CARBOHYDRATE POLYMERS
·
2021
·
IF 9.381
Jiawei Lu,Yi Chen,Meng Ding,Xiaokun Fan,Jiawei Hu,Yihua Chen,Jie Li,Zhihan Li,Wenyong Liu
In order to develop better wound dressings, a novel chitosan hydrogel (Cn-Nm gel) was designed and fabricated by using aldehyde-4-arm polyethylene glycol (4r-PEG-CHO) to crosslink the chitosan dissolved in alkaline solution, amino-4-arm polyethylene glycol (4r-PEG-NH 2 ) was chosen as the additive simultaneously. The special dissolution technique and macromolecular crosslinking structure endows the Cn-Nm gels with better performance than that of gels prepared by acid dissolving method with micromolecule crosslinker. First, Cn-Nm gels own strong toughness with 500 kPa tensile strength and 1000% elongation, about 400% swelling ratio and fast water absorption rate. Second, about 300 kPa adhesive strength and strippability between the gels and skin is achieved. More importantly, Cn-Nm gels show nearly 100% antibacterial rate towards Escherichia coli and Staphylococcus aureus . Excellent biocompatibility is also proved by the mouse fibroblasts tests. All of the performance makes this developed chitosan-based gel be the potential candidate as a wound dressing.
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DOI
PubMed
高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
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2021
·
IF 3.764
Xiaojun Zhao,Lijuan Liu,Weiting Yang,Qinhe Pan
The utilization of hydrogen energy is an effective way to alleviate the shortage of traditional energy, carbon emissions, and environmental pollution. As a hydrogen energy conversion device, fuel cells are severely limited by the slow oxygen reduction reaction on the cathode. Herein, we designed and synthesized the composite precursors of ZIF and chitosan, which was used for the preparation of a series of efficient carbon-based catalysts for oxygen reduction by pyrolysis. Among them, ZnCo-ZIF@CS-3-800 shows the best catalytic performance. Its onset potential and limited current density are nearly the same as those of Pt/C, and its half-wave potential is 9 mV higher than that of Pt/C. Moreover, it also exhibits excellent catalytic stability, durability, and methanol tolerance, promising great potential and prospects for application in fuel cells.
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高影响因子
REACTIVE & FUNCTIONAL POLYMERS
·
2023
·
IF 5.1
Yutong Song,Rui Zhang,Meijie Qu,Ruitong Zheng,Qingqing Zhao,Ping Tang,Yuezhen Bin,Hai Wang
Taking advantages of renewable resourced materials in the preparation of multifunctional aerogel fibers which integrate thermal insulation , piezoelectric and moisture electric generation could be a promising way of relieving pressure on both energy loss and generation. A series of chitosan-konjac glucomannan (CS-KGM) aerogel fibers was obtained by means of wet-spinning method followed by freeze-drying. The CS-KGM aerogel fibers with submicron porous morphology exhibit excellent thermal insulation performance. Single layer of CS-KGM aerogel fiber with only a thickness of 0.6 mm shows a thermal insulation temperature difference of 23 °C. A stable piezoelectric output voltage of 0.35 V can be generated from a single CS-KGM aerogel fiber during a 500 press-release cycle attributing to the intrinsic piezoelectricity of CS and the porous structure. Single aerogel fibers were coated with multi-walled carbon nanotubes as a way to prepare conductive aerogels. Meanwhile, the moisture electric output voltage can be as high as 160 mV and last for >8 h at 60% relative humidity for CS-KGM single aerogel fiber assisted by a thin layer of carbon nanotube coating. Overall, CS-KGM aerogel fibers prepared in this work has good compatibility and potential applications in thermal management and energy harvesting from low density resource, which provides a new strategy for the preparation of sustainable and multifunctional wearable materials.
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高影响因子
COLLOID AND POLYMER SCIENCE
·
2022
·Vol. 300
·期 9
·1075-1086
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IF 2.434
Zhao Jing,Cui Lu,Wang Xiaoran,Deng Chunyu
Thermosensitive hydrogels based on chitosan play an important role in the field of tissue engineering and drug delivery system, with excellent properties such as biocompatible, biodegradable, and minimally invasive. In this work, a dual ionically crosslinked injectable hydrogel was composed of polyelectrolyte complex (PEC) and sodium hydrogen carbonate (SHC) as non-toxic gel agent. The PEC was prepared by ionic interaction between positively charged chitosan and negatively charged thermosensitive polymer poly(NIPAm-co-AMPS). The injectable hydrogel with rapid gelation was obtained by optimizing feed ratio, SHC amount, concentration, and temperature. The swelling, temperature sensitive, rheological, and cytotoxic properties of the hydrogels were evaluated. The potential of hydrogels applied in drug delivery system was studied by measuring the release property in vitro, taking aspirin as drug model. The results showed that the hydrogel exhibited a sol–gel transition at about 37 ℃, when the volume ratio of CS (20 mg/mL), PNAM (4.0 mg/mL), and SHC (0.4 M) was 1:0.2:0.5; the hydrogel with good mechanical strength and gelation time of 1–3 min in the physiological conditions was obtained. The hydrogels prepared with high SHC concentration or more gel agents showed shorter gelation time and better thermostability. The hydrogel presented a 1-day sustained release of aspirin with no significant burst release in vitro. The release properties demonstrated that the hydrogels released aspirin in a sustained manner, about 87% in 24 h. L929 cells had good survival and proliferative rates within CS-PNAM/SHC hydrogel after 24 h, showing excellent biocompatibility. Therefore, the injectable thermos-responsive hydrogels formed by CS-PNAM/SHC and loaded with aspirin turned into a smart drug delivery system, showing great potential for controlled release.
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高影响因子
Materials Science & Engineering C-Materials for Biological Applications
·
2019
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IF 4.959
Fang Liao,Xiao-Yuan Peng,Fan Yang,Qin-Fei Ke,Zhen-Hong Zhu,Ya-Ping Guo
Chitosan (CTS) and mesoporous calcium silicate (MCS) have been developed for bone defect healing; however, their bone regeneration capacity still does not satisfy the patients with bone diseases. Gadolinium (Gd) is accumulated in human bones, and plays a beneficial role in regulating cell performance and bone regeneration. We firstly constructed Gd-doped MCS/CTS (Gd-MCS/CTS) scaffolds by a lyophilization technology. The interconnected arrangement of CTS films lead to forming macropores by using ice crystals as templates during the lyophilization procedure, and the Gd-MCS nanoparticles dispersed uniformly on the macropore walls. The biocompatible chemical components and hierarchical pores facilitated the attachment and spreading of rat bone marrow-derived mesenchymal stem cells (rBMSCs). Interestingly, the Gd dopants in the scaffolds effectively activated the Wnt/β-catenin signaling pathway, resulting in excellent cell proliferation and osteogenic differentiation capacities. The osteogenic-related genes such as alkaline phosphatase (ALP), runt-related transcription factor 2 (Runx2) and collagen type1 (COL-1) were remarkably up-regulated by Gd-MCS scaffolds as compared with MCS scaffolds, and their expression levels increased in a positive correlation with Gd doping amounts. Moreover, in vivo rat cranial defect tests further confirmed that Gd-MCS/CTS scaffolds significantly stimulated collagen deposition and new bone formation. The exciting finding suggested the beneficial effects of Gd 3+ ions on osteogenic differentiation and new bone regeneration, and Gd-MCS/CTS scaffolds can be employed as a novel platform for bone defect healing.
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PubMed
高影响因子
ChemistrySelect
·
2026
·Vol. 11
·期 34
·e74374
·
IF 2.3
Qingmin Yang,Jintao Ma,Xueqian Wu,Siyu Zhao,Chenyue Dong,Zhuoyue Wu,Yuhan Lin,Chunyan Guo,Xi Li,Chao Sun,Jiaojiao Cao,Linlin Zhu,Renyuan Song,Facui Yang
There is an urgent demand for efficient adsorbents to remove persistent organic pollutants from wastewater. Unlike previous protein‑based composites used mainly for metal cation separation, this study develops a positively charged amyloid‑like lysozyme@chitosan composite (PTL@CS) by incorporating chitosan into lysozyme, specifically targeting anionic dyes such as Congo red (CR). PTL@CS exhibits a stable structure enriched with synergistic functional groups (e.g., carboxyl, hydroxyl, amino) and demonstrates amyloid-like aggregation, confirmed by thioflavin T (ThT)/8-Anilino-1-naphthalenesulfonic acid (ANS) fluorescence assays, Fourier transform infrared (FTIR), and laser scanning confocal microscopy (LSCM). The material achieves exceptional CR adsorption capacity (up to 801 mg·g − 1 ), fitting the pseudo-second-order kinetics and the Langmuir isotherm models, indicating chemisorption-dominated monolayer adsorption. PTL@CS maintains high adsorption efficiency under acidic to neutral pH conditions as well as in complex ionic environments, exhibits excellent reusability, and shows low cytotoxicity toward IMR‑90 and human umbilical vein endothelial cells (HUVEC). These attributes underscore its potential as a sustainable, selective, and biocompatible adsorbent for next-generation water purification. Graphical Amyloid-like lysozyme@chitosan composite (PTL@CS) efficiently removes organic pollutants from water without causing environmental pollution, offering high adsorption capacity and reusability.
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高影响因子
International Journal of Polymeric Materials and Polymeric Biomaterials
·
2023
·
IF 3.2
Yangjing Ren,Shuying Han,Jia Chen,Jie Li,Mi Zhou,Zejian He,Zhen He
This work focuses on developing a novel bioscaffold for tympanic membrane (TM) repair. A strategy to fabricate porous scaffolds is proposed, which is based on the chitosan membranes that were cross-linked and modified by tert-butyl acetoacetate esterified polyethylene glycol, while their mechanical properties and hydrophilicity were also improved. With two different crosslink methods, direct and freeze cross-linking, the chitosan-polyethylene glycol membranes were fabricated. Based on the morphology, hydrophilicity, and mechanical property, the biomedical scaffold has good enough properties for TM repair and the freeze cross-linking membrane is better. Our work provides a simple and reliable method for the preparation of bioscaffolds.
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高影响因子
FIBERS AND POLYMERS
·
2023
·Vol. 24
·期 12
·4287-4300
·
IF 2.5
Tian Wanyun,Chen Luyi,Zhang Xue,Wu Yarong
In this study, chitosan was modified by two kinds of different siloxanes, γ-glycidoxypropyl-trimethoxysilane (GPTMS) and γ-glycidoxypropyl-dimethoxy- methylsilane (GPDMS), respectively, then applied for anti-pilling of cashmere knitted fabrics. The structure of the modified chitosan, the apparent morphology and the mechanical properties of the modified film were analyzed by FTIR, SEM and DMA, respectively. The hydrophilicity and swelling properties of the modified film were compared. The results showed that epoxy groups of siloxane reacted with amino groups of chitosan, and the –OR (R represents alkyl) groups of siloxane hydrolyzed and polycondensation conducted during the film-forming process. After modification, the mechanical properties of the film were more flexible, the hydrophilicity and swelling of the film was decreased. Cashmere knitted fabric was treated with the modified chitosan and glutathione was chosen as the model compound to explore the reaction between modified chitosan and cashmere fibers. The apparent morphology and elements distribution of the fibers were observed by SEM and EDS, respectively. The directional friction effect of the fibers was tested by fiber friction coefficient tester. The pilling grade, handle, whiteness and launderability of fabric were investigated. The results showed that the epoxy groups remaining in siloxane were reacted with the amino groups of cashmere fiber, which enhance the binding of the fiber and siloxane-modified chitosan, the siloxane-modified chitosan film formed on fibers in situ. The directional friction effect of the fiber significantly reduced, the tendency of fuzzes to the surface of the fabric was weakened and the probability of tangling of exposed fuzzings was reduced, the pilling grade of the fabric treated by modified chitosan reached level 4 and the fabrics had good launderability, the soft and smooth handle was still preserved. There was no obvious color difference of cashmere fabrics treated with siloxane-modified chitosan.
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高影响因子
Nuclear Materials and Energy
·
2023
·
IF 2.6
Xin Chen,Yichao Gong,Kun Kang,Yuefei Wang,Jiarui Li,Zhaokun Li,Tao Wu,Guojun Zhang
Li 2 TiO 3 /Li 4 SiO 4 ceramics have been regarded as promising tritium breeders due to their numerous merits. In this work, chitosan was employed as an effective binder to provide adhesion of Li 2 TiO 3 particles to Li 4 SiO 4 particles, resulting in Li 2 TiO 3 /Li 4 SiO 4 ceramics with improved performance. Chitosan could be removed during the sintering process and had little influence on the phase composition. The resulting Li 2 TiO 3 /Li 4 SiO 4 ceramics had higher density (92.5%T.D.), greater crushing loads (115.2 ± 20.8 N) and superior thermal properties (3.61 W/m∙K) when compared to the samples prepared without chitosan. SEM analyses displayed a dual-scale structure and the inter- and trans -granular fracture mode. Thermal cycling tests revealed that the phase composition was stable but the crushing load fell slightly. The crushing load remained at 92.4 ± 17.1 N after 12 cycles. Overall, chitosan plays an important role in the amelioration of interface combination between Li 4 SiO 4 and Li 2 TiO 3 , and thus significantly improve density, crushing load and thermal conductivity of Li 2 TiO 3 /Li 4 SiO 4 .
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高影响因子
Drug Design Development and Therapy
·
2023
·
IF 4.8
Shuya Zhao,Yunyang Zhang,Yun Chen,Xianghui Xing,Yu Wang,Guofeng Wu
Purpose To evaluate the effects of dentin pretreatment with chitosan-loaded oleuropein nanoparticles (CONPs) on the durability of resin–dentin bonding interfaces.Methods Eighty freshly extracted non-carious human third molars were randomly divided into four groups (n = 20 each): a de-ionized water (DW) group, a chitosan (CS) group, a chlorhexidine (CHX) group and a CONP group. The dentin in the DW, CS, CHX, and CONP groups were pretreated with de-ionized water, 1.0 mg/L CS solution, 2% chlorhexidine solution, and CONP suspension (prepared with 100 mg/L oleuropein), respectively, followed by the universal adhesive and resin composites. The bonded teeth of each group were randomly divided into two subgroups: an immediate subgroup and an aged subgroup. The bonded teeth of each group were then cut into the bonded beams. We measured their microtensile bond strength (μTBS), observed the characteristics of bonding interface by atomic force microscope, calculated the percentage of silver particles in a selected area for interfacial nanoleakage analysis, and evaluated the endogenous gelatinase activity within the bonding interface for in-situ zymogram analysis. Data were analyzed with two-way ANOVA and LSD multiple comparison test (P < 0.05).Results Regardless of after 24 h or after thermocycling, CONP exhibited better μTBS (P < 0.05) than the other three groups except that there was not a statistical significance (P > 0.05) in the CONP and CHX groups after 24 h. Besides, the CONP group presented significantly higher modulus of elasticity in the hybrid layers (P < 0.05), lower expression of nanoleakage (P < 0.05), and better inhibitory effect of matrix metalloproteinases than the other three groups before and after thermocycling.Conclusion Altogether, the CONPs had the potential to act as a dentin primer, which could effectively improve the dentin-resin binding durability.
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PubMed
高影响因子
ANALYTICAL LETTERS
·
2021
·
IF 2.329
Zhiting Ma,Wenyan Du,Zhubing Yan,Xuesen Chen,Yanfang Wang,Zhiquan Mao
Phloridzin is a phenolic acid associated with the genus Malus (Mill.) that causes apple replant disease. The removal of phloridzin is of great significance to alleviate this condition, and hence biochar was investigated for this purpose. The goal of this study was to improve the adsorption capacity of biochar for phloridzin by chemical modification. Biochar from apple branches and biochar modified with chitosan to were characterized by elemental analysis, Brunauer Emmett Teller analysis, Fourier transform infrared spectroscopy, X-ray diffraction, and scanning electron microscopy. Batch adsorption experiments were employed to select the optimal biochar dosage and adsorption time. The results showed that biochar treated for 24 h at 6 g L−1 achieved best adsorption properties and that the chitosan-modified biochar provided a higher adsorption capacity than the unmodified material. The influence of pH upon the adsorption was studied and the results were fitted with isotherm and kinetic equations. The results showed that adsorption process corresponds to a Langmuir isotherm and pseudo-second-order kinetics. The qmax of the biochar was increased from 15.93 to 28.96 mg g−1 by modification with chitosan. The pH was shown to play an important role in the adsorption process. The adsorption of phloridzin to biochar was demonstrated to be a single-layer multiple component adsorption process based on chemisorption. This study provides a theoretical basis to alleviate apple replant disease.
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高影响因子
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
·
2021
·
IF 3.981
Qikang Tian,Qianqian Han,Xin Zhu,Lan Zhang,Kun Chen,Zhishen Xie,Pan Wang,Xiangxiang Wu,Zhenqiang Zhang,Huahui Zeng
Celastrol is a promising drug candidate for treating diet-induced obesity, but the cytotoxicity and poor water solubility limit its clinical application. We prepared a novel celastrol conjugate (Cel-CMCS) with excellent water solubility (33.94 mg/mL), and then investigated its anti-obesity and toxic activities in diet-induced obese mice. Just as the parent celastrol, Cel-CMCS reduced body weight and body fat mass in an equally effective manner, but with lower toxicity. Collectively, Cel-CMCS provides a possible solution for the treatment of obesity in humans. In addition, the present study provided a practical experience of the development of carboxymethyl chitosan-based delivery system for poorly water-soluble drugs.
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高影响因子
危险品化学品经营许可证（带存储）