ChemMedChem
·
2016
·Vol. 12
·期 3
·235-249
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IF 2.98
Silong Zhang,Zhiyong Wang,Zhiye Hu,Changhao Li,Chu Tang,Kathryn E. Carlson,Junjie Luo,Chune Dong,John A. Katzenellenbogen,Jian Huang,Hai-Bing Zhou
Graphical Add a new element ! This is the first report of selenophene-core compounds as estrogen receptor (ER) ligands. In transcription assays, several selenophenes were profiled as superagonists for ERα; moreover, a few selenophenes exhibited antiproliferative activity similar to that of 4-hydroxytamoxifen in MCF-7 breast cancer cells while being nontoxic toward normal VERO cells. These new ligands could act as models for the development of novel agents leading to improved therapeutics that target the ER. The importance of the heterocyclic core elements with peripheral phenolic and alkyl substituents as a dominant structural motif of ligands for the estrogen receptor (ER) has been well recognized. In this study we expanded the structural diversity of core elements by preparing selenium-containing heterocycles and exploring the activities of these selenophenes on the two ERs, ERα and ERβ. Careful structure–activity relationship (SAR) analysis of their ER binding affinities showed that most selenophenes are ERβ-selective, with the position of the phenol substituents on the selenophene core and the nature of these substituents having a marked effect on their binding affinities. The compound bis(2-fluoro-4-hydroxyphenyl)selenophene ( 2 f ) has the highest relative binding affinity (RBA) of 24.3 for ERβ. In transcription assays, most selenophenes were found to exhibit partial to full agonist activity for both ER subtypes, with compounds bis(2-methyl-4-hydroxyphenyl)selenophene ( 2 b ), bis(4-fluoro-3-hydroxyphenyl)3-bromoselenophene ( 6 f ), and 2,3,5-tris(hydroxyphenyl)thiophenes ( 8 b and 8 d ) profiling as superagonists for ERα; however, several compounds display a range of ERα or ERβ antagonistic activities. A few selenophenes exhibited antiproliferative activity, with compound 8 c showing antiproliferative effects similar to that of 4-hydroxytamoxifen in breast cancer MCF-7 cells while being nontoxic to normal VERO cells. These new ligands could act as models for the development of novel agents leading to improved therapeutics that target the estrogen receptor.
研究领域:
药理学
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化学
·
癌症研究
·
分子生物学
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PubMed
高影响因子
INORGANIC CHEMISTRY
·
2025
·
IF 4.7
Ritao Huang,Jin Zhou,Yi Yang,Qingyuan Zeng,Jingxin Li,Langsheng Ling,Wei Tong,Zhaoming Tian
Two-dimensional rare earth (RE)-based honeycomb lattice magnets provide a fertile platform for exploring exotic magnetic ground states in view of reduced spatial dimensionality and anisotropic exchange interactions, while the reported 2D honeycomb lattice materials are quite limited. Herein, we report a family of quasi-two-dimensional layered RE-based honeycomb lattice magnets RE2Te4O11 (RE = Gd–Er and Yb), where the magnetic honeycomb layers are well separated by nonmagnetic TeO4 polyhedra with large interlayer distances of 8.353–8.452 Å. Magnetic susceptibility characterizations reveal that all synthesized RE2Te4O11 (RE = Gd–Er and Yb) compounds exhibit dominant antiferromagnetic (AFM) interactions; three RE2Te4O11 (RE = Gd, Tb, and Dy) family members show magnetic transitions with Néel temperatures (TN) of 1.97, 3.61, and 2.52 K, respectively. For Tb2Te4O11, a field-induced spin-flop transition is observed below TN = 3.61 K in the isothermal magnetization M(B) curves. Based on the analysis of the magnetocaloric effect (MCE), a crossover behavior is observed from the inverse MCE at low fields (ΔB < 1.8 T) to conventional MCE at high fields (ΔB > 1.8 T) below the TN in Tb2Te4O11; this is in contrast to the conventional MCE in all measured field regions in other RE2Te4O11 compounds.
研究领域:
凝聚态物理
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磁性材料
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低维量子系统
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固态化学
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DOI
PubMed
高影响因子
Journal of Materials Chemistry A
·
2025
·Vol. 13
·期 29
·23560-23569
·
IF 9.5
Pubao Peng,Yaru Gong,Wei Dou,Jiajun Nan,Yanan Li,Song Li,Yang Geng,Congmin Liang,Jiaqi Fan,Di Li,Dewei Zhang,Pan Ying,Yang Cao,Guodong Tang
SnSe demonstrates unparalleled potential in thermoelectric applications, combining non-toxicity, low cost, and abundant sources. Furthermore, polycrystals have good machinability and are easier to prepare. Here, we report a high peak ZT of 2.0 at 873 K in Pb and Er co-doped polycrystalline SnSe prepared through the hydrothermal method. An ultralow lattice thermal conductivity of 0.13 W m−1 K−1 at 873 K is obtained by introducing endogenous hetero-/homo-structural nanoprecipitates and Sn vacancies into the matrix to construct a multiscale scattering structure for phonons. Meanwhile, with the band alignment and flattening induced by Pb and Er co-doping, the effective mass is increased thus leading to a large Seebeck coefficient. Pb and Er co-doping not only optimizes the energy band structure of SnSe, but also optimizes the carrier concentration, thus simultaneously leading to enhanced electrical conductivity as well as enhanced electrical transport properties. Therefore, a high peak ZT of 2.0 is achieved in Pb and Er co-doped polycrystalline SnSe due to the markedly ultralow thermal conductivity and enhanced power factor. This work proposes a novel approach to synergistically regulate the electrical and thermal transport properties of polycrystalline SnSe-based thermoelectric materials through constructing endogenous hetero-/homo-nanostructures combined with band alignment.
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高影响因子
CRYSTENGCOMM
·
2020
·Vol. 22
·期 26
·4438-4448
·
IF 3.117
Dongxun Chen,Liangliang Zhang,Yanjie Liang,Weili Wang,Shao Yan,Jianqiang Bi,Kangning Sun
Yolk–shell structured Bi2SiO5:Yb3+,Er3+ upconversion nanophosphors have been successfully synthesized via a simple template-assisted route, in which the reaction of Yb3+/Er3+ co-doped bismuth precursor nanospheres with the silica capping layer in situ is ingeniously designed and controlled. The phase transition and morphology evolution are investigated in detail by X-ray powder diffraction and high-resolution electron microscopy to propose the formation mechanism of the yolk–shell nanostructure. The yielded Bi2SiO5:Yb3+,Er3+ nanophosphors can emit bright green upconversion luminescence under the excitation of a 980 nm laser diode, which enables them to be promising emitters for optoelectronic devices. The potential of the Bi2SiO5:Yb3+,Er3+ nanophosphors as an optical nanothermometer is also demonstrated. The proposed facile synthetic route, unique yolk–shell nanostructure and good upconversion luminescence performance lead the way to access these lanthanide-doped Bi2SiO5 nanophosphors for applications in biotechnology and optoelectronic devices.
研究领域:
材料科学
·
纳米技术
·
光电技术
·
生物技术
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DOI
高影响因子
RSC Advances
·
2019
·Vol. 9
·期 19
·10889-10896
·
IF 3.049
Xinxin Yan,Tiesheng Li,Linna Guo,Honglei Li,Penglei Chen,Minghua Liu
Pure cubic phase and uniform BiF3:Ln3+ (Ln = Ho, Er, Tm)/Yb3+ nanoparticles (NPs) were prepared by coprecipitation. The growth mechanism of BiF3:2%Er3+/20%Yb3+ NPs was proposed based on evolution analysis of the time-dependent morphology, in which BiF3:2%Er3+/20%Yb3+ was formed through the growth process of “nucleation to crystallization and Ostwald ripening”. The upconversion luminescence (UCL) properties and mechanism of BiF3:Ln3+ (Ln = Ho, Er, Tm)/Yb3+ under dual-wavelength excitation were also systematically investigated. The emission intensity of BiF3:2%Er3+/20%Yb3+ by dual-wavelength excitation (λ = 980 nm + 1550 nm) was 1.49 times more than that excited by 1550 nm or 980 nm individually. Furthermore, the properties of the bright white and multicolor UCL showed that yellow, purple, green, or pinkish light could be observed by controlling the doping concentration of Ln3+ (Ln = Yb, Er, Tm, and Ho), indicating that they had potential applications in backlight sources of color displays and security labeling. The temperature sensitivity of BiF3:2%Er3+/20%Yb3+ exhibited a downward tendency and its max value was about 0.0036 K−1 at 273 K. Cell toxicity tests showed that the UCNPs in phospholipid aqueous solution presented low cytotoxicity. Also, in vivo imaging and X-ray imaging revealed that the BiF3:2%Er3+/20%Yb3+ NPs had deep penetration and high contrast, which meant it could be used as a potential probe and contrast agent in in vivo optical bioimaging.
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高影响因子
JOURNAL OF POWER SOURCES
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2016
·
IF 6.333
Fanli Meng,Yi Luo,Yali Zhou,Jinwen Zhang,Yanzhen Zheng,Guozhong Cao,Xia Tao
A plasmon-enhanced upconversion composite Y 2 O 3 :Er/Au@TiO 2 (SYE/A@T) with a three-dimensional starlike morphology is prepared and then mixed with submicron TiO 2 (200 nm) to form a multifunctional scattering layer in TiO 2 -based dye-sensitized solar cells (DSSCs). In such starlike micronsized upconverter, Au nanoparticle-assisted plasmon effect can intensify the upconversion emission of Y 2 O 3 :Er, and simultaneously TiO 2 coating can improve the charge transport within SYE/A@T. Therefore, the SYE/A@T shows extended light-absorbing range to near-infrared region and improved light-scattering ability, leading to an improved photovoltaic performance of DSSCs. With the optimum mixing ratio, a conversion efficiency of 8.62% is attained, which is a significant improvement of 27.6% compared with the cell without adding SYE/A@T. Our work provides a feasible strategy to prepare an upconversion composite with plasmon-enhanced emission and enable this composite to accommodate the DSSCs system and improve the conversion efficiency of DSSCs.
研究领域:
材料科学
·
光伏技术
·
纳米光学
·
能源材料
·
表面等离激元
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DOI
高影响因子
Journal of Physical Chemistry C
·
2018
·
IF 4.484
Raheel Ahmed Janjua,Chan Gao,Rucheng Dai,Zhilei Sui,Muhammad Aqeel Ahmad Raja,Zhongping Wang,Xianxu Zhen,Zengming Zhang
Ultrasmall pure hexagonal phase NaYF4:Yb,Er is successfully prepared via the solvothermal method. The upconversion (UC) luminescence of hexagonal phase NaYF4:Yb,Er nanocrystals is ten times stronger than that of cubic phase nanocrystals with the same size of 6 nm. XRD results reveal that heating above 673 K leads to conversion of the hexagonal phase to the high-temperature cubic phase, whereas the cubic nanocrystals undergo phase transformation from normal cubic at room temperature to hexagonal at 673 K and further to high-temperature cubic above 773 K. The hexagonal nanocrystals exhibit emission enhancement after heat treatment up to 573 K. Further heating above 773 K induces a decreasing trend in emission due to the phase transition to the high-temperature cubic phase. The cubic phase exhibits decreasing luminescence with temperature due to strong cross relaxation and then increasing luminescence above the temperature of 673 K due to the hexagonal phase transformation. The luminescent properties of both the normal cubic phase and high-temperature cubic phase indicate that different crystal fields exist in these two phases due to the rearrangement of ligands around Er3+ at high temperature.
研究领域:
材料科学
·
纳米技术
·
发光材料
·
无机化学
·
光学材料
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DOI
高影响因子
Journal of Materials Chemistry B
·
2017
·Vol. 5
·期 26
·5128-5136
·
IF 4.543
Yike Fu,Heng Liu,Zhaohui Ren,Xiang Li,Jie Huang,Serena Best,Gaorong Han
Photodynamic therapy (PDT) and photothermal therapy (PTT) have been explored widely for application in cancer treatment. In this work, we describe the synthesis of CaTiO3:Yb,Er (CTO) nanofibers co-conjugated with Rose Bengal (RB) and gold nanorods (AuNRs), which offer the potential for combined upconversion photoluminescence (UCPL) and enhanced, synergistic PDT and PTT. Based on this delivery platform, RB and AuNRs served as the PDT and PTT agents, respectively. RB and AuNRs have strong and well-matched absorption with the green and red emissions of UCPL CTO nanofibers respectively, hence a single 980 nm continuous wave laser with deep tissue penetration can be employed to allow PDT and PTT to occur simultaneously. The nanocomposite can effectively convert the near-infrared (NIR) radiation from the laser into a combination of targeted hyperthermia and generation of reactive oxygen species (ROS). In comparison with PDT or PTT alone, the combined PDT/PTT treatment showed significantly enhanced suppression of the viability of Hep G2 cells in vitro, demonstrating its potential for use in oncology.
研究领域:
肿瘤学
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生物医学工程
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纳米医学
·
光动力治疗
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光热治疗
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DOI
高影响因子
EXPERIMENTAL EYE RESEARCH
·
2026
·
IF 3.1
Jiawei Shen,Jiayi Jiang,Gaoqin Liu,Weiming Liu,Hang Ren,Peirong Lu
Oral administration of TMAO elevated aqueous humor TMAO levels and effectively delayed cataract progression in diabetic rats. • TMAO inhibited the upregulated migration, apoptosis, ROS production and epithelial-mesenchymal transition levels induced by high glucose in lens epithelial cells. • RNA-seq confirmed that the attenuation of endoplasmic reticulum stress is a key mechanism underlying the protective effects of TMAO against high-glucose-induced phenotypic changes in lens epithelial cells. • TMAO protected lens epithelial cells against high-glucose-induced endoplasmic reticulum stress by improving the solubility of unfolded protein. • TMAO shows potential as a safe and effective treatment for diabetic cataract by targeting endoplasmic reticulum stress, without accelerating diabetic disease progression. This study aims to investigate the protective effects of trimethylamine N-oxide (TMAO), a natural occurring chaperone, on delaying diabetic cataract (DC) progression. Rats were divided into 4 experimental groups: untreated controls, TMAO treatment only, streptozotocin-induced diabetic mellitus (DM), and DM with TMAO therapy. After 10 weeks, aqueous humor TMAO levels and lens opacity were assessed. Immunofluorescence analyses and Western blotting were utilized to evaluate epithelial-mesenchymal transition (EMT)-related genes in lens epithelial cells (LECs). In vitro, HLE-B3 cells were treated with or without TMAO under high glucose (HG) environment (50 mmol/L), then collected for RNA-seq. Apoptosis and reactive oxygen species (ROS) were evaluated by flow cytometry while endoplasmic reticulum stress (ERS)-related genes were observed by western blotting. Elevated aqueous humor TMAO levels were detected in DC rats, compared to controls. In vivo and ex vivo, TMAO reduced HG-induced lens opacity and EMT in LECs. In vitro experiments demonstrated that HG resulted in enhanced apoptosis, migration, ROS and EMT-related genes in HLE-B3 cells while TMAO addition diminished these effects. RNA-seq revealed that the inhibition of ERS was the key factor to reverse the impacts of HG on LECs by TMAO and mechanistic investigations suggested that ERS-related pathway were significantly inhibited in TMAO treated LECs under HG or tunicamycin-induced ERS. Moreover, TMAO improved the solubility of lens protein in DC rats. Our study pioneered the confirmation of the protective role of TMAO in DC through inhibiting lens protein unfolding, suppressing ERS, and alleviating ERS-induced apoptosis, ROS and EMT in LECs.
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高影响因子
MICROCHIMICA ACTA
·
2026
·Vol. 193
·期 6
·369
·
IF 5.4
Ding Le,Bi Huifang,Liu Hanqing,Xu Jing,Wang Tao,Zhou Haifeng,Zhou Guangjun
A novel dual-signal sensing platform is developed for the simultaneous quantitative determination of resveratrol (Res) and ascorbic acid (AA), integrating fluorescence-based quantification with colorimetric visual recognition, with a sensing mechanism based on the inner filter effect (IFE) of a composite system consisting of upconversion nanoparticles (UCNPs), 3,3’,5,5’-tetramethylbenzidine (TMB), and ferric ions (Fe³⁺). In this system, Fe³⁺ first oxidizes colorless TMB to blue oxidized TMB (oxTMB), and the formed oxTMB further quenches the fluorescence of the UCNPs through the IFE. When Res or AA is introduced into the system, oxTMB is reduced back to colorless TMB, which results in the fading of the blue solution and the recovery of UCNP fluorescence, thus achieving the dual-signal detection of the two analytes through fluorescence-based quantification and colorimetric qualitative determination. Furthermore, 4-hydroxy-TEMPO is introduced as an AA-specific scavenger, which can effectively eliminate the interference of AA and achieve selective discrimination between Res and AA. This developed sensing platform integrates the prominent merits of simple operation, high sensitivity, excellent specificity, and visual readout. It provides not only a novel analytical strategy for the efficient detection of Res and AA but also broad application prospects in the field of analytical chemistry. Graphical abstract The alternative text for this image may have been generated using AI.
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PubMed
高影响因子
ENVIRONMENT INTERNATIONAL
·
2026
·
IF 10.2
Hong-Mei Li,Ju-Qin Kou,Ya-Jia Pu,Qian Wang,Yu-Xin Sheng,Jun-Ze Wang,Ya-Nan Tian,Yan-Rong Gao,Jia-He Sun,Xiao-Qi Zeng,Hai-Ming Xu
Background Benzophenones (BPs), widely used UV filters and endocrine disruptors globally known for their estrogenic effects, are raising growing concerns about chronic reproductive toxicity in males due to their increasing environmental concentrations. This study aims to reveal the effects and mechanisms of male reproductive injury induced by environmentally relevant concentrations of BPs exposure. Methods The study employed NHANES analysis, animal experiments, cell experiments, network toxicology, and molecular docking, and used transcriptome sequencing along with various biochemical and molecular experimental methods to measure downstream indicators. Results Analysis of the NHANES database indicates that BP-3 exposure showed dose-dependent associations with reduced total testosterone (TT)/estradiol (E2)/sex hormone-binding globulin (SHBG) and elevated testosterone deficiency (TD) risk. Effects attenuated but held direction after multi-pollutant adjustment. The results of animal experiments indicate that chronic exposure to BPs (PND1-PND240) impaired fertility and offspring development, reduced body weight, anogenital distance, and testis coefficient, and altered histopathology, sperm quantity, and quality. Differentially expressed genes were predominantly enriched in energy metabolism and integrity of actin cytoskeleton, and disulfidptosis-related metabolic/redox indicators were dysregulated in the testis. Notably, even short-term exposure to BP-3 disturbs the levels of disulfidptosis-associated metabolic drivers (PND1-PND56). In GC-2 cells, BP-3 reduced cell viability and antioxidant capacity, induced morphological alterations, elevated ROS level, and upregulated disulfidptosis markers. The involvement of disulfidptosis was confirmed by the addition of the antagonist TCEP and agonist KL-11743. Notably, estrogen receptor (ER) directly regulates disulfidptosis. Zeaxanthin dipalmitate (ZD) alleviates BPs-induced male reproductive injury by modulating disulfidptosis. Co-culture assays further confirmed BP-3 disrupts testicular metabolic coupling and triggers disulfidptosis. Conclusion BPs exposure induces male reproductive dysfunction via ER-mediated disulfidptosis. ZD can alleviate this dysfunction. Download: Download high-res image (208KB) Download: Download full-size image
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高影响因子
Nature Communications
·
2026
·
IF 18.1
Chun-Hui Duan,Pei-Pei Liu,Xin Sun,Wen-Hui Ma,Jia-Ying Pang,Zi-Han Zhang,Xiao Li,Lin-Fei Jiao,Hong-Zhen Du,Zhao-Qian Teng,Hou-Zao Chen,Chang-Mei Liu
Mitochondrial short-chain enoyl-CoA hydratase 1 deficiency (ECHS1D) is a rare and severe encephalopathy linked to neurodevelopmental disorders, yet the connection between metabolic dysfunction and impaired neurogenesis remains unclear. In this study, we demonstrate that the loss of Echs1 in neural stem/progenitor cells (NSPCs) leads to fatty acid accumulation, which hinders proliferation and differentiation while promoting apoptosis. Mechanistically, Echs1 deficiency increases crotonyl-CoA levels, resulting in global histone crotonylation (Kcr) with an enrichment of H3K9cr. Neurodevelopmental gene promoters, such as the endoplasmic reticulum (ER) stress regulator Atf4 , acquire H3K9cr. Atf4 then upregulates fatty acid synthase ( Fasn ), creating a feed-forward loop that exacerbates lipid accumulation. Inhibiting Fasn can rescue these defects. Alleviating ER stress through tauroursodeoxycholic acid (TUDCA) or Atf4 inhibition restores neurogenesis in vitro and enhances survival in vivo. This study uncovers an Echs1 -H3K9cr- Atf4 - Fasn axis that links metabolism to neurogenesis through epigenetic reprogramming and suggests TUDCA as a potential treatment for ECHS1D. In neural stem cells, ECHS1 deficiency rewires metabolism, driving a histone crotonylation-dependent feedback loop that impairs neurogenesis. The study reveals a mechanistic link between mitochondrial fatty acid oxidation and brain development and suggests tauroursodeoxycholic acid as a potential therapy.
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PubMed
高影响因子
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