Emerging Contaminants
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2026
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IF 6.9
Yao Li,Yao Li,Limei Chen,Xinliang Ding,Pengfei Zhu,Yukang Wu,Weijie Zhou
Perfluoroalkyl and polyfluoroalkyl substances (PFAS) are persistent, bioaccumulative, and toxic environmental contaminants of global concern. Thus, accurate and sensitive detection methods are urgently required to assess human exposure to emerging PFAS. In this study, we developed and validated a highly sensitive LC–MS/MS method for the simultaneous quantification of 19 PFAS in serum, including nine legacy compounds, six short-chain alternatives, and four emerging substitutes, using solid-phase extraction (SPE) for matrix clean-up. The method showed satisfactory recoveries (62.9–131%) and precision (relative standard deviation: 0.347–17.0%) rates, with lower detection limits than previously reported assays. Application to serum samples from 258 children (6–12 years old) from Wuxi revealed widespread PFAS exposure, characterized by high detection frequencies and increased concentrations. Fifteen PFAS were detected in over 80% of samples, including seven legacy compounds, six short-chain alternatives, and two emerging substitutes, with 6:2 chlorinated polyfluorinated ether sulfonate (6:2 Cl-PFESA)—a China-specific perfluorooctanoic acid (PFOS) alternative—reaching 5.16 ng·mL -1 . The multiple linear regression model revealed inverse associations between serum PFAS concentrations and age, BMI, and maternal educational level. Higher fish and vegetable intakes may be associated with increased serum concentrations of several PFAS, including perfluorononanoic acid, perfluorodecanoic acid, perfluoroundecanoic acid, perfluorododecanoic acid, perfluorotridecanoic acid, PFOS, and 6:2 Cl-PFESA, indicating that diet could contribute to children’s internal PFAS burden. These findings demonstrate the utility of the optimized analytical method for comprehensive exposure assessment and provide insights into the potential sources of PFAS exposure in school-aged children, particularly from dietary sources.
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高影响因子
JOURNAL OF NATURAL PRODUCTS
·
2026
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IF 3.7
Xiao Wang,Fengxin Chu,Shiyu Zhou,Bo Chen,Shuxian Zou,Qingshu Fei,Ren Ren,Mengxiang Su,Bin Di
Cannabidiol (CBD) exhibits broad anti-inflammatory and neuroprotective effects. Although CBD has been reported to act on multiple molecular targets, the direct protein interactors and molecular mechanisms underlying its complex pharmacological activities remain incompletely understood. In this study, we developed a biotinylated CBD probe (II-2) and a FITC-labeled CBD fluorescent probe (III-3) for affinity enrichment and cellular imaging, respectively. Probe-mediated target fishing identified UDP-glucose dehydrogenase (UGDH) as a potential CBD-interacting protein. Competitive pull-down and western blot analysis showed that the CBD-derived probe specifically enriched UGDH, and this enrichment was competitively attenuated by excess CBD. Biolayer interferometry was consistent with an apparent micromolar affinity association between CBD and UGDH under the assay conditions, with an apparent Kd of approximately 5.8 μM. Functional assays showed that CBD enhanced UGDH enzymatic activity in a LPS-induced inflammatory model without markedly altering UGDH protein expression. Immunofluorescence imaging further supported the intracellular spatial association between the CBD-derived fluorescent probe and UGDH. These findings suggest that UGDH is a potential CBD-interacting protein and provide an experimental basis for further elucidating the molecular basis of CBD-related anti-inflammatory activity.
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PubMed
高影响因子
Nanoscale
·
2026
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IF 5.2
Mengrou Wang,Lei Mao,Wenbo Jia,Xinbo Fu,Xin Wang,Jing Chen,Zhuoya Zhu,Zhiwei Zhao,Jun Wu,Damian Onwudiwe,Byung Seong Bae,Mehmet ERTUĞRUL,Muhammad Zaman Ashraf,Jianming Zhou,Qing Li,Wei Lei
Carbon dioxide (CO2 ) emissions have become a key environmental issue of widespread concern at present. Currently, the use of metal oxide based chem-resistive gas sensors are restricted due to their high operating temperature and short lifetime. Therefore, the development of efficient and rapid gas sensors are of great significance in modern research. Lead free double perovskite, Cs2AgBiBr6 (CABB), could be activated by ultraviolet light and generate a large number of free carriers, which have the potential to increase charge density and enhance the gas sensitivity. Photoinduced carriers provide sufficient reactants, which contributes to the activation between target gases and sensitive semiconductors. Heterojunction of ZIF-67/CABB combines gas adsorption by ZIF-67 and photo-activated gas sensitive response by CABB in one device, which response could reach up to -95.55% when illuminated with the light of 365 nm wavelength and 17.34 mW cm -2 incident power density. Average response/recovery time of ZIF-67/CABB heterojunction could reach to 39.07s and 5.04s under UV illumination. The adequate response/recovery time of this fabricated device is 38.89s and 3.17s, with maximum response when at the voltage bias of 5V, which attains the advanced level comparable with commercially available CO2 detectors. The heterojunction system decreases the dark current density from 3.89 A m -2 to 0.78 A m -2 , and also decrease the light current density from 18.48 A m -2 to 5.33 A m -2 compared with pristine CABB at 5 V bias through current-voltage characteristic curves, which promotes the response and stability of the device. The linear dynamic range of the heterojunction gas sensor is 1700ppm-14000ppm, with sensitivity of 0.0013%/ppm. After more than 35 mins continuous stably work, the current density still remains consistent. This efficient, wide working voltage range and stable device presents the future of high-performance photo induced gas detector applications.
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PubMed
高影响因子
JOURNAL OF APPLIED TOXICOLOGY
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2026
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IF 3.1
Yanping Lu,Yaqi Li,Yuqi Tong,Lian Huang,Zhaohui Zhang
Beryllium is widely used in nuclear technology, aerospace, and defense. Long-term beryllium exposure causes chronic beryllium disease (CBD) characterized predominantly by pulmonary fibrosis. Cellular senescence is an important mechanism underlying pulmonary fibrosis, and the IL-6/STAT3 pathway has been implicated as a central axis linking inflammation, senescence, and tissue remodeling. However, whether this pathway promotes beryllium sulfate (BeSO 4 )–induced pulmonary fibrosis through regulation of senescence remains unclear. Herein, Sprague–Dawley rats were exposed to BeSO 4 , and hematoxylin–eosin (H&E) and Masson's trichrome staining were used to assess lung injury and fibrosis. Immunohistochemistry (IHC) assays were used to assess fibrosis-related factors, pathway molecules, and senescence markers in the lung tissues. In vitro, A549 cells were pretreated with the IL-6/STAT3 inhibitor LMT-28 before BeSO 4 exposure, and alterations in cell morphology, proliferation, senescence-related markers, and fibrosis-related markers were evaluated. The results demonstrated that BeSO 4 exposure promoted cellular senescence and pulmonary fibrogenesis via activating IL-6/STAT3 signaling, whereas LMT-28 treatment significantly attenuated these processes. These findings elucidate the molecular mechanism by which BeSO 4 induces pulmonary fibrosis through cellular aging, providing a basis for the discovery of potential therapeutic targets.
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DOI
PubMed
高影响因子
POLYMER
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2026
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IF 5.1
Yifan Chen,Xintao Ma,Haoyu Yang,Hao Liu,Suqin He,Miaoming Huang,Wanlin Xu,Ruixia Duan,Wentao Liu
Bio-based polyamides are attractive candidates for sustainable engineering plastics. However, the high crystallinity of long-chain bio-based polyamides often leads to brittleness and limited impact resistance. In this study, a series of bio-based PA512/6 were synthesized via melt polycondensation by copolymerizing bio-based 1,5-pentanediamine, dodecanedioic acid, caprolactam, and 6-aminohexanoic acid. Adjusting the copolymer composition effectively regulated crystallization behavior, hydrogen-bonding density and molecular chain entanglement. FT-IR, 1 H NMR, and WAXD analyses confirmed the formation of PA512/6 dominated by the γ-crystalline phase with reduced crystal perfection. Thermal analysis revealed lower melting and crystallization temperatures than the corresponding homopolymers. Mechanical testing revealed a clear brittle-to-ductile transition as the PA6 content increased. Notably, PA512/6 0.7 exhibited an exceptional combination of tensile strength (57.9 MPa), ultra-high impact toughness (100 kJ/m 2 ) and high elongation at break (732%). Meanwhile, low water absorption was preserved, with 24-h uptake below 0.7%, together with good dimensional stability. This study provides valuable insights into the structure–property relationships of copolymerization and offers a viable strategy for developing high-performance, sustainable, bio-based polyamides.
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高影响因子
MATERIALS CHEMISTRY AND PHYSICS
·
2026
·
IF 5.2
Qinqin Qian,Haocheng He,Songyin Fu,Jia Xu,Ho-Pui Ho,Shuwen Zeng,Tao Jiang,Sheqin Lv,Chenjie Gu
The efficient and sensitive monitoring of the interleukin-6 (IL-6) is crucial for the clinical tracking and diagnosis of chronic obstructive pulmonary disease (COPD). Herein, a novel surface-enhanced Raman scattering substrate (RGO@MoS 2 /Ag NPs), comprising an efficient charge-transfer and adsorption layer of reduced graphene oxide (GO) encapsulated in molybdenum disulfide (MoS 2 ) and an electromagnetic enhancement layer of Ag nanoparticles, was developed for the highly sensitive, label-free detection of IL-6. Experimentally, a precursor film consisting of (NH 4 ) 2 MoS 4 and GO was first deposited onto a rough g -C 3 N 4 substrate via spin-coating process. Subsequently, the above precursor film was subjected to a two-step high-temperature annealing process for preparing the RGO@MoS 2 charge transfer layer. Finally, Ag NPs were sputtered onto the RGO@MoS 2 film to induce the localized surface plasmons for the further enhancement of the SERS performance. Leveraging the high specific surface area and exceptional charge transfer properties of RGO@MoS 2 , together with the high-density “hot spots” generated by surface Ag NPs, the fabricated SERS substrate exhibited remarkable electromagnetic and chemical enhancement effects. By using the rhodamine 6G (R6G) as the Raman reporter, it was determined that the lowest detection limit could be as low as 10 −9 M on the optimal SERS substrate, with an enhancement factor of 2.2 × 10 9 . Meanwhile, the substrate also exhibited good uniformity, with a relative standard deviation of 9.84%. Finally, the prepared SERS substrate was used to detect the IL-6, it showed good linear response in the range of 5.0-1000 pg/mL, with a detection limit as low as 0.41 pg/mL.
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高影响因子
COMPOSITES PART B-ENGINEERING
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2026
·
IF 14
Yiming Xiong,Yong-Ji Gong,Jixiang Ai,Xuebin Long,Min He,Shuhao Qin,Yufei Liu
Poor interfacial adhesion limits the performance of carbon fiber/polyamide 6 (CF/PA6) composites. Here, we develop an epoxy-based sizing agent with amide-functional emulsifiers to construct a cross-linked interphase with tunable amide content on CF surfaces. This interphase enhances surface energy and wettability, promoting hydrogen bonding with PA6. Crucially, the abundant amide groups act as heterogeneous nucleation sites, inducing a PA6 transcrystalline layer at the interface, which optimizes stress transfer. Consequently, modified CF/PA6 composites exhibit improved tensile strength (+11.6%), impact strength (+49.5%), flexural strength (+16.2%), and flexural modulus (+16.6%). This work elucidates the mechanism of amide-induced interfacial crystallization, offering a new strategy for high-performance CF/thermoplastic composites.
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高影响因子
JOURNAL OF MEMBRANE SCIENCE
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2026
·
IF 8.8
Zhifan Zhang,Yuanhong Shu,Shanshan Huo,An Zhou,Pan Feng,Haigang Qin,Xiaorong Meng
Efficient separation of NaCl and Na 2 SO 4 is essential for resource recovery from hypersaline wastewater. Herein, a crown ether-functionalized polyamide nanofiltration membrane (denoted as DA18C6-PA) was fabricated via interfacial polymerization (IP) using 1,10-diaza-18-crown-6 (DA18C6) as the sole aqueous-phase amine monomer and trimesoyl chloride (TMC) as the organic-phase monomer. The IP conditions were systematically optimized, and the separation performance of the resulting membrane toward Cl − and SO 4 2− ions in mixed salt solutions containing Na + , Li + , K + , and Mg 2+ was comprehensively evaluated. Density functional theory (DFT) calculations were further performed to elucidate the conformational transformation of the aza-crown ether during IP and its correlation with cation recognition. Compared with the conventional PIP-PA membrane, the DA18C6-PA membrane exhibited a more compact and uniform selective layer with enhanced surface electronegativity, leading to improved water permeance and superior SO 4 2− rejection. More importantly, IP-induced conformational distortion of the aza-crown ether reduced the crown ether cavity size, thereby enhancing the geometric matching and coordination stability toward Na + over Li + , K + , and Mg 2+ . Benefiting from the favorable geometric and coordination environment provided by the distorted aza-crown ether cavity for Na + -specific recognition, the DA18C6-PA membrane achieved an exceptionally high NaCl/Na 2 SO 4 separation factor of 176.2. This work establishes a molecular design strategy for integrating host–guest recognition into polyamide nanofiltration membranes via conformational regulation of reactive aza-crown ethers, offering new mechanistic insights into precise ion-selective separation.
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高影响因子
INTERNATIONAL JOURNAL OF REFRACTORY METALS & HARD MATERIALS
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2025
·
IF 4.6
Dongliang Chu,Weiguo Sun,Longsuo Guo,Xiaojun Yang
We obtained a series of B 6 O, B 4 C, ZrB 2 crystals at a pressure of 6 GPa and temperature of 1673–1973 K. These crystals were characterized by XRD and SEM. At a pressure of 6 GPa, the minimum synthesis temperature for B 6 O is 1673 K. The grain size of B 6 O in all the samples remained consistent at around 30–50 nm, with a uniform distribution in each sample. The bonding force between B 6 O grains is weak, and the B 6 O grain size remains relatively stable, showing minimal change with increasing temperature and time. In the sample synthesized at 1973 K, B 6 O icosahedra (multiply twinned particles, MTPs) with a diameter of 12 μm, B 4 C particles with a diameter of 25 μm, and flaky ZrB 2 were observed. We conducted theoretical calculations on B 6 O and B 4 C using density functional theory (DFT).
研究领域:
材料科学
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无机非金属材料
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高压物理
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计算材料学
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结构表征
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高影响因子
ACS Applied Polymer Materials
·
2026
·
IF 5.2
Zhou Zhou,Ce Zhao,Xinxin Yan,Lukuan Guo,Shilong Yang,Zhen Chen,Junlong Song,Jiaqi Guo
This work demonstrates a regioselectively designed cellulose derivative that enables colorless liquid-crystal-based anticounterfeiting with polarization-dependent readout. To overcome the intrinsic visibility and color dependence of conventional optical anticounterfeiting technologies, the hydroxyl group at the C6 position of cellulose was first selectively protected with trityl chloride, followed by ring-opening etherification of the C2 and C3 positions with propylene oxide to yield structurally defined 6-triphenylmethyl-2,3-hydroxypropyl cellulose (6T-HPC). A systematic comparison between 6-triphenylmethyl cellulose and its hydroxypropylated derivatives reveals that 6T-HPC retains liquid-crystalline ordering while completely suppressing visible structural color, thereby achieving an effective decoupling of liquid-crystal optical response from photonic-crystal coloration. Due to this unique optical behavior, a colorless liquid-crystal anticounterfeiting label was fabricated. The label remains fully transparent and invisible under ambient light, yet displays predefined patterns and optical textures when viewed under polarized conditions, enabling a “covert storage-polarized readout” mode of information encoding. This work demonstrates a precise molecular design strategy for tuning the optical functionality of cellulose derivatives and establishes a new route toward sustainable, high-security, and difficult-to-replicate colorless anticounterfeiting materials.
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高影响因子
Horticulturae
·
2024
·Vol. 10
·期 2
·
IF 3.1
Ahmad A. Suliman,Fathia A. Elkhawaga,Meisam Zargar,Maryam Bayat,Elena Pakina,Mostafa Abdelkader
Heat stress is one of the most critical environmental abiotic stresses that can negatively affect plant growth. This article investigates the role of a plant growth promoter (Benzylaminopurine) in tomato fields in regard to its ability to withstand high-temperature conditions resulting from greenhouse gas emissions and climate changes. Three genetically different tomato cultivars (Castlerock, GS 12-F1, and Fayrouz F1) were sprayed with 2% 6-Benzylaminopurine (BAP) at 300 and 600 ppm; then, growth and yield components, physio-biochemical characteristics, and antioxidant enzyme activities were determined. The results showed that the highest BAP concentration (600 ppm) enhanced the ability of tomato plants to withstand high temperatures and the maximum dose of BAP improved chlorophyll (71.7 spad units) in GS 12 leaves, while the same dose enhanced proline contents (24.91 mg/100 g FW), total antioxidants (83.35 µmol Trolox/g dw), total phenolics (20.99 mg/g dw), Superoxide dismutase (33.74 U/g), peroxidase (46.30 U/g), and polyphenol oxidase (64.10 U/g) in Fayrouz F1 leaves. Application BAP on tomatoes moderately improved fruit quality, such as ascorbic acid and maturity degree, while BAP applications reduced TSS and acidity. In this investigation, taste index was not affected by Benzylaminopurine application but by tomato genotype. The highest number of fruits/plant (45.7), fruit yield/plant (3.98 kg), and total yield (103 tons/ha) were obtained from the GS 12 genotype.
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高影响因子
JOURNAL OF ANALYTICAL CHEMISTRY
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2026
·
IF 1.5
Qi Haolong,Liu Haixin,Shen Xin,Zhang Yuanyuan,Xu Xiang,Yang Kexin,Wei Linyi,He Yongrui,Sun Tao,Cai Zhiqiang
Pillar[ n ]arenes ( n = 5–10), novel macrocycles, are gaining prominence in supramolecular studies owing to their distinctive three-dimensional architecture featuring a π-electron-rich cavity and have emerged as a key synthetic macrocyclic host in research. Extended pillar[ n ]arenes ( Ep[ n ]As ) notably feature sizable internal voids, adaptable structures, versatile cavity shapes, and ease of synthesis. This work presents the first example of imidazolium ionic liquid-functionalized Ep[ n ]As (BpP6A-C10-IM-C8[NTf 2 ]) as a gas chromatography stationary phase. The BpP6A-C10-IM-C8[NTf 2 ] column was prepared by the static method, exhibiting medium polarity and high column efficiency (4660 plates/m, k = 2.29). The separation performance of the prepared column was evaluated for analytes, including a mixture of 22 analytes, more than 12 positional isomers, and 8 cis- / trans- isomers. Furthermore, the chromatograms of the challenging isomers of bromonitrobenzenes, chloronitrobenzenes, bromobenzaldehydes, toluidines, and dimethylanilines on the BpP6A-C10-IM-C8[NTf 2 ] column were compared with those on the BpP6A-C10 column and commercial HP-5 and HP-35 columns. The BpP6A-C10-IM-C8[NTf 2 ] column also showed high selectivity for biphenyl isomers, including methylbiphenyls, iodobiphenyls, and bromobiphenyls.
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高影响因子
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