查找使用阿拉丁产品的科研文献

Highly efficient and stable perovskite solar cells based on E-beam evaporated SnO2 and rational interface defects passivation

Mengjia Li,Lihua Zhu,Xian Zhang,Chen Wang,Deyu Gao,Jiaheng Han,Chunlei Chen,Hongwei Song,Sai Xu,Cong Chen

Owing to the significant roles in balancing carrier transport, bandgap alignment, and perovskite crystallization, realizing high-quality electron transport layers (ETLs) and their effective electronic contact with the perovskite photoactive layer is crucial for future commercialization of perovskite solar cells (PSCs). Here, a high-quality SnO 2 ETL is firstly deposited at room temperature via the low-cost electron beam evaporation (E-beam) technology to help achieve an impressive PCE of 18.88% for rigid PSCs and a PCE of 15.73% for flexible devices. Then we introduced a novel passivating ligand molecule, 11 Maleimidoundecanoic acids (11MA), to help induce functional defects passivation at the interface of SnO 2 /Perovskite to coordinate with Pb 2+ in perovskite and Sn 4+ in SnO 2 via the functional groups (-C = O, -COOH). As a result, 11MA could help achieve the best PCE of 20.94% with negligible hysteresis for rigid devices. Also, doping 11MA in the perovskite photoactive layer further enhanced the PCE to 22.08% with much improved 2000 hours ambient stabilities. Finally, we fabricated different large-area rigid devices (10, 40, 100, and 600 mm 2 ) toward speeding up the commercialization of PSCs by industrial E-beam technology and rational defects passivation strategies.

Effective and selective extraction of Au(III) and Pd(II) from practical e-waste by tridentate thioether extractants

Xuan Huang,Ming Yi,Kewen Tang

To address resources shortage and environmental degradation, noble metal recovery from e-waste is in desperate need. Herein, to achieve selective extraction of gold (Au) and palladium (Pd) from practical e-waste, a series of tridentate thioether extractants are designed with ester functional groups at both ends of the thioether. By varying the chain length of the ester alkyl, the relationship between extractant structure and performance is further explored. The results indicate that the as-introduced tridentate structure facilitate the Au(III) and Pd(II) extraction, demonstrating a complex mechanism involving both coordination substitution and ion association. Notably, the extractant with the shortest carbon chain length and smallest molecular weight delivers outstanding extraction capacities of 920.2 mg/g for Au(III) and 280.7 mg/g for Pd(II). More importantly, it exhibits superior selectivity (∼100 %) for Au(III) and Pd(II) in complex metal solutions. This work guides the design of thioether-based extractants for sustainable recovery of noble metal from practical e-waste.

Inhibitory effect of (E)-2-hexenal as a potential natural fumigant on Aspergillus flavus in stored peanut seeds

Weibin Ma,Luling Zhao,Yanli Xie

The efficacy of eight kinds of green leaf volatiles (GLVs) was investigated as potential natural antifungal agents against Aspergillus flavus in this study. Based on the in vitro assay, volatile phase inhibitory effects of the selected eight GLVs were consistently more effective on A. flavus growth than contact phase inhibitory effects, and ( E )-2-hexenal exhibited the highest efficacy as it could totally inhibited growth of A. flavus at concentrations of 0.032   μL/mL air and 1.6   μL/mL under vapor and contact conditions, respectively. Furthermore, results obtained from the in vivo assay demonstrated that ( E )-2-hexenal possessed potent fumigant activity in reducing A. flavus infection in stored peanut seeds, as it could completely inhibit colonization of A. flavus at 0.32   μL/mL air. Both in vitro and in vivo assay results provided convincing evidence that ( E )-2-hexenal, one of the GLVs that is naturally present in many plants, can potentially be used as a highly efficient and eco-friendly antifungal fumigant to protect peanut seeds from contamination of A. flavus during storage.

Orientin inhibits cyclin E/cyclin A-CDK2 to induce growth arrest at senescence in human gastric cancer cells

Yang Yan,Yongfei Gu

Gastric cancer (GC) is a primary epithelial malignancy originating in the stomach. This research explored the influence and mechanism of Orientin on cellular senescence in GC. Orientin was predicted to regulate multiple cell cycle-related pathways, including cyclin-dependent protein kinase activity. Orientin docked with cyclin dependent kinase 2 (CDK2), cyclin A2 (CCNA2), cyclin E1 (CCNE1), and cyclin E2 (CCNE2) with binding energies of -9.1, -7.5, -7.2, and -8.3 kcal/mol, respectively. The IC 50 values of Orientin for AGS and HGC-27 cells were 24.33 μM and 39.28 μM, respectively. Orientin dose-dependently inhibited GC cell proliferation, promoted G0/G1 phase arrest, as well as downregulated CDK2, CCNA2, CCNE1, and CCNE2 expression. It enhanced senescence-associated β-galactosidase staining intensity, upregulated p16 and p21, and downregulated phosphorylated retinoblastoma (p-Rb). In vivo , Orientin also suppressed tumor progression, promoted p16 and p21 expression, and inhibited CCNE/CCNA-CDK2 signaling. Orientin exerts anti-cancer effects in GC through triggering cellular senescence and cell cycle arrest, likely via activating p16/p21-Rb signaling axis and inhibiting the CCNE/CCNA-CDK2 pathway. Download: Download high-res image (282KB) Download: Download full-size image

Design, Synthesis, and Insecticidal Activity of the Derivatives of Taiwanin E, an Insecticidal Lignan from Taiwania flousiana Gaussen

Feng Hao,Chenzhe Li,Yan Luo,Tingcai Dong,Chengyao Wang,Ziruo He,Jiting Li,Huaizhang Yang,Kun Wei,Yabin Yang,Le Cai

Rising environmental and health risks of synthetic pesticides have fueled the search for eco-friendly alternatives. Taiwania flousiana Gaussen, a rare evergreen, is a valuable source of bioactive compounds, with the lignan Taiwanin E (from its discarded bark in Yunnan, China) showing potential insecticidal activity. Herein, we chemically modified Taiwanin E to improve its solubility and insecticidal activity, and the resultant derivative E13 exhibited potent larvicidal activity against Armigeres subalbatus larvae. Enzyme assays, molecular docking, and dynamics simulations validated this activity, while DFT calculations clarified the structural basis for E13’s superior performance. Bee toxicity tests further confirmed its environmental safety. This study identifies Taiwanin E derivatives as promising sustainable alternatives to conventional insecticides, advancing eco-friendly pest control and enabling resource utilization of the endangered T. flousiana.

Gold-Nanoparticle-Based Multiplexed Immunochromatographic Strip for Simultaneous Detection of Staphylococcal Enterotoxin A, B, C, D, and E

Wenbin Wang,Liqiang Liu,Liguang Xu,Hua Kuang,Jianping Zhu,Chuanlai Xu

Staphylococcal enterotoxins (SEs) in food samples can cause severe gastroenteritis even at low doses. Detection of SEs with a single assay would not only improve reliability and portability, but would also save time. In this paper, for the first time, a multiplexed gold-nanoparticle-based immunochromatographic (ICT) strip that allows the simultaneous detection of the five main SEs has been reported: SEA, SEB, SEC, SED, and SEE. Based on the sandwich immunoassay of each SE, a multiplexed ICT strip with five test lines is developed. Sensitive and specific paired monoclonal antibodies facilitate the detection, allowing for high sensitivity and good specificity. The portable biosensor platform can simultaneously detect SEA, SEB, SEC, SED, and SEE at concentrations as low as 2.5, 2.5, 2.5, 1, and 5 ng mL −1 , respectively. The entire test can be performed within 15 min and requires no sophisticated instruments except a portable strip reader. To evaluate the multiplexed strip, naturally SEA and SEC contaminated milk samples and pure milk samples spiked with the five SEs are analyzed.

Paclitaxel-loaded redox-sensitive nanoparticles based on hyaluronic acid-vitamin E succinate conjugates for improved lung cancer treatment

Yu Song,Han Cai,Tingjie Yin,Meirong Huo,Ping Ma,Jianping Zhou,Wenfang Lai

(E)-2-Octenal suppresses the growth of a prochloraz-resistant Penicillium italicum strain and its potential antifungal mechanisms

Yuwei Luo,Xin Chen,Jin Xin Che,Yonghua Zhang,Qiuli Ouyang,Nengguo Tao

Blue mold caused by Penicillium italicum is one of the most devastating postharvest diseases in Citrus fruit. This work aims to determine the antifungal potential of ( E )-2-octenal, a component of plant essential oil, on the mycelial growth and disease incidence of a prochloraz-resistant strain of P. italicum isolated from an orchard in Luxi, Hunan Province, China. An in vitro assay revealed that the minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) of ( E )-2-octenal were 0.25 and 0.50 mL L −1 , respectively. An in vivo assay showed that wax + 4 × MFC ( E )-2-octenal treatment could reduce the blue mold incidence in Ponkan fruit inoculated with P. italicum without impairing fruit quality. Scanning electron microscopy analysis illustrated that the mycelia of P. italicum were anomalously twisted and shrunken upon treatment with ( E )-2-octenal. The primary antifungal targets were attributed to the cell membrane instead of the cell wall based on propidium iodide and calcofluor white staining results. In addition, ( E )-2-octenal induced massive accumulation of reactive oxygen species in hyphae in a dose-dependent manner, leading to oxidative stress and dysfunction of energy and respiration metabolism. At the same time, the activities of phosphofructokinase (PFK) and pyruvate kinase (PK) were decreased in ( E )-2-octenal-treated samples. Taken together, our present study suggested that ( E )-2-octenal could exert its antifungal activity against P. italicum by damaging the function of mitochondria and may be a potential antifungal substance for an alternative to chemical fungicides.

Novel synthesis of aluminum hydroxyfluorides AlFx(OH)3-x and application in E-1-chloro-3,3,3-trifluoropropene isomerization

Shiwei Feng,Chengping Zhang,Hengdao Quan

A facile, safe, and environmentally friendly preparation method is described for the synthesis of AlF x (OH) 3-x by the activation of γ-Al 2 O 3 using HCFO-1233zd( E ) under various temperatures. Comprehensive characterization techniques including XRD , XPS, N 2 sorption, SEM, TEM , 27 Al MAS NMR, FTIR, and py-IR were employed, revealing that at lower temperatures such as 275 °C and 300 °C, the synthesis yielded AlF(OH) 2 , while at higher temperatures like 350 °C and 375 °C, pyrochlore AlF 1.5 (OH) 1.5 and metastable hexagonal tungsten bronze-type (HTB) β-AlF 3 were formed, with α-AlF 3 detected at 325 °C. Notably, a significant quantity of AlF(OH) 2 can be obtained at 325 °C within a specific time frame. This amorphous phase exhibits weak Lewis acid sites and a lower acid density, rendering it significantly more effective in the isomerization of HCFO-1233zd( E ) compared to strong Lewis acid catalysts such as AlF 1.5 (OH) 1.5 and β-AlF 3 , which could promote coke formation, leading to catalyst deactivation . Moreover, due to its limited further fluorination at 290 °C, the optimal catalyst exhibits prolonged lifespan and high efficiency in HCFO-1233zd( E ) isomerization.

Redistribution of Intracellular Metabolic Flow in E. coli Improves Carbon Atom Economy for High-Yield 2,5-Dimethylpyrazine Production

Chen Yang,Jiajia You,Mengkai Hu,Ganfeng Yi,Rongzhen Zhang,Meijuan Xu,Minglong Shao,Taowei Yang,Xian Zhang,ZhiMing Rao

2,5-Dimethylpyrazine (2,5-DMP) is an important pharmaceutical intermediate and an important essence. Conventional chemical synthesis methods are often accompanied by toxic substances as by-products, and the biosynthesis efficiency of 2,5-DMP is insufficient for industrial applications. In this study, the tdh and soaao genes were overexpressed to enhance enzymatic and nonenzymatic reactions in metabolic pathways, and kbl was knocked out to block competitive branching carbon flow metabolic pathways. Finally, a genetically engineered Escherichia coli strain with the highest carbon recovery rate (30.18%) and the highest yield reported to date was successfully constructed, and 9.21 g·L–1 threonine was able to produce 1682 mg·L–1 2,5-DMP after 24 h. At the same time, an expression regulation strategy and whole-cell biocatalysis helped to eliminate the damage to cells caused by 2,5-DMP, aminoacetone, and reactive oxygen species generated by aminoacetone oxidase from S. oligofermentans, and the negative effect of 2-amino-3-ketobutyrate CoA ligase on the yield of 2,5-DMP in E. coli was also demonstrated.

Ultrasensitive strain sensor based on superhydrophobic microcracked conductive Ti3C2Tx MXene/paper for human-motion monitoring and E-skin

Yibing Bu,Taoyu Shen,Wenke Yang,Shiyin Yang,Ye Zhao,Hu Liu,Yanjun Zheng,Chuntai Liu,Changyu Shen

With the rapid development of wearable intelligent devices, low-cost wearable strain sensors with high sensitivity and low detection limit are urgently demanded. Meanwhile, sensing stability of sensor in wet or corrosive environments should also be considered in practical applications. Here, superhydrophobic microcracked conductive paper-based strain sensor was fabricated by coating conductive Ti 3 C 2 T x MXene on printing paper via dip-coating process and followed by depositing superhydrophobic candle soot layer on its surface. Owing to the ultrasensitive microcrack structure in the conductive coating layer induced by the mismatch of elastic modulus and thermal expansion coefficient between conductive coating layer and paper substrate during the drying process, the prepared paper-based strain sensor exhibited a high sensitivity (gauge factor, GF = 17.4) in the strain range of 0–0.6%, ultralow detection limit (0.1% strain) and good fatigue resistance over 1000 cycles towards bending deformation . Interestingly, it was also applicable for torsion deformation detection, showing excellent torsion angle dependent, repeatable and stable sensing performances. Meanwhile, it displayed brilliant waterproof, self-cleaning and corrosion-resistant properties due to the existence of micro/nano-structured and the low surface energy candle soot layer. As a result, the prepared paper-based strain sensor can effectively monitor a series of large-scale and small-scale human motions even under water environment , showing the great promising in practical harsh outdoor environments . Importantly, it also demonstrated good applicability for spatial strain distribution detection of skin upon body movement when assembled into electronic-skin (E-skin). This study will provide great guidance for the design of next generation wearable strain sensor.

Supplementation with Docosahexaenoic Acid and Vitamin E Improves Hepatic Triglyceride Accumulation Induced by High-Fat Diet in Mice

Gaofeng Yuan,Mengmeng Xu,Meijuan Tan,Jian Dong,Xiaoe Chen

The study aims to investigate the effect of combined supplementation with docosahexaenoic acid (C22:6 n-3, DHA) and vitamin E (VE) on the oxidative stress and liver triglycerides (TG) accumulation induced by high-fat diet (HFD) in mice. C57BL/6J mice are fed either a control diet or an HFD for 8 weeks. Animals are supplemented with DHA, VE, or DHA + VE, respectively. Supplementation with DHA alone shows significant improvement in oxidative stress and hepatic steatosis in mice. Supplementation with DHA significantly reduces the liver TG and total cholesterol contents, and the alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels, compared with the HFD. Supplementation with DHA also significantly decreases the mRNA expression level of sterol regulatory element-binding protein 1C. However, supplementation with VE alone does not show improvement in oxidative stress and hepatic steatosis. DHA + VE supply obtains a superior effect in alleviation of hepatic steatosis than DHA supplementation alone in mice fed by HFD. The efficacy of DHA potentiated by VE can be due to that VE enhances the effect of DHA in decrease of ALT and AST levels and increase of antioxidant enzyme activity and glutathione level in mice fed by HFD. Practical Applications : Supplementation with DHA significantly improves the oxidative stress and hepatic steatosis induced by HFD in mice. The efficacy of DHA in the alleviation of hepatic steatosis induced by HFD is potentiated by VE. These findings may provide a rational basis for the use of DHA and VE co-supplementation in patients with liver steatosis.