ENVIRONMENTAL RESEARCH
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2021
·
IF 6.498
Junyao Pan,Xueting Bai,Yiyao Li,Binhao Yang,Peiyu Yang,Fei Yu,Jie Ma
As the abuse of antibiotics has led to increasingly serious environmental pollution problems, studies have found that the adsorption method can be used to efficiently and quickly remove residual antibiotics in water with low cost and high efficiency. Metal-organic frameworks and their derived porous carbons have received widespread attention as a new type of adsorption material. In this study, HKUST-1 was synthesized by a hydrothermal method and carbonized to HDC-350 at 350 °C under an oxygen-free atmosphere. Through adsorption experiments, HDC-350 is found to show a superior adsorption effect for tetracycline (TC), with an adsorption capacity that reaches 136.88 mg g −1 . The TC adsorption mechanism was studied through characterization and analysis of HDC-350. The adsorption of TC by HDC-350 mainly relies on electrostatic attraction, hydrogen bonding, metal-organic complexation, and intermolecular interactions. This study shows that HKUST-1-derived porous carbon can be used to improve the water stability of HKUST-1, and, at the same time, can effectively adsorb TC in solution, which provides good conditions for practical research applications in the future.
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高影响因子
ENVIRONMENTAL POLLUTION
·
2023
·
IF 8.9
Zhijian Ke,Junyun Song,Jingrui Ma,Mengting Wang,Haiguang Mao,Chunli Xia,Lili Qi,Yidong Zhou,Jinbo Wang
Aspartame is one of the main varieties of artificial sweeteners. Although it has been approved as a food additive , the environmental hazards and ecological risks posed by aspartame are attracting more and more attention. In the present study, strain Pseudarthrobacter sp. AS-1 was isolated and characterized as an efficient aspartame degrader. Strain AS-1 was capable of degrading 200 mg L −1 aspartame within 10 h under conditions optimized at 30 °C and pH 8.0. At the same time, it was found that enzymes degrading aspartame in strain AS-1 were induced and secreted extracellularly. Degradation of aspartame in Pseudarthrobacter sp. AS-1 was identified as following: it was first demethylated to aspartyl-phenylalanine, then degraded to phenylalanine and aspartate , and finally the two amino acids were further degraded. In addition, strain AS-1 was able to remove more than 85% of aspartame in soil and river water. It is the first time that pure bacterial cultures were reported to have the capability of aspartame degradation. These findings add to our knowledge of the microbial metabolic mechanisms of aspartame.
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Clinical and Translational Medicine
·
2020
·Vol. 10
·期 4
·e154
·
IF 7.919
Xiaoxuan Yu,Hui Li,Po Hu,Yingjie Qing,Xiangyuan Wang,Mengyuan Zhu,Hongzheng Wang,Zhanyu Wang,Jingyan Xu,Qinglong Guo,Hui Hui
Background Although targeting histone deacetylases (HDACs) may be an effective strategy for core binding factor-acute myeloid leukemia (CBF-AML) harboring t(8;21) or inv(16), HDAC inhibitors are reported to be limited by drug-resistant characteristic. Our purpose is to evaluate the anti-leukemia effects of Baicalein on CBF-AML and clarify its underlying mechanism. Methods Enzyme activity assay was used to measure the activity inhibition of HDACs. Rhodamine123 and RT-qPCR were employed to evaluate the distribution of drugs and the change of ATP-binding cassette (ABC) transporter genes. CCK8, Annexin V/PI, and FACS staining certified the effects of Baicalein on cell growth, apoptosis, and differentiation. Duolink and IP assay assessed the interaction between HDAC-1 and ubiquitin, HSP90 and AML1-ETO, and Ac-p53 and CBFβ-MYH11. AML cell lines and primary AML cells-bearing NOD/SCID mice models were used to evaluate the anti-leukemic efficiency and potential mechanism of Baicalein in vivo. Results Baicalein showed HDAC-1/8 inhibition to trigger growth suppression and differentiation induction of AML cell lines and primary AML cells. Although the inhibitory action on HDAC-1 was mild, Baicalein could induce the degradation of HDAC-1 via ubiquitin proteasome pathway, thereby upregulating the acetylation of Histone H3 without promoting ABC transporter genes expression. Meanwhile, Baicalein increased the acetylation of HSP90 and lessened its connection to AML1/ETO, consequently leading to degradation of AML1-ETO in t(8;21)q(22;22) AML cells. In inv(16) AML cells, Baicalein possessed the capacity of apoptosis induction accompanied with p53-mediated apoptosis genes expression. Moreover, CBFβ-MYH11-bound p53 acetylation was restored via HDAC-8 inhibition induced by Baicalein contributing the diminishing of survival of CD34 + inv(16) AML cells. Conclusions These findings improved the understanding of the epigenetic regulation of Baicalein, and warrant therapeutic potential of Baicalein for CBF-AML.
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CHEMICAL ENGINEERING JOURNAL
·
2021
·
IF 13.273
Xiangyu Meng,Junyi Yang,Shiming Xu,Chenchen Zhang,Baochun Ma,Yong Ding
Molybdenum based compounds, such as MoC x , MoSe 2 , MoS 2 MoP x , MoO x and their derivatives, have been considered as the alternative catalysts for platinum (Pt) whether in electrocatalytic or photocatalytic hydrogen evolution reaction (HER). This means molybdenum based compounds have great application potential in solving the energy crisis and environmental pollution. Herein, for the first time, the unexplored Mo 2 B x (x = 1 or 4) were investigated as the active components in a visible-light driven photocatalytic hydrogen production system. Experimental results demonstrate that they both exhibit excellent hydrogen evolution activities when combined with CdS or organic photosensitizers. Additionally, for the same kind of light-harvesting material, the photocatalytic HER activity of Mo 2 B 4 is obviously better than that of Mo 2 B. This clearly indicates the photocatalytic activities of them are affected by the content of electron deficient atom boron (B) in Mo 2 B x samples and exhibits a strong B dependence in photocatalytic HER. The reason for this B dependency is studied in detail by photo/electrochemical methods and optical characterizations in this work, where it is essentially caused by the difference in the electron transfer (ET) rates between light-harvesting material and Mo 2 B x samples and just manifested as B dependency. Additionally, the relation between photocatalysis and electrocatalysis in HER is discussed.
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MICROPOROUS AND MESOPOROUS MATERIALS
·
2020
·
IF 4.551
Jun Yang,Ya-Xi Huang,Yuanming Pan,Jin-Xiao Mi
Researches on zeolite silicalite-1 have focused mainly on improving its performance, with little attention paid on green and economic synthesis. Herein, a novel route for green synthesis of pure silicalite-1 from the recycled mother liquor has been developed. This route starts from the hydrothermal reaction of natural quartz with NaOH to form a sodium silicate solution, which is then transformed into a silicic acid (H 2 SiO 3 ) gel by hydrochloric acid titration. Then the solid silicic acid (H 2 SiO 3 ) gel and fumed silica (SiO 2 ) are mixed with water under stirring to form a highly active slurry, which can be hydrothermally “dissolved” in a dilute NaOH aqueous solution. Using this slurry with a high SiO 2 /Na 2 O molar ratio of 5 : 1 as the silica source as well as tetrapropylammonium bromide (TPABr) as the organic template, MFI-type pure silicalite-1 has been successfully synthesized. After each synthesis, the mother liquor of centrifuged supernatant was recovered and recycled. The silica source and organic template were added to the recycled mother liquors for the synthesis of pure silicalite-1. The minimum TPABr/SiO 2 molar ratio needed to synthesize pure silicalite-1 in the initial run is 0.04 : 1. In comparison, only half the amount of the organic template is needed in subsequent runs with the recovered mother liquors. Through recycling, all reactants in the mother liquors were ultimately utilized without any waste, leading to not only effectively reducing the cost of silicalite-1 synthesis but also minimizing its environmental impact.
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高影响因子
INORGANIC CHEMISTRY COMMUNICATIONS
·
2020
·
IF 1.943
Jiuxiao Dong,Peiying Li,Hongyu Guan,Chunhua Ge,Yufeng Bai,Yuhui Zhao,Xiangdong Zhang
We use photosensitive resin as material, and adopt 3D printing and pyrolysis to prepare silica ceramics. HKUST-1 was grown on the ceramic surface by step-by-step in-situ growth method to obtain the HKUST-1/SiO 2 composite material. The HKUST-1/SiO 2 composite material was characterized by X-ray powder diffraction (XRD), fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), energy dispersive spectrometer (EDS), thermogravimetric analysis (TG). The HKUST-1/SiO 2 composite material not only has the characteristics of HKUST-1 and SiO 2 , but also can be designed into different complex shapes. In addition, the composite can be easy to separate from the product without centrifugation or filtration after the reaction is completed. The application of benzyl alcohol oxidation was an example to the performance of composite catalysts.
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Analytical Methods
·
2020
·Vol. 12
·期 22
·2827-2834
·
IF 2.596
Kai Hu,Jiamin Cheng,Jinge Li,Shan Ye,Huaixia Yang,Yanju Liu,Jinming Kong
The sensitive detection of biomarker cytokeratin fragment antigen 21-1 (CYFRA21-1) is crucial for early diagnosis and screening of non-small cell lung cancer (NSCLC). In this work, an electrochemical biosensor based on Nafion-initiated eATRP has been built for ultrasensitive detection of CYFRA21-1 DNA for the first time. Specifically, peptide nucleic acid (PNA) probes are immobilized onto a gold electrode surface and then hybridized with target DNA to form PNA/DNA heteroduplexes for the subsequent attachment of Nafion by the identified carboxyl–Zr4+–phosphoric acid chemistry. Finally, polymer chains are obtained by linking the monomer of ferrocenylmethyl methacrylate to the PNA/MCH/DNA/Zr4+/Nafion probes via eATRP. Under optimized steady-state conditions, the sensor offers a wide current response for CYFRA21-1 DNA from 10−11 to 10−16 M with a detection limit of 6.42 × 10−17 M. The proposed method of using Nafion as the eATRP initiator exhibits high sensitivity, reproducibility and stability and is a promising strategy for early diagnosis of NSCLC.
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JOURNAL OF ALLOYS AND COMPOUNDS
·
2019
·
IF 4.175
Xiaohua Zhang,Ning Chang,Jie Zhang,Yuanyuan Zhou,Zhenxing Yue,Longtu Li
In the present work, a series of (1-x)Ba 0.6 Sr 0.4 La 4 Ti 4 O 15 -xCaTiO 3 (x = 0.02, 0.03, 0.05, 0.1 and 0.2, BSLT-CT) functional ceramics were synthesized via co-firing the mixtures of Ba 0.6 Sr 0.4 La 4 Ti 4 O 15 and CaTiO 3 powders. Crystal structure and microwave dielectric properties were investigated together thermally stimulated depolarization currents (TSDC). Scanning electron microscopy (SEM) would be explored. X-ray diffraction confirms that these compounds display a single hexagonal phase with perovskite structure and the diffraction peaks shift to high angles with increasing CaTiO 3 content. Raman spectra uncover O h symmetry deviation and distortions of oxygen octahedra. The variation of the CaTiO 3 addition has a direct impact on the dielectric properties of the (1-x)BSLT-xCT ceramics at microwave frequency. TSDC was conducted to acquire the defects associated with extrinsic microwave loss mechanism. The main type of defect in BSLT-CT is oxygen vacancy ( V O • • ), namely involving in-grain and across-grain relaxation. The increase of CaTiO 3 prompts the increase of oxygen vacancy concentration, which may induce microwave loss. At x = 0.2, the microwave dielectric properties of specimens are ε r = 47.1, Q × f = 41,200 GHz and τ f = −5.3 ppm/°C, respectively.
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POLYMER
·
2019
·
IF 3.771
Yuehong Pang,Nianci Yang,Xiaofang Shen,Yi Zhang,Liheng Feng
Urinary 1-hydroxypyrene (1-OHP), one of the metabolite of polycyclic aromatic hydrocarbons (PAHs), has been extensively applied as a biomarker of animals and human exposure to PAHs. Herein, we synthesized a novel conjugated polymer poly-8-methoxy-7-methyl-5-(10-anthracen-9-yl)quinolone (PMMAYQ) using Suzuki coupling reaction, and then fabricated a homogeneous PMMAYQ/grahene multilayer film via layer-by-layer self-assembly technique and applied for electrochemical sensing of 1-OHP. Under the optimal conditions, {PMMAYQ-Graphene} 16 modified glass carbon electrode exhibited excellent response for detection of 1-OHP. A linear range from 0.5 to 120 nM was obtained with a low detection limit of 0.07 nM (S/N = 3) and a sensitivity of 0.5539 μA/μM. The electrochemical sensor exhibited excellent stability, accepted repeatability, and good selectivity. The developed method was employed for determination of 1-OHP in human urine samples and recoveries in the range of 95.6%–107.1% were achieved.
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BIOSCIENCE REPORTS
·
2018
·Vol. 38
·期 2
·
IF 2.899
Wang Qian,He Yuan,Lu Rui,Wang Wen-Ming,Yang Ke-Wu,Fan Hai Ming,Jin Yi,Blackburn G. Michael
The New Delhi metallo-β-lactamase (NDM-1) is an important clinical target for antimicrobial research, but there are insufficient clinically useful inhibitors and the details of NDM-1 enzyme catalysis remain unclear. The aim of this work is to provide a thermodynamic profile of NDM-1 catalysed hydrolysis of β-lactams using an isothermal titration calorimetry (ITC) approach and to apply this new method to the identification of new low-molecular-weight dicarboxylic acid inhibitors. The results reveal that hydrolysis of penicillin G and imipenem by NDM-1 share the same thermodynamic features with a significant intrinsic enthalpy change and the release of one proton into solution, while NDM-1 hydrolysis of cefazolin exhibits a different mechanism with a smaller enthalpy change and the release of two protons. The inhibitory constants of four carboxylic acids are found to be in the micromolar range. The compounds pyridine-2,6-dicarboxylic acid and thiazolidine-2,4-dicarboxylic acid show the best inhibitory potency and are confirmed to inhibit NDM-1 using a clinical strain of Escherichia coli. The pyridine compound is further shown to restore the susceptibility of this E. coli strain to imipenem, at an inhibitor concentration of 400 μM, while the thiazoline compound also shows a synergistic effect with imipenem. These results provide valuable information to enrich current understanding on the catalytic mechanism of NDM-1 and to aid the future optimisation of β-lactamase inhibitors based on these scaffolds to tackle the problem of antibiotic resistance.
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JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
·
2018
·Vol. 18
·期 4
·2601-2608
·
IF 1.354
Lin Jinrui,Ni Xiuyuan
In this study, a photochemical polymerization using graphene oxide (GO) as an initiator generated a new composite film with poly(1-vinylimidazole) (PVI) covered the GO sheets. Atomic force microscopy and infrared spectroscopy revealed the uniform layering of the PVI on the sheets. An
ITO/GO–PVI/Cu device was fabricated from this synthesized film, and it exhibited a write-once-read-many-times (WORM) memory functionality with resistance switching under an applied voltage of −3.2 V. The ON/OFF current ratio of the device reached 106. An analysis of the current–voltage
characteristics of the device indicated that the ON-state charge transport followed Ohmic conduction with metallic behavior, while the OFF-state charge transport was dominated by a trap-limited space charge limited conduction.
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Nano Life
·
2015
·
IF 0
Qiong Yi,Ling Li,Lu Fan,Keke Sun,Lebao Mao,Keke Liang,Li Liu
The adsorption of three kinds of azo dyes from aqueous solution on HKUST-1/graphene oxide (GO) composite was studied in view of the removal efficiency, adsorption isotherm, and regenerate of the sorbent. HKUST-1/GO was found to be with higher dyes removal efficiency than HKUST-1. All the adsorption isotherms of azo dyes on HKUST-1/GO composite followed Freundlich isotherm. The adsorbed azo dyes on HKUST-1/GO could be eluted by acetone, so HKUST-1/GO can also be used for enrichment of azo dyes as adsorbent.
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