ACS Sustainable Chemistry & Engineering
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2023
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IF 8.4
Runran Ma,Lizhu Fu,Nan Long,Haipeng Guo,Yujiao Hou,Ying Li,Peng Li,Jiabo Wang,Lidong Zhou,Weijun Kong
In this work, a novel ratiometric fluorescent nanosensor by coupling mesoporous silica spheres-coated nitrogen-doped carbon dots (N-CDs@SiO2) and bovine serum albumin-stabilized gold nanoclusters (BSA-AuNCs) was developed for sensitive detection of glyphosate. BSA-AuNCs nanocomposites were covalently connected onto the surface of amino-functionalized N-CDs@SiO2 nanospheres, causing the core-satellite probes with two fluorescence emissions at 436 and 651 nm, respectively, under a single excitation of 360 nm. The N-CDs@SiO2@BSA-AuNCs “signal on–off–on” ratiometric fluorescent probes could realize highly selective differentiation and accurate detection of glyphosate based on the fluorescence quenching of Cu2+ on BSA-AuNCs and glyphosate-induced fluorescence recovery due to the strong complexation of glyphosate toward Cu2+. The developed ratiometric fluorescent nanosensor exhibited excellent selectivity to glyphosate, wide detectability in a concentration range of 5–100 ng/mL, high sensitivity with a low detection limit of 3.4 ng/mL, as well as fascinating reliability and practicability in real malt samples with recoveries of 94.81–101.61%. This study provides a universal platform for versatile sensing of more trace analytes in complex matrices and can be extended for wide application in the environment and food safety fields.
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JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY
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2023
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IF 2.2
Yu Zhang,Jiazhe Kuang,Bin Li,Yuanzhu Mi,Ying Yang,Xuening Feng
In this work, a PAMAM@SiO2 demulsifier was synthesized by the reaction of a hyperbranched poly (amido amine) (PAMAM) and KH570 modified SiO2. The structure, morphology and composition of PAMAM@SiO2 were characterized by FT-IR, SEM and EDS. The effect of the concentration of PAMAM@SiO2, salinity and temperature on the demulsification performance was systematically studied. The results showed that the transmittance of aqueous phase after demulsification could reach as high as 92.1% at optimal conditions, and corresponding oil removal rate was 99.53%. Interfacial activity, three-phase contact angle, self-assembly of interfacial film and dynamic interfacial tension were investigated to explore the demulsification mechanism. Also, the aggregation process of oil droplets in emulsion was observed with a microscope. It indicates that the PAMAM@SiO2 demulsifier has a potential application in the treatment process of oily wastewater.
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Journal of Materials Chemistry B
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2023
·Vol. 11
·期 15
·3453-3472
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IF 7
Fan Xu,Minghua Li,Zujun Que,Mingliang Su,Wang Yao,Yu Zhang,Bin Luo,Yan Li,Zhanxia Zhang,Jianhui Tian
Combining chemotherapy and immunotherapy is a promising strategy for the treatment of non-small cell lung cancer (NSCLC) metastasis. However, platinum-based chemotherapeutics and immune checkpoint blockade-based cancer immunotherapy have toxic side effects and limitations. Ursolic acid (UA) and astragaloside IV (AS-IV) are natural compounds with anticancer activity sourced from Traditional Chinese medicine (TCM). However, their poor water solubilities and targeted deletions limit their medicinal value. In this study, we fabricated hyaluronic acid (HA)-modified UA/(AS-IV)-loaded polydopamine (PDA) nanomedicine (UA/(AS-IV)@PDA-HA) with a high yield at a low cost via simple synthesis. This represents a novel multifunctional nanomedicine that combines chemotherapy, photothermal therapy (PTT), and immunotherapy with an active tumor-targeting ability. The as-prepared nanomedicine not only increased the aqueous solubilities of UA and AS-IV, but also improved their active targeting abilities. HA binds specifically to the overexpressed cluster of differentiation 44 (CD44) on the surface of most cancer cells, thereby improving drug targeting. While evaluating the anticancer effect of UA/(AS-IV)@PDA-HA in vitro and in vivo, the PDA nanodelivery system significantly improved UA-mediated cytotoxicity and anti-metastatic ability against NSCLC cells. In addition, the system also improved the AS-IV-mediated self-immune response of tumor-related antigens, which further inhibited the growth and distant metastasis of NSCLC. Further, PDA nanomaterial-mediated PTT inhibited tumor growth substantially. UA/(AS-IV)@PDA-HA not only significantly eradicated the primary tumor but also strongly inhibited the distant metastasis of NSCLC in vitro and in vivo. Thus, it has immense potential for development as an efficient anti-metastatic agent for NSCLC.
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Frontiers in Bioengineering and Biotechnology
·
2023
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IF 5.7
Xiong Junfeng,Zhang Junkai,Zhong Yukun,Song Xiaoxia,Wang Haoying,Cheang U Kei
Ultraviolet lithography is a very promising technology used for the batch fabrication of biomedical microswimmers. However, creating microswimmers that can swim at low Reynolds number using biocompatible materials while retaining strong magnetic properties and excellent biomedical functionality is a great challenge. Most of the previously reported biomedical microswimmers possess either strong magnetic properties by using non-biocompatible nickel coating or good biocompatibility by using iron oxide particle-embedded hydrogel with weak magnetism, but not both. Alternatively, iron oxide nanoparticles can be coated on the surface of microswimmers to improve magnetic properties; however, this method limited the usability of the microswimmers’ surfaces. To address these shortcomings, this work utilized an in situ synthesis technique to generate high magnetic content inside hydrogel-based achiral planar microswimmers while leaving their surfaces free to be functionalized for SERS detection. The hydrogel matrices of the magnetically actuated hydrogel-based microswimmers were first prepared by ultraviolet lithography. Then, the high concentration of iron oxide was achieved through multiple continuous in situ coprecipitation cycles. Finally, the SERS detection capability of magnetically actuated hydrogel-based microswimmers was enabled by uniformly growing silver nanoparticles on the surface of the microswimmers. In the motion control tests, the microswimmers showed a high swimming efficiency, high step-out frequency, and consistent synchronized motion. Furthermore, the magnetically actuated hydrogel-based microswimmers were able to improve the detection efficiency of analytes under magnetic guidance.
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APPLIED CATALYSIS A-GENERAL
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2023
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IF 5.5
Huifang Liu,Chengpeng Liu,Ni Zhen,Jing Dong,Yingnan Chi,Changwen Hu
Recently, Pickering emulsions provide a green and efficient solution for interfacial catalysis. However, in an emulsion system the separation of products and the recycle of catalysts rely on time- and energy-consuming centrifugation and filtration. Herein, a straightforward emulsion assisted assembly strategy has been developed to fabricate amphiphilic polyoxoniobates (PONbs), [C n H 2n+1 N(CH 3 ) 3 ] 6 KHNb 6 O 19 /SiO 2 (C n -Nb 6 /SiO 2 ; n = 14, 16, and 18). The honeycomb-like C 16 -Nb 6 /SiO 2 composite not only can form stable Pickering emulsion in the n-octane/water system but also can effectively catalyze oxidative desulfurization under mild conditions. Notably, after the reaction, the oil phase and the emulsion phase were automatically separated: the clean oil was collected by decantation, while the recycled emulsion was directly used for the next run. Moreover, C 16 -Nb 6 /SiO 2 is highly robust and can be consecutively used for up to eleven cycles with negligible loss of its catalytic activity.
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COLLOIDS AND SURFACES B-BIOINTERFACES
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2023
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IF 5.8
Cijun Shuai,Xuan Chen,Chongxian He,Min Chen,Shuping Peng,Wenjing Yang
Ascorbic acid (AA) is a promising antitumor agent, yet its autooxidation is too slow which constrains the further application. Fortunately, the autoxidation process can be accelerated by transition metal catalysts , especially Fe 3+ ions. In this study, AA was loaded to Fe-doped mesoporous silica (designated as [email protected] 2 ), which was introduced into poly- L -lactic acid (PLLA) and then prepared into a scaffold. Mechanistically, [email protected] 2 degraded in acidic tumor microenvironment because excessive H + substituted Fe atoms in the iron silicate framework, releasing Fe 3+ and AA. The Fe 3+ boosted the pro-oxidation reaction of AA, generating numerous hydrogen peroxide (H 2 O 2 ) and Fe 2+ . Then, Fe 2+ reacted with H 2 O 2 to initiate Fenton reactions favoring hydroxyl radical generation, triggering oxidative damage on tumor cells to implement tumor-specific therapy. Results showed that the release amount of AA in acidic solution was about 3 times higher than that in neutral solution, which was attributed to the pH-dependency of the degradation of [email protected] 2 in scaffold. Furthermore, the scaffold generated numerous ascorbate radical intermediate and increased the H 2 O 2 concentration by 120.2%, demonstrating that Fe 3+ remarkably accelerated the oxidation rate of AA. Cell experimental results showed that the scaffold caused massive apoptosis of tumor cells, while no obvious cytotoxicity to normal cells, confirming the antitumor specificity of scaffold. This work paves a promising way to construct a biodegradable and catalytic scaffold, featuring effective tumor-specific therapy.
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TALANTA
·
2023
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IF 6.1
Xuan Ma,Yue Wang,Wenting Wang,Jake Heinlein,Lisa D. Pfefferle,Xuemeng Tian
In this study, a facile method has been developed to synthesize a novel type of porous magnetic molecularly imprinted polymers (Fe 3 O 4 -MER-MMIPs) for the selective adsorption and removal of meropenem. The Fe 3 O 4 -MER-MMIPs, with abundant functional groups and sufficient magnetism for easy separation, are prepared in aqueous solutions. The porous carriers reduce the overall mass of the MMIPs, greatly improving their adsorption capacity per unit mass and optimizing the overall value of the adsorbents. The green preparation conditions, adsorption performance, and physical and chemical properties of Fe 3 O 4 -MER-MMIPs have been carefully studied. The developed submicron materials exhibit a homogeneous morphology, satisfactory superparamagnetism (60 emu g −1 ), large adsorption capacity (11.49 mg g −1 ), quick adsorption kinetics (40 min), and good practical implementation in human serum and environmental water. Finally, the protocol developed in this work delivers a green and feasible method for synthesizing highly efficient adsorbents for the specific adsorption and removal of other antibiotics as well.
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Journal of Materials Chemistry C
·
2023
·Vol. 11
·期 14
·4634-4644
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IF 6.4
Yue Jian,Tianliang Xie,Litao Han,Dongxing Kou,Wenhui Zhou,Zhengji Zhou,Shengjie Yuan,Yuena Meng,Yafang Qi,Sixin Wu
As a promising absorber material for thin film solar cells, the highest reported power conversion efficiency (PCE) of Cu2ZnSn(S,Se)4 (CZTSSe) is still far from the detailed balance limit of efficiency due to the large VOC deficit. Back contact engineering plays an important role in promoting the CZTSSe solar cell towards realizing high PCE. In this study, a MoO3-modified layer with the highest oxidation state 6+ and better thermal stability was in situ introduced by spin-coating Na2S aqueous solution on the Mo electrode. The results demonstrate that the Na2S layer at the rear contact provides more Na to diffuse into the absorber, thus improving the crystallinity of the film and the quality of the p–n heterojunction, and the carrier collection in the neutral region and at the front interface of the devices is enhanced. The formation of the MoO3 layer can also inhibit the decomposition reaction between Mo and CZTSSe, which minimizes the secondary phases and voids, and improves the quality of the back interface. Moreover, the band alignment and interfacial barrier at the back contact were modified by the MoO3 layer, resulting in better carrier collection and the reduction of photogenerated carrier recombination. By optimizing the Na2S (MoO3) layer, the average PCE of the CZTSSe solar cell increased to 12.48% from 10.22% with the large VOC increments of 60 mV and FF increments of 5%, and the best performance was achieved, with an active area efficiency of 12.74% without the anti-reflection coating layer.
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JOURNAL OF FOOD SCIENCE
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2023
·Vol. 88
·期 5
·2009-2022
·
IF 3.9
Wenying Zou,Junjun Wang,Siyi Yang,Yue Tang,Xiaojuan Niu,Yuangen Wu
Most colorimetric methods based on nanozymes need to have excellent performance under acidic condition, so they are currently facing some challenges in the field of food hazard detection. Herein, a facile and rapid colorimetric sensor for kanamycin (KAN) detection in foods under neutral condition has been designed using the peroxidase-mimic activity of porous nanozyme like Co 3 O 4 nanodisk. Further investigations showed that the interaction mechanism between porous Co 3 O 4 nanodisk and substrates belongs to a ping–pong model, and the inhibition type of KAN on the peroxidase-mimic activity is noncompetitive inhibition. The constructed sensor has good sensitivity for KAN with the limit of 57 nM, and the color changes can be discerned visually when KAN exceeds 0.5 µM. Besides, the colorimetric sensor obtains excellent recovery results in chicken serum, milk, honey, and pork, which shows that the proposed sensing strategy can provide a rapid and convenient detection method for KAN in foods under neutral condition. Practical Application The established sensing strategy can rapidly distinguish whether KAN residue exceeds the permissible level within 10 min, which meets the requirement for on-site monitoring of antibiotics in foods, and also open up a new idea for other hazards detection under neutral condition.
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Materials Today Bio
·
2023
·
IF 8.2
Qing Zhang,Mengyu Xin,Shuang Yang,Qiuyu Wu,Xi Xiang,Tianqi Wang,Wen Zhong,Marco N. Helder,Richard T. Jaspers,Janak Lal Pathak,Yin Xiao
Targeting macrophages to regulate the immune microenvironment is a new strategy for bone regeneration with nano-drugs. Nano-drugs have achieved surprising anti-inflammatory and bone-regenerative effects, however, their underlying mechanisms in macrophages remain to be clarified. Macrophage polarization, immunomodulation, and osteogenesis are governed by autophagy. Rapamycin, an autophagy inducer, has shown promising results in bone regeneration, but high dose-mediated cytotoxicity and low bioavailability hinder its clinical application. This study aimed to develop rapamycin-loaded virus-like hollow silica nanoparticles ( [email protected] ) which are easily phagocytosed by macrophages and translocated to lysosomes. [email protected] induced macrophage autophagy, promoted M2 polarization, and alleviated the degree of M1 polarization as indicated by the downregulation of inflammatory factors IL-6, IL-1β, TNF-α, and iNOS, and upregulation of anti-inflammatory factors CD163, CD206, IL-1ra, IL-10, and TGF-β. These effects were nullified by cytochalasin B-induced inhibition of [email protected] uptake in macrophages. The conditioned medium (CM) collected from [email protected] macrophages promoted osteogenic differentiation of mouse bone marrow mesenchymal stromal cells (mBMSCs). In a mouse calvaria defect model, free rapamycin treatment was inhibited, but [email protected] robustly promoted bone defect healing. In conclusion, silica nanocarrier-mediated intracellular rapamycin delivery to macrophages effectively triggers autophagy-mediated M2 macrophage polarization, further enhancing bone regeneration by triggering osteogenic differentiation of mBMSCs.
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FOOD HYDROCOLLOIDS
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2023
·
IF 10.7
Shuhan Feng,Jianyong Yi,Youchuan Ma,Jinfeng Bi
Gelation of amidated pectin in the acid environment with the absence of calcium has been found, but the mechanism and gel properties are still not fully understood, especially the role of amide groups. In this study, a series of pectins with different degrees of amidation (DA) were prepared by ammonia reaction, and their structural characteristics including neutral sugar contents, molecular weight contribution, and molecular morphology were fully identified. Acid-induced hydrogels with various DA were then obtained to investigate the impact of amino groups on pectin gelation. Results showed that the higher the DA, the faster the gelation process, and the more stable the gel network. Dynamic rheological and pH stability tests confirmed the essential roles of low pH value (<3.5) and high DA (>49.76%) on the amidated pectin gelation without calcium. Hydrogen bonds were identified as the main interaction for the amidated gel mechanism and enabled the thermo-reversible properties of amidated gels. High content of amide groups allowed the formation of a denser gel network structure with greater mechanical strength, stronger thermo-reversibility, and higher pH stability.
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TALANTA
·
2023
·
IF 6.1
Haodong Cui,Wenxing Song,Xiaoling Ru,Wen Fu,Ling Ji,Wenhua Zhou,Zhen Zhao,Guangbo Qu,Xue-Feng Yu,Guibin Jiang
The ongoing outbreak of the novel coronavirus disease 2019 (COVID-19) draws worldwide concerns due to its long incubation period and strong infectivity. Although RT-PCR-based methods are being widely applied for clinical diagnosis, timely and accurate diagnosis towards COVID-19 causing virus, the SARS-CoV-2, is still limited due to labor-intensive and time-consuming operations. Herein, we report a new viral RNA extraction method based on poly-(amino ester) with carboxyl group (PC)-coated magnetic nanoparticles (pcMNPs) for the sensitive detection of SARS-CoV-2. This method combines the lysis and binding steps into one step, and refines multiple washing steps into one step, giving a turnaround time of less than 9 min. Furthermore, the extracted pcMNP-RNA complexes can be directly introduced into subsequent RT-PCR reactions without elution. This simplified viral RNA method could be well adapted in fast manual and automated high-throughput nucleic acids extraction protocols suitable for different scenarios. A high sensitivity down to 100 copies/mL and a linear correlation between 100 and 10 6 copies/mL of SARS-CoV-2 pseudovirus particles are achieved in both protocols. Benefitting from the simplicity and excellent performances, this new method can dramatically improve the efficiency and reduce operational requirements for the early clinical diagnosis and large-scale SARS-CoV-2 nucleic acid screening.
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