RSC Advances
·
2014
·Vol. 5
·期 5
·3792-3798
·
IF 3.708
Chao Qi,Ying-Jie Zhu,Guan-Jun Ding,Jin Wu,Feng Chen
In this paper, we report a simple and green strategy for the synthesis of hydroxyapatite (HAP) nanostructures with various morphologies (including nanoparticles, microtubes, nanorods and nanorod-assembled flower-like hierarchical structures) using adenosine 5′-monophosphate sodium salt (AMP) as an organic phosphorus source by solvothermal treatment in different solvents. The effects of the solvents and the reaction time on the morphology of the product as well as the formation mechanism of HAP nanostructures are investigated. In this strategy, the AMP biomolecules act as an organic phosphorus source for the formation of HAP nanostructures, and the solvents have effects on the morphology of the product. This strategy is environmentally friendly and surfactant-free. The as-prepared products are characterized by X-ray powder diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM) and thermogravimetric analysis (TG).
研究领域:
材料科学
·
生物医学工程
✓ 已验证
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Rongjiao Sun,Limei Zhu,Xianzhu You,Rong Chen,Jiante Li,Rongrong Pan,Yueqi Jin,Hua Zhou,Ying Tan,Jiajia Dong,Wanle Hu
5-Aminosalicylic acid (5-ASA) is widely used in the clinical treatment of ulcerative colitis (UC), but its effectiveness is limited by poor patient compliance and inadequate drug retention. Herein, a novel thermoresponsive nanogel (P(NVCL-co-GelMA)) was synthesized through the copolymerization of N-vinylcaprolactam (NVCL) and methacrylated gelatin (GelMA). This nanogel serves as an effective carrier for 5-ASA, transitioning from a sol to a hydrogel at physiological temperatures, thereby enhancing drug retention and reducing leakage. In vitro studies revealed that the nanogel has a lower critical solution temperature of approximately 34 °C and can form a gel within 60 s. It demonstrates superior bioadhesion, biocompatibility, and controlled release of 5-ASA. In a rat model of UC, the 5-ASA-loaded nanogel significantly improved weight loss and disease activity index scores compared to untreated rats. The hydrogel coating acts as a biophysical barrier on the intestinal mucosa, effectively blocking the irritation caused by metabolites and maximizing the therapeutic effect, comparable to that of commercial mesalazine enema (Salofalk). The P(NVCL-co-GelMA) nanogel represents a promising drug delivery system for the treatment of UC, offering extended drug retention, reduced leakage, and enhanced therapeutic efficacy.
研究领域:
药学
·
药物递送系统
·
结直肠疾病
✓ 已验证
产品关联
DOI
高影响因子
MICROPOROUS AND MESOPOROUS MATERIALS
·
2023
·
IF 5.2
Ne Ni,Xiuzhi Gao,Enhui Xing,Yuan Zhu,Jianqiang Liu,Mudi Xin,Ying Ouyang,Yibin Luo,Xingtian Shu
The promotional effects of phosphorous modification on ZSM-5 zeolites by phosphorus oxyacids (H 4 P 2 O 7 , H 3 PO 4 , H 3 PO 3 , and H 3 PO 2 ) with different molecular sizes were investigated with catalytic cracking of n -tetradecane as the probe reaction. It was verified that the diffusion of P precursor molecules into ZSM-5 channels was important to prevent aggregation of P species for better stabilization on tetra-coordinated framework aluminum . Meanwhile, the P–Al interaction was proposed based on results of 27 Al, 31 P, and 29 Si MAS NMR. With H 3 PO 2 as the P precursor, easy diffusion into ZSM-5 channels contributed to less formation of polyphosphates, homogeneous distribution of P species, better reserved crystallinity, microporous area and acidic sites for improving cracking performance of n -tetradecane.
研究领域:
化学工程
·
催化
·
材料科学
✓ 已验证
DOI
高影响因子
JOURNAL OF BIOTECHNOLOGY
·
2024
·
IF 4.1
Bowen Shen,Lin Zhang,Yu Zhou,Feifei Song,Shengping You,Rongxin Su,Wei Qi
5-Hydroxytryptophan (5-HTP), a precursor of the neurotransmitter serotonin in mammals, has demonstrated efficacy in treating various diseases such as depression, fibromyalgia and obesity. However, conventional biosynthesis methods of 5-HTP are limited by low yield and high reagent and process costs. In this study, the strain C1T7-S337A/F318Y with optimized promoter distribution was obtained, and the 5-HTP yield was 60.30 % higher than that of the initial strain. An efficient fermentation process for 5-HTP synthesis was developed using strain C1T7-S337A/F318Y with whey powder as a substrate for cell growth and inducer production. Shake flask fermentation experiments yielded 1.302 g/L 5-HTP from 2.0 g/L L-tryptophan (L-Trp), surpassing the whole-cell biocatalysis by 42.86 %. Scale-up to a 5 L fermenter further increased the yield to 1.649 g/L. This fermentation strategy substantially slashed reagent cost by 95.39 %, providing a more economically viable and environmentally sustainable route for industrial biosynthesis of 5-HTP. Moreover, it contributes to the broader utilization of whey powder in various industries.
研究领域:
生物工程
·
微生物学
·
医药化学
✓ 已验证
DOI
PubMed
高影响因子
Materials Chemistry Frontiers
·
2024
·
IF 6
Jia Liu,Zhiyang Wang,Xiaowei Wu,Shanyue Wei,Yiming Xie,Jing Chen,Can-Zhong Lu
Owing to the unique properties of high porosity, outstanding chemical stability, and designable structures, vast applications of covalent organic frameworks (COFs) have been explored in a wide range of areas including energy storage, catalysis, gas separation, etc. Nevertheless, from the perspective of electrochemical sensing, the conductivity of COFs is not satisfactory. Here, a two-dimensional (2D) hybrid nanosheet combining a COF, a supramolecular host, and nanomaterials was constructed by assembling cucurbit[8]uril (CB8) onto the surface of the COF, and achieved in situ growth of uniformly dispersed AuNPs with the aid of the modulation effect of CB8 to synergistically enhance the sensing performance. By taking advantage of the abundant active loading sites and large specific area of the 2D-COF, excellent conductivity of AuNPs, and host–guest binding ability of CB8, the prepared COF/CB8/AuNPs is utilized to modify the glassy carbon electrode (GCE) as an advanced electrochemical sensor for simultaneous detection of structurally similar analytes, e.g. antineoplastic agent 5-fluorouracil (5-FU) and RNA base uracil (U) using differential pulse voltammetry, achieving detection limits down to the nanomolar level (e.g. 0.037 and 0.074 μM for 5-FU and U, respectively) and the physiologically relevant linear detection range within the sub-micromolar window. Impressively, the prepared COF/CB8/AuNPs/GCE sensor is considerably robust in complicated biofluids, allowing for detecting 5-FU and U in unprocessed native synthetic urine (SU) and whole fetal bovine serum (FBS), which remained highly challenging for electrochemical sensors. This study elucidates the integration of COFs with supramolecular host systems, paving the way for the development of advanced electrochemical sensors for rapid and onsite detection in pharmaceutical diagnostic applications.
研究领域:
材料科学
·
电化学
·
医学诊断
✓ 已验证
产品关联
DOI
高影响因子
WATER RESEARCH
·
2015
·
IF 5.528
Lu Wang,Yulei Liu,Jun Ma,Feng Zhao
Sulphamethoxazole (SMX) is extensively used in humans and livestock, but its appearance in natural water raises environmental concerns. This study demonstrated that SMX and its degradation product , 3-amino-5-methylisoxazole (3A5MI), could be effectively degraded in microbial fuel cell (MFC) reactors. Approximately 85% of 20 ppm SMX was degraded within 12 h, and this was a more rapid biodegradation rate than has been previously shown in the literature. In addition, 3A5MI, a toxic chemical that forms in the SMX degradation process, can be further mineralized. The degradation products of SMX were detected by mass spectrometry, and three speculated by-products were confirmed with chemical standards. It was observed that nitrogen atoms of SMX were progressively eliminated during the degradation process, which may relate with the degradation of SMX and 3A5MI. An antibacterial activity test showed that the biotoxicity of SMX towards Shewanella oneidensis MR-1 and Escherichia coli DH5α was greatly reduced after MFC treatment. Moreover, the ATP level of the MFC microbe was nearly threefold higher than that in open-circuit controls, which may be related to the rapid degradation of SMX in MFCs. This study can facilitate further investigations about the biodegradation of SMX.
研究领域:
环境科学
·
微生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
APPLIED CATALYSIS A-GENERAL
·
2020
·
IF 5.006
Feng Lin,Yulong Ma,Yonggang Sun,Xiuqin Men,Yingbo Zhu,Tingting Gao,Kanghe Zhao
Strategies for catalytic lignin depolymerization to yield ethylbenzene chemicals are green, sustainable and environmentally friendly methods. In this study, a series of Ni-CeO 2 /H-ZSM-5 catalysts were prepared via the precipitation method, which catalytically degraded the β-O-4 chemical bonding structure to yield ethylbenzene chemicals. The 2-(2-methoxy-phenoxy)-1-phenylethanol substance (β-O-4) was selected as a typical lignin model compound for the investigation of the intrinsic depolymerization mechanism and the catalytic performance. The results demonstrated that the introduced CeO 2 active phase can effectively promote the catalytic conversion of the β-O-4 chemical bonding structure to ethylbenzene chemicals. Physicochemical data demonstrate that the reaction pathways and hydrogenation selectivity were effectively regulated and controlled by the tuning of the dehydration and hydrogenolysis processes via the introduction of CeO 2 , which realized the selective adjustment of the redox properties and the surface valence states of active species in the catalytic process due to its excellent oxygen transfer performance.
研究领域:
催化化学
·
生物质转化
·
材料科学
✓ 已验证
DOI
高影响因子
APPLIED SURFACE SCIENCE
·
2022
·
IF 7.392
Min Jiang,Furui Hu,Guifen Feng,Hongguang Zhang,Huayu Hu,Tao Gan,Zuqiang Huang,Yanjuan Zhang
The catalytic oxidation of biomass-derived 5-hydroxymethylfurfural (HMF) to prepare 2,5-furandicarboxylic acid (FDCA) is a promising route to produce biomass-based functional materials. It is significant to develop non-noble metal-based catalysts for efficient conversion of HMF to FDCA. In this study, a facile and green technology was developed to prepare hierarchical porous carbon foam (CF)-supported MnO 2 (MnO 2 /CF) catalyst by in-situ growth of MnO 2 nanoparticles on blocky CF, and the catalytic activity of MnO 2 /CF for the oxidation of HMF to FDCA was evaluated. Under mild reaction conditions, the MnO 2 /CF catalyst achieved 99.8% conversion of HMF and 97.0% yield of FDCA, which was well beyond the catalytic performance of single MnO 2 . The results indicated that the CF with hierarchical porous structure and oxygen-containing groups could facilitate the diffusion of reactant molecules and regulate the crystal structure and morphology of MnO 2 . The synergistic interaction of CF and MnO 2 effectively enhanced specific surface area, surface acid-base sites, oxygen vacancy concentration, and charge transfer efficiency of MnO 2 /CF composite, contributing to favorable catalytic performance. Additionally, the MnO 2 /CF catalyst showed promising stability and reusability. This work provides new insights into the development of efficient, stable, and economical non-noble metal-based catalysts for catalytic conversion of biomass-based chemicals.
研究领域:
化学工程
·
材料科学
✓ 已验证
DOI
高影响因子
Journal of Cleaner Production
·
2024
·
IF 9.7
Shanshan Shao,Yu Cao,Jiaxin Jiang,Xiaohua Li,Yongbo Yu
In this study, metal-loaded HZSM-5 was prepared with metal ion extracted from the cathode materials of spent lithium batteries (lithium iron phosphate, LFP; lithium nickel-cobalt manganate, NCM) with citric acid for the improved production of light aromatic hydrocarbons by catalytic pyrolysis of rape straw. Because of the dealuminization effect of citric acid on HZSM-5, mesopores were introduced, and the diffusion and conversion of pyrolysis gas over acid sites were improved. After metal loading with acid-leaching solution, the amount of weak and total acids in metal-loaded HZSM-5 increased a lot, which was conducive to the dehydration, deoxygenation, decarbonylation and aromatization of pyrolysis, and the production of monocyclic aromatic hydrocarbons (MAHs). With 0.1 mol/L citric acid for LFP and NCM treatment, the metal-loaded catalyst showed a higher yield of benzene, toluene and xylene (BTX) of 11.10 wt% during catalytic pyrolysis of rape straw. Compared with 0.1-NCM-H5, a higher yield of MAHs was obtained over 0.1-LFP-H5 with a more favorable pore structure and higher amounts of weak and total acid sites. In general, the high-valued utilization of agricultural wastes and spent lithium batteries was realized in this study to produce clean energy.
研究领域:
能源与环境科学
·
催化化学
✓ 已验证
DOI
高影响因子
JOURNAL OF CATALYSIS
·
2019
·
IF 7.723
Rui Chen,Changjun Yang,Quanquan Zhang,Bingguang Zhang,Kejian Deng
A new iron tetra(2,3-bis(butylthio)maleonitrile)porphyrazine (FePz(SBu) 8 ) has been synthesized, then it was loaded on H-ZSM-5 zeolite to obtain a supported biomimetic photocatalyst H-ZSM-5/FePz(SBu) 8 . Using H 2 O 2 as oxidant, the photocatalytic selective oxidation of glucose in water under visible light (λ ≥ 420 nm) irradiation was carried out in presence of H-ZSM-5/FePz(SBu) 8 . Under such conditions, the glucose can be efficiently converted into value-added chemicals such as glucaric acid, gluconic acid, arabinose, glycerol and formic acid . More importantly, in comparison with pure FePz(SBu) 8 and pure H-ZSM-5 zeolite, the H-ZSM-5/FePz(SBu) 8 exhibited a higher photocatalytic activity for glucose oxidation and the formation of glucaric acid was observed only when H-ZSM-5/FePz(SBu) 8 was used, deriving from the synergistic effect between FePz(SBu) 8 and H-ZSM-5 zeolite. Some reaction parameters of glucose oxidation catalyzed by the H-ZSM-5/FePz(SBu) 8 were discussed, such as loading amount of FePz(SBu) 8 , H 2 O 2 :glucose ratio, glucose concentration, and so on. It was demonstrated that the Soret-band of FePz(SBu) 8 contributed more to the visible light photocatalytic activity than the Q-band during the photocatalytic process. The stability of H-ZSM-5/FePz(SBu) 8 during the photocatalytic process was further evaluated by the reusability test. In addition, the generation of reactive oxygen species was determined by electron spin resonance (ESR) technology and scavenger experiments. A possible reaction pathway of glucose oxidation was also discussed.
研究领域:
化学工程
·
环境科学
✓ 已验证
DOI
高影响因子
JOURNAL OF COORDINATION CHEMISTRY
·
2018
·
IF 1.703
Zi-Mei Ding,Wen-Li Cao,Xiao-Jing Hang,Xiao Ma,Hui Zheng,Kang-Zhen Xu,Jie Huang
The green nitrogen-rich coordination compound Cd(SCZ)2(AFT)2 (1) (AFT =4-amino-3-(5-tetrazolate)-furazan and SCZ = semicarbazide) was first synthesized and characterized by EA and Fourier Transform Infrared (FT-IR). The single crystal was cultivated and determined with X-ray diffraction. It revealed that 1 crystallizes in the monoclinic space group P21/c. A Cd2+ ion is coordinated by four N atoms and two O atoms to form a distorted octahedral structure. Among them, two nitrogen atoms are from the two AFT ions and the other four atoms are from two SCZ molecules. The thermal decomposition behavior of 1 was studied with DSC and TG-DTG methods. The apparent activation energy (E), thermal stability, and safety parameters (T
SADT, T
TIT, and T
b) were calculated for 1. Moreover, entropy of activation (ΔS
≠), enthalpy of activation (ΔH
≠), free energy of activation (ΔG
≠), specific heat capacity (C
p), and impact sensitivity were also discussed in detail.
研究领域:
化学
·
材料科学
✓ 已验证
DOI
高影响因子
APPLIED CATALYSIS A-GENERAL
·
2019
·
IF 4.63
Linhuo Gan,Li Lyu,Tianruo Shen,Shuai Wang
Sulfonic acid-functionalized lignin-derived mesoporous carbon (LDM C-S O 3 H) was prepared using phenolation and evaporation induced self-assembly method followed by sulfonation. The obtained LDM C-S O 3 H bearing sulfonic acid density of 0.6528 mmol/g possessed a well-ordered two-dimensional hexagonal mesoporous characteristics. A 5-hydroxymethylfurfural (5-HMF) yield of 98.0% with a full fructose conversion was obtained using LDM C-S O 3 H as catalyst at 140 °C for 2 h in DMSO. Reactive kinetics studies revealed that fructose conversion in DMSO without catalyst or catalyzed by LDMC-SO 3 H may obey pseudo-first-order kinetics, and the activation energy of latter (72 kJ/mol) was much lower than that of former (114 kJ/mol). Adsorption kinetics studies indicated that almost no 5-HMF adsorbed onto LDM C-S O 3 H probably had a great contribution to the high selectivity of up to 98.0%, while the fructose adsorption on LDM C-S O 3 H was a diffusion-controlling adsorption process with more following Bangham kinetic model and Weber-Morris kinetic model owing to the characteristics of ordered mesostructure of LDM C-S O 3 H. Moreover, LDM C-S O 3 H exhibited superior reusability and stability in catalytic performance with a 5-HMF yield higher than 88.0% in six runs probably due to the synergistic effect of mesopore structure with a special surface and -SO 3 H groups with a relatively high content. These research results will contribute to a better understanding of structure-performance relationship of LDM C-S O 3 H used as an efficient catalyst in the fructose-to-5-HMF transformation as well as the high-value utilization of lignin in the field of catalysis.
研究领域:
催化化学
·
生物质利用
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）