Journal of Energy Chemistry
·
2025
·
IF 14.9
Lina Hu,Zengyu Han,Ya Chen,Yaoda Liu,Lei Li,Jie Su,Zhengfei Dai,Dong-Shuang Wu
The development of pH‐robust electrocatalysts is highly desirable but challenging for the hydrogen evolution reaction (HER) in water electrolysis. Among the noble metal groups, ruthenium (Ru) holds the promise in balancing the cost and activity in HER, but it is restricted by the strong H adsorption and the sluggish Heyrovsky step. It appeals for a rational d -band manipulation to neutralize the hydrogen adsorption to promote the HER kinetics. Herein, we profiled a confined structure with RuCo alloy nanoparticles in N-doped carbon nanofiber (RuCo@NCNF) by a facile electrospinning-pyrolysis process for HER electrocatalysis. An electron transfer from Co to Ru is indicated in the RuCo@NCNF composite to enhance the electron-donating character of Ru active sites to couple the HER. Resultantly, the optimized Ru 1 Co 2.5 @NCNF catalyst stably exhibits the Pt-beyond HER activity in both alkaline (10 mV at 10 mA cm −2 ) and acidic electrolytes (23 mV at 10 mA cm −2 ), while delivering competitive HER performance in neutral electrolytes. Density functional theory (DFT) calculations also confirm that the Ru-Co electronic interactions can effectuate the d -band center downshift, moderating the adsorption energies of hydrogen (Δ G H* ) and H 2 O for efficient hydrogen production. This study provides a reference for the rational design of Ru-based pH-robust HER electrocatalyst through confined nanoalloy structures.
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DOI
高影响因子
FOOD HYDROCOLLOIDS
·
2023
·
IF 10.7
Ye Zi,Cuiping Shi,Guangyi Kan,Jiawei Peng,Huan Gong,Xichang Wang,Jian Zhong
The development of genipin modification methods has attracted much attention to improve the functional properties of proteins in the fields of food science . In this work, two types of pH-responsive genipin-crosslinked bovine bone gelatin conjugates with high surface hydrophobicity were developed for emulsion stabilization. One was genipin molecule-crosslinked gelatin conjugates prepared at acidic pH and the other was genipin macromer-crosslinked gelatin conjugates prepared at neutral and basic pH. The degrees of crosslinking increased with the increase of preparation pH. They increased with the increase of genipin-to-gelatin mass ratios at acidic pH, whereas decreased with the increase of genipin-to-gelatin mass ratios at neutral and basic pH. The surface hydrophobicity values, molecular weights, and emulsifying properties (creaming stability, emulsion activity index, and emulsion stability index) of the obtained conjugates increased with the increase of both preparation pH and genipin-to-gelatin mass ratios. This work provided useful knowledge to understand how the preparation parameters (preparation pH and genipin-to-gelatin mass ratio) and genipin structures (molecule and macromer) affect a protein's degrees of crosslinking, physicochemical properties, and emulsifying properties.
研究领域:
食品科学
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高分子化学
·
胶体与界面科学
·
生物技术
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DOI
高影响因子
ELECTROPHORESIS
·
2019
·
IF 2.754
Ping Yan,Keke Zhang,Lingyu Wang,Wenjun Tong,David D. Y. Chen
Dynamic pH junction is an online focusing method in CE based on the electrophoretic mobility difference of analytes in the sample matrix and the background electrolyte. An advantage of this method over the conventional CE is that the sensitivity can be significantly improved. By injecting a long sample plug in the capillary and focusing the analytes at the pH boundary between the background electrolyte and sample matrix, the LOD can be improved by 10–100 folds. The dynamic pH junction method can be easily coupled with ESI-MS. In this work, we used this method for the analysis of microcystins (MCs). The detection limits and dynamic ranges were studied. The separation was optimized by adjusting the injection time, and concentrations and pH values of the background electrolyte. The optimization of analyte focusing leads to enhanced detection response compared to conventional injections, achieving 200–400 fold higher averaged peak heights for four microcystin (MC) variants. More importantly, this method was successfully used for the quantitative analysis of microcystins (MCs) in crude algae samples from natural water bodies, making it promising for practical applications.
研究领域:
环境科学
·
分析化学
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DOI
高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
·
2022
·
IF 5.999
Xiaomei Dai,Xiaojun Liu,Lele Yang,Siyuan Yuan,Qingqing Xu,Yu Li,Feng Gao
Intracellular bacterial infections pose enormous challenges to food safety and public health. Antibiotic-based polymer prodrugs have been used to treat intracellular bacterial infection. However, the overuse of antibiotics may lead to the emergence of antibiotic resistance . In this work, we aimed to develop antibiotic-free pH-responsive polymeric prodrugs to combat intracellular S. aureus infection. Amphiphilic poly(ethylene glycol)- b -poly[(3-phenylprop-2-ene-1,1-diyl)bis(oxy)bis(enthane-2,1- diyl)diacrylate] (PEG- b -PCAE) was obtained by radical polymerization and they could self-assemble to form micelles . PEG- b -PCAE micelles could uptake by macrophage. Upon exposure to the acidic phagolysosome, PEG- b -PCAE micelles could release cinnamaldehyde (CA) through hydrolysis of the acetal linkage. PEG- b -PCAE could kill intracellular bacteria by damaging the bacterial membrane. Furthermore, PEG- b -PCAE micelles could generate reactive oxygen species (ROS) in macrophages and subsequently activate immune system to clear bacteria by inducing macrophages differentiation to M1 phenotype. PEG- b -PCAE micelles could accelerate the wound healing process of the S. aureus -infected model in vivo . It is anticipated that multifunctional antibiotic-free PEG- b -PCAE micelles with intrinsic antibacterial activities hold promise for improved outcomes in intracellular S. aureus infections.
研究领域:
微生物学
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免疫学
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药物化学
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DOI
高影响因子
TECHNOLOGY AND HEALTH CARE
·
2019
·
IF 0.787
Liu Quan,Zheng Chao,Zhao Hui,Wang Kan,Tao Wei
The incidence of cancers has increased year by year and the early diagnosis for cancer is important to prevent cancers. Due to abnormal metabolism of tumor cells, the acidification of extracellular environment is an important feature for cancer cells. To achieve efficient and accurate pH measurement, this paper proposes a new detection method based on the fluorescence characteristics of CdSe quantum dots detection, which uses CdSe QDs with unique optical properties as sensitive substances for pH detection. PBS buffer (0.2 mol/L) with different pH has been used to simulate cell metabolites at different pH values and use 365 nm laser source to excite mixture liquid. The emitted light was detected by a fluorescence detection device. A mathematical model between fluorescence intensity and pH was finally obtained. The experimental results show the method show better effectiveness than other pH detection methods and has a high resolution of 0.037 within a pH range of 6.1–7.8 and a measurement resolution of 0.037 pH units. This method has high temperature stability and short testing time, which shows high potential for pH detection. This method has its superiority in all the testing methods. It exhibits a new way of generalizing to pH detection.
研究领域:
生物化学
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生物医学工程
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癌症研究
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光学
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纳米技术
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DOI
PubMed
高影响因子
Journal of Macromolecular Science Part A-Pure and Applied Chemistry
·
2022
·
IF 2.216
Feifei Shao,Tao Xue,Yijing Wang,Yesheng Xu,Xinjie Wang,Xinxin Li
The smart responsive materials have become one of the hottest areas of research in oil/water separation field and there are various studies on preparation technologies. However, most of the materials reported were prepared by coating or coupling to attach functional polymer to substrates, which generally had unstable physical and chemical properties and were difficult to be applied in harsh environments. In this work, we fabricated a smart and durable oil/water separation material by one-step foaming method to graft pH-responsive copolymer onto a polyurethane foam (PUF) substrate. The foam exhibited reversible wettability under different pH environments, had excellent oil adsorption capacity (24.78–64.27g/g) and high oil/water separation efficiency (above 98%). Besides, the foam also showed stable performance and excellent recyclability in a series of durability experiments, including mechanical abrasion, light radiation and chemical immersion. The foam with simple preparation process and excellent stability will have promising application prospects in the field of oil/water separation.
研究领域:
材料科学
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化学工程
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环境科学
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高分子科学
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DOI
高影响因子
International Journal of Nanomedicine
·
2023
·
IF 8
Lian Deng,Xiongjie Zhu,Zhongjian Yu,Ying Li,Lingyu Qin,Zhile Liu,Longbao Feng,Rui Guo,Yanfang Zheng
Background Although single-drug chemotherapy is still an effective treatment for esophageal cancer, its long-term application is limited by severe side-effects, poor bioavailability, and drug-resistance. Increasing attention has been paid to nanomedicines because of their good biological safety, targeting capabilities, and high-efficiency loading of multiple drugs. Herein, we have developed a novel T7 peptide-modified pH-responsive targeting nanosystem co-loaded with docetaxel and curcumin for the treatment of esophageal cancer.Methods Firstly, CM-β-CD-PEI-PEG-T7/DTX/CUR (T7-NP-DC) was synthesized by the double emulsion (W/O/W) method. The targeting capacity of the nanocarrier was then investigated by in vitro and in vivo assays using targeted (T7-NP) and non-targeted nanoparticles (NP). Furthermore, the anti-tumor efficacy of T7-NP-DC was studied using esophageal cancer cells (KYSE150 and KYSE510) and a KYSE150 xenograft tumor model.Results T7-NP-DC was synthesized successfully and its diameter was determined to be about 100 nm by transmission electron microscopy and dynamic light scattering. T7-NP-DC with docetaxel and curcumin loading of 10% and 6.1%, respectively, had good colloidal stability and exhibited pH-responsive drug release. Good biosafety was observed, even when the concentration was as high as 800 μg/mL. Significant enhancement of T7-NP uptake was observed 6 hours after intravenous injection compared with NP. In addition, the therapeutic efficacy of T7-NP-DC was better than NP-DC and docetaxel in terms of growth suppression in the KYSE150 esophageal cancer model.Conclusion The findings demonstrated that T7-NP-DC is a promising, non-toxic, and controllable nanoparticle that is capable of simultaneous delivery of the chemotherapy drug, docetaxel, and the Chinese Medicine, curcumin, for treatment of esophageal cancer. This novel T7-modified targeting nanosystem releases loaded drugs when exposed to the acidic microenvironment of the tumor and exerts a synergistic anti-tumor effect. The data indicate that the nanomaterials can safely exert synergistic anti-tumor effects and provide an excellent therapeutic platform for combination therapy of esophageal cancer.
研究领域:
纳米医学
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肿瘤学
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药学
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分子生物学
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DOI
PubMed
高影响因子
Nanoscale
·
2022
·Vol. 14
·期 35
·12762-12772
·
IF 8.307
Ge Lv,Ziwei Wang,Wenjing Li,Guannan Zhu,Beibei Liu,Bin Song,Min Wu,Xiao Gong
To obtain multicolor carbonized polymer dots (CPDs), acid-assisted hydrothermal/solvothermal reactions are an effective strategy. However, the long wavelength fluorescence of boron–nitrogen codoped CPDs (BN-CPDs) is rarely reported. In this work, we used concentrated hydrochloric acid to regulate the fluorescence (from green to orange) of BN-CPDs via a solvothermal reaction. Meanwhile, 3-formylphenylboronic acid with a benzene ring structure was employed as the boron source, which helped the formation of the internal conjugated structure of CPDs to obtain long wavelength fluorescent CPDs. The fluorescence properties of BN-CPDs were investigated, which indicated the concentration- and solvent-dependent properties of the BN-CPDs. Based on the experimental results, we assume that the multicolor emission of the BN-CPDs originates from the synergistic effects of the degree of graphitization and surface states. Due to the special fluorescence properties of the BN-CPDs, pH sensing and trace water detection in dichloromethane solution can be effectively achieved. The results of the study reveal the potential of BN-CPDs in sensing applications.
研究领域:
材料科学
·
分析化学
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DOI
高影响因子
MATERIALS CHEMISTRY AND PHYSICS
·
2025
·
IF 4.7
Muhammad Umar Farooq,Rustem R. Zairov
A smart drug delivery system (DDs) based on PEGylated (polyethylene glycol) gold/zinc oxide (PEG-Au/ZnO) loaded with doxorubicin (DOX) and chlorine-e6 (Ce6) was successfully synthesized, characterized, and evaluated against breast malignancy. With and without laser exposure, the DOX-PEG-Au/ZnO–Ce6 nanoprobe bypassed the internal barriers and exhibited much higher synergistic therapeutic activity than Ce6 and DOX alone. The controlled release kinetics of DOX in combination with Ce6 could inhibit tumor growth and remarkably enhance the sensitivity of chemotherapy. Apart from the chemotherapeutic effect, the residual PEG-Au/ZnO could amplify the reactive oxygen species (ROS) generation through cascade reactions, which will benefit the release of free zinc ions in the lysosome of inflammatory cells. Taken together, the as-prepared DOX-PEG-Au/ZnO–Ce6 nanoprobe is expected to facilitate the management of chemo-photodynamic combination therapy as Trojan horses to eliminate cancer and improve the quality of life for the patient by reducing acute toxic side effects.
研究领域:
药学
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肿瘤学
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纳米医学
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生物材料学
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产品关联
DOI
高影响因子
RSC Advances
·
2020
·Vol. 10
·期 56
·33894-33902
·
IF 3.119
Feng Tian,Chen Xu,Mingyue Xu,Haiqing Gao,Ziyi Xiao,Ling Li,Yingxi Wang
Drug resistance is a major obstacle in cancer treatment, and designing a material that monitors real-time drug release remains a top priority. In this study, metal–organic frameworks doped with lanthanum and thulium were synthesized and then coated with aminated silica to form La/Tm-MOF@d-SiO2 as a drug carrier. Doxorubicin hydrochloride (DOX) was selected as a drug model, and the drug loading and release were investigated. It was found that the release of DOX under acidic conditions reached an optimal level, indicating the pH-responsiveness of La/Tm-MOF@d-SiO2. Under acidic conditions (pH = 5.8), upconversion fluorescence was generated after loading DOX on La/Tm-MOF@d-SiO2. At pH = 5.8, the longer the drug released, the stronger the upconversion fluorescence. It was found that the upconversion fluorescence intensity is directly proportional to the amount of drug released; thus, the real-time monitoring of DOX release in tumor cells can be performed based on the upconversion fluorescence.
研究领域:
材料科学
·
肿瘤学
·
药剂学
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DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2020
·
IF 10.652
Ruimeng Wang,Long Liu,Sidra Subhan,Yaseen Muhammad,Yang Hu,Meiyun Huang,Yi Peng,Zhongxing Zhao,Zhenxia Zhao
The pH-switchable UiO-66 were engineered via in-situ amino acids (AA) doping for the highly selective adsorption of anionic dyes (i.e. sunset yellow FCF (SY)). Three AA doped samples, i.e. UiO-66-V (valine), UiO-66-T (threonine), and UiO-66-Y (tyrosine), have fabricated hierarchical structure and endowed –NH 2 surface in framework structure concurrently. These AA doped UiO-66s awarded highly selective adsorption and fast diffusivity towards the mentioned anionic dyes. More interestingly, enriched –NH 2 groups endowed AA doped UiO-66s a significant pH-responsive character for selectivity of anionic/cationic dyes. Textural characterization and adsorption measurement confirmed that high surface areas (>1070 m 2 /g) with defected pores and –NH 2 surface significantly enhanced adsorption uptake (352.8 mg/g) and diffusion rate (168 × 10 −3 min −1 ) for SY on AA doped UiO-66s, about 1.9 and 5.9 times respectively as that on pristine UiO-66. The AA doped UiO-66s exhibited one order of magnitude higher selectivity (>390) for SY against MB than that of original UiO-66. More importantly, the alteration in surface charge (–NH 2 H + ⇌ O H - -NH 3 + ) endorsed a great variation in the selectivity of AA doped UiO-66s to dyes when adjusting pH from 4 to 8, showing an excellent pH on-off switchable property. Also, it realized a stable self-adsorption/desorption recycling process via pH-switching for 6 consecutive cycles. With these features, the pH-switchable defected UiO-66 realized highly efficiency adsorption and non-thermal separation/regeneration process for anionic dyes.
研究领域:
材料科学
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环境科学
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化学工程
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DOI
高影响因子
Polymer Chemistry
·
2017
·Vol. 8
·期 43
·6675-6687
·
IF 5.375
Da Huang,Yaqiang Wang,Fei Yang,Hong Shen,Zuquan Weng,Decheng Wu
Recently, nanoparticles self-assembled from amphiphilic supramolecular linear-dendritic block copolymers (LDBCs) have attracted great interest, since the combination of linear and dendritic polymers can incorporate the unique properties of the different segments but avoid some inherent drawbacks of dendrimers, not to mention that the components can be flexibly adjusted to enrich their functionality. In this study, LDBCs formed by host–guest recognition of polyacetal dendrimers with a β-cyclodextrin core and adamantane-terminated zwitterionic poly(sulfobetaine) could self-assemble into micelles and vesicles by varying the hydrophilic/hydrophobic ratio. Owing to the acid-labile characteristic of the dendritic segments, the micelles and vesicles were degradable and could release their payloads in a pH-responsive manner. The incorporation of zwitterionic linear segments gave the micelles and vesicles a charge-reversal ability and excellent resistivity to protein absorption, leading to higher affinity to cell membranes than conventional PEG-coated nanoparticles. In addition, the potential of these nanoparticles as anticancer drug carriers was preliminarily evaluated by using doxorubicin as a model drug and the results indicated that the DOX-loaded micelles and vesicles exhibited remarkable anticancer activity. This study cast a new light on the application of dendrimers and these micelles and vesicles constructed from LDBCs may be promising candidates as anticancer drug delivery platforms for cancer therapy.
研究领域:
生物材料学
·
药剂学
·
肿瘤学
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DOI
高影响因子
危险品化学品经营许可证（带存储）