Materials Today Bio
·
2025
·
IF 10.2
Gang Li,Pengqi Zhu,Caifang Gao,Ye Cai,Ru Feng,Jinghua Sun,Ruiping Zhang
Vitiligo is a depigmenting autoimmune disease driven by oxidative stress and immune-mediated melanocyte destruction. Current therapies are limited by poor drug permeability, systemic side effects, and insufficient efficacy. Herein, we developed a novel carbomer-based hydroxypropyl-β-cyclodextrin-encapsulated crisaborole/curcumin hydrogel (Cri/Cur@CD-Gel) for combinational transdermal intervention of vitiligo via dual antioxidant and anti-inflammatory pathways. Hydroxypropyl-β-cyclodextrin (HP-β-CD) inclusion complexation overcame the inherent hydrophobicity of crisaborole (Cri) and curcumin (Cur), significantly enhancing their aqueous solubility, stability, and transdermal permeability. Leveraging its skin-adhesive properties, the carbomer hydrogel matrix enhanced drug retention and enabled sustained release at lesion sites, thereby improving drug bioavailability. In vitro , Cri/Cur@CD, leveraging the solubilizing power of HP-β-CD, restored melanocyte viability under oxidative stress, scavenged ROS, normalized mitochondrial membrane potential, and elevated cAMP levels to enhance melanogenesis and tyrosinase activity. In vivo , Cri/Cur@CD-Gel achieved significant repigmentation in monobenzone-induced vitiligo mice, markedly reducing epidermal ROS, CD8+ T-cell infiltration, and inflammatory cytokines (TNF-α, IL-1β, and IL-6). This study demonstrates that the combination of HP-β-CD-based encapsulation and carbomer hydrogel delivery serves as a potential topical administration platform for co-delivering hydrophobic crisaborole and curcumin, and establishes a promising strategy to alleviate vitiligo, that concurrently addresses oxidative damage, inflammatory responses, and melanocyte regeneration.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Theranostics
·
2017
·
IF 8.766
Meng Li,Yijia Guan,Andong Zhao,Jinsong Ren,Xiaogang Qu
Development of sensitive detectors of Aβ aggregates and effective inhibitors of Aβ aggregation are of diagnostic importance and therapeutic implications for Alzheimer's disease (AD) treatment. Herein, a novel strategy has been presented by self-assembly of peptide conjugated Au nanorods (AuP) as multifunctional Aβ fibrillization detectors and inhibitors. Our design combines the unique high NIR absorption property of AuNRs with two known Aβ inhibitors, Aβ15-20 and polyoxometalates (POMs). The synthesized AuP can effectively inhibit Aβ aggregation and dissociate amyloid deposits with NIR irradiation both in buffer and in mice cerebrospinal fluid (CSF), and protect cells from Aβ-related toxicity upon NIR irradiation. In addition, with the shape and size-dependent optical properties, the nanorods can also act as effective diagnostic probes to sensitively detect the Aβ aggregates. This is the first report to integrate 3 segments, an Aβ-targeting element, a reporter and inhibitors, in one drug delivery system for AD treatment.
研究领域:
生物医学工程
·
神经科学
·
纳米医学
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF SEPARATION SCIENCE
·
2017
·Vol. 40
·期 7
·1556-1563
·
IF 2.557
Xinhong Yu,Xu Ling,Li Zou,Zilin Chen
A novel polymeric monolith column with a β-cyclodextrin-graphene composite was prepared for extraction of methyl jasmonate. A simple, sensitive, and effective polymeric monolith microextraction with high-performance liquid chromatography method has been presented for the determination. To carry out the best microextraction efficiency, several parameters such as sample flow rate, sample volume, and sample pH value were systematically optimized. In addition, the method validation showed a wide linear range of 5–2000 ng/mL, with a good linearity and low limits of detection for methyl jasmonate. The proposed method was successfully applied for the determination of methyl jasmonate in wintersweet flowers with recoveries of 90.67%. The result was confirmed by high-performance liquid chromatography with mass spectrometry.
研究领域:
分析化学
·
植物生理学
✓ 已验证
DOI
高影响因子
CHEMOSPHERE
·
2022
·
IF 8.943
Boyin Yan,Songxue Wang,Zhiquan Liu,Da Wang,Wenxin Shi,Fuyi Cui
In this work, the UV 254 /H 2 O 2 process was utilized to remove β-N-methylamino- l -alanine (BMAA), a kind of cyanobacteria neurotoxin, and the influence of reaction parameters and environmental factors on the degradation of BMAA has been systematically investigated. The results showed that BMAA could be effectively removed in the UV 254 /H 2 O 2 system compared to UV or H 2 O 2 alone and OH was confirmed as the main ROS to degrade BMAA. The degradation rate of BMAA increased first and then decreased with the increase of pH and the maximum k obs was 0.1545 min −1 obtained at pH 9. The removal of BMAA in the UV 254 /H 2 O 2 system was inhibited in actual water, while the degradation rate of BMAA in actual water could still exceed 90% by appropriately extending the reaction time. The decrease in the degradation efficiency of BMAA in actual water was primarily due to the ultraviolet light absorption and competition effects of NOM, and anions (Cl − and HCO 3 − ) would also inhibit the degradation of BMAA. Five by-products ([M − H] - = 118, 103, 88, 87 and 59) were identified in this study and the degradation pathways of BMAA were proposed. The production of by-products was attributed to the fracture of the C–N bond and hydroxylation reaction. This study is worthwhile to deepen the understanding of the degradation mechanism of BMAA in the UV 254 /H 2 O 2 system.
研究领域:
环境科学
·
毒理学
✓ 已验证
DOI
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2020
·
IF 7.1
Xiaoqing Cui,Bo Yang,Shen Zhao,Xuewei Li,Meng Qiao,Ran Mao,Yan Wang,Xu Zhao
In this paper, a sensitive and selective electrochemical sensor was constructed for nickel (II) detection by employing the electrode material of zeolitic imidazolate framework-8@dimethylglyoxime/β-cyclodextrin/reduced graphene oxide (ZIF-8@DMG/β-CD/RGO). The material was characterized and analyzed by Fourier transform infrared (FT-IR), X-ray diffraction (XRD), Transmission electron microscopy (TEM) and Nitrogen adsorption-desorption isotherms in detail. In these composite, ZIF-8 served as the supporting material of DMG which was the selective complexing agent to Ni (II), RGO employed conductivity while β-CD prevented the aggregation of RGO sheets. With these features, the sensor showed a wide linear range of 0.01–1.0 μM and a low detection limit of 0.005 μM (S/N = 3). Interferences of diethanol, citric acid , humic acid, Triton X-100 and some common metal ions can be ignored to some extent. Finally, the sensor was applied to Ni (II) detection in real water sample.
研究领域:
分析化学
·
环境监测
·
纳米材料
·
电化学传感
·
重金属检测
✓ 已验证
DOI
高影响因子
JOURNAL OF COORDINATION CHEMISTRY
·
2020
·
IF 1.41
Kun Lu,Zihan Zhu,Lin Peng,Hai Fu,Xinlong Wang,Enbo Wang
An unusual metal-organic framework, {H[Ag(I)L][Mo(VI)4O13]}n (1) (L=(4-((1H-1,2,4-triazol-1-yl)methyl)phenyl)methanol)), has been obtained under ionothermal conditions. According to the single-crystal X-ray diffraction analysis, 1 is a new 3-D framework based on β-[Mo8O26]4− type polymolybdate anions with two kinds of channels (A and B) along the b-axes and c-axes in the framework. The neighboring inorganic Mo8-Ag chains are linked by the organic ligands through the Ag centers resulting in 2-D layers. These adjacent 2-D layers extend into a 3-D framework through Ag1 nodes and β-[Mo8O26]4− anions, respectively, resulting in a topological symbol (64 · 82)2(64 · 82). In addition, the gas adsorption, proton conduction and luminescent properties of 1 are also discussed in detail. Moreover, the electrochemical impedance spectroscopy (EIS) measurements show a conductivity (1.9 × 10−4 S cm−1 at 65 °C and 95% relative humidity (RH)), with an activation energy of 0.41 eV for 1. The mechanism of proton conduction for 1 is proved to be the vehicular mechanism.
研究领域:
材料科学
·
化学
✓ 已验证
DOI
高影响因子
ANALYTICAL CHEMISTRY
·
2025
·
IF 6.7
Jia Chen,Xuliang Ouyang,Chenxiao Yu,Juan Xiang
Low-mass soluble β-amyloid oligomers (LSAβO) are critical Alzheimer’s disease (AD) biomarkers with significant diagnostic and therapeutic potential. However, their application in early screening and detection is limited by the reliance on complex analytical instruments and procedures. To address this, we developed a visual sensing platform for LSAβO detection using a functionalized pNIPAM-DNA hydrogel. Exploiting the temperature-responsive nature of pNIPAM, the hydrogel selectively incorporates and enriches LSAβO from solution via temperature-induced expansion and contraction. LSAβO binding to aptamers on the hydrogel triggers the formation of G-quadruplex DNAzymes, which catalyze the oxidation of 3,3′,5,5′-tetramethylbenzidine to generate a visible colorimetric signal. The hydrogel’s small pore size further enhances selectivity by excluding larger oligomers during real sample analysis. This sensor exhibits a linear detection range of 0.1–7.5 nM for LSAβO and a detection limit of 50 pM. Combining LSAβO enrichment and size exclusion, this functionalized pNIPAM-DNA hydrogel platform provides a cost-effective, highly sensitive, selective, and high-throughput approach for preliminary LSAβO screening and detection.
研究领域:
生物化学
·
医学诊断
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CARBOHYDRATE POLYMERS
·
2019
·
IF 6.044
Yao Hu,Chao Qiu,Zhengyu Jin,Yang Qin,Chen Zhan,Xueming Xu,Jinpeng Wang
Stable Pickering emulsions were prepared by using hybrid β-cyclodextrin/short linear glucan nanoparticles (β-CD/SLG NPs). The β-CD/SLG NPs displayed spherical shape and with an average size at around 60 nm. Newly formed SLG-β-CD structure in the nanoparticles was thought the main reason for the improved thermal stability, alleviated aggregation, and improved dispersity in aqueous systems. Depending on the contact angle and zeta-potential results, unique emulsifying mechanism of β-CD/SLG NPs was existed. The formation of inclusion complex between β-CD and oil molecules accelerated the adsorption of the whole nanoparticles at the oil-water interface, while the swelling of SLG contributed to the long-term stability (6 months) of emulsions. Once the hybrid ratio of β-CD/SLG NPs reached saturation (1:1), excess β-CD led to co-emulsifying effect of both the hybrid regions and easily dissociated β-CD regions. These hybrid β-CD/SLG NPs showed superiority with great potential in applications to the food, cosmetic, and pharmaceutical industries.
研究领域:
食品科学
·
材料科学
·
化学工程
✓ 已验证
DOI
高影响因子
RSC Advances
·
2014
·Vol. 4
·期 69
·36675-36681
·
IF 3.708
Jiangang Gao,Shaobo Yu,Benpei Zheng,Qingping Song,Xingxing Peng,Ying Lin,Gang Zou,Qijin Zhang
A triblock PEG-based polymer (CP1113) with a clear ABA structure was synthesized from 1,13-tridecanedioic acid (DA13) and mono-methoxy-poly(ethylene glycol) (MePEG) via condensation reaction. An inclusion complex (IC1113) with β-cyclodextrin (CD) was prepared by co-precipitation and the IC formation was confirmed by transmittance determination with a UV-Vis spectrometer. Fourier transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD), and thermogravimetry analysis (TGA) were adopted to characterize IC1113 and the experimental data showed that a channel-type polypseudorotaxane was formed. For further investigating the inclusion behaviors, 1H-NMR spectroscopy was used to determine the molar ratio between CP1113 and β-CD and 2D ROSEY spectra were recorded to elucidate the IC formation mechanism. The results revealed that β-CD threaded onto the polymer main chain at a molar ratio of 7.8 : 1 and the molar ratio of EG segments to β-CD in IC1113 was ca. 8.28 : 1. It was concluded that β-CD accommodated both the methylene and the PEG segments and herein hydrophobic and hydrogen-bonds interactions played the most important roles with a hydrophobic stabilizing and hydrogen-bond inducing effect, which “amplified” the hydrophobic interaction between β-CD and the methylene segment along the hydrophilic PEG segments.
研究领域:
材料科学
·
化学
✓ 已验证
DOI
高影响因子
Journal of the Iranian Chemical Society
·
2017
·Vol. 14
·期 9
·2017-2022
·
IF 1.407
Qin Xingxiu,Bakheet Almojtaba AbdAlkhalig Ahmed,Zhu Xiashi
Fe 3 O 4 @ionic liquids β-cyclodextrin polymer(Fe 3 O 4 @mono-6-deoxy-6-(1-ethyl-imidazolium)-β-cyclodextrin iodide polymer, Fe 3 O 4 @ILs-β-CDCP) was prepared. Magnetic solid phase extraction coupled with high-performance liquid chromatography for the separation/analysis of congo red (CR) in water and drysaltery was established. Fe 3 O 4 @ILs-β-CDCP showed a higher adsorption capacity toward CR. CR was adsorbed rapidly by Fe 3 O 4 @ILs-β-CDCP (adsorption efficiency: 95%) and eluted by ethanol (elution efficiency: 96%) at room temperature. Under the optimal conditions, preconcentration factor of the proposed method was 20-fold. The linear range, correlation coefficient ( R
2 ), detection limit (DL) and relative standard deviation were found to be 0.005–100.00 µg mL −1 , 0.9910, 1.8 g L −1 and 0.61% ( n = 3, c = 5.00 µg mL −1 ), respectively. The adsorption mechanism of CR on Fe 3 O 4 @ILs-β-CDCP was studied through the FTIR analysis. The accuracy of the developed method was confirmed by spiking city water, lake water, pond water and drysaltery. Fe 3 O 4 @ILs-β-CDCP can be used repeatedly for 10 times. This proposed method had been successfully applied to the determination of CR in real samples.
研究领域:
分析化学
·
环境科学
✓ 已验证
DOI
高影响因子
RENEWABLE ENERGY
·
2025
·
IF 9.1
Yingfu Tian,Tianliang Lu,Hongjin Qu,Xiaomei Yang,Lipeng Zhou
Efficient conversion of ethyl levulinate (EL) in high concentration to γ-valerolactone (GVL) at moderate temperature via catalytic transfer hydrogenation strategy is highly desirable. In this work, hydrothermally synthesized Sn-β zeolite with high Sn content was employed as a catalyst to realize this aim. Fully crystallized Sn-β zeolite with high Sn content ( n Si / n Sn = 60) was successfully synthesized within 12 days using MgCl 2 as a promoter. The synthesized zeolites were characterized by XRD, SEM, UV-vis spectroscopy, FT-IR spectroscopy and XPS. The L acid density of Mg-Sn-β-60-12d increased to 90 μmol g −1 compared to Mg-Sn-β-100-7d (56 μmol g −1 ). 92% yield of GVL was achieved on Mg-Sn-β-60-12d using high concentration of EL (1.2 mol L –1 ) as reactant at 130 o C for 8 h. The performance of Mg-Sn-β is better than that of Sn-β with same n Si / n Sn . The reaction mechanism over Mg-Sn-β was discussed. In addition, Mg-Sn-β-60-12d showed excellent stability and reusability during five runs.
研究领域:
化学工程
·
催化材料科学
✓ 已验证
产品关联
DOI
高影响因子
CHINESE JOURNAL OF POLYMER SCIENCE
·
2019
·Vol. 37
·期 7
·664-673
·
IF 2.804
Liu Ya-Di,Zhang Qiang,Yu Xin-Hong,Liu Jian-Gang,Han Yan-Chun
For poly(9,9-dioctylfuorene) (PFO), β phase (coplanar conformation with the intra-chain torsion angle of 165°) has a greater conjugation length and higher degree of order compared to those of α phase, which favors charge carrier transport. However, the highest content of β phase obtained so far is 45%. We propose to increase the content of β phase by promoting the solution aggregation of PFO molecules and extending film-forming time. For this purpose, 1,8-diiodooctane (DIO) is added to PFO o -xylene solution, which enhances the interaction of PFO chains and improves the planarity of PFO backbone, resulting in the formation of ordered aggregation. The aggregates act as nucleation centers to promote the formation of β phase. The content of β phase increases with increasing DIO concentration and reaches a platform of 39% as DIO is more than 4 vol%. Furthermore, the film is kept in a sealed environment with o -xylene atmosphere for 3 h, thus the PFO molecules have enough time to diffuse to the crystallization front and achieve disorder-order transition. As a result, the crystallinity of PFO is improved significantly and the content of β phase increases to 52%, reaching the highest value reported so far.
研究领域:
高分子化学
·
材料科学
·
凝聚态物理
·
纳米技术
·
光电材料
·
有机电子学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）