BRITISH JOURNAL OF PHARMACOLOGY
·
2017
·Vol. 174
·期 8
·672-688
·
IF 5.491
Hang Zeng,Yiming Jiang,Pan Chen,Xiaomei Fan,Dongshun Li,Aiming Liu,Xiaochao Ma,Wen Xie,Peiqing Liu,Frank J Gonzalez,Min Huang,Huichang Bi
Background and Purpose Currently, ursodeoxycholic acid and obeticholic acid are the only two FDA-approved drugs for cholestatic liver diseases. Thus, new therapeutic approaches need to be developed. Here we have evaluated the anti-cholestasis effects of Schisandrol B (SolB), a bioactive compound isolated from Schisandra sphenanthera . Experimental Approach Hepatoprotective effect of SolB against intrahepatic cholestasis, induced by lithocholic acid (LCA), was evaluated in mice. Metabolomic analysis and gene analysis were used to assess involvement of pregnane X receptor (PXR). Molecular docking, cell-based reporter gene analysis and knockout mice were used to demonstrate the critical role of the PXR pathway in the anti-cholestasis effects of SolB. Key Results SolB protected against LCA-induced intrahepatic cholestasis. Furthermore, therapeutic treatment with SolB decreased mortality in cholestatic mice. Metabolomics and gene analysis showed that SolB accelerated metabolism of bile acids, promoted bile acid efflux into the intestine, and induced hepatic expression of the PXR-target genes Cyp3a11, Ugt1a1 , and Oatp2, which are involved in bile acid homeostasis. Mechanistic studies showed that SolB activated human PXR and up-regulated PXR target genes in human cell lines. Additionally, SolB did not protect Pxr -null mice from liver injury induced by intrahepatic cholestasis, thus providing genetic evidence that the effect of SolB was PXR-dependent. Conclusion and Implications These findings provide direct evidence for the hepatoprotective effects of SolB against cholestasis by activating PXR. Therefore, SolB may provide a new and effective approach to the prevention and treatment of cholestatic liver diseases.
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高影响因子
CHEMOSPHERE
·
2020
·
IF 5.778
Junyang Zhang,Haijian Tong,Wenkai Pei,Wenhua Liu,Fengyan Shi,Yan Li,Yuning Huo
A synergistic system of integrated photocatalysis-adsorption-membrane separation in a rotating reactor was designed. The composite membrane was prepared via filtration process under vacuum, and it was composed of graphene oxide (GO) acted as the separation membrane, activated carbon (AC) as the adsorbent and Ag@BiOBr as the photocatalyst, respectively. In this Ag@BiOBr/AC/GO membrane system, rotation of the membrane could avoid the light-shielding effect from organic color pollutants to achieve the complete removal of pollutants. More importantly, the synergistic effect among photocatalysis , adsorption and membrane separation in rotating reactor was significant for the efficient removal of rhodamine B (RhB). In the Ag@BiOBr/AC/GO composite membrane, GO membrane layer could reject the organic molecular by the assistance of AC layer with efficient adsorption capacity, and Ag@BiOBr at outer layer could photodegrade the organics under visible light irradiation. The photocatalysis process could solve the problem of membrane fouling and adsorption could assist GO membrane for stopping the permeation of pollutants. Meanwhile, GO membrane was not only beneficial for catalyst recovery, but also could concentrate the pollutants via the membrane separation to accelerate the photocatalytic degradation . At the same time, both the photocatalysis degradation and membrane separation could promote the adsorption ability of AC. This synergistic system showed the significant potential for the practical application in the future.
研究领域:
环境科学
·
材料科学
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PubMed
高影响因子
Journal of Environmental Sciences
·
2023
·
IF 6.9
Lei Zheng,Lixia Sun,Jiangbo Qiu,Junling Song,Luyi Zou,Yue Teng,Yongzhong Zong,Hongyan Yu
The coexistence of inorganic and organic contaminants is a challenge for real-life water treatment applications. Therefore, in this research, we used NH 2 -MIL-125(Ti) to evaluate the single adsorption of hexavalent chromium (Cr(VI)) or Rhodamine B (RhB) in an aqueous solution and further investigate simultaneous adsorption experiments to compare the adsorption behavior changes. The main influencing factors, for example, reaction time, initial concentration, reaction temperature, and pH were studied in detail. In all reaction systems, the pseudo-second-order kinetic and Langmuir isotherm models were well illuminated the adsorption progress of Cr(VI) and RhB. Thermodynamic studies showed that the adsorption process was spontaneous and endothermic. As compared to the single system, the adsorption capacity of Cr(VI) in the binary system gradually decreased as the additive amount of RhB increased, whereas the adsorption capacity of RhB in the binary system was expanded brilliantly. When the binary reaction system contained 100 mg/L Cr(VI), the removal rate of RhB increased to 97.58%. The formation of Cr(VI)-RhB and Cr(III)-RhB complexes was the cause that provided facilitation for the adsorption of RhB. These findings prove that the interactions during the water treatment process between contaminants may obtain additional benefits, contributing to a better adsorption capacity of co-existing contaminant.
研究领域:
环境科学
·
化学工程
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高影响因子
JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY
·
2012
·Vol. 50
·期 10
·2053-2067
·
IF 3.919
Yan-Ling Luo,Wei Yu,Feng Xu,Li-Li Zhang
A novel double brush-shaped copolymer with amphiphilic polyacrylate- b -poly(ethylene glycol)- b -poly acrylate copolymer (PA- b -PEG- b -PA) as a backbone and thermosensitive poly( N -isopropylacrylamide) (PNIPAM) long side chains at both ends of the PEG was synthesized via an atom transfer radical polymerization (ATRP) route, and the structure was confirmed by FTIR, 1 H NMR, and SEC. The thermosensitive self-assembly behavior was examined via UV-vis, TEM, DLS, and surface tension measurements, etc. The self-assembled micelles, with low critical solution temperatures (LCST) of 34–38 ° C, form irregular fusiform and/or spherical morphologies with single, double, and petaling cores in aqueous solution at room temperature, while above the LCST the micelles took on more regular and smooth spherical shapes with diameter ranges from 45 to 100 nm. The micelle exhibits high stabilities even in simulated physiological media, with low critical micellization concentration (CMC) up to 5.50, 4.89, and 5.05 mg L −1 in aqueous solution, pH 1.4 and 7.4 PBS solutions, respectively. The TEM and DLS determination reveled that the copolymer micelle had broad size distribution below its LCST while it produces narrow and homogeneous size above the LCST. The cytotoxicity was investigated by MTT assays to elucidate the application potential of the as-prepared block polymer brushes as drug controlled release vehicles. © 2012 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2012
研究领域:
高分子化学
·
材料科学
·
药物递送
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高影响因子
JOURNAL OF PHYSICAL CHEMISTRY B
·
2011
·
IF 3.603
Jiucun Chen,Mingzhu Liu,Honghong Gong,Yinjuan Huang,Chen Chen
A well-defined thermoresponsive poly(ethylene glycol)-block-poly(N-isopropylacrylamide)-block-poly(ε-caprolactone) (PEG43-b-PNIPAM82-b-PCL87) triblock copolymer was synthesized by combination of atom transfer radical polymerization (ATRP), ring-opening polymerization (ROP), and click chemistry. The synthesis included the four steps, and all the structures of the polymers were determined. The thermoresponsive triblock copolymer can disperse in water at room temperature to form core–shell–corona micelles with the hydrophobic PCL block as core, the thermoresponsive PNIPAM block as shell, and the hydrophilic PEG block as corona. At temperatures above the lower critical solution temperature (LCST) of the PNIPAM block, the PNIPAM chains gradually collapse on the PCL core to shrink the size and change the structure of the resultant core–shell–corona micelles with temperature increasing.
研究领域:
材料科学
·
高分子化学
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DOI
高影响因子
CHINESE CHEMICAL LETTERS
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2022
·
IF 8.455
Kun An,Jia Gao,Yihang Chen,Jingjing Nie,Yongjin Li,Junting Xu,Binyang Du
A series of linear poly(ethylene oxide)- b -poly(4-vinylbenzyl chloride)- b -poly(4‑ ter t-butylstyrene) (PEO 113 - b -PVBC 130 - b -P t BS x or E 113 V 130 T x ) triblock terpolymers with various lengths x (=20, 33, 66, 104, 215) of P t BS block were synthesized via a two-step reversible addition-fragmentation chain transfer (RAFT) polymerization. The E 113 V 130 T x triblock terpolymers were non-crystalline because the PVBC and P t BS blocks strongly hindered the crystallization of PEO block. The effects of P t BS block length x on the phase structures of E 113 V 130 T x triblock terpolymers were investigated by combined techniques of small-angle X-ray scattering (SAXS) and transmission electron microscopy (TEM). It was found that with increasing x from 20 to 215, the phase structure of E 113 V 130 T x triblock terpolymers became more ordered and changed from disordered structure , hexagonally-packed cylinder (HEX), hexagonally perforated layer (HPL), to lamellar (LAM) phase structures. Temperature-variable SAXS measurements showed that the HEX, HPL and LAM phase structures obtained for E 113 V 130 T 66 , E 113 V 130 T 104 and E 113 V 130 T 215 by thermal annealing, respectively, were thermodynamically stable in the temperature range of 30–170 °C.
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高影响因子
JOURNAL OF THE AMERICAN CERAMIC SOCIETY
·
2015
·Vol. 99
·期 3
·881-887
·
IF 2.61
Meichao Gao,Dafeng Zhang,Xipeng Pu,Xin Shao,Hong Li,Dongdong Lv
Eu 3+ -doped BiOCl with different doping concentrations was synthesized by a simple combustion method. The as-synthesized photocatalysts were characterized by X-ray diffraction, scanning electron microscope, transmission electron microscope, Raman spectroscopy, X-ray photoelectron spectroscopy, electron paramagnetic resonance spectroscopy, and UV–vis diffuse reflectance spectroscopy. The experimental results show that Eu 3+ was successfully doped into the lattice of BiOCl. The as-synthesized Eu 3+ -doped BiOCl photocatalysts show a more intense continuous absorption in UV light region, accompanied with decreased energy band gap. Moreover, the Eu 3+ doping leads to the formation of oxygen vacancies, small crystallite size, and high specific surface areas. Compared with pure BiOCl, the Eu 3+ -doped BiOCl photocatalysts exhibits much higher photocatalytic activity for Rhodamine B (RhB) under UV light irradiation. As-obtained Eu 3+ -doped BiOCl can be easily reused with excellent stability. In addition, the mechanism of the improved photocatalytic properties of Eu 3+ -doped BiOCl was discussed in detail.
研究领域:
材料科学
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环境科学
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高影响因子
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
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2022
·Vol. 33
·期 22
·17587-17598
·
IF 2.779
Yu Bo,Miao Chun,Wang Dandan,Li Hongji,Sun Dongshu,Jiang Wei,Liu Chunbo,Che Guangbo
The development of high-efficiency heterojunction with improved photocatalytic property is regarded as a promising way to decontaminate wastewater. In this study, Z-Scheme g-C 3 N 4 /H-TiO 2 heterojunctions with different proportions were synthesized. The photocatalytic degradation of rhodamine B (RhB) was studied under visible light irradiation. Among them, 10% g-C 3 N 4 /H-TiO 2 photocatalyst had the best performance, and the degradation rate of RhB was 65% within 120 min. In addition, 10% g-C 3 N 4 /H-TiO 2 photocatalyst had high stability, and its photocatalytic activity did not decrease significantly after four cycles. Through photocurrent analysis, it is found that the photogenerated carriers have obviously excellent separation and transfer characteristics, which makes the 10% g-C 3 N 4 /H-TiO 2 photocatalyst have good degradation performance. Electron paramagnetic resonance (ESR) experiments showed that ·OH and ·O 2 − were active radicals during degradation.
研究领域:
环境科学
·
材料科学
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高影响因子
SYNTHETIC METALS
·
2021
·
IF 3.266
Yueqiang Ma,Yuchang Du,Chunxia Li,Yan Zhang,Hongmei Du,Jinsheng Zhao,Junhong Zhang,Yu Xie
In this work, starting from cyclopenta[2,1-b;3,4-b′]dithiophene (CPDT) and tris(thienothiophene) (3TT) as donor units, and diketopyrrolopyrrole (DPP) as the acceptor unit, three new solution-processable donor-acceptor conjugated copolymers (P1, P2, P3) were successfully synthesized through the palladium-catalyzed Stille coupling reaction. The monomer molar feeding ratios (CPDT:DPP:3TT) of the three polymers are 3:2:1, 2:1:1, 3:1:2, respectively, which are named as PCPT-1, PCPT-2, and PCPT-3. For comparison purpose, we also synthesized the binary copolymers between CPDT and DPP (PCP), CPDT and 3TT (PCT), and compared their properties with the ternary copolymers. The optical band gaps of the five polymers were all lower than 1.9 eV, and they all showed abundant color changes. During the oxidation process , PCPT-1 changed from purple to cyan-gray and turned to earthy brown finally, PCPT-2 changed from purple in a neutral state to blue-gray in an oxidized state. Similarly, PCPT-3 turned from purple to cement gray and finally oxidized to light blue. PCP polymer changed from dark green in a neutral state to cement gray in an oxidized state, PCT polymer changed from purple in a neutral state to Light gray purple in an oxidized state. The electrochromic kinetic performance study showed that the response time of the five polymers was about 1 s within a 4-second interval. In the dynamic stability test of 750 cycles (6000 s), the five polymers demonstrated good stability. The contrast retention of polymer PCPT-2 at 570 nm reached to as high as 96.17%.
研究领域:
材料科学
·
化学
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高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2020
·
IF 10.652
Le Cheng,Jiachun Feng
With the progress of intelligent electronic equipment, flexible and wearable strain sensors are being widely used in various applications such as electronic skins and smart robot. In this work, we proposed a facile method for the preparation of stretchable strain sensors as well as compressible strain sensors by using commercially available melamine form (MF). Firstly, MF was coated with reduced graphene oxide (rGO) to construct conductive networks via layer-by-layer assembly of polyethyleneimine and graphene oxide followed by chemical reduction. Thermoplastic elastomer poly (styrene- b -ethylene-butylene- b -styrene) (SEBS) was then infused into the MF@rGO scaffolds through solution absorption method. By adjusting the concentration of SEBS solution used, stretchable and compressible strain sensors were fabricated and both of them exhibited excellent mechanical properties, sensitive responsiveness and electromechanical durability. The deformation capacity of these two types of sensors could reach as high as 50% strain and the maximum gauge factors of stretchable and compressible strain sensors was 2.43 and 1.74, respectively. Stable signals during at least 1000 cycles for both stretchable and compressible strain sensors were well maintained. The potential sensing application of real-time monitoring of human motions was also demonstrated.
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高影响因子
ACS Omega
·
2019
·
IF 2.584
Yuanping Jiang,Cong Yan,Dawei Shi,Zhengying Liu,Mingbo Yang
The inadequate rheological properties limit the film blowing process of biodegradable polylactic acid (PLA), thus hindering its potential application in environmentally friendly packaging films and mulch films. Herein, biodegradable polyethylene glycol (PEG) and d-lactide were used to synthesize three kinds of poly-d-lactic acid (PDLA)-b-PEG-b-PDLA (DPD) triblock copolymers, and their effects on stereocomplex (sc) structure formation and rheological properties of the composites were studied. The results showed that the poly l-lactic acid (PLLA)/DPD4k sample introduced the highest sc content, storage modulus, and complex viscosity value compared with PLLA/DPD2k and PLLA/DPD10k at the same loading condition, indicating that the PEG4k chains can better accelerate the formation of a sc network between DPD4k and the PLLA matrix. The introduction of 10 wt % DPD4k also resulted in about 38 times longer relaxation time and a strain-hardening behavior during the steady biaxial extension of PLLA. At last, the continuous film blowing process was successfully conducted in the PLLA/DPD4k composites, which acquired a stable blow-up ratio of 3.07. On the basis of the above results, the soft chain-grafted PDLA copolymer may provide a novel method for film blowing of biodegradable PLA.
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DOI
PubMed
高影响因子
Open Life Sciences
·
2025
·Vol. 20
·期 1
·
IF 1.7
Chengrong Huang,Hao Zhang,Jing Wang,Jianfei Li,Qian Liu,Qiyin Zong,Yunyun Zhang,Qin Wang,Qiang Zhou
A growing body of evidence has shown that hepatitis B surface antigen (HBsAg) mutations can influence the occurrence of occult hepatitis B infection (OBI), particularly amino acid substitutions in small hepatitis B surface proteins (SHBs). The mechanistic basis for these results, however, remains unclear. This study was designed to explore the potential impact and mechanisms of OBI-related SHBs mutations on serum HBsAg. Huh7 and HepG2 cells were transfected with plasmids encoding wild-type (WT) or OBI-related SHB mutation-containing sequences, after which a chemiluminescence approach was used to detect HBsAg levels in cell culture supernatants. Western blotting was further used to assess HBsAg and endoplasmic reticulum stress (ERS)-related protein levels in lysates prepared from these cells, while the localization of HBsAg within cells was assessed via immunofluorescent staining. Cells transfected with OBI-related SHB mutation-encoding plasmids exhibited lower supernatant HBsAg levels than cells transfected with WT plasmids. Intracellular and extracellular HBsAg levels in these mutant plasmid-transfected cells were lower relative to those for WT plasmid-transfected cells, and HBsAg accumulation within the ER was detected via immunofluorescent staining in cells transfected with OBI-related SHB mutation-encoding plasmids, ERS-related protein content was also significantly increased in mutant plasmid-transfected cells as compared to those in the WT group. These results suggest that proteins harboring OBI-related mutations may tend to accumulate in the ER, thereby triggering an ERS response and impairing the transcription and translation of HBsAg via the activation of the unfolded protein response and ER-associated protein degradation pathway. These effects ultimately reduce the overall assembly of HBV virions in the ER and their associated secretion.
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PubMed
高影响因子
危险品化学品经营许可证（带存储）