Nature Communications
·
2025
·
IF 15.7
Xu Hualiang,Yang Tiantai,Lei Yuan,Fu Xiaowei,Liu Zhimeng,Li Shanshan,Jiang Liang,Lei Jingxin
Conventional materials typically maintain a stable solid state under specific application conditions. However, materials that combine high mechanical strength with reversible switching states are highly desirable for advanced technologies. Here, we present hydrogen-bond nanoconfined self-destructive polymers (HNSPs) that have robust mechanics and reversible solid-fluid switching capability at 25 °C. Upon exposure to moisture, HNSPs spontaneously transition from solid to fluid, with humidity-tunable switching rates. HNSPs with weight ratios (Rm) of 1.7 is 1.69 times higher self-destructive rate than those with Rm of 2.1, and at 90% relative humidity (RH), Rm=2.0 samples exhibit an 804.27% higher self-destructive efficiency than at 60% RH. Heating can reverse the fluid back to a solid, enabling reversible, humidity-programmable behavior. Mechanistically, large ordered hydrogen-bond clusters, reduced chain entanglement, and abundant hydrophilic groups collectively facilitate switching. This work provides a simple yet versatile strategy for designing robust, switchable self-destructive polymers, broadening their potential in next-generation devices.
研究领域:
材料科学
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高分子化学
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智能材料
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纳米技术
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环境响应系统
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF FLUORESCENCE
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2025
·
IF 3.1
Liu Yinuo,Dai Zhengyuan,Wang Ying,Fu Shanshan,Li Li,Ding Yaping
This study developed a fluorescent molecularly imprinted sensor (CDs@MIPs) for the highly selective detection of the anticancer drug 6-mercaptopurine (6-MP). 6-MP is an anti-cancer drug with myelosuppressive and hepatotoxic effects. If used improperly, it can cause serious adverse reactions in humans and other organisms. The sensor was fabricated via the sol-gel method using blue-emissive nitrogen-doped carbon dots (CDs) as the fluorophore and 3-aminopropyl triethoxysilane (APTES) as the functional monomer. The sensor leveraged molecularly imprinted technology to construct specific recognition cavities, which enabled highly efficient and sensitive detection of 6-MP. Under the optimal experimental conditions and at 325 nm excitation, with the increase of 6-MP concentration, the fluorescence intensity of the sensor at the emission of 415 nm gradually decreases. The sensor demonstrated a linear detection range of 5.0-120.0 µM (Y = − 6.55X + 792.39) with a detection limit of 1.67 µM (S/ N = 3). It exhibited strong anti-interference capability, excellent reproducibility and stable fluorescence performance. When applied to the detection of Mercaptopurine tablets, the method achieved recovery rate of 97.80%-108.63%, providing a highly sensitive and cost-effective analytical approach for clinical drug monitoring.
研究领域:
分析化学
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生物传感器
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药物分析
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纳米材料
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癌症治疗
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF POLYMER RESEARCH
·
2025
·Vol. 32
·期 12
·452
·
IF 2.8
Xiao Shujuan,Li Hao,Lu Xiaohui,Yu Shouwu
Emulsified oil has dynamic stability, and its harmless treatment has become a challenging problem worldwide. Membrane filtration technology has garnered significant attention in the field of oil-water separation due to its low cost, high efficiency, and environmental friendliness. In this study, NH 2 -CAU-1 was incorporated into a polyphenylsulfone (PPSU) matrix to fabricate superhydrophilic and antifouling mixed matrix membranes (MMMs) via the phase inversion method, which were subsequently used for the separation of several oil-in-water emulsions. By adjusting the NH 2 -CAU-1 loading capacity, the mechanical properties, wettability, separation performance, and antifouling properties of the MMMs were optimized. The results indicated that when the NH 2 -CAU-1 loading is 0.1 wt%, the MMMs exhibited superhydrophilicity (water contact angle is 4.2°) and underwater superoleophobicity (underwater oil contact angle is 153.4°), achieving a separation efficiency of over 99.55% for various oil-in-water emulsions, with an irreversible fouling rate of only 2.66%.
研究领域:
材料科学
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环境工程
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膜技术
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分离科学
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产品关联
DOI
高影响因子
Nature Communications
·
2025
·Vol. 16
·期 1
·10680
·
IF 15.7
Xie Wenhao,Deng Quanzheng,Wu Jibiao,Li Fangsen,Dan Wenyan,Wang Xuefeng,Han Lu,Gu Hongbo
Semiconducting polymers are crucial in flexible and wearable intelligent organic electronic devices. However, their crystallization remains a significant challenge because the crystallization kinetics is limited by the rigid conjugation structure and strong intermolecular π - π stacking. This leads to energetic disorder in electronic structure and poor charge transport, which severely hinders electrical performances of devices. Herein, we report highly oriented semiconducting polymers with enhanced crystallinity prepared by low-temperature plasma-driven evaporation process, during which polymer chains cross the energy barrier and crystallization kinetic for approaching torsion-free conformations. This material possesses an extended intrachain conjugation, ordered interchain stacking, high crystallinity and narrowed density of states contribution, which causes the extraordinary electrical response to stimulations with the emphatic Seebeck coefficient and power factor 1017% and 8295% times those of spin-coated film, respectively.
研究领域:
有机电子学
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聚合物物理
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材料科学
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柔性电子学
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热电材料
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产品关联
DOI
PubMed
高影响因子
Journal of Analysis and Testing
·
2025
·
IF 7
Chen Jiajing,Lin Juan,Ouyang Dan,Lin Zian
Metabolomics, based on laser desorption/ionization mass spectrometry (LDI-MS), has been successfully utilized for the high-throughput metabolic analysis of biofluids. This technique shows great promises as a powerful tool for disease screening. Although various nanomaterials have been developed as alternatives to traditional organic matrices in LDI-MS, the signals of most metabolites are limited due to their low abundance in complex biofluids. Herein, four hydroxyl-functionalized covalent organic frameworks (COFs) were designed as substrates for LDI-MS, named COF-OH- n ( n = 0–3, demonstrating the number of hydroxyl units). Since hydroxyl groups can facilitate proton transfer and promote the ionization process effectively, hydroxyl-rich COF-OH-2 enabled sensitive and efficient LDI-MS analysis of serum directly, resulting in highly reproducible serum metabolic profiles (SMPs). An orthogonal partial least squares discriminant analysis (OPLS-DA) model was successfully used to distinguish 30 gout patients from 38 healthy volunteers, with an area under the curve (AUC) of 0.974. Furthermore, the roles of 12 biomarker candidates, which were characterised following statistical analysis, in the metabolic pathway of gout were initially explored. Furthermore, the roles of 12 biomarker candidates, which were characterized following statistical analysis, in the metabolic pathway of gout were initially explored. This work demonstrates the potential of COF-OH-2-assisted LDI-MS in clinical metabolic analysis and offers a rational design strategy for advanced LDI-MS substrates.
研究领域:
分析化学
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代谢组学
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质谱分析
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纳米材料
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临床诊断
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产品关联
DOI
高影响因子
JOURNAL OF MATERIALS SCIENCE
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2025
·Vol. 60
·期 47
·24439-24453
·
IF 3.9
Wang Yabo,Duan Xiaohui,Wei Yiguo,Du Gangfeng,Tian Zhengshan,Bai Suzhen,Pan Zihong,Bai Ruibing
An efficient Ag 2 WO 4 /BiFeO 3 heterojunction was successfully synthesized using a facile hydrothermal and in situ precipitation method. A comprehensive investigation was conducted into the morphological, structural, and optical properties of the Ag 2 WO 4 /BiFeO 3 heterojunction. The optimally synthesized Ag 2 WO 4 /BiFeO 3 heterojunction demonstrated an impressive removal efficiency toward Lanasol Red 5B (95.62%) within 100 min under simulated solar irradiation, which was 5.18-fold higher than pristine BiFeO 3 . The engineered heterojunction effectively optimized the electron transfer pathway, significantly enhancing the separation efficiency of photogenerated electrons and holes. A notable selectivity of the Ag₂WO₄/BiFeO₃ heterostructure was observed in the photocatalytic degradation of organic dyes under simulated solar irradiation. The removal efficiencies followed the order: Lanasol Red 5B (95.62%) > Congo red (50.47%) > Methyl red (47.16%) > Safranin T (22.22%) > Rhodamine B (8.07%) > Methyl orange (3.04%). Furthermore, active species trapping experiments confirmed that holes and superoxide radicals were the predominant reactive species driving the photocatalytic process. This simple synthesis method opens up new possibilities for developing efficient BiFeO 3 -based photocatalysts for environmental remediation purposes.
研究领域:
材料科学
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环境修复
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光催化
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纳米材料
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化学工程
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产品关联
DOI
高影响因子
Science China-Chemistry
·
2025
·
IF 9.7
Li Ran,Yin Hang,Jing Wen-Kai,Cheng Jia-Lin,Qin Xue-Rong,Lu Tong-Bu,Wang Hong-Juan,Yu Zi-You
As important catalysts for C–C coupling, copper-based materials have great potential for electrocatalytic reduction of CO 2 to C 2+ products. In this work, Cu 2 O catalysts modified with different lanthanide hydroxides were successfully synthesized and used for CO 2 electroreduction. The results showed that compared with Cu 2 O/Gd(OH) 3 and Cu 2 O/Yb(OH) 3 catalysts, Cu 2 O/La(OH) 3 exhibited the highest electrocatalytic performance for CO 2 reduction. This catalyst was able to maintain a high Faraday efficiency for C 2+ products ( \({\rm FE}_{{\rm C}_{2+}}\) ) of about 60% within the current density range of 400–800 mA cm −2 . The highest \({\rm FE}_{{\rm C}_{2+}}\) reached 66% at 600 mA cm −2 and the partial current density for C 2+ products reached a maximum of 488 mA cm −2 . Meanwhile, the catalyst could run stably for 40 h with a remained \({\rm FE}_{{\rm C}_{2+}}\) of about 60%. Multiple characterizations reveal that the introduction of La(OH) 3 promotes the formation of *CO intermediates, and also helps to stabilize the Cu(I) species in Cu 2 O under cathodic potentials, thus facilitating the C–C coupling for C 2+ production. This work provides a new strategy to enhance the C 2+ production via stabilizing Cu(I).
研究领域:
电催化
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二氧化碳还原
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材料化学
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可持续能源
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产品关联
DOI
高影响因子
JOURNAL OF NANOBIOTECHNOLOGY
·
2025
·Vol. 23
·期 1
·729
·
IF 12.6
Fu Weicong,Huang Tian,Wang Yi-Xin,Zhao Jing,Shen Jianliang,Yang Qining
Multidrug resistant (MDR) bacterial infections, particularly those involving methicillin-resistant Staphylococcus aureus (MRSA), pose a grave threat to global population health, necessitating novel therapeutic approaches capable of circumventing existing resistance mechanisms. Biomimetic enzymes, which generate bactericidal reactive oxygen species (ROS) by mimicking natural enzyme activity, represent a highly promising solution. This study reports a straightforward one-step synthesis method for vanadium dioxide (VO₂) nanoparticles, which function as potent biomimetic enzymes exhibiting both oxidase-like and peroxidase-like activities. When combined with near-infrared laser irradiation (808 nm, 1 W/cm²) for photothermal therapy (PTT), these VO₂ nanoparticles not only mediate local hyperthermia with a photothermal conversion rate of up to 36.9%, but also significantly enhance ROS generation through biomimetic catalysis. This achieves potent synergistic effects between photothermal therapy and chemodynamic therapy (CDT). This combined therapy exhibits potent antibacterial activity against suspended methicillin-resistant Staphylococcus aureus (MRSA) and effectively disrupts preformed biofilms. Furthermore, in a subcutaneous abscess mouse model, VO₂-mediated PTT-CDT treatment efficiently eradicated bacteria, alleviated local inflammation, promoted tissue repair and angiogenesis. In summary, this readily synthesised VO₂ nanozyme system offers an efficient and translatable therapeutic strategy for tackling challenging multidrug-resistant bacterial infections. Graphical
研究领域:
纳米医学
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抗菌治疗
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酶模拟
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光热治疗
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感染性疾病
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产品关联
DOI
PubMed
高影响因子
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
·
2025
·
IF 3.8
Tang Yanyan,Chen Qinglin,Zeng Mingmin,Ma Xiao,Zhu Ling,Zuo Zhibo,Lan Qingchun,Wu Yongquan
A significant limitation of existing fluorescent probes is their broad reactivity toward multiple biothiols, including cysteine (Cys), homocysteine (Hcy), and glutathione (GSH). The structural similarity and overlapping reactivity of these thiol-containing species present a critical challenge for the selective discrimination of individual targets within complex biological environments. To address this limitation, we present M-Cys , a cysteine-selective frequency upconversion luminescence (FUCL) probe engineered from heteroanthracene-based fluorophores. By utilizing anti-Stokes emission, M-Cys enables near-infrared (NIR) excitation at 808 nm while simultaneously emitting NIR light (742 nm), thereby overcoming the limitations associated with conventional Stokes-shifted probes. This innovative design achieves a three-fold enhancement in sensitivity compared to traditional 690-nm excitation, with a detection limit of 23.2 nM, in contrast to 65.9 nM, attributable to reduced background interference and improved signal-to-noise ratios for FUCL. Comprehensive selectivity assays confirm M-Cys 's specificity for cysteine over competing biothiols, thereby ensuring reliable biological discrimination. In addition to in vitro experiments, M-Cys significantly enhances high-contrast imaging of exogenous cysteine in live cells and facilitates in vivo FUCL visualization in murine models. This methodology leverages FUCL's deep tissue penetration and minimal phototoxicity. By integrating unprecedented sensitivity with translational applicability, this study establishes a versatile optical platform that advances high-precision probes for clinical diagnostics. Graphical abstract
研究领域:
分子生物学
·
生物分析化学
·
光学成像
·
转化医学
·
化学生物学
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产品关联
DOI
PubMed
高影响因子
MOLECULAR NEUROBIOLOGY
·
2025
·Vol. 63
·期 1
·44
·
IF 4.3
Xie Min,Cheng Yu,Yang Lizhen,Lin Zijin,Shen Hao,Zhou Xinhua,Liu Zheng,Xing Jieyu,Zhou Sigui,Chen Haiyun
Parkinson’s disease (PD) is the second most prevalent neurological disorder without a clear etiology and specific cure. Microglia-mediated neuroinflammation plays a pivotal role in the pathogenesis and progression of PD, which is influenced by various factors and involves multiple signaling pathways. CT-011, synthesized by combining nitrone-tetramethyl pyrazine (TMP) and caffeic acid through an ester bond, has shown neuroprotection against ischemic stroke and glutamate-induced neuronal damage in animal models. The purpose of this study is to explore the impact of CT-011 on PD-related neuroinflammation and its potential in treating PD. Results showed that CT-011 significantly inhibited lipopolysaccharide (LPS)-induced release of pro-inflammatory cytokines and mediators in BV2 microglial cells. CT-011 also effectively mitigated LPS-induced mitochondrial membrane potential (MMP) reduction, mitochondrial and intracellular reactive oxygen species (ROS) production. Meanwhile, CT-011's anti-inflammatory effect was related to its inhibition of the TLR4-mediated MyD88/NF-B and PI3K-mediated AKT/GSK3β pathways. More significantly, CT-011 repressed the NLRP3 inflammasome activation. Additionally, CT-011 protected primary neurons against microglial-mediated neurotoxicity in vitro , and ameliorated dopaminergic neuronal damage in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced PD mice with a consistent anti-neuroinflammatory effect in vivo. These results demonstrate that CT-011 effectively inhibits microglia-mediated neuroinflammation and exerts neuroprotective effects on dopamine neurons, thus making it a promising therapeutic candidate for PD.
研究领域:
神经药理学
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神经退行性疾病
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分子神经科学
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炎症研究
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产品关联
DOI
PubMed
高影响因子
CELLULOSE
·
2025
·
IF 4.8
Liang Long,Shao Xinyi,Zhou Huyi,Han Shanming,Li Hongbin,He Zhibin,Shen Kuizhong,Fang Guigan,Wu Ting
Rice straw can be a valuable fiber raw material as a substitute of wood for the pulp and paper industry. However, rice straw is underutilized due to technical challenges in the pulping processes. In this study, a novel bio-chemi-mechanical pulping combines high-temperature aerobic fermentation pretreatment with alkaline hydrogen peroxide impregnation and two-stage mechanical refining. Firstly, aerobic fermentation destroyed the fiber structure of rice straw, loosened the connecting bond between carbohydrates and lignin and made the surface of rice straw rough and porous through microbial decomposition of lignocellulose. Subsequently, the molecular structure of rice straw was further altered by the synergistic action of NaOH and H 2 O 2 , and the efficiency of mechanical refining was further improved based on aerobic fermentation pretreatment at high-temperature (max. ~ 65–70 °C). Experimental results show that under the optimal process conditions, the fermentation pre-treatment resulted in about 65% energy saving, 27% water retention value improvement, and 112% increase in tensile strength at a given pulp freeness. The objective of this study is to transform rice straw lignocellulosic biomass into high-quality pulp with improved physical properties, while simultaneously lowering energy consumption.
研究领域:
制浆造纸技术
·
生物资源工程
·
生物质利用
·
绿色化学
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产品关联
DOI
高影响因子
Nature Communications
·
2025
·Vol. 16
·期 1
·10341
·
IF 15.7
Gao Chongwei,Chen Ming,Li Jiantao,Lee Sungsik,Sun Tian,Wang Xunan,Zhang Shuhua,Feng Guang,Zhai Dengyun,Kang Feiyu
The simultaneous achievement of fast-charging and high specific capacity remains a critical challenge for lithium-ion battery negative electrodes. Here we report a layered manganese-based Prussian blue analogue, synthesized through vacancy control and subsequent thermal transformation. As a conversion-type negative electrode, this material exhibits high-rate performance, delivering a specific capacity of 510 mAh g −1 at a specific current of 8 A g −1 , and operates at a moderate average voltage of approximately 1.2 V vs. Li/Li + , which mitigates lithium plating risks. This high-rate capability stems from the analogue’s specific linkage configurations, which facilitate a high content of active transition metal and strong Li + adsorption at nitrogen sites. The high transition metal content enables a high reversible capacity, while strong Li + adsorption promotes an efficient initial crystalline-to-amorphous transformation. This process induces dynamically reversible component migration during subsequent cycling, thereby enhancing conversion reaction kinetics. Our findings provide insights into the application of Prussian blue analogues as fast-charging negative electrode materials.
研究领域:
材料科学
·
储能
·
电化学
·
电池技术
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产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）