APPLIED CLAY SCIENCE
·
2022
·
IF 5.907
Hongjing Cheng,Zhaohua Yang,Feipeng Du,Hui Liu,Qiao Zhang,Yunfei Zhang
Recently, developing facile, cheap, and efficient nano‑silver catalysts for the reduction of waste 4-nitrophenol (4-NP) to useful 4-aminophenol (4-AP) has attracted more and more attention. In this study, a facile mechanical foaming method was used to fabricate Ag/halloysite nanotubes/polyvinyl alcohol sponges (Ag/Hal/PVA) for enhanced degradation of 4-NP. It included the preparation, morphology and composition characterization, and catalytic performance test of Ag/Hal/PVA. The morphology and composition of Ag/Hal/PVA were characterized by field emission scanning electron microscopy , Fourier transform infrared spectra , Raman spectra , X-ray photoelectron spectroscopy, thermo-gravimetric analysis, and XRD, respectively. BET and UV–vis spectrum measurements were used to test the adsorption and catalytic performance of Ag/Hal/PVA for 4-NP. The results showed that silver nanoparticles (AgNPs) were evenly distributed in the Hal/PVA sponge. Moreover, halloysite nanotubes (Hal) greatly improved the specific surface area and the loading capacity for AgNPs of the sponge due to the hollow tubular structure of Hal. The specific surface area of the Ag/Hal/PVA was about 1.62 m 2 /g. The obtained Ag/Hal/PVA exhibited a good catalytic activity and the apparent rate constant was 0.297 min −1 , and a good stability up to 5 cycles without a significant loss of its catalytic activity. This study provided a facile strategy for the development of cheap Ag/Hal/PVA sponges for high efficient reduction of 4-NP, which has potential application in the filed water treatment
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JOURNAL OF TOXICOLOGICAL SCIENCES
·
2016
·Vol. 41
·期 3
·371-381
·
IF 1.224
Wei-Feng Xu,Yan-Sen Li,Peng-Yuan Dai,Chun-Mei Li
4-nitrophenol (PNP) is generally regarded as a diesel exhaust particle (DEP). Arginine plays an important role as a new feed additive, possessing highly efficient antioxidant activities. Here we investigated the effects of dietary supplementation with arginine against ovarian damage induced by PNP in rats. A total of thirty-two female rats postnatal day 28 (PND 28) were randomly divided into four groups. Two groups were fed with basal diet or 13 g/kg arginine in diet for 4 weeks, respectively; the other two groups were given PNP (100 mg/kg b.w.) daily by subcutaneous injection for 2 weeks following pretreatment with either basal diet or arginine diet for 2 weeks. The values of body weight gain (BWG), average daily gain (ADG) and percentage weight gain (PWG) upon PNP treatment were significantly reduced than those in other groups. The relative liver weight in the PNP group was significantly decreased compared with the control group. Treatment with PNP significant reduced the number of corpora lutea, although serum 17β-estradiol (E2) and progesterone (P4) concentrations were unchanged. The morphology of the ovaries in PNP-treated rats displayed necrosis, follicular deformation and granulosa cells irregular arrangement. Moreover, exposure to PNP enhanced production of malondialdehyde (MDA) and hydrogen peroxide (H2O2), and decreased the activities of total superoxide dismutase (T-SOD) and catalase (CAT), and the co-administration of arginine can attenuate the oxidative stress caused by PNP. These results suggest that arginine may have a protective effect against ovarian damage induced by PNP owing to its antioxidant capacity effect.
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高影响因子
JOURNAL OF HAZARDOUS MATERIALS
·
2023
·
IF 13.6
Shu-Ting Zhang,Tao Li,Shi-Kai Deng,Jim C. Spain,Ning-Yi Zhou
Nitroanisoles are used widely as synthetic intermediates and explosives. Although bacteria have been reported to degrade 4-nitroanisole (4NA) under aerobic conditions , the key enzymes and the catalytic mechanism have remained elusive. Rhodococcus sp. strain JS3073 was isolated for its ability to grow on 4NA as the sole carbon and energy source. In this study, whole cell biotransformation experiments indicated that 4NA degradation is initiated by O -demethylation to form 4-nitrophenol (PNP), which undergoes subsequent degradation by a previously established pathway involving formation of 1,2,4-benzenetriol and release of nitrite. Based on comparative transcriptomics and heterologous expression, a novel three-component cytochrome P450 system encoded by pnaABC initiates the O -demethylation of 4NA to yield formaldehyde and PNP. The pnaABC genes encode a phthalate dioxygenase type reductase (PnaA), a cytochrome P450 monooxygenase (PnaB), and an EthD family protein (PnaC) with putative function similar to ferredoxins. This unusual P450 system also has a broad substrate specificity for nitroanisole derivatives. Sequence analysis of PnaAB revealed high identity with multiple self-sufficient P450s of the CYP116B subfamily. The findings revealed the molecular basis of the catabolic pathway for 4NA initiated by an unusual O -demethylase PnaABC and extends the understanding of the diversity among P450s and their electron transport chains.
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Journal of Extracellular Vesicles
·
2023
·Vol. 12
·期 9
·12364
·
IF 16
Jie He,Hengyu Li,John Mai,Yuqing Ke,Chunhui Zhai,Jiao Jiao Li,Lai Jiang,Guangxia Shen,Xianting Ding
Extracellular vesicle (EV) surface proteins, expressed by primary tumours, are important biomarkers for early cancer diagnosis. However, the detection of these EV proteins is complicated by their low abundance and interference from non-EV components in clinical samples. Herein, we present a MEmbrane-Specific Separation and two-step Cascade AmpLificatioN (MESS2CAN) strategy for direct detection of EV surface proteins within 4 h. MESS2CAN utilises novel lipid probes (long chains linked by PEG2K with biotin at one end, and DSPE at the other end) and streptavidin-coated magnetic beads, permitting a 49.6% EV recovery rate within 1 h. A dual amplification strategy with a primer exchange reaction (PER) cascaded by the Cas12a system then allows sensitive detection of the target protein at 10 EV particles per microliter. Using 4 cell lines and 90 clinical test samples, we demonstrate MESS2CAN for analysing HER2, EpCAM and EGFR expression on EVs derived from cells and patient plasma. MESS2CAN reports the desired specificity and sensitivity of EGFR (AUC = 0.98) and of HER2 (AUC = 1) for discriminating between HER2-positive breast cancer, triple-negative breast cancer and healthy donors. MESS2CAN is a pioneering method for highly sensitive in vitro EV diagnostics, applicable to clinical samples with trace amounts of EVs.
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ACS Sustainable Chemistry & Engineering
·
2023
·
IF 8.4
Zhenlong Song,Yuzhen Hu,Song Li,Jianguo Liu,Xinghua Zhang,Longlong Ma,Lungang Chen,Qi Zhang
Valorizing lignin into valuable chemicals requires the selective breaking of a large number of C–O bonds found in the β–O–4 structure. In this study, we present a one-pot strategy that utilizes two NiO/TiO2 catalysts for the photocatalytic depolymerization of β–O–4 alcohols. The S-1.6%NiO/TiO2 catalyst is used for the dehydrogenation of β–O–4 alcohols at 450 nm. Then, the L-0.8%NiO/TiO2 catalyst is employed for the hydrogenolysis of β–O–4 ketones at 365 nm. Remarkably, the dehydrogenation–hydrogenolysis tandem reaction can be conducted in one pot, which affords high yields of ketones and phenols (up to 89%) from β–O–4 alcohols. Additionally, the L-0.8%NiO/TiO2 catalyst prepared in this article is the smallest NiO/TiO2 photocatalyst reported to date, and the size of NiO in the S-1.6%NiO/TiO2 catalyst is even small enough to enter the lattice of TiO2. We successfully regulated the reaction selectivity by controlling the loading method and the amount of NiO. Our work offers a promising solution for efficiently cleaving target bonds in lignin and provides insights into the design of efficient photocatalysts.
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CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
·
2015
·Vol. 31
·期 6
·1051-1055
·
IF 0.875
Fang Xiaoting,Guo Hongyu,Yang Fafu,Bai Xiaoyan
By the Schiff-base condensation of formacyl calix[4]crown( 2 ) with raw chitosan, a novel calix[4]crown-grafted chitosan chelating polymer( 3 ) was conveniently prepared in good yield. The structure of polymer 3 was confirmed by elemental analysis, infrared(IR) spectrometry and X-ray diffraction(XRD) analysis. The elemental analysis suggests that the grafting degree of calixcrown unit was 22% on the amino groups of chitosan. The morphological characteristic of polymer 3 was studied by scanning electron microscopy(SEM). Polymer 3 possessed loose porous and smooth morphology of surface. The dyes adsorption abilities of polymer 3 for a series of organic dyes[Orange I(OI), Neutral red(NR), Victoria blue B(VB) and Brilliant green(BG)] were studied by solid-liquid adsorption experiments. The adsorption percentages increased from 45%―60%(raw chitosan for dyes) to 75%―90%(polymer 3 for dyes). The highest adsorption percentage reached 89% for VB. The saturated adsorption capacities for OI, NR, VB and BG were as high as 622, 564, 854 and 781 mg/g, respectively. The adsorption abilities kept stable at 70%―90% in the scope of pH=5―9. The adsorption abilities for anionic dye(OI) decreased gradually with the increase of pH and the opposite trend was observed for cationic dyes(NR, BG, VB). The adsorption percentages were 70%―90% after five times’ cycles for adsorption.
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高影响因子
Chinese Journal of Natural Medicines
·
2014
·
IF 0
De-Biao YAN,Dong-Ping ZHANG,Ming LI,Wen-Yuan LIU,Feng FENG,Bin DI,Qing-Long GUO,Ning XIE
To synthesize a series of 3-, 4-, and/or 11-trihydroxy modified bergenin derivatives and evaluated their cytotoxic activity in vitro . The phenolic hydroxyl groups of bergenin were protected by benzyl groups with benzyl bromide. Treatment of dibenzyl bergenin with the corresponding acid in the presence of EDC·HCl and DMAP in CH 2 Cl 2 , followed by hydrogenation over Pd/C catalysts, afforded derivatives of bergenin esters. All of the target compounds were identified by IR, MS, and 1 H NMR. Twenty-six novel and three known derivatives of bergenin esters were synthesized. Their cytotoxicity values were evaluated by the MTT assay on the inhibition of DU-145 and BGC-823 cells in vitro . Several triply-substituted ( 3a, 4a, 5a, 6a, 7a ) and doubly-substituted ( 8b, 9b ) bergenin derivatives exhibited higher cytotoxic activity than bergenin. The result showed that the size of substituents and the lipophilicity of the bergenin esters displayed an important role on their cytotoxic activity.
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HYDROMETALLURGY
·
2016
·
IF 2.29
Zhang Peng,Dong Linfei,Zhang Dongxiang,Lei Shi,Hongmei Yang,Jinying Li,Wang Yaling,V.V. Tarasov
Calix[4]arene derivatives including diethyl phosphite groups were used for the first time for separating Nd(III) from nitrate media. Calix[4]arene derivatives were synthesized and characterized by infrared spectroscopy (IR), mass spectroscopy (MS), and 1 H NMR. Four calix[4]arene derivatives, CalixF (①), DCalixF (②), PCalixF (⑤), and POCalixF (⑥), were used in a solvent extraction method. The effects of aqueous acidity, diluent, temperature, shaking time, and Nd(III) concentration were investigated. The results showed that the extraction ability of ⑤ and ⑥ with a phosphate functional group at the upper rim were best for the extraction of Nd(III). Derivative ⑥ had better complexing capacities than ⑤ for the generation of a phenolic hydroxyl group at the lower rim. The enthalpy (∆ H O ), Gibbs free energy (∆ G O ), and entropy (∆ S O ) changes for the extraction were obtained from a thermodynamic study. The results showed that the extraction of Nd(III) from a nitric acid system might be an endothermic reaction since the process was naturally spontaneous and increasing the temperature during extraction was determined to be thermodynamically feasible. The extraction of Nd(III) was governed by a two-stage chemical reaction and diffusion process. In the first stage, the process was controlled by a fast chemical reaction at the liquid-liquid interface. The composition of the Nd(III)-calix[4]arene derivative complex was determined to be [Nd(NO 3 ) 3 ] 2 [L]. The second stage was the diffusion of extracted products towards equilibrium. Calix[4]arene derivative ⑥ was found to be an efficient extractant for the separation of Nd(III) and would be a potential extractant for the disposal of radioactive waste in spent fuel .
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高影响因子
Journal of Materials Chemistry C
·
2023
·Vol. 11
·期 31
·10509-10519
·
IF 6.4
Chengcheng Zhou,Ding Shen,Xingpeng Chai,Boyang Shi,Wenya Zhu,Guowei Wang
The rapid development of the semiconductor industry puts forward higher requirements on the properties of insulating dielectrics. As a supramolecular compound, calix[4]arene has a unique cavity structure, showing potential for a low-k material. We herein reported a novel strategy to functionalize the 4-tert-butylcalix[4]arene with different numbers of benzocyclobutene (BCB) units (2 or 4) and spacers (–(CH2)3– or –(CH2)6–) by sequential substitution and hydrosilylation reactions. These precursors can be cured under heating to form a crosslinked film. The optimized curation condition was screened by differential scanning calorimetry (DSC) measurement. Combining with a comparison experiment using a precursor with calix[4]arene but without BCB units, the wide-angle X-ray scattering (WAXS) pattern and thermal analysis provided solid evidence that the high thermal stability of the film (glass transition temperature (Tg) > 110 °C, 5 wt% loss temperature >367 °C, and the coefficient of the thermal expansion < 87.88 ppm °C−1) was majorly contributed by calix[4]arene, while the excellent dielectric properties (the lowest dielectric constant Dk = 2.23 and the average dielectric loss Df < 1.5 × 10−3) were synergistically affected by both calix[4]arene and BCB units. The static water contact angle was mostly higher than 100° and high hydrophobicity was confirmed, which can meet the additional requirements in practical application. The low dielectric constant synergized by calix[4]arene and the BCB unit is hoped to aid in developing a novel strategy for low-k materials.
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SOLAR ENERGY MATERIALS AND SOLAR CELLS
·
2021
·
IF 7.267
Xiaowei Zhou,Chao Gao,Hao Luo,Zhiwei Liu,Haixu Liu,Haifeng Gao,Qing Zhou,Wenbo Li,Xiaoyun Teng,Wei Yu
In this paper, we reported a modified preparation process for Cu 2 ZnSn(S,Se) 4 (CZTSSe) films. For this process, Al 2 O 3 capping layers were deposited on precursor films before selenization. It was found the capping layer can prevent the formation of separate Cu x Se phase on top of the film and facilitate a homogeneous growth of the crystalline grains during selenization. Detailed characterizations revealed the reason: the Al 2 O 3 capping layers can inhibit the incorporation of Se into the film in low-temperature region (below 350 °C). So the reaction between Se and Cu, which is thermodynamically preferential in this temperature region, can be prevented. As the disappearance of Cu x Se, the traditional top-to-down crystallization mode was substituted by a homogeneous crystallization mode. Therefore, CZTSSe films with homogeneous crystallization properties were achieved. By using the capping layers, the efficiencies of the solar cells were improved. In particular, the open-circuit voltage (V OC ) of the solar cell increased by ~18% by using the capping layers.
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高影响因子
Separations
·
2021
·Vol. 8
·期 6
·72
·
IF 2.777
Xiqiang Liu,Hui Zhang,Yunlong Liu
Apatite is an important carrier of rare earth elements (REEs) and phosphorite is a potential REEs resource. However, the influence of hydrothermal fluids on the migration and enrichment of REE in apatite remains controversial. The experimental study of the interaction between REE-bearing fluid and apatite is one of the essential ways to understand the chemical behavior of rare earth elements in apatite. In this study, we conducted the fluid–mineral reaction experimental study (at 400 °C, 50 MPa and 4–16 wt %) between high lanthanum (La) content hydrothermal solution and low REE content to reveal the influence of different salinities on the diffusion of rare earth elements in fluorapatite. Based on in situ geochemical analyses of experimental products, we show that the diffusion coefficients of La in fluorapatite are between 3.24 × 10−15and 5.88 × 10−15m2/s. The salinity of the fluid has a great influence on the diffusion coefficient, with the increase of salinity, the diffusion coefficient increase.Keywords:water–mineral reaction;fluorapatite;lanthanum;diffusion
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高影响因子
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
·
2025
·
IF 4
Sishi Huang,Xiaoyue Yang,Jing Zhao,Muhammad Zeeshan,Chunjuan Wang,Desong Yang,Xiaoqiang Han,Guoqiang Zhang
Rhizoctonia solani is a significant soil-borne pathogenic fungus that poses a significant threat to the economically important agricultural crops. 4-(Diethylamino)salicylaldehyde (DSA) is a secondary metabolite produced by Streptomyces sp. KN37, which has antifungal activity, meanwhile its inhibitory mechanism is still unclear. In this study, we explored the antifungal efficacy of DSA and its potential mechanism of inhibiting R. solani . It was found that DSA exhibited significant antifungal activity against six tested plant pathogenic fungi, with R. solani being the most sensitive (EC 50 = 26.904 μg/mL). Notably, DSA effectively reduced the mycelial mass and inhibited sclerotia germination, demonstrating a good control efficacy of cucumber damping-off disease. Morphological observation showed that DSA significantly disrupted the shape and ultrastructure of the mycelium. Transcriptomic and metabolomic analyses revealed that DSA impacted the integrity of the cell membrane, redox processes, and energy metabolism in R. solani . The results of fluorescence staining, relative conductivity, H 2 O 2 content, and antioxidant enzyme activity showed that the accumulation of ROS in hypha cells after DSA treatment possibly resulted in damage to cell membrane integrity. Furthermore, the reduction in ATP content, along with decreased ATPase and citrate synthase activity, indicates that energy production may be inhibited. Molecular docking analysis further showed that DSA may competitively inhibit citrate synthase, thereby inhibiting cell energy production and ultimately inducing apoptosis. Our study provides new insights into the potential mechanism by which DSA inhibits the mycelial growth of R. solani .
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