JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
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2026
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IF 4.4
Haoyi Xu,Xiaoning Deng,Ying Zhang,Yuwei Pan
Chelating agents significantly enhanced SDZ degradation in UV/Fe 2+ /H₂O₂ system. • The CA-enhanced systems operate efficiently across pH 3–8. • OH was the dominant reactive species, O₂· − and 1 O₂ played minor roles in SDZ removal. • Degradation pathways produced intermediates with lower toxicity than SDZ. • The system showed broad-spectrum reactivity and stability in natural freshwater. Antibiotics, widely detected in aquatic environments, pose significant threats to ecosystems and human health due to their recalcitrance in conventional wastewater treatment processes. This study systematically investigated the enhancement effects and mechanisms of three chelating agents (CAs) including NTA, EDTA and EDDS on sulfadiazine (SDZ) degradation in the UV/Fe 2+ /H₂O₂ system. Results showed that CAs significantly improved SDZ removal efficiency by complexing iron ions, promoting Fe 2+ /Fe 3+ cycling thereby enhancing photo-induced Fenton reactions. The NTA/UV/Fe 2+ /H₂O₂ system exhibited the highest performance, achieving 90.5% SDZ removal within 20 min, followed by EDTA (90.1%) and EDDS (88.7%) and without CAs (<35%). The CAs/UV/Fe 2+ /H₂O₂ system maintained high efficiency over a broad pH range (3–8), overcoming the pH limitation of traditional UV-Fenton processes. Electron paramagnetic resonance (EPR) and quenching experiments confirmed ·OH was the dominant reactive oxygen species and O₂· − and 1 O₂ also played minor roles. Degradation pathways of SDZ included ·OH oxidation, S N bond cleavage, and ring-opening reactions, producing intermediates with lower toxicity than SDZ. Meanwhile, the CAs/UV/Fe 2+ /H₂O₂ system could effectively remove various antibiotics (e.g., sulfamethoxazole, tetracycline) and maintain stability in the presence of inorganic anions and humic acid. Moreover, the CAs/UV/Fe 2+ /H₂O₂ system performed well in natural fresh water matrices, highlighting its practical application potential for antibiotic-contaminated water treatment. Download: Download high-res image (100KB) Download: Download full-size image
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Nature Communications
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2026
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IF 18.1
Tang Yu,Li Jiale,Li Yanfang,Ran Pan,Zou Weixin,Yan Shicheng,Dong Lin
Achieving stable and selective electrocatalytic nitrate reduction (NO 3 RR) at high current densities demands a fundamental understanding of the hydrogenation mechanism. We demonstrate that alloying cobalt with ruthenium (RuCo) switches the dominant hydrogenation pathway from the Eley-Rideal (E-R) mechanism, involving solvated protons, to the Langmuir-Hinshelwood (L-H) mechanism, utilizing adsorbed protons. Microkinetic modeling, in situ spectroscopy and density functional theory (DFT) calculations reveal that the competitive E-R pathway on pure Co causes sluggish hydrogenation kinetics and low Faradaic efficiency. In contrast, the L-H pathway on RuCo sustains high hydrogen coverage ( θ H ≈ 0.45), enabling efficient hydrogen-atom transfer for high-rate and deep hydrogenation. Leveraging this mechanistic insight, we achieve a satisfactory ammonia yield rate of 135.53 ± 1.18 mg h −1 cm −2 with 100% Faradaic efficiency and robust 1000-h stability at 1 A cm⁻². This work provides critical understanding of electrochemical hydrogenation pathways for designing efficient catalysts operating under industrially relevant conditions.
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Advanced Science
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2026
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IF 14.1
Kai Wang,Kai Jiang
An imbalance in the bone–vessel-coupled regeneration process is one of the key factors hindering the effective treatment of diabetic bone defects, which are rooted in the impaired function of mitochondria. Inspired by the bilayered heterogeneous structure of the periosteum, a bilayered, biomimetic, Janus piezoelectric scaffold (JPS) with endogenous piezoelectric effects was developed to regulate energy metabolism. JPS comprises a zinc-doped apatite–gelatin–poly-L-lactic acid membrane fabricated using electrospinning and integrated with a resveratrol-loaded microsphere composite hydrogel. Without requiring an external power source, JPS is designed to respond to local micromechanical stimulation and generate electroactive cues, while synergizing with the controlled release of resveratrol to regulate angiogenesis-related signaling and endothelial metabolic reprogramming. Single-cell sequencing indicated that bone microenvironment remodeling may be associated with H-type vessels, which are bone-specific microvasculatures. JPS provides a continuous power source in a high-sugar environment, thereby reconstructing the bone–vessel coupled regeneration process. JPS treatment stimulated the vascular features associated with H-type vessel-mediated bone regeneration in vascular organoids. The JPS group showed a substantially enhanced bone volume of 21.1% vs. 8.5% in the control in a diabetic calvarial defect model. This study presents an efficient material platform for addressing clinical challenges associated with diabetic bone regeneration.
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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2025
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IF 6.2
Kuan Gao,Qin Geng,Changbao Hu,Wenhui Zhang,Xin Li,Ping Tong,Anshu Yang,Zhihua Wu,Hongbing Chen
Interactions between food allergens and polyphenols can provide a method to alleviate food allergies. This study investigated the effect of differently structured polyphenols complexed with Ara h 2 based on high-throughput virtual screening, utilizing a spectroscopic, thermodynamic, bone marrow-derived dendritic cells (BMDCs) model, BMDCs-T cells coculture model, KU812 cells model, and molecular simulation analyses for the allergenicity evaluation. Hesperidin (HSD), neohesperidin (NH), and neohesperidin dihydrochalcone (NHDC) exhibited a high binding energy and interacted with Ara h 2 through hydrogen bonding, primarily at two additional binding sites. This interaction led to protein unfolding and reduced hydrophobicity, particularly in the NH–Ara h2 complex. In addition, NH-bound Ara h2 has a lower potential for sensitization due to its reduced immunoglobulin E (IgE) binding capacity compared with Ara h 2 during gastrointestinal digestion. This is further supported by the decreased expression of costimulatory factors in BMDCs, the reduced release of allergenic cytokines, and the maintained balance of Th1, Th2, Th17, and Treg. The same trend was followed by the HSD and NHDC complexes. These findings suggest that glycosidic bond positions play a more significant role in reducing sensitization than does the flavonoid structure. Therefore, this study can assist in developing oral-specific immunotherapy of individuals with peanut allergies under the potential interaction mechanism of polyphenols and Ara h 2.
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Insects
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2025
·Vol. 16
·期 11
·1080
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IF 2.9
Xiuwei Li,Jiaqi Xing,Meng Yang,Naiwei Chen,Yaping Liang
Simple SummaryThe oriental armyworm (Mythimna separata) is a highly destructive migratory pest threatening cereal crops. With rising insecticide resistance and environmental concerns, novel bio-based alternatives are critically needed. This study evaluates hypaconitine—a diterpenoid alkaloid derived fromAconitum coreanum—for its insecticidal potential. We demonstrate that hypaconitine acts not only as a potent stomach poison and antifeedant, but also exploits a key physiological vulnerability in the pest: the high metabolic cost of sustained detoxification. Treated larvae exhibit prolonged development, severe pupal deformities, reduced adult emergence, and shortened lifespan—classic signs of fitness loss. Biochemical analyses confirm strong, prolonged induction of detoxification enzymes (CarE, GST, CYP450), indicating that the insect’s own defense response becomes a liability. By turning the pest’s detoxification system against itself, hypaconitine disrupts multiple life stages with a multi-modal mode of action that reduces the likelihood of rapid resistance evolution. These findings position hypaconitine as a promising, eco-friendly lead compound for next-generation bioinsecticides targeting resistant lepidopteran pests.Mythimna separata(Walker) (Lepidoptera: Noctuidae) is a major migratory pest causing severe damage to cereal crops such as maize, wheat, and rice across Asia, and is also found in many parts of Oceania. With increasing insecticide resistance, botanical alternatives are urgently needed. This study evaluated the insecticidal potential of hypaconitine, a C19-diterpenoid alkaloid fromAconitum coreanum, againstM. separatalarvae. Hypaconitine exhibited significant stomach toxicity and strong antifeedant activity. It also caused pronounced growth inhibition, prolonged larval and pupal development, reduced pupation and adult emergence, induced morphological deformities, and significantly shortened adult longevity. Crucially, biochemical assays revealed sustained, time- and concentration-dependent upregulation of key detoxification enzymes—carboxylesterase (CarE), glutathione S-transferase (GST), and cytochrome P450 (CYP450)—over 72 h, indicating that hypaconitine imposes severe metabolic fitness costs rather than being readily detoxified. These effects collectively demonstrate that hypaconitine’s insecticidal efficacy arises not only from direct toxicity but also from exploiting the physiological trade-offs inherent in xenobiotic defense. Its multi-modal action—combining larvicidal, antifeedant, growth-regulatory, and metabolism-disrupting effects—presents a novel strategy for bioinsecticide development with a lower risk of resistance evolution. These findings highlight hypaconitine as a promising candidate for sustainable, integrated management ofM. separataand other resistant lepidopteran pests.
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JOURNAL OF THE EUROPEAN CERAMIC SOCIETY
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2023
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IF 5.7
Yage Li,Shuaibing Wu,Feng Liang,Gongye Lv,Yu Tian,Haijun Zhang,Yong Liu,Guoqi Liu
Rod-like h-BN with an average diameter of 2 µm was synthesized at a relatively low temperature of 1200 °C through a catalytic pyrolysis precursor strategy using boric acid and melamine as starting materials, and Co(SO 3 NH 2 ) 2 ·4 H 2 O as a catalyst precursor. Subsequently, novel low-carbon Al 2 O 3 -C refractories were prepared via a replacement of the graphite with the as-synthesized rod-like h-BN. When 1 wt% h-BN rods were added to replace graphite, after 3 h coking at 1400 °C, the cold modulus of rupture, cold compressive strength , oxidation resistance , and thermal shock resistance of the specimen were increased by 16.4%, 24.8%, 31.2%, and 52.2%, respectively, compared with these of the control specimen. Moreover, the introduction of h-BN rods in the matrix enhanced the non-wetting ability of the refractory with molten slag, thus the rod-like h-BN modified low carbon refractory presented better slag corrosion resistance with reference to the specimen without h-BN rods.
研究领域:
材料科学
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耐火材料
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高温性能
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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2026
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IF 6.2
Kuan Gao,Qin Geng,Wenhui Zhang,Xin Li,Ping Tong,Anshu Yang,Zhihua Wu,Hongbing Chen
The effects of pH-shifting combined with quercetin binding on peanut Ara h 2 were evaluated using multispectroscopy, cell models, molecular simulation, and correlation analysis. After dual treatment, Ara h 2 exhibited significant structural changes, as evidenced by decreased intrinsic fluorescence and converted α-helix into β-sheet, leading to reduced IgE-binding capacity and diminished ability of dendritic cells and T cells to differentiate toward the Th2 pathway due to the masking of epitopes. Moreover, the binding sites of quercetin gradually shifted toward the hydrophobic core of Ara h 2 with pH changes, which inhibited fluctuations in the aa50–70 region. Finally, according to the correlation analysis, pH-shifting combined with quercetin binding may reduce the allergenicity of Ara h 2 by the migration of many Trp and Tyr residues to the protein surface, which disrupted the conformational epitopes. Therefore, this study provides an approach for the development of hypoallergenic peanut products.
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CHEMICAL ENGINEERING JOURNAL
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2026
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IF 12.5
Zhongwei Wang,Zhu Liu,Yipeng Tang,Wulin Yang,Yan Qing,Yiqiang Wu,Shoulu Yang
Most industrial adhesives are derived from petroleum-based feedstocks, raising concerns about sustainability and environmental impact. Although bio-based alternatives have been explored, they often suffer from limited mechanical strength and poor water resistance. In this study, a high-performance bio-based epoxy adhesive was developed using raw black liquor as a direct source of kraft lignin. The synthesis involved epoxidation followed by cross-linking polymerization with diethylenetriamine and maleic anhydride. After thermal curing at 180 °C for 2 h, the adhesive exhibited an exceptional lap shear strength of 32 MPa on aluminum substrates, outperforming all previously reported lignin-based adhesives and even most commercial adhesives. This enhanced adhesion is attributed to structural amido-ester covalent bonds in the adhesive, as well as the multiple three-dimensional hydrogen bond networks formed between the hydroxyl/amino groups on the amido-ester chains and the substrate interface. The adhesive also demonstrated a level of water resistance. The experimental results were strongly supported by DFT and MD simulations, which confirmed the role of interfacial hydrogen bonding in adhesion. This work presents a scalable approach for valorizing lignin-rich industrial waste streams into advanced adhesive systems with competitive performance.
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LIFE SCIENCES
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2026
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IF 5.1
Pan Huang,Kexin Zhang,Ying Chen,Jiaxin Cheng,Shuangshuang Yang,Lin Shi,Yajuan Wang,Qin Zhang
Elevated homocysteine (Hcy) is an independent risk factor for hypertension, and kidney is an important organ for Hcy metabolism and blood pressure regulation, and its damage is closely related to the process of hypertension. Recent evidence suggests that ferroptosis, an oxidative stress-related form of cell death, contributes significantly to hypertensive organ damage. However, whether Hcy aggravates renal injury in H-type hypertension by destroying renal hydrogen sulfide (H 2 S) metabolism and driving ferroptosis is still lack of direct evidence. In this study, the H-type hypertensive rat model induced by high methionine diet combined with HK-2 cell model was studied. We observed a significant increase in blood pressure and plasma Hcy in the Hcy group, accompanied by renal dysfunction and renal tubular injury. Specifically, in the renal tissue of Hcy group rats, the levels of KIM-1, Fe 2+ and malondialdehyde (MDA) were increased, glutathione/glutathione disulfide (GSH/GSSG) ratio decreased, SLC7A11 expression was down-regulated, and GPX4 activity was inhibited. Concurrently, H 2 S levels and cystathionine-beta-synthase (CBS) activity were decreased. In vitro experiments using HK-2 cells confirmed that Hcy could down-regulate the expression of CBS, cystathionine-gamma-lyase (CSE), SLC7A11, GPX4 and GSH/GSSG ratio, and up-regulate MDA and reactive oxygen species (ROS) levels. Treatment with H 2 S donor (NaHS) or ferroptosis inhibitors (Ferrostatin-1, Fer-1) could rescue these changes. Collectively, our results demonstrate that high Hcy promotes hypertension by suppressing endogenous H 2 S generation, downregulating the SLC7A11/GPX4 signaling axis, and inducing ferroptosis. These findings reveal a new mechanism by which Hcy aggravates hypertension by inhibiting H 2 S synthesis and inducing ferroptosis.
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MICROPOROUS AND MESOPOROUS MATERIALS
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2026
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IF 4.7
Baomin Wang,Haoxiang Yang,Chengcheng Fan,Fei Liu,Wenxin Lu
Alkali-activated materials show excellent capture capacity on heavy metals, but the mechanisms to immobilize heavy metals remain inadequately explored. This work investigated the main hydration product C-A-S-H gels for encapsulation of heavy metals such as Pb(II), Zn(II) and Cd(II). Furthermore, the adsorption behavior and mechanisms of Pb(II) in pore solutions by C-A-S-H were examined. These findings reveal that aluminum is incorporated into the silicon chains of C-S-H in the form of aluminum-oxygen tetrahedra, thereby generating C-A-S-H. The bonding ratio, which depends on the Ca/Si ratio, reaches its peak value of 0.139 when the Ca/Si ratio is 0.9. In highly alkaline environments, amphoteric Pb(II) and Zn(II) form hydroxyl coordination polyhedra, enhancing silicon chain polymerization, whereas Cd(II) is immobilized via ion exchange with Ca(II), resulting in solid solutions. For C-A-S-H with a Ca/Si ratio of 0.6, Pb(II) adsorption occurs predominantly through physical interactions. However, as the Ca/Si molar ratio increases, the effect chemisorption and ion exchange become more significant along with the formation of Pb 8 Ca(Si 2 O 7 ) 3 . C-A-S-H gel with a Ca/Si ratio of 0.9 has the highest Pb(II) adsorption capacity, reaching 92.55 mg/g.
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ACS Applied Materials & Interfaces
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2017
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IF 7.504
Jian-Min Li
The author reports an anthracene vapor-assisted transport growth (∼4.8% in yield) of freestanding atomically thin pristine two-dimensional (2D) hexagonal boron nitride (h-BN) nanoplates directly from bulk powders. A room-temperature dilute magnetism was first observed in the pyrolytic 2D [0001] h-BN nanoplates, which is attributed to the missing N atom numbers (NN) or existence of a nitrogen-vacancy (Nv) with volume fraction ∼1.46%. Upon the postannealing in ammonia, the unsupported ammoniated 2D h-BN nanoplates showed an enhanced robust ferrimagnetism with the effective magnetic moment as high as 0.024 μB/per N, and Néel temperature at 174.9 K. At 295 K, a symmetric electron paramagnetic resonance peak signal was experimentally measured at g ∼ 2.1267, revealing the presence of an unpaired electron trapped at a B atom site in B-rich h-BN. As a promising 2D dilute magnetic semiconductor candidate, our finding favors the ammoniated atom-thin h-BN nanoplate for realization of spintronic nanodevices operating at room temperature.
研究领域:
材料科学
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凝聚态物理
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纳米技术
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自旋电子学
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磁学
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ACS Applied Materials & Interfaces
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2026
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IF 8.2
Yuan Ma,Yongli Li,Lan Jiang,Xin Kong,Xin You,Liang Liu,Rui Bao,Zhenhua Ge,Hao Cui,Feng Liu,Jianhong Yi
The energy-intensive Haber-Bosch process for ammonia synthesis necessitates sustainable alternatives, electrochemical nitrate reduction (eNO3RR) is emerging as a promising route to address nitrate pollution. However, it faces a critical bottleneck: the low ammonia selectivity arising from competitive hydrogen evolution. Herein, we introduce copper carbon dots-supported iron phthalocyanine (Cu-CDs/FePc) - a electrocatalyst featuring dynamic Cu–Fe dual sites that steer tandem e–/H+ delivery for efficient NH3 electrosynthesis. It achieves an outstanding ammonia yield of 17.69 mg h–1 mgcat.–1 with a remarkable Faradaic efficiency of 91.0% at −0.7 V vs RHE in acid conditions, which surpasses many reported transition metal-based electrocatalysts for eNO3RR. In-situ FTIR spectroscopy and density functional theory (DFT) calculations elucidate that dynamic Cu–Fe dual sites orchestrate directional electron–proton relay chains through electronic complementarity: Electron-deficient Cu2+ centers intensify NO3– adsorption/activation, while electron-enriched Fe2+ sites drive *NO2 protonation, and interfacial charge shuttling initiates valence oscillations (Cu+/Cu2+ and Fe2+/Fe3+) effectively lower rate-determining step energy barrier, thereby boosting ammonia selectively while simultaneously suppressing hydrogen evolution. Furthermore, the catalyst exhibits robust stability over 100 h and practical versatility in zinc-air battery systems. This work presents a rational design strategy for high-performance eNO3RR catalysts, offering a significant advance toward efficient green ammonia synthesis and environmental remediation.
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