PEST MANAGEMENT SCIENCE
·
2023
·
IF 4.1
Tianze Li,Min Lv,Houpeng Wen,Jiawei Du,Zhen Wang,Shaoyong Zhang,Hui Xu
Background Phytopathogenic fungi can cause a direct loss in economic value of agriculture. Especially Valsa mali Miyabe et Yamada, a devastating phytopathogenic disease especially threatening global apple production, is very difficult to control and manage. To discover new potential antifungal agents, a series of thiosemicarbazone derivatives of 3-acetyl- N -benzylindoles were prepared. Their antifungal activities were first tested against six typically phytopathogenic fungi including Curvularia lunata , Valsa mali , Alternaria alternate , Fusarium graminearum , Botrytis cinerea and Fusarium solani . Then their mechanism of action against V. mali was investigated. Results Derivatives displayed potent antifungal activity against V. mali . Notably, 3-acetyl- N -benzylindole thiosemicarbazone (IV-1: EC 50 : 0.59 μ g mL −1 ), whose activity was comparable to that of a commercial fungicide carbendazim (EC 50 : 0.33 μ g mL −1 ), showed greater than 98-fold antifungal activity of the precursor indole. Moreover, compound IV-1 displayed good protective and therapeutic effects on apple Valsa canker disease. By scanning electron microscope (SEM) and RNA-Seq analysis, it was demonstrated that compound IV-1 can destroy the hyphal structure and regulate the homeostasis of metabolism of V. mali via the ergosterol biosynthesis and autophagy pathways. Conclusion 3-Acetyl- N -(un)substituted benzylindoles thiosemicarbazones (IV-1–IV-5) can be studied as leads for further structural modification as antifungal agents against V. mali . Particularly, these ergosterol biosynthesis and autophagy pathways can be used as target receptors for design of novel green pesticides for management of congeneric phytopathogenic fungi. © 2023 Society of Chemical Industry.
研究领域:
农业科学
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植物病理学
·
化学
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DOI
PubMed
高影响因子
INORGANIC CHEMISTRY
·
2022
·
IF 5.436
Zhiyong Bai,Lehui Liu,Zhoubin Lin,Kang Min Ok
A novel guanidinium-templated ultraviolet (UV) nonlinear optical zinc carbonate crystal, [C(NH2)3]2Zn(CO3)2 (GZCO), has been synthesized in a closed system at low temperatures. GZCO crystallizing in the tetragonal noncentrosymmetric nonpolar space group, P41212 exhibits a three-dimensional anionic framework constructed by interconnected [Zn6C6O32] 12-membered ring channels with inorganic CO3 triangles and ZnO4 tetrahedra. Notably, the anhydrous GZCO shows a very high thermal stability among guanidine-based hybrid NLO materials benefiting from the confinement effect of the organic cations within inorganic channels. The UV–visible transmittance spectrum reveals that GZCO has a short UV cutoff edge of 210 nm, corresponding to the large band gap of 5.9 eV. GZCO exhibits a mild second-harmonic generation efficiency of 0.5 × KH2PO4 with type-I phase-matching behavior.
研究领域:
材料科学
·
光学
·
化学
✓ 已验证
DOI
高影响因子
LABORATORY INVESTIGATION
·
2018
·Vol. 98
·期 12
·1642-1656
·
IF 4.263
Cao Zhanqi,Hao Zhaojun,Xin Ming,Yu Lugang,Wang Lei,Zhang Ying,Zhang Xinke,Guo Xiuli
Tumor cell-endothelial adhesion is one of the key steps in tumor cell haematogenous dissemination in metastasis and was previously shown to be mediated by interaction of galectin-3 with the transmembrane mucin protein MUC1. In this study, the effect of exogenous as well as endogenous galectin-3 on adhesion of two cell lines (low MUC1-expressing human prostate cancer PC-3M cells and non-small-cell lung cancer A549 cells) to monolayer of umbilical vein endothelial cells (HUVECs) was investigated. We found that suppression of endogenous galectin-3 expression reduced tumor cell adhesion to HUVECs and also decreased cell invasion and migration. Exogenous galectin-3 promoted tumor cell adhesion to HUVECs by entering cells. Both exogenous and endogenous galectin-3 upregulated the expression of β-catenin and increased β-catenin nuclear accumulation, and subsequently upregulated the expression of N-cadherin and CD44. We deduced that both exogenous as well as endogenous galectin-3 promoted low MUC1-expressing cancer cell adhesion to HUVECs by increasing the expression of N-cadherin and CD44 via an increase of nuclear β-catenin accumulation. These results were confirmed further by using a β-catenin/TCF transcriptional activity inhibitor, N-cadherin or CD44 siRNAs. Taken together, our results suggest a new molecular mechanism of galectin-3-mediated cell adhesion in cancer metastasis.
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产品关联
DOI
PubMed
高影响因子
ACS Sensors
·
2025
·
IF 9.1
Xiao Ma,Rong Tan,Hong Chen,Jiawei Zhang,Lei Ge,Tingting Zhao,Xinyu Wang,Kaikai Yuan,Hairui Fang,Dong Wang
Nitrogen dioxide (NO2), the main component of pollutants in atmospheric environments, causes and exacerbates respiratory diseases, especially during outdoor sports even at the 100 ppb level. Currently, environmental gas detection still faces challenges such as high detection limits, low SNR, and low sensitivity. A NO2 sensor based on In(OH)3-α-Fe2O3–ZnO was prepared using a hydrothermal method, featuring an ultralow detection limit of 82 ppt, an exceptionally high SNR of 574,000, and an ultrahigh sensitivity of 252.25 mV/ppm (100 ppb to 1 ppm). And this sensor exhibits excellent response, selectivity, and repeatability. These excellent sensing characteristics come from the adsorbed oxygen on the surface of the material with the formation of n–n heterojunctions. Additionally, a low-power, portable, and cost-effective environmental monitoring system (named Smart Breath Sentinel (SBS)) was designed to intelligently upgrade ordinary masks. SBS enables real-time wireless environmental gas monitoring with integrated humidity compensation to ensure accurate measurements in high-humidity environments. SBS has already been tested in multiple environments, and the test results have proven the feasibility of SBS. This sensor based on In(OH)3-α-Fe2O3–ZnO demonstrates significant potential for applications aimed at enhancing human safety.
研究领域:
环境科学
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材料科学
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传感技术
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产品关联
DOI
PubMed
高影响因子
Probiotics and Antimicrobial Proteins
·
2024
·
IF 4.4
Zheng Xiumei,Zhang Zhe,Shan Tianhu,Zhao Maozhen,Lu Haiyan,Zhang Lanwei,Liang Xi
Atherosclerosis is a major cause of cardiovascular disease (CVD). The trimethylamine (TMA)-trimethylamine N-oxide (TMAO) pathway is a key crossover pathway highly associated with diet, gut microbiome, and atherosclerosis. The Bifidobacterium animalis subsp. lactis F1-3–2 ( Bif. animalis F1-3–2, No. CCTCCM2020832) was screened through in vitro and in vivo experiments in the early stage of this study with excellent lipid-lowering and anti-inflammatory function. By building an atherosclerosis model and focusing on TMAO, the specific mechanism of Bif. animalis F1-3–2 to improve atherosclerosis was explored. The study found that Bif. animalis F1-3–2 effectively improved the accumulation of aortic plaque in atherosclerotic mice. The strain improved lipid metabolism in serum and liver. It decreased the serum TMA and TMAO, regulated bile acid composition, participated in the farnesoid X receptor (FXR) pathway to improve lipid metabolism, and further reduced the aortic macrophage foam cell accumulation. In addition, the strain could improve the structure of the intestinal microbiome and reduce the proportion of Firmicutes and Bacteroidetes. The abundance of Turicibacter , Clostridium sensu stricto_1 , and Romboutsia was reduced at the genus level. The differential microbiota is highly correlated with bile acid metabolism, which is speculated to be involved in ameliorating atherosclerotic lipid metabolism disorders. Graphical abstract
研究领域:
微生物学
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心血管疾病
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营养学
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代谢组学
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DOI
PubMed
高影响因子
JOURNAL OF MOLECULAR LIQUIDS
·
2023
·
IF 6
Zihao Dong,Yajuan Qu,Yuyang Jiao,Ke Xue,Wenguang Zhu,Hai Liu,Jianguang Qi,Yinglong Wang
A series of poly(1-vinyl-3-methylimidazole dimethyl phosphate- co -N-isopropylacrylamide) oligomers was synthesized by reversible addition-fragmentation chain transfer polymerization. The co-oligomers exhibited a pH-tunable lower critical solution temperature (LCST) phase transition in aqueous solutions. By changing the pH of the aqueous solution (HCI), the hydrogen bonding between the internal molecules of the co-oligomers and water molecules was weakened, which effectively reduced the cloud-point temperature. Poly(1-vinyl-3-methylimidazole dimethyl phosphate- co - N -isopropylacrylamide) oligomers exhibit an upper critical solution temperature (UCST) type of phase transition in an ester solution, which is associated with the formation and breaking of hydrogen bonds within the co-oligomers molecules. FT-IR analysis revealed the effect of temperature on hydrogen bonding between the functional groups. Energy decomposition, Electrostatic Potential (ESP), Atoms-in-Molecules (AIM), and Interaction region indicator (IRI) analyses demonstrated the presence of hydrogen bond donors N–H and imidazole ring C–H, and hydrogen bond acceptors C = O and P = O in the co-oligomers. The sites of hydrogen bonding between the co-oligomers and the solvent molecules as well as intermolecular forces were found to be the main factors contributing to the LCST/UCST-type phase transition.
研究领域:
高分子化学
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物理化学
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DOI
高影响因子
CHEMISTRY & BIODIVERSITY
·
2021
·Vol. 18
·期 11
·e2100301
·
IF 2.408
Zhuojin Yang,Yi Zheng,Nafisa Tursumamat,Mingyan Zhu
Isorhamnetin is a natural flavonoid which shows a variety of biological activities such as antioxidant, anti-inflammatory and antitumor. In order to identify the cellular binding protein of isorhamnetin as potential anti-cancer target, we first synthesized 3′- O -substituted quercetin as isorhamnetin homologues and evaluated the growth inhibitory activity of these derivatives on breast, colon and prostate cancer cell lines. The preliminary results showed that the 3′- O modification did not affect the cytotoxic activity of the scaffold. Analysis of the co-crystal structure and the docking pose of isorhamnetin with reported binding protein of isorhamnetin or quercetin indicated the 3′- O -substitution groups located outside of the binding pocket, which is in accordance with activity of 3′- O derivatives. Then a biotin conjugate of isorhamnetin with a tetraethylene glycol (PEG) 4 linker at the 3′ position was synthesized and the resulting probe retained the anti-proliferative activity on cancer cell lines, while the cellular fluorescence analysis showed the distribution of probe inside the cells which indicated the probe had limited cell permeability. Finally, pull down assay both in situ inside cells and in the cell lysates indicated the isorhamnetin biotin probe was capable of protein labeling in cell lysates. These findings provide the isorhamnetin 3′- O -biotin probe as a tool to reveal the target proteins of isorhamnetin. Graphical
研究领域:
药理学
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癌症研究
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化学
·
分子生物学
✓ 已验证
DOI
PubMed
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
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2017
·
IF 5.401
Xiao Wang,Ying Zheng,Lan Xu
An electrochemical strategy for adenine detection was described. In order to generate a 3D net-work composite film, gold nanoparticles (Au NPs) capped with 3-thiophene acetic acid (3-TAA) were used to couple with molecular imprinting technique (MIT). In the presence of the 3-TAA capping Au NPs (Au NPs-T), the electrode-surface-tethered 3-TAAs were polymerized to form a homogeneous conductive material immobilized into the electrode. Through this sensor fabrication, Au NPs-T associating with the Au electrode resulted in enhanced sensitivity and MIT contributed to the specificity.
研究领域:
电化学
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生物传感器
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纳米技术
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分析化学
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分子印迹
✓ 已验证
DOI
高影响因子
JOURNAL OF RARE EARTHS
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2012
·
IF 0.901
Xiaoming PENG,Yufeng HU,Chuanwei JIN,Zhixin WANG,Chao MIAO,Zheyu LI
Viscosities were measured for the ternary systems Y(NO 3 ) 3 +La(NO 3 ) 3 +H 2 O, La(NO 3 ) 3 +Ce(NO 3 ) 3 +H 2 O, and La(NO 3 ) 3 +Nd(NO 3 ) 3 + H 2 O and their binary subsystems Y(NO 3 ) 3 +H 2 O, La(NO 3 ) 3 +H 2 O, Ce(NO 3 ) 3 +H 2 O, and Nd(NO 3 ) 3 +H 2 O at 293.15, 298.15 and 308.15 K. The results were used to test the applicability of simple equations for the viscosity of the mixed solutions. The predictions agreed well with measured values, implying that the viscosities of the examined electrolyte solutions could be related to those of their constituent binary solutions using these simple equations.
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产品关联
DOI
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2022
·
IF 9.221
Xiao-Fan Wu,Qingmei Ge,Nan Jiang,Mao Liu,Hang Cong,Zhu Tao
Utilizing a novel concept of chiral amplification induced by host-guest interactions, a new macrocyclic compound , benzo[3]uril (BU[3]), was formed in a chiral microenvironment via the encapsulation of L -cysteine∙H + (L-Cys∙H), and the electrochemiluminescence properties of BU[3] were sensibilized with the formation of a supramolecular complex . Based on this principle, an ultra-sensitive chiral electrochemiluminescence sensor was constructed to recognize the enantiomer of penicillamine (PA). This sensor exhibited high selectivity and sensitivity for L -PA compared to other reported values, with a detection limit of 10 -12 mol·L -1 within a linear range of 10 -5 –10 -10 mol·L -1 , and no obvious electrochemiluminescence response to D -PA. The sensor presents high stability, good reproducibility, strong anti-interference ability, and acceptable recovery, which suggests an ability to quantitatively detect L -PA in an aqueous environment.
研究领域:
分析化学
·
材料科学
·
电化学
·
手性和超分子化学
✓ 已验证
DOI
高影响因子
JOURNAL OF POWER SOURCES
·
2021
·
IF 9.127
Yingmin Jin,Xin Zong,Xuebai Zhang,Chaojun Liu,Dong Li,Zhenggang Jia,Gen Li,Xuanguang Zhou,Junhua Wei,Yueping Xiong
Composite solid electrolyte (CSE) consisting of Li + conductive fillers and polymer matrix has become attractive for high energy-density lithium batteries . Current researches focus on the “ceramic in polymer”-type CSE due to the severe agglomeration of ceramic particles. Consequently, the destroyed percolation network impedes the further improvement in ionic conductivity . In this work, we report a novel structural design of ceramic-enriched CSE consisting of three-dimensional (3D) interconnected Li 1.3 Al 0.3 Ti 1.7 (PO 4 ) 3 (LATP), polyvinylidene fluoride (PVDF) and LiN(SO 2 ) 2 (CF 3 ) 2 (LiTFSI). The 3D LATP network is constructed through the surface functionalization of LATP particles by polymethyl methacrylate (PMMA). Owing to the intermolecular interaction between PMMA and PVDF, the incorporation of PMMA-coated LATP (denoted as LATP@PMMA) enables the uniform distribution of ceramic phase and generates interconnected LATP network. Noticeably, such an electrolyte maximizes the utilization of inorganic fillers through the facile treatment of zero-dimensional materials, which is comparable to those 3D template-derived fillers. Furthermore, continuous Li + conduction pathways through LATP framework and LATP/PVDF interphase are guaranteed by the enhanced affinity of LATP towards PVDF matrix and the intrinsic Li + complexation capability of PMMA. Remarkable cycling performances of the LiNi 0.5 Co 0.2 Mn 0.3 O 2 /LATP@PMMA-PVDF/Li batteries confirm the feasibility of 3D ceramic-enriched composite electrolyte in the application of solid-state lithium batteries.
研究领域:
材料科学
·
电化学
·
电池技术
✓ 已验证
DOI
高影响因子
INORGANIC CHEMISTRY
·
2021
·
IF 5.165
Liling Cao,Shengzi Zhang,Dan Zhao,Bingxuan Li,Tao Yan,Guangsai Yang,Zheshuai Lin,Min Luo,Ning Ye
A new d10 transition-metal iodate fluoride, namely, Cd3(IO3)(IO4)F2·0.1CdO, was successfully designed and synthesized via the mid-infrared hydrothermal method. It crystallizes in the polar space group R3m and features the coexistence of the [IO3]− and [IO4]3– groups. Cd3(IO3)(IO4)F2·0.1CdO has a strong second-harmonic-generation response of about 3.0 times that of KDP(KH2PO4), large birefringence (0.133 at 546.1 nm), and a wide energy band gap (4.00 eV). In addition, the power laser damage threshold (LDT) measurement indicated that it possesses a high LDT of 84.29 MW/cm2, which is about 30 times that of AgGaS2. These superior properties showed that Cd3(IO3)(IO4)F2·0.1CdO may be an excellent nonlinear-optical crystal for visible and mid-infrared application.
研究领域:
材料科学
·
光学
·
晶体学
✓ 已验证
DOI
高影响因子
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