greatly attenuates the reactive oxygen species (ROS) treatment strategy based on peroxidase-activity nanozymes. Therefore, nanozymes with multiple properties that generate ROS and further GSH-depletion functions would be of great benefit to improve antimicrobial efficacy. Herein, focusing on the green, safe and abundant functional prospects of metal–phenolic networks (MPNs) and the strong prospect of biomedical applications, we have synthesized copper tannic acid (CuTA) nanozymes with dual functional properties similar to peroxidase-like activity and GSH depletion. CuTA can catalyze the decomposition of H2O2 to hydroxyl radicals (˙OH). In addition, CuTA nanozymes can efficiently deplete available GSH, thus enhancing ROS-mediated antimicrobial therapy. The antibacterial results show that CuTA has an excellent antibacterial effect against E. coli.
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WATER RESEARCH
·
2024
·
IF 11.4
Zi-Bo Jing,Wen-Long Wang,Yu-Jia Nong,Lu Peng,Zi-Chen Yang,Bei Ye,Min-Yong Lee,Qian-Yuan Wu
Low-pressure mercury lamps emitting at 254 nm (UV254) are used widely for disinfection. However, subsequent exposure to visible light results in photoreactivation of treated bacteria. This study employed a krypton chloride excimer lamp emitting at 222 nm (UV222) to inactivate E. coli . UV222 and UV254 treatment had similar E. coli -inactivation kinetics. Upon subsequent irradiation with visible light, E. coli inactivated by UV254 was reactivated from 2.71-log to 4.75-log, whereas E. coli inactivated by UV222 showed negligible photoreactivation. UV222 treatment irreversibly broke DNA strands in the bacterium, whereas UV254 treatment primarily formed nucleobase dimers. Additionally, UV222 treatment caused cell membrane damage, resulting in wizened, pitted cells and permeability changes. The damage to the cell membrane was mainly due to the photolysis of proteins and lipids by UV222. Furthermore, the photolysis of proteins by UV222 destroyed enzymes, which blocked photoreactivation and dark repair. The multiple damages can be further evidenced by 4.0–61.1 times higher quantum yield in the photolysis of nucleobases and amino acids for UV222 than UV254. This study demonstrates that UV222 treatment damages multiple sites in bacteria, leading to their inactivation. Employing UV222 treatment as an alternative to UV254 could be viable for inhibiting microorganism photoreactivation in water and wastewater.
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ANIMAL REPRODUCTION SCIENCE
·
2025
·
IF 3.3
Chaoyue Cao,Xue Qin,Yiwen Sha,Haoqi Xiao,Zhenheng Lai,Yi Zheng,Rui Cai,Weijun Pang
Vitamin E (VE) is widely used as an antioxidant in boar semen preservation. Its low water solubility and limited bioavailability, however, compromise its functional efficacy during storage. To address these limitations, we developed a lecithin-stabilized vitamin E nanoemulsion (NE) to enhance its dispersibility and antioxidant efficacy. Semen from Duroc boars was diluted in Beltsville thawing solution (BTS) containing either 0.6 mM NE, 4 mM free VE, or no additive, and stored at 17 °C. Compared to VE and control groups, NE significantly enhanced sperm motility, preserved the structural integrity of the plasma and acrosomal membranes, and maintained mitochondrial function, while reducing oxidative stress and DNA fragmentation over a 7d storage period ( P < 0.01). Untargeted metabolomics revealed that NE supplementation regulated key pathways including unsaturated fatty acid metabolism and glutathione-related antioxidation. Artificial insemination (AI) trials involving 637 sows confirmed that NE-treated semen improved total and healthy piglet numbers per litter ( P < 0.05), without adverse effects. These findings suggest that NE provides an effective and practical strategy for enhancing boar semen preservation and reproductive outcomes in porcine production.
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BRAIN RESEARCH
·
2025
·
IF 2.6
Naizhu Wang,Jingkun Wu,Zhaofei Song,Hongbin Wang,Yan Zhao
Hypertension in the brain may lead to hypertensive intracerebral hemorrhage (HICH), a devastating disease. This study, grounded on bioinformatics insights, aims to investigate the functions of Selectin E (SELE) and forkhead box P1 (FOXP1) in the progression of HICH. Increased SELE expression was detected in the striatum of a mouse model of HICH generated via angiotensin II and L-NAME treatments. Knockdown of SELE alleviated hemorrhage, neutrophil infiltration, and blood–brain barrier (BBB) rupture in the mouse brain. FOXP1, poorly expressed in the HICH mice, was found to repress SELE transcription by binding to its promoter region. Overexpression of FOXP1 resulted in analogous alleviating effects in the HICH mice; however, the effects were abrogated by the additional SELE overexpression. In vitro , human brain microvascular endothelial cells (HBMECs) were treated with thrombin to generate a cellular model of ICH, followed by co-culture with HL-60 cell-derived neutrophils. The FOXP1 overexpression reduced the adhesion of neutrophils, and it alleviated HBMEC apoptosis and permeability while enhancing angiogenesis. Still, these effects were counteracted by the SELE upregulation. In conclusion, this study demonstrates that SELE upregulation upon FOXP1 loss is associated with neutrophil infiltration and BBB rupture in HICH.
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ChemistrySelect
·
2025
·Vol. 10
·期 32
·e02772
·
IF 2
Dan Zhao,Shunkai Zhang,Weili Yang,Cheng Xue,Guanglite Shen,Wenhui Zhang,Huixia Feng,Nali Chen,Lin Tan
Graphical Through the calculation based on the e-DLVO theory, investigate the aggregation situation of sulfonated phenolic resin in diverse aquatic environments. Plastic waste is widely recognized as a global environmental threat. Nanoplastics (NPs), derived from the degradation of macroplastics and microplastics, pose potential risks to human health. The aggregation behavior of NPs in aquatic systems is primarily governed by electrolyte concentration and pH. In this study, the aggregation behavior of NPs, represented by sulfonated lignin phenolic resin (SLPFR), was systematically investigated in aqueous solutions containing a series of monovalent and divalent electrolytes. Aggregation kinetics experiments, adsorption studies, material characterization, and extended-Derjaguin–Landau–Verwey–Overbeek (e-DLVO) theoretical calculations demonstrated that electrostatic interaction is the dominant force governing the aggregation of SLPFR NPs. Different electrolyte types alter the surface charge of NPs, consequently increasing the electrostatic repulsion and steric hindrance between particles. These findings provide significant insights for better assessing the aggregation of NPs in diverse aquatic environments and their associated environmental impacts and risks.
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BIOMACROMOLECULES
·
2015
·
IF 5.75
Menglin Wang,Jin Sun,Yinglei Zhai,He Lian,Cong Luo,Lin Li,Yuqian Du,Dong Zhang,Wenya Ding,Shuhong Qiu,Yuhai Liu,Longfa Kou,Xiangfei Han,Rongwu Xiang,Yongjun Wang,Zhonggui He
To improve the bioavailability of orally administered drugs, we synthesized a pH-sensitive polymer (poly(ethylene glycol)–poly(2-methyl-2-carboxyl-propylene carbonate)–vitamin E, mPEG–PCC–VE) attempting to integrate the advantages of enteric coating and P-glycoprotein (P-gp) inhibition. The aliphatic polycarbonate chain was functionalized with carboxyl groups and vitamin E via postpolymerization modification. Optimized by comparison and central composite design, mPEG113–PCC32–VE4 exhibited low critical micelle concentration of 1.7 × 10–6 mg/mL and high drug loading ability for tacrolimus (21.2% ± 2.7%, w/w). The pH-responsive profile was demonstrated by pH-dependent swelling and in vitro drug release. Less than 4.0% tacrolimus was released under simulated gastric fluid after 2.5 h, whereas an immediate release was observed under simulated intestinal fluid. The mPEG113–PCC32–VE4 micelles significantly increased the absorption of P-gp substrate tacrolimus in the whole intestine. The oral bioavailability of tacrolimus micelles was 6-fold higher than that of tacrolimus solution in rats. This enteric polymer therefore has the potential to become a useful nanoscale carrier for oral delivery of drugs.
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Journal of Integrative Neuroscience
·
2025
·Vol. 24
·期 7
·39656
·
IF 2.7
Guoying Dong,Yuxiao Liu,Huijun Liu,Chen Qiao,Xia Chen,Linxiao Wang
Background:Dyslipidemia during midlife represents a significant risk factor for neuropathological alterations associated with cognitive decline. Given the currently incurable nature of dementia, implementation of preventive strategies and early therapeutic interventions prior to disease progression are paramount. Emerging evidence suggests that hyperbaric oxygen (HBO) therapy exhibits neuroprotective properties in various neurological conditions. However, whether HBO treatment modulates lipid metabolism dysregulation and subsequent neurodegeneration remains unanswered. This investigation aimed to elucidate the therapeutic potential of HBO treatment in ameliorating cerebral dysfunction and metabolic perturbations using apolipoprotein E (ApoE)-deficient (ApoE-/-) mice.Methods:ApoE-/- mice received HBO treatment for 10 consecutive days, and then behavioral assessment tests were performed. Serum and brain tissue were collected to measure oxidative stress levels and inflammatory factors.Results:Compared with ApoE-/- group, cognitive declines was significantly reversed in mice of the ApoE-/-+HBO mice. The blood lipid profiles of ApoE-/- mice were also improved after HBO treatment, accompanied by a reduction in body weight. Moreover, HBO treatment was found to ameliorates neuronal injury and amyloid-β deposition in the hippocampus of ApoE-/- mice. Further studies have revealed that the benefits of HBO treatment occurred through the reduction of inflammatory factors and attenuation of oxidative stress.Conclusions:These findings indicate that HBO treatment effectively improves the intracerebral microenvironment of ApoE-/- mice, providing a novel regulatory mechanism of protection against dyslipidemia-associated brain deficits by HBO treatment.
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INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2025
·
IF 3.9
Hao Liu,Shiyang Yan,Wei Wang,Xin Shi,Luming Yang,Haibin Gu
Electronic skin (e-skin), an emerging class of flexible integrated electronic devices, is designed to replicate the multifaceted functionalities of human skin, playing a critical role in the realms of wearable technology and healthcare monitoring. Despite their potential, the existing e-skins often fall short in achieving the robust mechanical strength, multifunctionality, and biocompatibility necessary for real applications. Durability and aesthetic appeal are also highly valued. This study introduced an innovative, ultratough, multifunctional transparent leather-based e-skin that can address these challenges. By employing the natural microstructure of tanned goatskin as a substrate, this work created this e-skin with an interpenetrating network structure containing a cross-linked copolymer of acrylic acid (AA) and hydroxypropyl acrylate (HPA) and integrated a variety of functional fillers, including Zr-CQDs (zirconium-doped carbon quantum dots) for conductivity, curcumin for antibacterial properties, and the eutectic solvent comprised of ethylene glycol and choline dihydrogen citrate for antifreezing and moisturizing capabilities. This e-skin exhibited remarkable mechanical properties with a tensile strength of 11.92 MPa and exceptional toughness of 5.26 MJ/m3, alongside 70% light transmission, showcasing its transparency. Its multimodal sensing capabilities enabled precise monitoring of diverse environmental stimuli, including strain, temperature, humidity, and bioelectrical signals, representing a significant advancement in wearable sensor technology. This work not only breathes new life into traditional leather materials for contemporary applications but also paves the way for sustainable and functional e-skin innovations, pushing the boundaries of wearable technology.
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