CHEMICAL ENGINEERING JOURNAL
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2024
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IF 13.3
Zhiqiang Fang,Yangkai Xiong,Lei Huang,Jipeng Li,Daxiong Hu,Qitong Mao,Hao Jiang,Xuewei Tang,Panpan Tang,Zheng Li,Guoqing Wang
Polymer coatings are inherently susceptible to deformation and irreversible damage when they are subjected to external forces during service. Self-healing coatings integrated with exceptional mechanical robustness and corrosion resistance are essential for industrial applications but have been deemed challenging. Here, we present a NIR-triggered self-healing coating by combining a toughness epoxy network with melanin-modified silica (MMS). Moreover, to investigate the impact of pore size and porosity of silica on the corrosion protection performance, three types of various silica particles are selected as building blocks. The melanin-modified fumed silica/epoxy coatings demonstrate superior elongation (275 %), outstanding tensile strength (5.31 MPa) and high toughness (7.37 MJ·m 3 ). Moreover, the introduction of the MMS can not only improve the anticorrosion performance (|Z| 0.01 Hz value of 1.24 × 10 10 Ω·cm 2 ) but also realize fast photo-thermal repair (60 s). Our strategy furnishes a universal layout prototype for the manufacture of robust self-healing coatings with a scalable and cost-effective preparation method.
研究领域:
材料科学
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化学工程
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DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2024
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IF 7.7
Meiyan Sun,Dongmei Li,Yan Xi,Xiaotong Qin,Yuting Liao,Xiaozhi Liu,Shiru Jia,Yanyan Xie,Cheng Zhong
Skin wounds are repaired by a complex series of events and overlapping phases in which bacterial infection and insufficient angiogenesis at the wound site delay the healing process. Thus, functional wound dressings with enhanced antibacterial activity and angiogenic capacity have attracted attention. Herein, bacterial cellulose (BC)-based dressings were successfully fabricated by functionalization with a polydopamine (PDA) coating and copper sulfide nanoparticles (CuS NPs). Under 808 nm laser illumination, the BC/PDA/CuS composite membranes exhibited outstanding adjustable photothermal and photodynamic activities as well as controlled Cu 2+ release, endowing the composite membranes with synergetic antibacterial activity. Specially, a bactericidal efficiency of 99.7 % and 88.0 % for Staphylococcus aureus and Escherichia coli was achieved after treatment with BC/PDA/CuS5 sample under NIR irradiation (0.8 W/cm 2 , 10 min), respectively. Moreover, the BC/PDA/CuS5 composite membrane could enhance the angiogenesis due to the released Cu 2+ . In vivo experiments revealed that the BC/PDA/CuS5 composite membrane dressing could accelerate the wound closure process of the full-thickness skin defects with S. aureus by synergistically reducing inflammation, enhancing collagen deposition, and promoting vascularization under NIR irradiation. Additionally, the BC/PDA/CuS5 composite membrane exhibited high biocompatibility and biosafety. This work offers a new strategy to prepare multifunctional BC-based dressing for clinical wound healing.
研究领域:
材料科学
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生物医学工程
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伤口愈合
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纳米技术
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生物相容性
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DOI
PubMed
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2024
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IF 9.4
Shun Xing,Haifeng Zhang,Zhenhao Hou,Feng Peng,Lidan Liu,Donghui Wang,Naijian Ge,Xuanyong Liu
Portal vein tumor thrombus (PVTT) formed by cancer cell invasion is a major cause of high mortality in hepatocellular carcinoma (HCC), and the formation of thrombus will be accelerated by bacterial colonization on the surface of the implant after surgery. In this work, Polypyrrole-coated arsenic-loaded layered double hydroxide films were in situ constructed on the nickel-titanium alloy for the efficient killing of tumour cells by thermo-therapeutic synergistic chemotherapy. The good near-infrared photothermal conversion ability of polypyrrole enables the sample surface temperature to be raised to about 51 °C at a low photothermal power (0.5 w/cm 2 ), while the elevated temperature could further accelerate the release of drug arsenic. In addition, when NIR light is not applied, the polypyrrole coating also cleverly acts as a “barrier layer” to reduce the natural release of arsenic in normal tissues to avoid toxicity issues. In vivo and in vitro experiments have demonstrated that the platform exhibits excellent antitumor and antibacterial abilities. In contrast to the systemic toxicity issues associated with systemic circulation of nanotherapeutic drugs, this in situ functional film is expected to be used in localised interventions for precise drug delivery, and is also more suitable for surgical treatment scenarios in PVTT surgeries.
研究领域:
肿瘤学
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生物材料学
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医学工程
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DOI
PubMed
高影响因子
Materials Today Chemistry
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2024
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IF 6.7
Na Chen,Yan Bai,Yuan Fang Li,Lei Zhan,Cheng Zhi Huang
Nitric oxide (NO)-based gas therapy has received ever-increasing attention in treatment of many diseases, especially cancer. However, the selective organelle targeted delivery and controllable release of NO remains highly desirable. In this work, a sequentially targeting delivery nanoplatform has been constructed by encapsulating heat-responsive S -nitrosocysteine (the NO donor, SNC) conjugated mitochondria-targeting carbon dots (MitoCDs) and indocyanine green (ICG) within liposomes which are further modified with aptamer that can specifically bind to nucleolin overexpressed on the surface of several cancer cells. MitoCDs were prepared via one-step hydrothermal reaction using citric acid and m -diethylaminophenol as starting materials and used without any external targeting molecules. ICG molecules were employed as NIR-triggered photothermal agent followed by NO precisely controlled release in mitochondria. By combining gas and photothermal treatment, the nanocarrier produced a synergistic and superior killing effect on several cancer cell lines. And the cell growth inhibition of NCL-CSI@Lip on HEp-2 cells raised up to 72.39 %. Such an ‘all-in-one’ mitochondria-targeted NO nanocarrier may lead to new way for overcoming the problem of multidrug resistance in intracellular drug delivery.
研究领域:
药学
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癌症研究
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纳米技术
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生物医学工程
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DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2025
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IF 8.5
Huanran Qu,Yuanyuan Zhang,Minghao Chen,Shiyang Shao,Jianqiang Chen,Yundi Wu,Xilong Wu
Glioblastoma is the most aggressive and heterogeneous astrocytic tumor, with its intracranial location limiting the efficacy of conventional therapies. This study presents the synthesis of a multifunctional nanocomplex utilizing borophene nanosheets (B NSs) as a substrate. Gold nanoparticles (Au NPs) are modified onto the surface of B NSs to create Schottky heterojunctions (B Au). This is followed by co-precipitation solvothermal synthesis incorporating silver sulfide (Ag 2 S) and hyaluronic acid (HA) as a capping agent, yielding B-Au-Ag 2 S-HA (BAA-HA). The Schottky heterojunction reduces the bandgap and accelerates charge carrier separation, significantly enhancing the sonodynamic therapy (SDT) efficiency of B NSs. In comparison to B NSs, BAA-HA exhibits significantly improved photothermal conversion efficiency under 1064 nm laser irradiation, facilitating the cascade catalysis of glucose oxidase-like (GOx-like) and catalase-like (CAT-like) enzymes. This accelerates glucose and H 2 O 2 decomposition, increasing O 2 supply to amplify SDT efficacy and induce immunogenic cell death (ICD), inducing a robust anti-tumor immune response. Ultrasound-targeted microbubble destruction technology is employed to transiently open the blood-brain barrier, allowing for targeted delivery of BAA-HA to glioblastoma cells via HA-mediated recognition of the CD44 receptor. Additionally, the NIR-II fluorescence properties of Ag 2 S enable precise tumor imaging, guiding multimodal synergistic therapy. This platform provides a promising strategy for treating deep-seated tumors, integrating therapeutic and diagnostic functions to enhance efficacy and precision.
研究领域:
肿瘤学
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纳米医学
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生物材料学
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DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
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2025
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IF 13.2
Yaru Zhang,Wenyu Xie,Jiamin Luo,Rui Gao,Zhimin Gao,Xinyi Wang,Yongxin Huang,Chen Lin,Meiling Tan,Zhiyao Hou
Effectively activating macrophages to engulf tumor cells has attracted intensive attention in cancer immunotherapy. However, tumor cells can upregulate anti-phagocytic signals (such as CD47 molecules) to bind with signal regulatory protein-α (SIRPα), ultimately providing a “don’t eat me” signal to evade phagocytosis. Blockading CD47 alone is insufficient to stimulate macrophages phagocytosis due to the absence of endogenous activating signals (“eat me” signal). Herein, a mesoporous silica (MSN) modified by Cu 9 S 5 nanoparticle with mimicking enzyme activities were synthesized and utilized to electrostatically load the anti-CD47 antibodies (aCD47), generating MCC nanozymes, to improve macrophage-mediated cancer immunotherapy. MCC nanozymes can target tumor cells by specifically binding to the cell-surface CD47, disabling the “don’t eat me” signal. Meanwhile, under near infrared light (1064 nm) stimulation, MCC nanozymes exhibit the enhanced glutathione oxidase-like and peroxidase-like enzymatic activities by the photothermal effect, which lead the reactive oxygen species (ROS) generation to induce endoplasmic reticulum (ER) stress amplification, resulting the exposure of calreticulin (CALR) for providing the endogenous “eat-me” signals to macrophages. In a 4T1 breast cancer model, even under mild photothermal condition, MCC nanozymes effectively inhibit tumor growth and metastasis. Collectively, this dual-regulatory strategy presents a promising approach for macrophage-mediated cancer immunotherapy.
研究领域:
肿瘤学
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免疫学
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DOI
高影响因子
Small
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2024
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IF 13
Ning Yang,Zhicheng Qian,Renqiang Yuan,Weikun Li,Xin Tan,Zonghao Liu,Qianli Zhang,Liqin Ge,Ling Liu
Acute thrombosis and its complications are leading global causes of disability and death. Existing thrombolytic drugs, such as alteplase and urokinase (UK), carry a significant bleeding risk during clinical treatments. Thus, the development of a novel thrombolysis strategy is of utmost urgency. Based on the previous work, the hollow structure of microcapsules (MC) is fabricated. Subsequently, armor-piercing MC, known as Fucoidan/S-Nitrosoglutathione/Melanin@MC (FGM@MC) is obtained, using a layer-by-layer (LBL) self-assembly method. Utilizing near-infrared (NIR) light as a trigger, the FGM@MC demonstrated photothermal thrombolysis at the site of thrombus due to its stable and outstanding photothermal properties. Simultaneously, photothermal stimulation leads to the release of a significant amount of nitric oxide from the FGM@MC, resulting in cavitation effects for mechanical thrombolysis. In vivo experiments confirmed the stable release of nitric oxide under NIR light irradiation. Treatment of femoral vein thrombosis in rats revealed that the thrombolytic effectiveness of FGM@MC+NIR (53.71%) is comparable to that of UK (59.70%). Notably, FGM@MC does not interfere with the coagulation function of rats and exhibits a favorable safety profile. In conclusion, this study demonstrates that the drug-free armor-piercing microcapsule has significant potential in the treatment of thrombosis, offering a safe and effective alternative to traditional thrombolytic therapies.
研究领域:
生物医学工程
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药学
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治疗学
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材料科学
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产品关联
DOI
PubMed
高影响因子
CARBOHYDRATE POLYMERS
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2024
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IF 10.7
Chenyu Sang,Shaowei Wang,Xiaoyue Jin,Xiaoyu Cheng,Huining Xiao,Yiying Yue,Jingquan Han
The rapid development of hydrogels has garnered significant attention in health monitoring and human motion sensing. However, the synthesis of multifunctional conductive hydrogels with excellent strain/pressure sensing and photoresponsiveness remains a challenge. Herein, the conductive hydrogels (BPTP) with excellent mechanical properties, fatigue resistance and photoresponsive behavior composed of polyacrylamide (PAM) matrix, 2,2,6,6-tetramethylpiperidin-1-yloxy-oxidized cellulose nanofibers (TOCNs) reinforcement and polydopamine-modified black phosphorus (BP@PDA) photosensitizer are prepared through a facile free-radical polymerization approach. The PDA adhered to the BP surface by π-π stacking promotes the optical properties of BP while also preventing BP oxidation from water. Through hydrogen bonding interactions, TOCNs improve the homogeneous dispersion of BP@PDA nanosheets and the mechanical toughness of BPTP. Benefiting from the synergistic effect of PDA and TOCNs, the conductive BPTP integrates superior mechanical performances, excellent photoelectric response and photothermal conversion capability. The BPTP-based sensor with high cycling stability demonstrates superior strain sensitivity ( GF = 6.0) and pressure sensing capability ( S = 0.13 kPa −1 ) to monitor various human activities. Therefore, this work delivers an alternative construction strategy for generating high-performance conductive hydrogels as multifunctional wearable sensors.
研究领域:
材料科学
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生物医学工程
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传感技术
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DOI
PubMed
高影响因子
Communications Materials
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2026
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IF 9.1
Li Qinghua,Gao Tianfu,Rao Xinhao,Ren Zhelei,Duan Haodi,Xie Xiaomin,Liao Jiaxin,Xue Shuwen,Xu Bin,Jin Xiao,Zhao Weifeng,Bai Jinke
Translating advanced luminescent materials into field-deployable screening tools remains a core challenge, demanding synergy between advanced optical materials and device engineering. Here, we demonstrate a portable dual-mode near-infrared semi-quantitative screening device. the luminescence performance of the core emitting materials, specifically lead-free Nd³⁺/Yb³⁺ co-doped Cs₂NaYCl₆ double perovskite phosphors, was first optimized through a machine-learning (ML) guided approach. Subsequently, these optimized phosphors were integrated to enable the device. Specifically, the Nd³⁺-doped emitter targets the 885 nm characteristic absorption band of alcohol while exhibiting anomalous thermal quenching, whereas the Nd³⁺/Yb³⁺ variant leverages 78.66% energy transfer efficiency to yield stable 985 nm emission (70% retention at 500 K) matching the characteristic absorption band of water. These optimized phosphor-converted LEDs were integrated into a compact detector featuring a coaxial dual-disc stepper mechanism and a customized three-stage circuit that amplifies faint optical signals into a five-level visual indicator. This configuration enables rapid screening of alcohol (30–60%) and water content (45–100%). Validated on commercial samples, this work establishes a holistic platform bridging high-precision instrumentation and real-world portability.
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高影响因子
Biomaterials Science
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2026
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IF 6.1
Rongjie Gao,Feiyan Chen,Yong Li,Zhengshuai Tang,Jinliang Liu
While combination therapies generally exhibit superior therapeutic outcomes compared to single-modality treatments, current photodynamic–chemodynamic (PDT/CDT) combination strategies remain limited by two major factors: (i) the restricted tissue penetration depth of light and (ii) the insufficient endogenous hydrogen peroxide (H2O2) concentration within the tumor microenvironment (TME), both of which compromise therapeutic efficacy. To overcome these obstacles, we developed an innovative hybrid nanorobot (EcN + UCNPs@mSiO2–MnO2–ZnPc) that integrates engineered Escherichia coli Nissle 1917 (EcN) with orthogonally emissive upconversion nanoparticles (C@3S). Specifically, MnO2 decomposes into Mn2+ under acidic TME conditions, subsequently catalyzing the conversion of H2O2 into cytotoxic hydroxyl radicals (˙OH) and oxygen, which exhibits dual effects of tumor cell eradication and hypoxia alleviation. Meanwhile, C@3S transforms 980 nm laser radiation into blue-violet emission, activating the EcN that preferentially colonizes tumor regions and overexpresses respiratory chain enzyme II (NDH-II), thereby replenishing H2O2 in situ and sustaining chemodynamic therapy (CDT). Additionally, zinc phthalocyanine (ZnPc) is excited by the 808 nm-converted red emission to generate singlet oxygen (1O2), further enhancing reactive oxygen species (ROS) accumulation and amplifying oxidative stress in tumor cells. Collectively, our findings demonstrate significant tumor growth inhibition through this self-amplifying ROS-generation mechanism. This multifunctional hybrid nanorobot offers a promising platform for precision cancer therapy with spatiotemporal controllability.
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PubMed
高影响因子
ACS Applied Materials & Interfaces
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2026
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IF 7.8
Leilei Zhang,Haoheng Bai,Weiqi Sun,Luqi Wang,Minyan Duan,Qianying Liu,Chao Zhou,Xueyang Fang,Tao Zhang
Triple-negative breast cancer (TNBC) treatment with traditional phototherapeutics generally suffers from short light penetration depth and limitations of the hypoxic tumor microenvironment. Developing effective therapeutic modalities tailored to TNBC’s features remains highly desirable yet challenging. Herein, we propose a near-infrared dual windows (NIR-II) photoacoustic (PA) cavitation-based strategy to amplify oxidative stress and induce metabolic disruption in TNBC cells, achieving effective tumor suppression. With a fabricated nanoagent (DTG), we integrated the oxygen-independent therapeutic effects of photomechanical damage, cavitation-promoted oxidative damage and glucose oxidase (GOx)-mediated glucose depletion. Specifically, under NIR-II pulsed laser (PL) irradiation, PA cavitation generates collapsing bubbles and shock waves, causing mechanical injury to tumor cells. Meanwhile, GOx depletes intratumoral glucose, blocking glycolysis, reducing adenosine triphosphate (ATP) production, and generating hydrogen peroxide (H2O2) that would be further converted into more toxic hydroxyl radicals (•OH) by the photocavitation to suppress the tumors effectively. In addition, the strong NIR-II PA signal produced from the DTG facilitates high-resolution deep-tissue imaging to provide precise therapeutic guidance. Thus, these findings establish the multimodal strategy as a potent candidate for TNBC management.
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PubMed
高影响因子
ACS Applied Materials & Interfaces
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2026
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IF 7.8
Peng Wang,Anfei Chen,Mekhrdod S. Kurboniyon,Dilshod Nematov,Bibo Lou,Rongxin Tang,Qi Wang,Dan Zhang,Qiaoling Chen,Chong-Geng Ma
The development of efficient and stable near-infrared (NIR) phosphor-converted LEDs has significantly advanced NIR photonics. However, widely reported Cr3+-activated NIR luminescent materials remain limited in performance and fail to satisfy the increasing demands of diverse applications. Herein, a Cr-free alternative utilizing a rigid garnet host is proposed. Through the design and synthesis of a novel Fe3+-activated phosphor, Ca3Sn2Ga2SiO12:Fe3+ (CSGS: Fe3+), efficient broadband NIR emission centered at 770 nm and spanning 600–1100 nm is successfully realized. This material achieves an internal quantum efficiency (IQE) of 62.38% and an external quantum efficiency (EQE) of 46.56%, while maintaining 62% of its emission intensity at 423 K. Its overall balanced performance exceeds that of most reported Fe3+-based systems. Supported by first-principles calculations, this study systematically clarifies the electronic structure, mechanical properties, site preference, and valence stability of Fe3+, elucidates the excited-state transition behavior, and proposes a crystal-field-induced site-selective luminescence mechanism. This work not only presents a high-performance Fe3+-activated NIR phosphor, but also provides theoretical insights and practical guidance for material design and optimization in solid-state lighting, nondestructive testing, and spectral analysis.
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PubMed
高影响因子
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