TALANTA
·
2021
·
IF 6.057
Wenpeng Gong,Li Zhang,Ying Yu,Bixia Lin,Yumin Wang,Manli Guo,Yujuan Cao
Hydrogen sulfide is typical metabolic marker and environmental pollutant which is worthwhile to determine. Herein, a low background and high sensitivity fluorescent strategy based on double modifications of metal organic framework material CAU-10-NH 2 is proposed for the determination of hydrogen sulfide. Firstly, a functional monomer 3,5-diaminobenzoic acid is employed to modify on the CAU-10-NH 2 , the product CAU-10-NH-dAba has strong fluorescent performance at 412 nm under an excitation wavelength of 320 nm. Subsequently, it is further modified by the azide group to form CAU-10-NH-dAba-N 3 . This azidation inhibits the fluorescent signal. However, in the presence of hydrogen sulfide, the azide group is specifically reduced to amidogen, and results in the recovery of the fluorescence. The CAU-10-NH-DABA-N 3 was characterized by solid state NMR , XPS, fluorescence, IR, XRD, SEM and specific surface area. After the optimization of pH value, temperature and interaction time, the detection results of hydrogen sulfide demonstrate the linear range of this strategy is from 20 to 140 nM with a detection limit of 1.51 nM, which is significantly better than that of the CAU-10-NH 2 merely modified by 3,5-dinitrobenzoic acid. Meanwhile, the satisfactory assay results of hydrogen sulfide in serum sample and Pearl river water suggest a potential application prospect of this strategy in clinical diagnosis and environment monitoring.
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DOI
PubMed
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2023
·
IF 8.6
Guangping Lei,Yang Lu,Zihan Liu,Yayun Zhang,Guojun Xi,Huiyuan Cheng,Wenji Rao,Xuhuan Guo
The greenhouse effect associated with excessive CO 2 emission has led to a series of environmental issues, thus developing excellent adsorbents for CO 2 capture from flue gas offers a sustainable approach. To combine the merit of multiple functional components, novel FeTPP@MIL-101(Cr) was prepared by incorporation of 5,10,15,20-tetrakis(4-methylphenyl)porphyrinato iron (III) chloride (FeTPP) into MIL-101(Cr) cages via in-situ packaging strategy. The cage-confined FeTPP can both regulate the pore structures of MIL-101(Cr) and provide additional binding sites for CO 2 adsorption. Profiting from extra interactions for CO 2 component and the “sieving effect” for N 2 component induced by incorporation of FeTPP, the discrepancy of isosteric heat for CO 2 and N 2 was largely amplified. Notably, the CO 2 /N 2 selectivity (15/85, v / v ) calculated by ideal adsorbed solution theory (IAST) increased from 17.1 (MIL-101 (Cr)) to 41.8 (FeTPP@MIL-101 (Cr) with FeTPP loading of 4.98 wt%) at 273 K, 100 kPa, which is 2.44 times larger than that of pristine MIL-101 (Cr) and also exceeds most reported adsorbents.
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高影响因子
JOURNAL OF CHEMICAL AND ENGINEERING DATA
·
2016
·
IF 1.835
Ying Zhang,Xiong Zheng,Maogang He,Yutian Chen
Ethers are usually used as gasoline additives, and now 2-methoxy-2-methylpropane (MTBE) is the most widely used fuel additive. The speed of sound in MTBE with a specified mass purity higher than 0.990 (GC) was measured by the Brillouin light scattering method in the temperature range of 293.15–673.15 K and for pressures up to 10 MPa, including saturated liquid/vapor, liquid, and supercritical fluid. The correlations for the speed of sound in saturated liquid/vapor and liquid were proposed by employing the experimental results. Comparing the calculated results with the experimental data, the average absolute deviations are 0.50% for saturated liquid, 0.20% for saturated vapor, and 0.24% for liquid. The tendency of speed of sound to temperature and pressure was also analyzed.
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高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2024
·
IF 3.8
Zhaohui Lu,Shengtai Zhou,Chuxiang Zhou,Hao Zhang,Huawei Zou,Xiancheng Ren
Silicone rubber is able to provide excellent thermal protection and accommodates large deformation rates. However, the ablative properties of silicone rubber deteriorate significantly when it is subjected to ablation at large strain rates. To attempt to address the above problem, different types of metal oxides were adopted to enhance the ablative properties of vinyl methyl silicone rubber (VMQ), especially for enhancing the ablative performance at 10% tensile strain rate. The results revealed that the combined use of iron(II, III) oxide (Fe3O4) and zirconium dioxide (ZrO2) was instrumental in improving the ablative properties of VMQ-based composites at 10% tensile strain rate and a heat flux of 1 MW/m2. To further enhance the ablative performance, the ratio of Fe3O4 and ZrO2 was optimized through an experimental design method. Results showed that when the ratio of Fe3O4 and ZrO2 was 1.4:1, the maximum back-face temperature of a 3 mm thick silicone rubber composite remained below 200 °C, while the surface temperature was well above 2000 °C when it was stretched to a tensile strain rate of 10%. This work provides a reference for preparing high-performance flexible thermal ablative composites that exhibit promising application in aerospace and fire protection sectors, among others.
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高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Ya Han,Yingjian Yu
Germanium (Ge)-air batteries have garnered substantial attention as a promising energy conversion system owing to their remarkable safety, high anode utilization, high theoretical chemical equivalent and high power density, and are expected to be used in portable electronic products such as electronic watches and hearing AIDS. However, traditional Ge-air batteries with liquid and gel electrolytes face challenges such as volatility, dehydration at high temperatures, and freezing at extremely low temperatures, which limit their operational lifespan and performance in extreme environments. In this study, a carboxymethyl cellulose (CMC) organic gel polymer electrolyte (CMC organic GPE) was synthesized through free radical polymerization and investigated its application in Ge-air batteries over a wide temperature range for the first time. The incorporation of CMC and dimethyl sulfoxide (DMSO) organic solvents reduced the crystallinity of GPEs, disrupted hydrogen bonding between water molecules, and minimized water loss, thereby enhancing the ionic conductivity of the electrolyte. Furthermore, the electrolyte exhibited excellent water retention and frost resistance. Ge-air batteries utilizing CMC organic GPEs not only provide an exceptional discharge life of 370 h at room temperature but also operated at low temperatures (−10 °C) and extremely high temperatures (80 °C). The optimized GPEs enabled the Ge-air battery to achieve a prolonged discharge life of 207 h at a high temperature of 70 °C and a current of 400 µA, as well as a peak power density of 1.37 mW cm −2 at 80 °C. This study offered novel opportunities for the exploration of Ge-air batteries that are suitable for extreme environments.
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高影响因子
Arabian Journal of Chemistry
·
2022
·
IF 6.212
Zizhen Zhao,Chen Fu,Yuping Zhang,Yingying Zhang,Xiaoxi Yang,Ailing Fu
The incidence of HCC continues to increase rapidly in recent years. the principle of developing anti-HCC drugs is to specifically kill tumor cells, without affecting the function of normal cells. Here we synthesized a novel protonic compound bis(5-amino-1,10-phenanthroline) (P-BAP), and the antitumor activity was explored in vitro and in vivo . The results showed that P-BAP could selectively inhibit the proliferation of tumor cells, and induce HCC apoptosis. In HCC-bearing mice, P-BAP could effectively retard the tumor growth, even completely eliminate the tumors at the dose of 5 mg/kg, and meanwhile P-BAP had no significant effect on mouse body weight. Mechanism analysis revealed that P-BAP could down-regulate the protein expressions of pleomorphic adenoma gene like-2 (PLAGL2), HIF-1α and β-catenin, and up-regulate the levels of pro-apoptotic protein BAX and BNIP3. In addition, P-BAP could reduce mitochondrial respiratory chain complex activities, leading to insufficient ATP production. The study provides a new approach for designing selective antitumor drugs, and suggests that P-BAP would be a potential candidate for HCC therapy.
研究领域:
肿瘤学
·
药理学
·
分子生物学
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DOI
高影响因子
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2022
·
IF 5.895
Xue-Yan Dai,Shi-Yong Zhu,Jian Chen,Mu-Zi Li,Milton Talukder,Jin-Long Li
Lycopene (Lyc) has anti-inflammatory and antioxidant biological functions. Di-2-ethylhexyl phthalate (DEHP) is an extremely harmful and persistent environmental pollutant and is a threat to animal health. The toll-like receptor (TLR)/MyD88 pathway is an important pathway in the inflammatory response. To illustrate the potential antagonistic action of Lyc against DEHP by the TLR/MyD88 pathway, 140 ICR mice were randomly assigned groups and continuously gavaged with corn oil, distilled water, different DEHP concentrations (500 or 1000 mg/kg BW/day), and/or Lyc (5 mg/kg BW/day) for 28 days. The data show that Lyc effectively attenuates the DEHP-induced activation of the TLR/MyD88 pathway, the upregulation of JNK expression, the content of IL-6 and TNF-α, and the downregulation of the IL-10 content, which eventually inhibit the inflammatory response and mitochondrial injuries. These findings underline the TLR/MyD88 pathway as a potential therapeutic target in DEHP and Lyc as a new therapeutic method to inhibit DEHP toxicity.
研究领域:
毒理学
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免疫学
·
药理学
✓ 已验证
DOI
PubMed
高影响因子
ACS Applied Bio Materials
·
2020
·
IF 0
Xiaoyi Lv,Xiaoyun Xu,Tian Miao,Xufeng Zang,Chao Geng,Yanping Li,Bo Cui,Yishan Fang
9,10-Diphenylanthracene cubic nanoparticles (DPA CNPs) with aggregation-induced emission characteristic (AIEgens) were synthesized through a facile reprecipitation method; then, a bright and stable electrochemiluminescence (ECL) signal can be observed when the DPA CNPs were modified at the glassy carbon electrode (GCE) in the presence of Tri-n-propylamine (TPA). This phenomenon is ascribed to the molecules with restricted movement that greatly blocked the energy leakage during the relaxation of the excited state, which facilitated the emission of energy in the form of photons. In addition, the size confinement effect of DPA CNPs in the aggregated state effectively enhanced the ECL emission. The application of DPA CNPs with AIE characteristics in an electrochemiluminescence immunosensor has not been reported. In this contribution, a free-label aggregation-induced electrochemiluminescence immunosensor based on DPA CNPs was fabricated and a simple strategy for ultrasensitive detection of aflatoxin B1 (AFB1) was proposed. The ECL signal is quenched linearly in the range of 0.01 pg/mL to 100 ng/mL for AFB1, and the detection limit is 3 fg/mL. In summary, the prepared sensor exhibits high sensitivity, acceptable accuracy, good anti-interference ability and stability, and satisfactory detection toward AFB1 in walnut samples. Therefore, the fabricated immunosensor will have significant applications in the fields of food, medicine, and so on.
研究领域:
食品安全检测
·
生物医学工程
·
分析化学
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DOI
INTERNATIONAL IMMUNOPHARMACOLOGY
·
2020
·
IF 3.943
Simiao Qiao,Xingpan Lian,Mengfan Yue,Qin Zhang,Zhifeng Wei,Li Chen,Yufeng Xia,Yue Dai
Previously, we reported that oral administration of madecassoside, the main active triterpene in Centella asiatica L., exerted anti-arthritis effect by inducing the generation of regulatory T (Treg) cells in small intestine. This study investigates the action site and mechanism of madecassoside to induce Treg cells. In collagen-induced arthritis (CIA) of rats, oral administration of madecassoside significantly alleviated arthritis symptoms, but its main metabolite madecassic acid did not, suggesting that madecassoside functions in the parent form. Madecassoside was shown to increase the number of Treg cells and promote the expression of Foxp3 and IL-10 in rat ileum rather than duodenum and jejunum, as detected using the immunohistochemistry assay and quantitative PCR assay, respectively. Unexpectedly, madecassoside was absent of significant effect on in vitro Treg cell differentiation and the expression of Foxp3 and IL-10. A combined use of broad-spectrum antibiotics resulted in significant reduction of the anti-arthritis effect of madecassoside in CIA rats. The 16S rRNA gene sequence showed that madecassoside could reverse the changes of gut microbiota under arthritis condition, and enrich several bacteria such as Lachnospiraceae, Butyricicoccus, Faecalibacterium, Butyricicoccus pullicaecorum and so on. GC-MS assay showed that madecassoside elevated the levels of acetic acid and butyric acid, but not other short chain fatty acids (SCFAs) in the cecum contents of CIA rats. Butyric acid rather than acetic acid could induce the in vitro differentiation of Treg cells and the expression of Foxp3 and IL-10. Accordingly, when madecassoside was co-administered with heptanoyl CoA, the competitive inhibitor of butyrate synthase, its effect on butyric acid production, Treg cell proportion and arthritis nearly disappeared. These findings indicate that oral madecassoside induces the generation of Treg cells and therefore displays anti-arthritis effect in the parent form but not metabolites, and the ileum is the main action site. The mechanism of madecassoside can be summarized as: expansion of the richness of butyrate-producing bacteria-up-regulation of intestinal butyrate level-induction of Treg cell differentiation and IL-10 expression.
研究领域:
免疫学
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药理学
·
微生物学
·
风湿病学
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DOI
PubMed
高影响因子
ACTA PAEDIATRICA
·
2021
·Vol. 110
·期 7
·2221-2229
·
IF 2.299
Jing Li,Meixue Chen,Jinfeng Wang,Lingling Lu,Xiang Li,Yuan Le
Aim This study aimed to profile the microRNA levels in Chinese Henoch-Schonlein purpura (HSP) children and to explore their association with inflammatory factors and T helper 17 (Th17)/regulatory T (Treg). Methods Forty-five HSP children and 27 healthy controls were enrolled in this study, and microRNA levels were profiled with a microRNA microarray. The levels of selected microRNAs were determined by quantitative real-time PCR, and the levels of serum IgA, interleukin-6, interleukin-10 and interleukin-17A were detected by enzyme-linked immunosorbent assay. Additionally, Th17 and Treg cells were analysed by flow cytometry. Results There were 9 up-regulated and 27 down-regulated microRNAs in the PBMCs of Chinese HSP children. Among them, miR-1-3p, miR-19b-1-5p and miR-29b-1-5p were up-regulated, while miR-483-5p and miR-1246 were down-regulated. Additionally, these selected microRNAs could differentiate HSP patients from healthy controls. Interestingly, miR-29b-1-5p was correlated with IgA, miR-19b-1-5p, miR-483-5p and miR-1246 were correlated with interleukin-6, while miR-1-3p and miR-1246 were correlated with Th17/Treg. Conclusion This study reveals that the altered microRNAs could differentiate HSP from the healthy, and were associated with inflammatory factors or Th17/Treg. It is indicated that alteration in these microRNAs may contribute to the HSP pathogenesis and may become therapeutic targets or diagnostic biomarkers for HSP.
研究领域:
儿科
·
免疫学
·
分子生物学
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DOI
PubMed
高影响因子
JOURNAL OF NANOBIOTECHNOLOGY
·
2024
·Vol. 22
·期 1
·1-23
·
IF 10.6
Deng Zihan,Yang Chuan,Xiang Tingwen,Dou Ce,Sun Dong,Dai Qijie,Ling Zhiguo,Xu Jianzhong,Luo Fei,Chen Yueqi
Osteoarthritis (OA) is a common degenerative joint disease that can cause severe pain, motor dysfunction, and even disability. A growing body of research indicates that gut microbiota and their associated metabolites are key players in maintaining bone health and in the progression of OA. Short-chain fatty acids (SCFAs) are a series of active metabolites that widely participate in bone homeostasis. Gold nanoparticles (GNPs) with outstanding anti-bacterial and anti-inflammatory properties, have been demonstrated to ameliorate excessive bone loss during the progression of osteoporosis (OP) and rheumatoid arthritis (RA). However, the protective effects of GNPs on OA progression are not clear. Here, we observed that GNPs significantly alleviated anterior cruciate ligament transection (ACLT)-induced OA in a gut microbiota-dependent manner. 16S rDNA gene sequencing showed that GNPs changed gut microbial diversity and structure, which manifested as an increase in the abundance of Akkermansia and Lactobacillus . Additionally, GNPs increased levels of SCFAs (such as butyric acid), which could have improved bone destruction by reducing the inflammatory response. Notably, GNPs modulated the dynamic balance of M1/M2 macrophages, and increased the serum levels of anti-inflammatory cytokines such as IL-10. To sum up, our study indicated that GNPs exhibited anti-osteoarthritis effects via modulating the interaction of “microbiota-gut-joint” axis, which might provide promising therapeutic strategies for OA.
研究领域:
纳米技术
·
风湿病学
·
微生物学
·
免疫学
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DOI
PubMed
高影响因子
MICROCHEMICAL JOURNAL
·
2025
·
IF 5.1
Tiantian Xu,Shijie Xing,Jinyu Wang,Xin Zhang,Shu-Xuan Liang
It is crucial to select highly efficient adsorbents to separate and enrich trace analytes during sample pretreatment process. In this study, NiFe 2 O 4 pyridyl-based microporous organic network (NiFe 2 O 4 /PMON) was prepared using a fast and simple ultrasonic assisted method, which could be completed within 2 h. A magnetic solid phase extraction method based on 3 mg NiFe 2 O 4 /PMON as an extraction adsorbent was developed. Combining with GC–MS, an effective method for simultaneous detection of 10 triazine herbicides was established. The proposed method showed high sensitivity (LODs range of 0.19–0.46 ng/L), good precision (RSD below 8.3 %), and strong reliability, with spiked recovery rates between 70.5 and 108.4 %. NiFe 2 O 4 /PMON exhibited strong affinity for triazine herbicides through π–π, hydrophobic and hydrogen bond interactions. This study provides new ideas for the composite method of magnetic nanoparticles with MON. In addition, by extending the combination of MON and magnetic oxides, it can be used for the efficient detection of pesticide residues in water.
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高影响因子
危险品化学品经营许可证（带存储）