CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 12.5
Chao Liu,Yanqiao Ren,Can Hong,Xuyu Li,Mengqing Guo,Le Zhao,Yan Liu,Chuansheng Zheng,Xiangliang Yang,Yanbing Zhao
Transarterial chemoembolization (TACE) is a first-line clinical therapy on hepatocellular carcinoma (HCC). However, the presence of TACE resistance leads to less than satisfactory treatment outcomes and prognosis. By genomic analysis on the 147 HCC patients in the Gene Expression Omnibus (GEO) database, in the present work, the key role of glycolysis on hypoxia and immunosuppressive tumor microenvironment (TME) was well verified, contributing to the development of TACE resistance. Aiming to the issue, radiofrequency (RF)-responsive liposome hydrogels (3BP-TSLIP) was successfully prepared by thin-film hydration of temperature sensitive polymers (DSPE- p NIPAM), cationic lipid, the glycolytic inhibitor 3-bromopyruvate (3BP) and other phospholipids. 3BP-TSLIP showed temperature sensitive sol-gel phase transition at nearby body temperature, allowing to a sufficient embolization by intubating super-selectively into tumor-feeding arteries. By synergizing with RF irradiation, 3BP-TSLIP inhibited tumor glycolysis, reduced lactic acid (LA) efflux, and alleviated hypoxia. It was attributed to the protection of TSLIP to 3BP from hydrolysis and its unique RF-heating effect, facilitating to glycolysis suppression of 3BP by RF-thermo-sensitization. In the VX2 tumor-bearing rabbit model, 3BP-TSLIP showed favorable embolization to tumor-feeding arteries, and the enhanced antitumor efficacy by co-treating with RF irradiation. 3BP-TSLIP can serve as RF responsive embolic agent for opening a new avenue to overcome TACE resistance.
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DOI
高影响因子
Applied Sciences-Basel
·
2025
·Vol. 15
·期 13
·7318
·
IF 2.5
Jiawei Cui,Yan Li,Ming Yan
D-allulose is a rare sugar with promising applications in food and health industries, owing to its low caloric value and multiple health benefits. In this study, we systematically investigated a thermostable D-allulose 3-epimerase (TcDAEase) fromThermogemmatispora carboxidivoransfor food-compatible continuous production. The enzyme exhibited remarkable thermostability, with over 70% activity retained at 80 °C, and showed broad pH tolerance across the range of 8.0 to 13.0. Notably, TcDAEase exhibited high catalytic activity toward D-allulose and D-fructose even without the addition of metal ions. Moreover, food-grade Mg2+was identified as enhancing enzyme activity by 14.3%, thus ensuring compliance with Generally Recognized as Safe (GRAS) standards for food applications. To improve industrial applicability, the enzyme was immobilized using a chitosan-diatomaceous earth (DE) matrix via three-step adsorption–crosslinking–embedding strategy. The immobilized TcDAEase achieved 48.7% ± 2.4% activity recovery and retained 90.3% ± 1.5% activity over seven reaction cycles. Furthermore, continuous production of D-allulose was realized in a packed-bed reactor, operating stably at 60 °C, pH 8.0 and 5 mM Mg2+for 150 days, producing 756 kg of D-allulose with a conversion yield exceeding 89.7% of the theoretical maximum. Overall, this study provides a feasible strategy for the continuous and efficient production of high-value-added D-allulose in the food industry.
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高影响因子
Science China-Life Sciences
·
2025
·
IF 9.5
Feng Yue,Lin Zishen,Wang Haoran,Men Zhaoyue,Shen Jiakun,Ma Xi
Deoxynivalenol (DON) is a prevalent mycotoxin in animal feed that particularly impacts weaned piglets, causing liver damage, growth retardation, and posing significant public health risks. However, the precise mechanisms underlying DON-induced liver damage and optimal treatment approaches remain unclear. The pregnane X receptor (PXR) holds a pivotal position in hepatic xenobiotic elimination and drug metabolism. This research aimed to explore the involvement of PXR in DON-induced liver injury and evaluate the potential of the PXR agonist, 3-indolepropionic acid (IPA), to alleviate liver damage and associated diarrhea in weaned piglets under practical farming conditions. The results demonstrated that DON initiates p53-mediated hepatocyte apoptosis in weaned piglets. RNA-seq and hepatocyte-specific PXR knockout (PXR-HKO) mice revealed PXR’s regulatory role in DON-induced hepatocyte apoptosis. IPA reduces DON-induced hepatocyte apoptosis in piglets, mice, and hepatocyte cell lines by enhancing PXR expression and facilitating nuclear translocation. Furthermore, AlphaFold3 predictions and Co-IP assays demonstrate that DON diminishes PXR-p53 binding, thereby amplifying p53-mediated apoptotic transactivation. In conclusion, this study elucidates a novel mechanism by which PXR decreases its binding to p53 upon DON exposure, thereby promoting hepatocyte apoptosis. Additionally, it validates the positive impact of IPA in mitigating liver damage and diarrhea caused by DON in weaned piglets.
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DOI
PubMed
高影响因子
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
·
2025
·
IF 6
Weiwei Lu,Xiantao Liang,Jianmin Liu,Fangfen Jing,Mingzhu Jin,Xinyang He,Tao Wang,Rongtai Yu
Heavy metal pollution in water poses severe threats to ecosystems and human health, demanding urgent development of efficient and sustainable adsorbents. Herein, we report a novel amino-functionalized phenolic resin (APF) synthesized via a facile self-assembly strategy using 3-aminophenol and formaldehyde. This approach eliminates the need for toxic crosslinkers or complex post-modification steps, offering a green and scalable route for nanoscale polymer fabrication. The APF particles were engineered with controlled amino group density and hierarchical porosity through optimizing monomer ratios, achieving abundant active sites for multi-metal interactions. The APF adsorbent exhibits exceptional adsorption capacities for both cationic and anionic heavy metals, notably achieving 297.75 mg·g −1 for Cd 2+ – surpassing conventional clay composites and rivaling advanced MOFs. Its multifunctional groups (–NH 2 , –OH) enable synergistic mechanisms: (1) electrostatic attraction for Cr 6+ oxyanions at low pH, (2) chelation-dominated Cd 2+ capture via amino coordination, and (3) ion exchange for Pb 2+ /As 3+ . This work advances the design of cost-effective, multi-mechanistic adsorbents for comprehensive heavy metal remediation.
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高影响因子
CHEMBIOCHEM
·
2026
·Vol. 27
·期 1
·e202500945
·
IF 2.8
Min Huang,Jiayi Han,Hao Li,Junhao Lin,Qingbo Jiao,Zexing Cao,Qunfang Lei,Wenjun Fang,Gerui Ren,Zhijun Song,Ying Zheng,Ruibo Wu,Hujun Xie
Growing interest in sustainable nutrition has improved the importance of understanding the interactions between (-)-Epigallocatechin-3-gallate (EGCG), a polyphenol in green tea, and proteins for functional food development. In this study, we investigated the regulatory effects of EGCG on the aggregation behavior of zein, ovalbumin, and their complexes. The addition of EGCG at 100 μg mL −1 led to significant changes in particle sizes of zein, ovalbumin, and zein-ovalbumin complexes, increasing them from 215.6, 3485.3, and 2081.0 nm to 4822.3, 7857.0, and 5895.7 nm, respectively. The zeta potentials of these samples decreased from 8.4, −2.6, and 5.0 mV to −5.3, −0.66, and 2.13 mV, respectively, indicating a reduction in net surface charges and promotion of protein aggregation. UV–vis absorption spectroscopy revealed hyperchromic effects and blue shifts upon EGCG addition, suggesting conformational changes. Molecular dynamics simulations further revealed that EGCG contributed to the structural stabilization of both individual proteins and their complexes by reinforcing hydrophobic and electrostatic contacts at the molecular interface. These findings provide molecular-level insights into the regulatory role of EGCG in protein assembly and offer guidance for the rational design of plant-animal protein complexes with tailored functional properties for food applications. Graphical EGCG plays a significant regulatory role in protein aggregation behavior. EGCG interacts with protein molecules, promoting conformational changes and aggregation, particularly in systems involving zein and ovalbumin. This study highlights the potential application of EGCG in the development of functional foods.
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DOI
PubMed
高影响因子
Energy Material Advances
·
2023
·
IF 12.9
Zhongyue Wang,Cheng Tang,Zhi Wang,Qing Zhang,Peng Lv,Kehan Yu,Jiajin Zheng,Wei Wei
Developing high-energy cathode for sodium ion batteries (SIBs) that enables 3-electron reaction is the most effective way to reduce high cost and solve range anxiety and safety hazards. Here, a novel NASICON-type Na 4 MnCr(PO 4 ) 3 (NMCP) is synthesized as a high-energy cathode for SIBs. The as-prepared 6.4 wt% carbon-coated NMCP (NMCP@C) cathode annealed at 700 °C delivers a discharge capacity of 107.3 mA h g −1 @0.1C, high rate capability up to 15C, and well capacity retention of 69.3% after 500 cycles at 5C within 1.4 ~ 4.3 V. Meanwhile, it also provides an exciting reversible capacity of 164.3 mA h g −1 @0.1C within 1.4 ~ 4.6 V and an ultrahigh energy density of 523.6 Wh kg −1 . Moreover, high sodium ion diffusion coefficients ( D Na+ , 10 −12 ~ 10 −9 cm 2 s −1 ) demonstrate the superior electrode process kinetics, and both solid solution and 2-phase reactions are involved in the sodium ion extraction/insertion process through ex situ x-ray diffraction analyses. Na 3.3 La 0.3 Zr 1.7 Si 2 PO 12 with 3 wt% Na 2 B 4 O 7 additive (NLZSP(NBO3)) ceramic electrolyte is utilized to assemble NMCP@C//NLZSP(NBO3)//Na solid-state sodium metal batteries for the first time, which reveals an initial discharge capacity of 99.1 mA h g −1 (1.4 ~ 4.3 V) and 121.7 mA h g −1 (1.4 ~ 4.6 V) at 0.1C and an excellent cycling performance (capacity retention of 75.8%/72.6% after 100 cycles at 0.2C) at 30 °C. All these confirm that NMCP@C is a high-energy cathode with great practical potential for all-solid-state SIBs.
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高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
·
2019
·
IF 4.175
Feng-Hua Zhang,Yu-Chong Wang,Lei Wang,Jian Liu,Hong-Liang Ge,Bin Wang,Xin-Yu Huang,Xue-Dong Wang,Zong-Tao Chi,Wan-Feng Xie
Metal oxide semiconductor (MOSC) sensors based on nanocrystalline MoO 3 , In 2 O 3 , and their composites are considered to be very sensitive to detect low concentrations of ethanol, ozone, hydrogen, formaldehyde, and nitrogen dioxide . Here, we firstly introduced In 2 (MoO 4 ) 3 phase, which has excellent negative thermal expansion and high electric conductivity properties, into In 2 (MoO 4 ) 3 @In 2 O 3 crystalline nanocomposites . The gas-sensing performance of the In 2 (MoO 4 ) 3 @In 2 O 3 nanocomposites was studied upon exposure to the ethanol gas with different concentration from 5 to 300 ppm at the optimum temperature (300 °C). What's more, the device possesses ultra-high response of 110 and selectivity to ethanol. Particularly, it can effectively work in high humidity (RH = 80%) with super long-term stability of as long as 90 days, compared with the pristine In 2 O 3 sensor and previous reports. The presented novel In 2 (MoO 4 ) 3 @In 2 O 3 sensor offers great opportunities for future ethanol detection under harsh conditions.
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高影响因子
MATERIALS LETTERS
·
2014
·
IF 2.269
Shanshan Ji,Peixia Yang,Jinqiu Zhang,Ye Lian,Jie Zhang,Maozhong An
BMIm-OTF (1-Butyl-3-methylimidazolium trifluoromethanesulfonate) ionic liquid was used for the first time to prepare Cu 1.00 In 0.83 Ga 0.23 Se 1.64 thin films . The standard CIGS sample was calibrated using its inductively coupled plasma optical emission. The morphological properties were detected using scanning electron microscopy . The band gap of the CIGS thin film was approximately 1.55 eV, as measured using UV–visible absorption spectra . The carrier concentration and average Hall coefficient of the CIGS thin films were 2.741×10 20 cm −3 and 2.277×10 −2 cm 3 /C, respectively.
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高影响因子
PHOTOCHEMISTRY AND PHOTOBIOLOGY
·
2012
·Vol. 88
·期 4
·840-843
·
IF 2.413
Zhan Zhou,Qianming Wang,Jintai Lin,Yanna Chen,Chuqin Yang
Herein, a novel fluorescent indicator for the real-time monitoring of amines is described. This probe contains a complex of europium-(thenoyltrifluoroacetone) 3 (Eu(TTA) 3 ) that efficiently reacts with primary and secondary amines. The electron-withdrawing trifluoroacetyl undergoes a nucleophilic addition with amines, and the complex was used to selectively detect BuNH 2 and Et 2 NH (quenching concentration for BuNH 2 : 10 −4 m , for Et 2 NH: 1.2 × 10 −3 m ) by monitoring emission; no changes were observed in the emission spectrum of Eu(TTA) 3 in the presence of Et 3 N, [Bu 4 N]Cl, or PhNH 2 in aqueous solution (THF/H 2 O = 1:1). The ratio of emission intensity to amine concentration was linear by the least-squares fitting method.
研究领域:
分析化学
·
生物传感
·
分子探针
·
稀土化学
·
有机合成
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DOI
高影响因子
LANGMUIR
·
2018
·
IF 3.789
Xiangyu Ge,Jinjin Li,Chenhui Zhang,Zhongnan Wang,Jianbin Luo
The robust liquid superlubricity of a room-temperature ionic liquid induced by tribochemical reactions is explored in this study. Here, 1-ethyl-3-methylimidazolium trifluoromethanesulfonate ([EMIM]TFS) could realize stable superlubricity (μ < 0.01) with water at the interfaces of Si3N4/SiO2. A superlow and steady friction coefficient of 0.002–0.004 could be achieved under neutral conditions (pH of 6.9 ± 0.1) after 600 s of running-in process. Various factors that could affect superlubricity were explored, including concentration of [EMIM]TFS, sliding speed, applied load, and volume of the lubricant. The results reveal that superlubricity can be achieved with [EMIM]TFS aqueous solution under a broad scope of conditions. The results of surface analysis show that a steady composite tribochemical layer comprising [EMIM]TFS, silica, ammonia-containing compounds, and sulfides was formed by tribochemical reactions between [EMIM]TFS and Si3N4 during the running-in period. The film thickness calculation reveals that the achieved superlubricity is in a mixed lubrication regime that comprises boundary lubrication and thin film lubrication. The superlubricity state is governed by a firm composite tribochemical layer, a molecular adsorption layer (electric double layer of [EMIM]TFS), and a fluid layer. The liquid superlubricity achieved by the ionic liquid is helpful for the development of new ionic liquids with superlubricity characteristics and is of great significance for scientific understanding as well as engineering applications.
研究领域:
摩擦学
·
材料科学
·
表面化学
·
润滑工程
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高影响因子
MATERIALS TECHNOLOGY
·
2018
·
IF 1.232
Binggong Yan,Lei Kang,Masashi Kotobuki,Fei Wang,Xiaodi Huang,Xuan Song,Kaiyong Jiang
NASICON-structured Li1.5Al0.5Ge1.5(PO4)3 (LAGP) has been a promising solid-state glass-ceramic electrolyte for all-solid-state lithium ion batteries. However, the non-ideal ionic conductivity, non-uniformity of chemical composition, distortion and micro-cracks, etc., have limited its practical application. Considering these issues, in this work, we first of all introduce partial substitution of Al3+ by Ga3+. To avoid segregation of secondary phase, microwave sintering technology to prepare LAGP was used. With the help of microwave irradiation, sintering could be finished in just 30 min, and the size of crystals was homogeneous across the cross-section. No distortion and micro-cracks could be identified. Characterisations such as DTA, XRD, SEM and EIS were used to evaluate the material and electrochemical properties of the Li1.5Al0.5-xGaxGe1.5(PO4)3 (x = 0.1 ~ 0.5) samples. A high bulk conductivity of 6.67 × 10−4 S/cm at room temperature has been achieved when x = 0.1 and the activation energy was about 0.66 eV.
研究领域:
材料科学
·
电化学
·
储能技术
·
陶瓷学
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高影响因子
DALTON TRANSACTIONS
·
2023
·Vol. 53
·期 3
·996-1003
·
IF 4
Qiang Zhang,Xin Ding,Bin Liu,Yuhua Wang
The development of novel phosphors with excellent luminescence properties for white light-emitting diodes (WLEDs) is always a formidable task. Compared with the traditional laborious and aimless “trial and error” experiments, a mineral-inspired prototype strategy can provide an efficient and accurate method. Herein, for the first time, a novel yellow-emitting phosphor NaBaY2(PO4)3:Eu2+ was discovered using the mineral-inspired prototype strategy and cation substitution method. The phosphor was prepared via the high-temperature solid-state reaction method, and its crystal structure, luminescence properties and potential application for WLEDs were systematically investigated. The NaBaY2(PO4)3 phase was derived from the K2Mg2(SO4)3-type mineral structure and a photoluminescence study revealed that the phosphor can emit bright yellow light with a maximum at 545 nm upon excitation at 351 nm. A WLED lamp was fabricated by the use of a blend of commercial blue-emitting BaMgAl10O17:Eu2+, yellow-emitting NaBaY2(PO4)3:Eu2+ and red-emitting (Ca, Sr)AlSiN3:Eu2+ phosphors with a 380 nm LED chip. The CIE, CCT, Ra and efficiency of the as-fabricated LEDs were measured to be equal to (0.366, 0.365), 4327 K, 91.2 and 40.8 lm W−1, respectively. These results suggest that NaBaY2(PO4)3:Eu2+ could be a promising candidate for n-UV WLEDs.
研究领域:
材料科学
·
无机化学
·
光电子学
·
半导体照明
·
发光材料
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高影响因子
危险品化学品经营许可证（带存储）