INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION
·
2019
·
IF 2.792
Yuanfeng Wu,Yuke Shen,Ye Zhu,Jothame Mupunga,Ligen Zou,Chao Liu,Shiwang Liu,Jianwei Mao
After consuming broccoli, isothiocyanates can be produced by the hydrolytic action of myrosinase from plant and/or microbiota. Using male C57BL/6 mice, the present study investigated the effects of broccoli ingestion on the myrosinase-like activity, NAD(P)H:quinone oxidoreductase 1 (NQO1) activity, diversity and composition of the gut microbiota. Compared with the control group, continuously feeding raw or hydrolysed broccoli increased the myrosinase-like activities of the colon and caecum contents, and also improved the NQO1 activity of the colon mucosa. Significant difference between the broccoli and control feeding groups were found. 16S rRNA gene sequencing indicated that broccoli ingestion profoundly affected the composition of the gut bacteria community. The correlation between the gut bacterial community composition and microbiota myrosinase-like activity was also studied. However, one type of glucosinolate, sinigrin, had no effect on these activities, indicating that broccoli component(s), other than glucosinolate, had increased the NQO1 and myrosinase-like activities.
研究领域:
营养学
·
微生物学
·
分子生物学
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DOI
PubMed
高影响因子
LIQUID CRYSTALS
·
2014
·
IF 2.349
Fafu Yang,Jin Yuan,Congcong Li,Hongyu Guo,Xiaoyun Yan
Series of triphenylene derivatives with multiple NH groups 3a, 3b, 4a, 4b, 5a and 5b were designed and synthesised by simple procedures in high yields. Their structures were confirmed by Fourier transform infrared spectroscopy (FTIR), nuclear magnetic resonance (NMR), mass spectrometry (MS) and elemental analysis. Their mesophase behaviours were studied by differential scanning calorimetry, polarising optical microscopy and X-ray diffraction. The triphenylene derivatives 3a and 3b with two NH groups and triphenylene derivatives 4a and 4b with three NH groups possess excellent mesomorphic properties. Compounds 4a and 4b exhibited wider mesophase than compounds 3a and 3b. Triphenylene derivatives 5a and 5b with five NH groups have no mesomorphic properties. These results suggested the units of hydrogen bonds played the crucial roles on mesomorphic properties and acylthiosemicarbazide group with three NH groups was a good functional group for producing excellent mesomorphic properties.
研究领域:
材料化学
·
物理化学
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DOI
高影响因子
PROGRESS IN ORGANIC COATINGS
·
2017
·
IF 2.858
Fei Gao,Jiancheng Cao,Qibo Wang,Ren Liu,Shengwen Zhang,Jingcheng Liu,Xiaoya Liu
A series of ultraviolet (UV)-curable self-healing polyurethane (PU) oligomers were synthesized by incorporating different contents of 2-ureido-4[1H]-pyrimidone and polycarbonate diols (PCDL) with different molecular weights at the end of PU chains. The structure of the oligomers were determined through Nuclear magnetic resonance ( 1 H NMR) and Fourier transform infrared spectroscopy. The PU oligomers were used to produce UV-curable self-healing coatings, the properties of which were investigated and the properties of the coatings with different functionality were studied. The results revealed that the performance of the coating was higher when a higher molecular weight of PCDL was used and With functionality increasing, the crosslinking density of the coating ascends, resulting in higher self-healing temperature and upper pendulum hardness and gloss of the coating. To balance the self-healing ability and mechanical properties of the coating, a series of coating formulations were designed by adding different types and amounts of active diluents. Double bond conversion, thermostability, and self-healing ability were investigated to determine the effect of active diluents on coating performance. The results demonstrated that the resultant coating have excellent adhesion, gloss, and thermostability. Coatings prepared used all types of active diluents had favorable self-healing ability, except for that prepared using 2-acryloyloxymethyl-2-ethyltrimethylene diacrylate. Excellent self-healing and mechanical properties were obtained when 20 w.t.% of triethoxylated trimethylolpropane triacrylate was used.
研究领域:
材料科学
·
化学工程
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DOI
高影响因子
PROGRESS IN ORGANIC COATINGS
·
2020
·
IF 4.469
Hongyi Shi,Weiqu Liu,Chunhua Liu,Maiping Yang,Yankun Xie,Shuo Wang,Fengyuan Zhang,Liyan Liang,Ke Pi
Herein, h-BN powders were sonicated in an aqueous solution of polyethylenimine (PEI) to simultaneously exfoliate and functionalize h-BN nanosheets with Lewis acid-base interaction. The structure and morphology of PEI modified h-BN nanosheets (PEI-BNNSs) were characterized by FTIR, TGA, AFM and TEM. The as-prepared PEI-BNNSs were served as anticorrosive nanofillers for waterborne epoxy (EP) coatings on Q235 carbon steel. The corrosion behaviors of EP and PEI-BNNSs/EP coating systems in 3.5 wt % NaCl aqueous solution were evaluated by electrochemical workstation. It is worth noting that the protection efficiency (PE) values of 1 wt % PEI-BNNSs/EP and 2 wt % PEI-BNNSs/EP coating systems are as high as 99.99 % compared to EP coating systems. Moreover, the impedance modulus (|Z| f = 0.01 Hz ) of the 1 wt % PEI-BNNSs/EP coating system was 3–4 orders of magnitude higher than the EP coating after 90 days of immersion. The electrochemical results revealed that PEI-BNNSs can significantly enhanced the corrosion resistance of waterborne epoxy coatings.
研究领域:
材料科学
·
腐蚀与防护
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纳米技术
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DOI
高影响因子
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
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2022
·
IF 7.139
Qu Tang,Xiaobo Zhou,JinXia Liu,Mingmin Wu,Haiwei Ji,Qi Wang,Guo Li,Hui Cong,Yuling Qin
The use of Formic acid as an alternative to fossil fuels is promising, both from economical and ecological standpoints, and has received great of attention owing to its inherently superiority in recent decades. Nevertheless, efficient and low-cost solid catalyst for formic acid dehydrogenation at room temperature still constitutes a biggish challenge. Moreover, comparing to increase the catalytic performance of catalysts, very little attention payed to the kinetic mechanism of dehydrogenation reaction because of the lack of effective characterization artifice. Here, the as-prepared Ni@Pd nanoparticles by a sequential reduction process can be useful catalyst for formic acid decomposition at room temperature without a promoter. Thanks to the effective catalyst and isotope distribution technique, preliminary mechanistic results firstly reveal that hydrogen is obtained via a H-atom recombination on isolated sites after the proton exchange randomly between activated H and solvent.
研究领域:
材料科学
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催化化学
·
能源科学
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DOI
高影响因子
CURRENT PHARMACEUTICAL DESIGN
·
2022
·Vol. 28
·期 9
·743-750
·
IF 3.31
Ning Zhouyu,Yang Lina,Yan Xia,Wang Dan,Hua Yongqiang,Shi Weidong,Lin Junhua,Meng Zhiqiang
Background: To investigate the effects of the Lenvatinib@H-MnO2-FA administration system on the proliferation and apoptosis of Intrahepatic cholangiocarcinoma (ICC) and the underlying molecular mechanism. Materials and Methods: In this research, hollow MnO2
(H-MnO2) was synthesized via the modified Stöber method, and H-MnO2 was modified with polyethylene glycol-bis (Amine) (NH2-PEG-NH2) and folic acid (FA) to obtain H-MnO2-PEG-FA (H-MnO2-FA).
Lenvatinib was coated in the hollow cavity of H-MnO2-PEG-FA to further form a nanometre drug-carrying system (Lenvatinib@H-MnO2-PEG-FA). Lenvatinib@H-MnO2-FA was characterized through transmission electron microscopy (TEM)
and scanning electron microscopy (SEM). Fourier transform infrared spectroscopy (FT-IR) was used to verify that Lenvatinib was loaded on nanoparticles. Functionally, confocal laser scanning microscopy (CLSM), 2-(4-Amidinophenyl)-6-indolecarbamidine dihydrochloride (DAPI) staining, and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium
bromide (MTT) assay were performed to determine the effect of Lenvatinib@H-MnO2-FA on the proliferation and apoptosis of ICC cells (9810 cells). Finally, the protein levels of Raf-1MEK1/2-ERK1/2 signalling pathway components were detected through Western blotting analysis.
Results: We successfully synthesised a Lenvatinib@H-MnO2-PEG-FA administration system. The resulting nanomaterials had excellent biological stability and improved targeting effects. Functionally, Lenvatinib@ H-MnO2-FA inhibited the proliferation
of 9810 cells. The Bcl-2 protein level was significantly downregulated, and the caspase-3 protein level was significantly upregulated, indicating that Lenvatinib@H-MnO2- PEG- FA promoted the apoptosis of 9810 cells. Mechanistically, Lenvatinib@H-MnO2-FA
increased the phosphorylation levels of Raf, MEK1/2, and ERK1/2. Conclusion: H-MnO2-FA can more effectively deliver Lenvatinib to inhibit proliferation and promote apoptosis in ICC, which could be the promising drug delivery nano-vehicles for delivery drugs.
研究领域:
药理学
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肿瘤学
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纳米技术
·
细胞生物学
·
分子生物学
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DOI
PubMed
高影响因子
CERAMICS INTERNATIONAL
·
2026
·
IF 6
Runduo Teng,Changhao Feng,Yanting Wang,Wenjun Tu,Tianyu Lan,Qiyuan Fu,Jingyu Long
N-butanol is widely used in fields such as chemical engineering and pharmaceutical synthesis; therefore, trace-level, highly sensitive detection of n-butanol is of great significance. In this study, an n-butanol gas sensor based on silver (Ag)-decorated yttrium ferrite (YFeO 3 ) nanotubes was fabricated using the electrospinning followed by the impregnation method. Compared with the pure YFeO 3 , the Ag-decorated YFeO 3 nanotubes exhibited an enhanced response of 162.06 toward 10 ppm n-butanol. This remarkable gas-sensing performance is primarily attributed to the synergistic effects of the mixed-valence states of iron, abundant surface oxygen vacancies, and the Ag spillover effect. Moreover, it exhibits excellent long-term stability and a detection limit as low as 76.5 ppb. These results indicate that Ag-decorated YFeO 3 nanotubes hold significant potential for trace n-butanol detection.
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产品关联
DOI
高影响因子
Nature Catalysis
·
2026
·
IF 48.3
Ding Liang,Yao Ze-Cheng,Tang Tang,Wan Xin,Liu Xiaozhi,Jiang Zhe,Fu Jiaju,Shi Zhuo-Qi,Tai Jing,Lyu Zhen-Hua,Dong Jichen,Li Qing,Su Dong,Shui Jianglan,Hu Jin-Song,Wan Li-Jun
High-performance cathode catalysts are essential for proton-exchange membrane fuel cells. Intermetallic nanocrystals are promising candidates but suffer from intrinsic activity–durability trade-offs because their comprehensive catalytic properties are determined by several intertwined structural factors that cannot be optimized independently by existing synthesis techniques. The challenge lies in the inherent thermodynamic and kinetic constraints during synthesis. Here we develop a decoupled synthesis strategy that leverages block-copolymer micelle confinement, which enables the customized synthesis of libraries of intermetallic nanocrystals, simultaneously achieving ultra-small size, ultra-high ordering degree, tailorable loading density, narrow size distribution, compositional uniformity, and broad compositional and substrate universality. The developed Pt 3 Co intermetallic nanocrystal/Ketjenblack catalyst achieves a rated power density of 1.08 W cm −2 and 92% rated power retention after 30,000 cycles under light-duty-vehicle conditions and 900 h of stable operation at 10 A. It also delivered a 70.2% cell efficiency without degradation and 98.4% specific power retention after 90,000 cycles of heavy-duty-vehicle applications. This performance led us to project a lifetime of 240,000 h.
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产品关联
DOI
高影响因子
Materials
·
2026
·Vol. 19
·期 18
·3966
·
IF 3.7
Zhe Tong,Xinghao Song,Wenxing Lei,Yajun Zhang,Jiaojiao Li,Li Zhao
The incorporation of various types of fillers is critical to enhancing the starved oil lubrication performance of PEEK matrix composites. In this work, PEEK composites reinforced with h-BN and SCFs were fabricated via a hot-pressing method, and the friction and wear behaviors under dry sliding and starved oil lubrication were systematically investigated. Surface oil wettability and Vickers hardness were characterized, and tribological tests were conducted on a ball-on-disk reciprocating tribometer. Worn surface topography and wear mechanisms were elucidated through laser scanning confocal microscopy and scanning electron microscopy. The results show that h-BN effectively reduces the friction coefficient through its solid lubrication effect, while SCFs significantly improve the hardness and load-bearing capacity of the PEEK matrix. Under dry sliding conditions, the PEEK composite containing h-BN and SCFs achieves the lowest wear rate of 10.3 × 10−5mm3/(N·m), which is 74.6% lower than that of pure PEEK, indicating a synergistic anti-wear effect. Under starved oil lubrication, PEEK/h-BN maintains the smoothest and lowest friction, and the presence of SCFs further improves wear resistance of PEEK composites despite a slight increase in friction. In addition, the fillers’ incorporation reduces the surface oil wettability of the PEEK composites; the dominant wear mechanism hence transforms from severe adhesive wear and plastic deformation in pure PEEK to mild abrasive wear.
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DOI
高影响因子
Nature Communications
·
2026
·
IF 18.1
Fang Geqian,Alhajjar Nour,Yu Wenjun,Marinova Maya,Ben Tayeb Karima,Lin Jian,Roland Thomas,Simon Pardis,De Waele Vincent,Ordomsky Vitaly V.,Khodakov Andrei Y.
Selective photocatalytic oxidation of methane to liquid oxygenates under ambient conditions remains challenging due to the inert C–H bond and propensity for over-oxidation. Controlling carrier transfer and reactive oxygen species is therefore essential to the selective methane photooxidation. Ultrasmall zirconium metal–organic framework (UiO-66-H) nanocrystals in situ grown on titania form a heterojunction that promotes efficient charge separation and tunes the interfacial band alignment. Comprehensive experiments and characterization reveal that this heterojunction precisely regulates • OH and • OOH generation, enabling controlled, radical-mediated oxidation of methane with a competitive oxygenate yield and nearly 100% selectivity at room temperature using air as an oxidant. In this work, ultrasmall metal–organic framework–semiconductor heterojunctions with a built-in electric field provide an effective route for developing efficient, low-cost photocatalysts for methane chemical valorization under mild, solar-driven conditions.
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DOI
PubMed
高影响因子
ACS ES&T Engineering
·
2026
·
IF 6.3
Xu Pan,Jiangkun Xie,Mingze Jiao,Liang Shan,Hongyuan Qi,Wenjun Huang,Zan Qu,Naiqiang Yan,Haomiao Xu
Methane selective catalytic reduction (CH4-SCR) represents a promising strategy for nitrogen oxides (NOx) abatement, yet its practical application is hindered by catalyst deactivation in the presence of water, caused by competitive adsorption on acid sites and irreversible hydroxylation of active metal species. In this study, we developed a dual-functional In@H-Beta/Fe2O3 catalyst through sequential ion-exchange and impregnation. This architecture confines indium species within the channels of H-Beta zeolite, while Fe2O3 nanoparticles are dispersed on the external surface, creating a synergistic system featuring a hydrophobic layer and strong Fe–O–In interfacial interactions. Under 5% H2O conditions, the optimized catalyst achieves 85% NOx conversion (vs 40% for conventional In@H-Beta). The enhanced water resistance is attributed to two factors: first, Fe2O3 establishes a physical barrier that protects acid sites and stabilizes InO+ active sites via Fe–O–In bonding, thereby inhibiting hydroxylation; second, strong interfacial Fe–O–In interactions further stabilize InO+ active sites against aqueous deactivation. Additionally, the Fe2+/Fe3+ redox cycle is proposed to facilitate O2 activation. In situ DRIFTS studies under 5% H2O confirm effective CH4 activation, as indicated by markedly more intense C–H stretching bands compared with In@H-Beta. The reaction pathway involves NO activation over Brønsted acid sites to form nitrate species, and CH4 activation on InO+ sites generating methyl radicals, which subsequently participate in NOx reduction. This work offers a new design strategy for developing highly active and water-tolerant CH4-SCR catalysts suitable for industrial flue gas treatment.
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产品关联
DOI
高影响因子
ACS Catalysis
·
2026
·
IF 13.6
Jun-Bin He,Lian Wu,Wenli Yuan,Hai-Xue Pan,Binju Wang,Gong-Li Tang
Achieving highly regioselective C–H bond functionalization at the bridgehead carbon of a single molecule is a fascinating, yet formidable challenge. BcmD, a P450 enzyme, catalyzes the regioselective hydroxylation at the sp3-hybridized bridgehead carbon of the bicyclo[4.2.2]piperazinedione ring scaffold during bicyclomycin biosynthesis. Herein, we provide mechanistic details of BcmD to understand its substrate binding and the origin of its regioselectivity. The high-resolution structure of SoBcmD from Streptomyces ossamyceticus in complex with its natural substrate, together with site-directed mutagenesis and computational simulations, reveals that the precise substrate positioning, enabled by specific hydrogen-bonding and hydrophobic interactions with crucial residues, determines the regioselectivity. Intriguingly, we identify SoBcmD as a peroxygenase that could utilize H2O2 as an oxidant to catalyze regioselective hydroxylation. Mechanistic analysis indicates that H2O2 activation in SoBcmD involves a homolytic cleavage process, mediated by a hydrogen-bonding network comprising residues T277, A273, and the substrate. Furthermore, structure-based channel analysis and mutagenesis demonstrate that the I157V mutant exhibits significantly enhanced peroxygenase activity. These findings advance our understanding of regioselectivity control in BcmD and provide valuable guidance for engineering P450 peroxygenases for the C–H bond activation at the chemically challenging bridgehead carbon sites.
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DOI
高影响因子
危险品化学品经营许可证（带存储）