Bio-Design and Manufacturing
·
2021
·Vol. 4
·期 4
·902-911
·
IF 6.302
Zeng Zhiyong,Jiang Guohua,Liu Tianqi,Song Gao,Sun Yanfang,Zhang Xueya,Jing Yanting,Feng Mingjia,Shi Yufei
Abstract Injection therapy for diabetes has poor patient compliance, and the pain occurring at the site of subcutaneous injections causes significant inconvenience to diabetic patients. In this work, to demonstrate the benefits of an alternative drug delivery technique that overcomes these issues, methacrylated gelatin hydrogel-forming microneedles integrated with metformin were developed to adjust blood glucose levels in diabetic rats. Gelatin methacryloyl microneedles (GelMA-MNs) with different degrees of substitution were successfully prepared by a micro-molding method. The resultant GelMA-MNs exhibited excellent mechanical properties and moisture resistance. Metformin, an anti-diabetic drug, was further encapsulated into the GelMA-MNs, and its release rate could be controlled by the three-dimensional cross-linked network of microneedles, thereby exhibiting sustained drug release behaviors in vitro and implying a better therapeutic effect compared with that of subcutaneous injection in diabetic rats. The drug release period could be significantly prolonged by improving the cross-link density of GelMA-MNs. The results of hypoglycemic effect evaluation show that the application of GelMA-MNs for transdermal delivery in diabetic rats has promising benefits for diabetes treatment.
Graphic abstract
研究领域:
生物医学工程
·
药物递送
·
糖尿病治疗
✓ 已验证
DOI
高影响因子
Forensic Toxicology
·
2023
·Vol. 41
·期 2
·241-248
·
IF 2.2
Guo Caixia,Yan Hui,Liu Wei,Xiang Ping,Di Bin,Shen Min
Purpose An analytical method using liquid chromatography with tandem mass spectrometry (LC–MS/MS) was established and validated for screening 425 drugs and poisons in dried blood spots (DBSs). Methods Blood (20 μL) was spotted on Whatman FTA™ classic card to prepare DBS sample, then extracted with 150 μL methanol and analyzed by LC–MS/MS using a multiple reaction monitoring method. Results The limit of detection of the compounds were 0.1–10 ng/mL. The values for recovery and matrix effect were 40.3–114.9% and 40.2–118.4%, respectively. This method was successfully applied to DBS samples from 105 humans suspected of drug poisoning, which was stored for 3–5 years at room temperature. Thirty-three kinds of drugs, including benzodiazepines, antipsychotics, antidepressants, antipyretic analgesics, non-steroidal anti-inflammatory drugs, antibiotics, antiepileptic drugs, new psychoactive drugs were confirmed in 102 cases, while no compound was detected in the other 3 cases. Estazolam, a benzodiazepine widely used in clinical practice as a sedative, hypnotic, and anti-anxiety drug, was the most frequently detected substance, occurring in 34.2% of the cases. Conclusions Most drugs in DBS could still be detected after storage for 3–5 years, but ambroxol, zopiclone, carbofuran, chlorpyrifos, and valproic acid were not detectable after 3–5 years of storage at room temperature. The components measured in DBS were consistent with those measured in whole blood at the collection time, thereby confirming that DBS samples have the advantage of stable storage at room temperature.
研究领域:
分析化学
·
法医学
·
药理学
✓ 已验证
DOI
PubMed
高影响因子
Nature Communications
·
2023
·Vol. 14
·期 1
·1-9
·
IF 16.6
Zhu Bin,He Shanshan,Yang Yan,Li Songwei,Lau Cher Hon,Liu Shaomin,Shao Lu
Advances in membrane technologies are significant for mitigating global climate change because of their low cost and easy operation. Although mixed-matrix membranes (MMMs) obtained via the combination of metal-organic frameworks (MOFs) and a polymer matrix are promising for energy-efficient gas separation, the achievement of a desirable match between polymers and MOFs for the development of advanced MMMs is challenging, especially when emerging highly permeable materials such as polymers of intrinsic microporosity (PIMs) are deployed. Here, we report a molecular soldering strategy featuring multifunctional polyphenols in tailored polymer chains, well-designed hollow MOF structures, and defect-free interfaces. The exceptional adhesion nature of polyphenols results in dense packing and visible stiffness of PIM-1 chains with strengthened selectivity. The architecture of the hollow MOFs leads to free mass transfer and substantially improves permeability. These structural advantages act synergistically to break the permeability-selectivity trade-off limit in MMMs and surpass the conventional upper bound. This polyphenol molecular soldering method has been validated for various polymers, providing a universal pathway to prepare advanced MMMs with desirable performance for diverse applications beyond carbon capture.
研究领域:
材料科学
·
环境工程
·
化学工程
✓ 已验证
DOI
PubMed
高影响因子
MICROCHIMICA ACTA
·
2017
·Vol. 184
·期 10
·3747-3753
·
IF 4.58
Jia Haiyan,Yang Taotao,Zuo Yinxiu,Wang Wenmin,Xu Jingkun,Lu Limin,Li Ping
The authors describe a voltammetric immunosensor with antibody immobilized on a glassy carbon electrode (GCE) modified with N-doped graphene (N-GS), electrodeposited gold nanoparticles (AuNPs) and chitosan (Chit). The preparation is simple and the thickness of the electrodeposited films can be well controlled. Due to the specific advantages of N-GS, AuNPs and Chit, the electrode has a large specific surface, improved conductivity, high stability. A new label-free immunosensor for the model antigen (alpha fetoprotein, AFP) detection was then designed by employing N-GS-AuNP-Chit as the antibody immobilization and signal amplification platform. Differential pulse voltammetry and electrochemical impedance spectroscopy were used for the characterization of the stepwise assembly process. Under the optimized conditions, at a typical working potential of +0.20 V (vs. SCE), and by using hexacyanoferrate as an electrochemical probe, the immunosensor has a detection limit as low as 1.6 pg mL −1 and a linear analytical range that extends from 5 pg mL −1 to 50 ng mL −1 . AFP was quantified in spiked human serum samples with acceptable precision.
Schematic of sensitive and effective label-free electrochemical immunosensor for the detection of AFP based on N-GS-AuNP-Chit as signal amplification matrix.
研究领域:
生物医学工程
·
分析化学
·
电化学
✓ 已验证
DOI
高影响因子
Nature Communications
·
2023
·Vol. 14
·期 1
·1-12
·
IF 16.6
Wang Wei,Chen Shan,Liao Xuelong,Huang Rong,Wang Fengmei,Chen Jialei,Wang Yaxin,Wang Fei,Wang Huan
In situ formation of a stable interphase layer on zinc surface is an effective solution to suppress dendrite growth. However, the fast transport of bivalent Zn-ions within the solid interlayer remains very challenging. Herein, we engineer the SEI components and enable superior kinetics of Zn metal batteries under harsh conditions through regulating the sequence of interfacial chemical reaction. With the differences in chemical reactivity of trimethyl phosphate co-solvent and trifluoromethanesulfonate anions in the Zn 2+ -solvation shell, Zn 3 (PO 4 ) 2 and ZnF 2 are successively generated on Zn metal surface to form a gradient ZnF 2 –Zn 3 (PO 4 ) 2 interphase. Mechanistic studies reveal the outer ZnF 2 facilitates Zn 2+ desolvation and inner Zn 3 (PO 4 ) 2 serves as channels for fast Zn 2+ transport, contributing to long-term cycling at subzero temperatures. Impressively, the gradient SEI enables a high lifespan over 7000 hours in Zn symmetric cell and a capacity retention of 86.1% after 12000 cycles in Zn–KVOH full cell at –50 °C.
研究领域:
电化学
·
材料科学
·
电池技术
✓ 已验证
DOI
PubMed
高影响因子
BIODEGRADATION
·
2021
·Vol. 32
·期 1
·99-112
·
IF 3.909
Qiao Weichuan,Miao Jiahui,Jiang Hongmei,Yang Qiwen
Perfluoroalkyl carboxylates (PFCAs) is toxic to the environment and human health. However, the degradation characteristics of fluorotelomer alcohols (FTOHs), precursors of PFACAs biodegradation, in the sludge during aerobic composting remain unclear. In this study, the degradation characteristics of 6:2 FTOH in sewage sludge by composting were researched and the influences of 6:2 FTOH on the composting process and microbial communities of the sludge were evaluated. After 52 days of composting, 6:2 FTOH retained only 0.73% of its original concentration, and its half-life was less than 1 d; 6:2 FTOH was degraded finally to perfluorohex unsaturated acid, perfluoropentanoic acid, 5:3 polyfluorinated acid (FTCA), 4:3 FTCA, and perfluorobutanoic acid through two pathways; and 6:2 FTCA and 6:2 fluorotel unsaturated acid were the intermediate products. Notably, dosing with 6:2 FTOH affected the composting process of sewage sludge. Additionally, 50 mg/kg 6:2 FTOH resulted in a decrease in the microbial richness and diversity of sludge compost. When compared with the compost without 6:2 FTOH, the proportion of Proteobacteria had increased, and the proportion of Firmicutes had decreased as the concentration of 6:2 FTOH increased. The negative effect of a dosage of 50 mg/kg 6:2 FTOH was more obvious than the effect of other treatments. This study expanded our understanding of the risk of sludge contaminated by 6:2 FTOH being used as a fertilizer after composting.
研究领域:
环境科学
·
废物管理
·
微生物学
✓ 已验证
DOI
PubMed
高影响因子
Journal of Inorganic and Organometallic Polymers and Materials
·
2019
·Vol. 30
·期 4
·1011-1032
·
IF 1.637
Cid A.,Simal-Gandara J.
In recent decades, the industrial use of nanoparticles (NPs) and, especially, metal nanoparticles (MNPs), has attracted widespread attention because of their special physicochemical properties. The ability of MNPs to self-arrange into ordered, nanometrically sized structures and form nanometric colloids has enabled their use as nanocatalysts the properties of which can be tailored through ordered growth of their crystal structures. In fact, these nanocatalysts provide a unique opportunity to tune material properties at the nanometric scale. Thus, altering the size or shape of the nanoparticles allows materials of identical composition but different properties to be obtained. The versatility of MNPs (and, especially, those containing the transition metals copper, nickel and palladium) led us to review their synthetic procedures, most salient physicochemical properties, and existing and potential applications (chemical sensing and plasmon resonance included).
研究领域:
材料科学
·
化学工程
✓ 已验证
DOI
高影响因子
MICROCHIMICA ACTA
·
2020
·Vol. 187
·期 7
·1-10
·
IF 6.232
Zhang Xue,Shen Yan-Feng,Li Xin-Xin,Yang Jin-Rong,Liu Zhao-Sheng,Huang Yan-Ping
An organic-inorganic hybrid monolithic column doped with gold nanorods (AuNRs) was prepared and evaluated for solid phase extraction (SPE) of polycyclic aromatic hydrocarbons (PAHs). Excellent dispersibility of AuNRs in binary green porogen system consisting of 1-hexyl-3-methylimidazolium tetrafluoroborate and deep eutectic solvents (DESs) was confirmed by energy dispersive spectrometry (EDS). The particle size of the resulting AuNRs (70–90 nm) was thoroughly examined by a transmission electron microscopy (TEM). The redox system including ammonium persulfate (APS) and tetramethylethylenediamine (TEMED) was used to initiate in situ polymerization at 4 °C to prepare the hybrid monolith. The mesoporous structure of the AuNR hybrid monoliths was confirmed by scanning electron microscopy (SEM) and nitrogen adsorption. With enrichment factors (EFs) of 150- to 292-fold, the developed method was successfully applied to the determination of 10 PAHs in wastewater samples. The recoveries at a spiked level were in the range 84.9 to 99.5% with limit of detections (LODs) and relative standard deviations (RSDs) ranging from 0.02 to 0.10 μg L −1 and 1.5 to 4.2%, respectively. The correlation coefficients ( R 2 ) for the calibration function obtained were better 0.9991 for the target compounds. Compared to the AuNR-free monolith, the extraction efficiency of the AuNR-incorporated monolith is more than two times higher. The results indicated that the doping of AuNRs is an effective approach to obtain the hybrid monolithic column with good separation ability for PAHs.
Graphical abstract
研究领域:
分析化学
·
环境科学
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
·
2018
·Vol. 135
·期 4
·2317-2328
·
IF 2.209
Yin Xin,Li Jie,Zhang Guojie,Gu Hao,Ma Qing,Wang Shumin,Wang Jun
N -trinitromethyl-4,5-dicyano-2 H -1,2,3-triazole was readily synthesized from 4,5-dicyano-2 H -1,2,3-triazole. Its crystal structure was obtained for the first time and its crystalline density in 296 K was 1.729 g cm −3 . It shows high nitrogen and oxygen content up to 77.6%, high calculated solid heat of formation (564 kJ mol −1 ), and superior detonation pressure and detonation velocity ( D = 8619 m s −1 , P = 30.8 GPa). This new hydrogen-absent explosive shows high impact and friction sensitivities ( IS : 1.25 J, FS : 32 N), which is lower than commercial primary explosive 2-diazonium-4,6-dinitrophenol (DDNP) ( IS : 1 J, FS : 5 N). The relationship between intermolecular interaction and sensitivity as well as thermal stability of the title compound was investigated by Hirshfeld surface analysis and fingerprint plot. Its thermodynamic properties were studied by non-isothermal kinetic methods based on the results of differential scanning calorimeter. It is interesting that apparent activation energy ( E a ) at T p1 (210.89–214.17 kJ mol −1 ) is higher than those at T p2 (133.90–134.87 kJ mol −1 ). In addition, gaseous product of this new energetic compound was analyzed by the rapid scanning Fourier transform infrared spectroscopy from 20 to 200 °C and its detonation products was theoretically predicted. Based on the decomposition products, its decomposition mechanism was discussed under inert atmosphere. It is undoubted that these significant physicochemical properties make N -trinitromethyl-4,5-dicyano-2 H -1,2,3-triazole a potential hydrogen-absent primary explosive.
研究领域:
化学
·
材料科学
·
物理化学
✓ 已验证
DOI
高影响因子
Frontiers of Chemical Science and Engineering
·
2019
·Vol. 14
·期 2
·267-274
·
IF 2.809
Xu Hao,Lei Chi,Wu Qinming,Zhu Qiuyan,Meng Xiangju,Dai Daniel,Maurer Stefan,Parvulescu Andrei-Nicolae,Müller Ulrich,Xiao Fengshou
SSZ-39 zeolite with AEI framework structure is a good catalyst candidate for the methanol-to-olefins (MTO) reaction. However, the diffusion limitation and coke formation often results in fast deactivation of the SSZ-39 zeolite catalyst. One solution for this challenge is to introduce mesoporosity in the SSZ-39 zeolite. Herein, we report the synthesis of mesoporous SSZ-39 zeolite using an organosilane surfactant, N , N -dimethyl- N -(3-(trimethoxysilyl)propyl)octan-1-aminium chloride, as a mesopore template and N , N -dimethyl- cis -2,6-dimethylpiperidinium as a micropore template. The obtained zeolites were characterized by X-ray diffraction, N 2 sorption, scanning electron microscopy, temperature programmed desorption of ammonia, and magic angle spinning nuclear magnetic resonance of 27 Al. The results show that the mesoporous SSZ-39 zeolite has high crystallinity, meso/microporosity, high surface area, cuboid morphology, and abundant acidic sites. More importantly, this mesoporous SSZ-39 zeolite exhibits enhanced catalyst lifetime in the MTO reaction due to the presence of mesoporosity for fast mass transfer, compared with a conventional SSZ-39 zeolite without mesoporosity.
研究领域:
材料科学
·
催化化学
✓ 已验证
DOI
高影响因子
International Journal of Minerals Metallurgy and Materials
·
2023
·Vol. 30
·期 9
·1740-1747
·
IF 4.8
Cai Dawei,Zhang Li,Wang Wanlin,Zhang Lei,Sohn Il
Mold flux serves the crucial metallurgical function of absorbing inclusions, directly impacting the smoothness of the casting process as well as the cast slab quality. In this study, the dissolution behavior and mechanism of TiO 2 and TiN inclusions in molten CaO–SiO 2– B 2 O 3 -based fluorine-free mold flux were explored by in situ single hot thermocouple technology combined with X-ray photoelectron spectroscopy. The results showed that TiO 2 inclusions are effectively dissolved by the molten slag within 76 s, during which the original octahedral [TiO 6 ] 8− structures are destroyed and convert to the networker tetrahedral [TiO 4 ] 4− structures. However, the dissolution rate is much lower for TiN inclusions than for TiO 2 inclusions. This can be attributed to the fact that the TiN particles need to be oxidized and then dissolved in the molten slag to form tetrahedral [TiO 4 ] 4− and octahedral [TiO 6 ] 8− structures during the TiN inclusion dissolution process, which is accompanied by the generation of a large amount of N 2 gas. Moreover, CaTiO 3 crystals tend to nucleate and grow on bubble surfaces with sufficient octahedral [TiO 6 ] 8− structures and Ca 2+ ions, eventually resulting in the molten slag being in a solid–liquid mixed state.
研究领域:
冶金学
·
材料科学
·
铸造过程
✓ 已验证
DOI
高影响因子
BIOLOGICAL TRACE ELEMENT RESEARCH
·
2023
·
IF 3.9
Celebı Demet,Celebı Ozgur,Aydin Elif,Baser Sumeyye,Güler Mustafa Can,Yildirim Serkan,Taghizadehghalehjoughi Ali
Multidrug-resistant bacteria is one of the most important public health problems. Increasing rates of antibacterial resistance also affect the outcomes of medical approaches. Cancer treatment because of immune system deficiency (chemotherapy or steroids usage) commonly can cause infection. Lung cancer is the dominant cause of cancer-related deaths, and infection is the most common cause of death among those patients. In this study, it was aimed to determine the antimicrobial, antibiofilm, and anticancer activity of boron compounds. A549 lung cancer cell line was infected with Acinetobacter baumannii (ATCC 19606), Klebsiella pneumoniae (ATCC 700603), and Pseudomonas aeruginosa (ATCC 27853). In order to determine the fractional inhibitory concentration (FIC) index, antibiotics and boron compound concentrations prepared according to the minimum inhibitory concentration (MIC) values were determined by the checkerboard method. In our study results, the antibiofilm activity was an average of 46% in A. baumannii +boron compounds, 45% in P. aeruginosa +boron compounds, and 43% in K. pneumoniae . Cell culture analysis results show a decrease in viability and antioxidant capacity and an increase in total oxidant status after adding boron compounds to the culture. Immunofluorescence results show a correlation with MTT, and boron compounds increased 8-OHdG expression in comparison to antibiotic administration. In conclusion, boron compounds have promising effects on bacteria, especially in resistant bacteria spp.
研究领域:
医学
·
微生物学
·
肿瘤学
✓ 已验证
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）