Biomaterials Science
·
2021
·Vol. 9
·期 7
·2553-2561
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IF 6.843
Peiqi Yuan,Yilun Luo,Yu Luo,Lie Ma
Considering the key roles of macrophages in tissue repair and immune therapy, designing smart biomaterials able to harness macrophage phenotypes on demand during the healing process has become a promising strategy. Here, a novel “sandwich” cell culture platform with near-infrared (NIR) responsive dynamic stiffness was fabricated to polarize bone marrow-derived macrophages (BMDMs) in situ for revealing the relationship between the macrophage phenotype and substrate stiffness dynamically. Under NIR irradiation, calcium ions (Ca2+) diffused through the middle layer of the IR780-mixed phase change material (PCM) due to the photothermal effect of IR780, resulting in an increase of hydrogel stiffness in situ by the crosslinking of the upper layer of the hyaluronic acid-sodium alginate hydrogel (MA-HA&SA). The up-regulation of inducible nitric oxide synthase (iNOS) and tumor necrosis factor-α (TNF-α) was quantified by immunostaining and enzyme-linked immune sorbent assay (ELISA), respectively, indicating the transformation of macrophages from the anti-inflammatory to pro-inflammatory phenotype under dynamic stiffness. The nuclear Yes-associated-protein (YAP) ratio positively correlated with the shift of the macrophage phenotype. The modulation of macrophage phenotypes by stiffness-rise without the stimuli of cytokines offers an effective and noninvasive strategy to manipulate immune reactions to achieve optimized healing or therapeutic outcomes.
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BIOMATERIALS
·
2020
·
IF 10.317
Fenfen Li,Tuanwei Li,Debo Zhi,Pengping Xu,Wenshen Wang,Yi Hu,Yuanyuan Zhang,Shaozhen Wang,J. Matula Thomas,J. Beauchamp Norman,Weiping Ding,Lifeng Yan,Bensheng Qiu
Encouraging progress in multifunctional nanotheranostic agents that combine photothermal therapy (PTT) and different imaging modalities has been made. However, rational designed and biocompatible multifunctional agents that suitfable for in vivo application is highly desired but still challenging. In this work, we rationally designed novel ultrasmall multifunctional nanodots (FS-GdNDs) by combining the bovine serum albumin (BSA)-based gadolinium oxide nanodots (GdNDs) obtained through a biomineralization process with a small-molecule NIR-II fluorophore (FS). The as-prepared FS-GdNDs with an ultrasmall hydrodynamic diameter of 9.3 nm exhibited prominent NIR-II fluorescence properties, high longitudinal relaxivity (10.11 mM −1 s −1 ), and outstanding photothermal conversion efficiency (43.99%) and photothermal stability. In vivo studies showed that the FS-GdNDs with enhanced multifunctional characteristics diaplayed satisfactory dual-modal MR/NIR-II imaging performance with a quite low dose. The imaging-guided PTT achieved successful ablation of tumors and effectively extended the survival of mice. Cytotoxicity studies and histological assay demonstrated excellent biocompatibility of the nanodots. Importantly, this novel FS-GdNDs can undergo efficient body clearance through both hepatobiliary and renal excretion pathways. The novel ultrasmall multifunctional FS-GdNDs with excellent features hold tremendous potential in biomedical and clinical applications.
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DALTON TRANSACTIONS
·
2020
·Vol. 49
·期 18
·6074-6083
·
IF 4.174
Rongyun Jiang,Jian Yang,Yangqi Meng,Duanting Yan,Chunguang Liu,Changshan Xu,Yuxue Liu
Zn2Ga3−x−yCrxNdyGe0.75O8 (ZGGO:Crx,Ndy) persistent luminescent nanoparticles (PLNPs) (x = 0, 0.02; and y = 0, 0.01, 0.02, 0.03, 0.04) were synthesized via a hydrothermal method in combination with a following heat treatment under vacuum. The effects of Nd3+ concentration on chemical composition, size distribution, luminescence property, the persistent energy transfer from Cr3+ to Nd3+ and afterglow imaging were studied in detail. When the Nd3+ concentration was increased from 0 to 0.04, the particle size increased from 45.4 to 86.2 nm. The afterglow emissions in the NIR-I (696 nm) and NIR-II (1067 nm) regions, which are ascribed to the 2E, 4T2 → 4A2 transitions of Cr3+ and the 4F3/2 → 4I11/2 transition of Nd3+, respectively, were simultaneously acquired after stopping the 635 nm excitation. Among the nanoparticles with different concentrations, ZGGO:Cr0.02,Nd0.02 exhibits the strongest NIR-II afterglow intensity and the corresponding energy transfer efficiency from Cr3+ to Nd3+ is found to be 25.9%. In addition, enhanced X-ray excited afterglow imaging can be observed in Nd3+/Cr3+ codoped nanoparticles dispersed in water, human serum albumin solution and simulated lysosomal environment compared to the Cr3+ singly doped nanoparticles. Renewable NIR afterglow imaging was realized through an X-ray reexcitation strategy. In particular, both the X-ray excitation strategy accompanied by NIR-I afterglow emission and the red light (635 nm) excitation strategy accompanied by NIR-II afterglow emission exhibit high tissue penetration capability. This study provides a further understanding of how to develop a suitable strategy for realizing deep tissue autofluorescence-free bioimaging.
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CONSTRUCTION AND BUILDING MATERIALS
·
2020
·
IF 4.419
Qiang Gao,Xiaomei Wu,Rong Zhu
In this work, BiOCl x Br 1−x microflowers were synthesized as building blocks for superhydrophobic NIR reflective coatings. The molar ratio of Cl to Br had a great influence on the microstructure and optical properties of BiOCl x Br 1−x . As the increase of x value, the microflower structure tunes from loose to dense. The NIR solar reflectance of BiOCl x Br 1−x ranges from 0.860 to 0.935. The BiOCl x Br 1−x coatings reduced the inner temperature of the heat box by approximately 3.9 °C. Due to the three-dimensional hierarchical structure of BiOCl x Br 1−x microflowers, superhydrophobic cool coatings can be fabricated on various building materials, such as concretes, aluminum plates, and glasses. Moreover, the superhydrophobic coatings exhibit superior antifouling performance, contributing to retain high NIR reflectance of the coatings for a long time. Therefore, the prepared superhydrophobic NIR reflective coatings with superior antifouling property have great potential to be used for building energy-saving.
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CHEMICAL ENGINEERING JOURNAL
·
2020
·
IF 10.652
Jundong Shao,Jing Zhang,Chao Jiang,Jing Lin,Peng Huang
As a prominent member of two dimensional (2D) materials, MXenes have shown encouraging photophysical properties and so there is highly desirability to explore their phototherapeutic potential in cancer. Herein, we demonstrate a facile top-down strategy for the synthesis of nitride-based MXene, titanium nitride quantum dots (Ti 2 N QDs) in solution. With a size of around 5 nm, the obtained Ti 2 N QDs exhibit extraordinarily high photothermal conversion efficiency under laser irradiation in both first and second near-infrared (NIR) biowindows (NIR-I, 808 nm, 48.62%; and NIR-II, 1064 nm, 45.51%). In vitro and in vivo assessments demonstrate that the Ti 2 N QDs possess excellent biocompatibility, photoacoustic (PA) effect, and photothermal therapy (PTT) efficiency. Moreover, the Ti 2 N QDs showing obvious aggregation in tumors after 4 h post-injection, which enables facilitate PA imaging-guided PTT in both NIR-I/II biowindows without noticeable toxicity. Encouragingly, the Ti 2 N QDs with appropriate degradation property also show an applicable excretion rate from the body in vivo , which ensures sufficient stability in circulation to accomplish therapeutics roles and then can be smoothly discharged from the body after that. These results indicate the high potential of biodegradable Ti 2 N QDs in PA imaging-guided PTT in both NIR-I/II biowindows for precision cancer treatment.
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BIOMACROMOLECULES
·
2019
·
IF 5.667
Pengfei Sun,Ting Huang,Xiaoxiao Wang,Gaina Wang,Zhijia Liu,Guosong Chen,Quli Fan
Near-infrared (NIR) light-responsive, injectable hydrogels are among the most promising drug delivery systems for localized anticancer therapy owing to its minimally invasive administration and remote-controlled manner. However, most currently reported NIR-responsive hydrogels were usually generated through physical mixing of thermosensitive polymers and photothermal conversion agents. In this study, a novel type of dynamic-covalent hydrogel (GelPV-DOX-DBNP) with NIR light-triggered drug release behavior was rationally designed for chemo-photothermal combination treatment of tumors. Concretely, this NIR-responsive hydrogel was formed by specific benzoxaborole-carbohydrate interactions between benzoxaborole (BOB)-modified hyaluronic acid (BOB-HA) and fructose-based glycopolymer (PolyFru), where photosensitizer perylene diimide zwitterionic polymer (PDS), reductant ascorbic acid (Vc), anticancer drug doxorubicin (DOX) as well as photothermal nanoparticles (DB-NPs) were encapsulated, simultaneously. Upon 660 nm light irradiation, both PDS and Vc within the designed hydrogel can convert oxygen into hydrogen peroxide, which could make hydrogel be degraded through the breakage of dynamic covalent bonds based on benzoxaborole-carbohydrate interactions, leading to NIR light-activatable release of DOX and DB-NPs from GelPV-DOX-DBNP. Furthermore, the released DB-NPs can convert 915 nm light irradiation into heat, enabling the application of GelPV-DOX-DBNP as a NIR-responsive drug delivery platform for both chemotherapy and photothermal therapy (PTT). In vivo results prove that GelPV-DOX-DBNP exhibited a markedly enhanced chemo-photothermal synergistic therapy for 4T1 tumor model mice, compared to chemotherapy alone or PTT. This work presents a new strategy to construct NIR light-responsive hydrogel as one alternative drug delivery system for anticancer applications.
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Regenerative Biomaterials
·
2023
·
IF 6.7
Zhong Jun,Zheng Xiang,Wen Yuan,Li Yuewei,Zhang Jianting,Kankala Ranjith Kumar,Wang Shibin,Chen Aizheng
The inadequate quantity of hydrogen peroxide (H2O2) in cancer cells promptly results in the constrained success of chemodynamic therapy (CDT). Significant efforts made throughout the years, nevertheless, researchers are still facing the great challenge of designing a CDT agent and securing H2O2 supply within the tumor cell. In this study, taking advantage of H2O2 level maintenance mechanism in cancer cells, a nanozyme-based bimetallic metal-organic frameworks (MOFs) tandem reactor is fabricated to elevate intracellular H2O2 levels, thereby enhancing CDT. In addition, under near-infrared excitation, the upconversion nanoparticles (UCNPs) loaded into the MOFs can perform photocatalysis and generate hydrogen, which increases cellular susceptibility to radicals induced from H2O2, inhibits cancer cell energy, causes DNA damages and induces tumor cell apoptosis, thus improving CDT therapeutic efficacy synergistically. The proposed nanozyme-based bimetallic MOFs-mediated CDT and UCNPs-mediated hydrogen therapy act as combined therapy with high efficacy and low toxicity.
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Advanced Healthcare Materials
·
2023
·
IF 10
Yihang Ruan,Huilan Zhuang,Xuemei Zeng,Lili Lin,Xuechun Wang,Panpan Xue,Shan Xu,Qi Chen,Shuangqian Yan,Wei Huang
The colon tumor microenvironment has a high concentration of H 2 S and glutathione, which is highly immunosuppressive and adverse to multiple therapeutic methodologies such as ferroptosis. Here, an engineered microbial nanohybrid based on Escherichia coli ( E. coli ) and Cu 2 O nanoparticles to specific colon tumor therapy and immunosuppression reversion is reported. The as-prepared E. coli @Cu 2 O hybrid can accumulate in tumor sites upon intravenous injection, and Cu 2 O nanoparticles convert to Cu x S by consuming the endogenous H 2 S, which exhibits strong photothermal conversion at near-infrared II (NIR II) biological window. Furthermore, E. coli @Cu 2 O is able to induce cellular ferroptosis and cuproptosis through inactivation of glutathione peroxidase 4 and aggregation of dihydrolipoamide S-acetyltransferase, respectively. Photothermal-enhanced ferroptosis/cuproptosis achieved by E. coli @Cu 2 O reverses the immunosuppression of colon tumors by triggering dendritic cell maturation (about 30%) and T cell activation (about 50% CD8 + T cells). Concerted with immune checkpoint blockade, the engineered microbial nanohybrid can inhibit the growth of abscopal tumors upon NIR illumination. Overall, the designed microbial nanohybrid can achieve tumor-specific photothermal-enhanced ferroptosis/cuproptosis and immunosuppression reversion, showing promise in precise tumor therapy in future clinical translation.
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Advanced Therapeutics
·
2023
·
IF 4.6
Mingxun Li,Yibin Wu,Chunfeng He,Xinxin Li,Ji Tao,Chunrong Qu,Wen-Hua Chen,Zhen Cheng
Mitochondrial membrane potential (Δ Ψ m)-targeting molecular probes play an essential role in diagnosing and treating diseases. Recently, the second near-infrared window (NIR-II, 1000–1700 nm) fluorescent imaging has been actively studied as an attractive imaging modality. However, small molecule Δ Ψ m-targeting NIR-II probes are rarely reported, especially for highly efficient imaging and treatment of tumors. Herein, a small molecule probe named TQPTPP is designed and synthesized by conjugation of a novel D-A type dye TQT1009 with Δ Ψ m-targeting molecule alkyl triphenylphosphine (TPP) through a polyethylene glycol-8 (PEG 8 ) linker. The conventional ICG dye is also coupled with TPP through PEG 8 to produce ICGTPP as a comparison. TQPTPP showed a fluorescence quantum yield of 0.041% and excellent photothermal conversion efficiency (61.4%). It can be self-assembled into nanoparticles and still preserve Δ Ψ m-targeting capability. Tumor imaging is further performed, and results showed a long tumor retention time of TQPTPP (maximum tumor signal on day five and signal-to-noise ratio up to nine). As a comparison, ICGTPP remained a single molecule with Δ Ψ m-targeting capability. But it has shorter tumor retention and lower photostability. These results suggested the novel D-A small molecule ΔΨ m-targeting NIR-II probe TQPTPP provided a new tool for diagnosing and treating tumors.
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TALANTA
·
2023
·
IF 6.1
Lin Yuan,Yingbin Su,Runfeng Zhang,Jie Gao,Bing Yu,Hailin Cong,Youqing Shen
Organic small molecule fluorescent groups have injected new material support into the field of medical imaging due to their unique luminescence mechanism and easy tuning of structure. The great potential of NIR-II window imaging forces us to continuously optimize the structure of organic fluorophores to design better fluorescent molecules for fluorescence imaging-guided surgery. An ideal organic small molecule fluorescent group: it can penetrate into the inside of the organism, clearly present the internal structure and the edge contour of different tissues, so as to perfectly achieve internal imaging and accurately guide external surgery. In vivo, fluorescent groups do not damage normal tissues and organs. However, problems such as low quantum yield and poor biocompatibility greatly limit the clinical transformation of NIR-II fluorescent small molecules. To avoid the shortcomings of NIR-II fluorescent probes as much as possible and better realize image-guided surgery, in this experiment, the biplane donor unit was incorporated into the twisted D-π-A-π-D structure to expand the conjugated structure of the fluorescent group, which not only realized NIR-II emission, but also had high quantum yield and biosafety.
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CERAMICS INTERNATIONAL
·
2023
·
IF 5.2
Zhongxiang Shao,Xianju Zhou,Li Li,Yongjie Wang,Faling Ling,Chuan Jing,Xiao Tang,Zhongmin Cao
The broadband near-infrared (NIR) phosphor converted light emitting diode (NIR pc-LED) has garnered unprecedented attention due to its crucial role in NIR applications. However, there remains a scarcity of efficient broadband NIR luminescence materials capable of emitting NIR light with wavelengths greater than 800 nm. This study reports the synthesis, crystal structure and photoluminescence (PL) properties for double perovskite Sr 2 ScTaO 6 :Cr 3+ phosphors which exhibit a broadband NIR emission in the 650–1250 nm range, peaking at∼815 nm with the full width at half maximum (FWHM) of 161 nm. The observed broadband emission arises from two distinct Cr 3+ centers, namely Sc 3+ and Ta 5+ octahedral sites within the Sr 2 ScTaO 6 structure, as demonstrated by luminescence and decay kinetic analysis. A significant enhancement of the thermal stability and a remarkable broadening of the FWHM (from 161 to 275 nm) are achieved by employing Yb 3+ co-doping strategy. The efficient energy transfer from Cr 3+ to Yb 3+ was confirmed through emission and excitation spectra, as well as luminescence decay measurements. Finally, Sr 2 ScTaO 6 :Cr 3+ -Yb 3+ phosphor was integrated with a 470 nm blue LED chip to fabricate a NIR pc-LED device, and its potential application in night vision was evaluated.
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CERAMICS INTERNATIONAL
·
2023
·
IF 5.2
Xuejiao Li,Zilong Xu,Dongyue Liu,Guolong Chen,Yuxiao Wang,Bo Li,Rui Li,Na Fan,Lianwei Shan,Xin Liu,Limin Dong
Near-infrared responsive photothermal therapy is an emerging and non-invasive cancer treatment. However, the inability of real-time imaging tracking and monitoring for the photothermal agents (PTAs) severely limits the accuracy of treatment. In this study, a series of visual xGd-WO 3 @PEG PTAs were synthesized by a one-pot solvothermal method. The effect of different Gd doping amounts on the structure, morphology, and photothermal performance has been investigated in detail. Under the near-infrared laser irradiation, the samples exhibited satisfied photothermal properties of hyperthermia in a short time. The photothermal conversion efficiency and stability of the xGd-WO 3 @PEG (x = 7 %) were further investigated. Subsequently, the near-infrared thermal and CT imaging performance was studied. The in vitro cell viability on LO2 normal and 4T1 cancer cells have also been conducted. The results showed the xGd-WO 3 @PEG nanomaterials have excellent potential in imaging-guided photothermal cancer therapy.
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