Advanced Science
·
2026
·
IF 14.1
Dan Zhao,Lingling Zhang,Yue Wen,Lianghui Cheng,Sidan Tian,Fanling Meng,Liang Luo
Pyroptosis holds great promise for evoking robust anti‐tumor immunity, but many pyroptosis induction strategies rely on caspase‐3 (Casp‐3) activation and face challenges of the immunosuppressive nature of apoptosis and the frequent silencing of gasdermin E (GSDME), a substrate of Casp‐3, in tumors. Here, we report a strategy to rewire the pyroptotic pathway by bypassing Casp‐3 to directly activate gasdermin D (GSDMD). We identify a small‐molecule agonist, (E)‐2,3‐diiodobut‐2‐ene‐1,4‐diol (DIBDO), which undergoes deiodination to release iodide ions upon activation by the tumor‐abundant nucleophile glutathione, thereby catalytically generating singlet oxygen and molecular iodine. This cascade induces oxidative damage that downregulates key mediators of caspase‐9 and caspase‐8 pathways, thereby down‐regulating Casp‐3 activation. This mechanism selectively triggers GSDMD‐mediated pyroptosis, provoking robust immunogenic cell death and inflammatory cytokine release to reconfigure the tumor immune microenvironment. In murine tumor models, DIBDO enhances tumor infiltration of cytotoxic T cells and synergizes with checkpoint blockade therapy to suppress both primary and distal tumors. It can also serve as an in situ or exogenous vaccine to elicit potent and durable antitumor immunity. This work presents a paradigm‐shifting approach to cancer immunotherapy by decoupling pyroptosis from Casp‐3 dependence, offering a promising avenue to expand the scope of immunogenic cell death‐based treatments. This work introduces a small‐molecule agonist, DIBDO, that bypasses Casp‐3 to directly trigger GSDMD‐mediated pyroptosis in tumors. Activated by glutathione, DIBDO generates singlet oxygen and molecular iodine, blocking Casp‐3 pathways and inducing immunogenic cell death. This reconfigures the tumor microenvironment, transforms the tumor cells into in situ or exogenous vaccine, offering a novel paradigm for cancer immunotherapy.
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DOI
PubMed
高影响因子
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
·
2025
·
IF 4.7
Jinkai Wang,Yingzhe Wang,Yingchao Zhang,Xiangzhuo Han,Zhanchen Cui,Zuosen Shi
We present a polymer optical waveguide sensor for fluoride ion (F − ) detection utilizing D–π–A dipolar molecules functionalized with tert-butyl dimethyl siloxane (TBS) groups. The sensing mechanism relies on F − -induced cleavage of Si O bonds through a desilylation reaction, which triggers a corresponding fluorescence quenching at 607 nm. By employing a 532 nm excitation laser and exploiting evanescent field interactions at waveguide interfaces, we developed an optical sensing platform that enables both qualitative identification and quantitative measurement of trace F − concentrations through real-time fluorescence monitoring. The sensor demonstrates exceptional performance with an ultra-low detection limit of 2.25 ppb and rapid response characteristics (≈3 s). The device architecture permits configuration into multiple parallel detection channels, making it particularly promising for high-efficiency environmental monitoring and biomedical applications requiring simultaneous multi-sample analysis. Furthermore, the sensor exhibits excellent anti-interference capability and specific detection performance, demonstrating reliable detection characteristics both in the presence of other interfering substances and in practical sample applications. The combination of superior sensitivity, rapid response, and scalable design positions this platform as a significant advancement in optical chemical sensing technology
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高影响因子
JOURNAL OF MOLECULAR STRUCTURE
·
2025
·
IF 4.7
Hanfei Xiang,Yonghe Zhang,Zhefeng Wang,Jie Sun,Zhengcheng Zhang,Zengrui Xing,Peng Zhang,Zhenghua Ju
A donor-acceptor1-acceptor2 (D-A1-A2) pyridine derivative (P263) was designed and synthesized. The theoretical calculations showed that the mixed character of the locally excited (LE) and intramolecular charge transfer (ICT) in the T n states could be beneficial to achieve high spin-orbit coupling (SOC) values, thereby promoting efficient intersystem crossing (ISC). The fluorescence emission spectra of P263 exhibited an obvious solvent-dependent emission behavior, which was attributed to the effective ICT through the introduction of dual acceptor units. In addition, the protonation/deprotonation processes of the nitrogen atoms in the pyridine units induced the alterations in the emission spectra, rendering P263 a fluorescent sensor for proton ( H + ) detection. Moreover, the pyridine units could form the hydrogen-bonding interactions with the poly(vinyl alcohol) (PVA) matrix, which was favorable for the suppression of the nonradiative decays and the stabilization of the triplet excitons. The obtained P263@PVA film through doping P263 into PVA showed room-temperature phosphorescence (RTP) properties with a long lifetime of 535 ms and the quantum yields of 3.62 %.
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高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2025
·
IF 7.7
Jian Li,Tingting Wang,Xun Zhang,Xinhui Su,Nian Liu
High-resolution optoacoustic visualization of amyloid-β (Aβ) plaques facilitates assessment of Alzheimer's disease (AD)’s states and related pathological mechanisms. However, it still lacks effective Aβ-probes due to suboptimal optoacoustic properties. In this study, we proposed the use of N, N-dimethylaniline as the Aβ recognition unit and chalcogenapyrylium as the acceptor to construct a novel D-π-A typed probe (DMA-Te). This design not only enhances the near-infrared optoacoustic signal but also maintains this enhancement upon Aβ fibrils binding through the preservation of twisted intramolecular charge transfer state. Furthermore, the stringent structure of DMA-Te exhibits high blood-brain barrier permeability and Aβ-binding capacity. Leveraging these advantages, dual-wavelength optoacoustic microscopy can effectively visualize Aβ plaques and diminished blood vessels in the AD brain. Therefore, this study presents a promising optoacoustic probe for the detailed depiction of AD progression.
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高影响因子
CRYSTENGCOMM
·
2017
·Vol. 19
·期 17
·2349-2358
·
IF 3.474
Yu-Peng Zhou,Zhang-Wen Wei,Zhuo-Jia Lin,Hui-Tao Ling,Zhengang Guo,Mei Zhang,Chi-Keung Lam,Bao-Hui Ye,Hsiu-Yi Chao
With the idea of supramolecular hosts encircling monoanions, a series of urea-containing trinuclear cationic copper complexes were designed, prepared and structurally analyzed. Copper(I) acetylides [Cu3(μ-dppm)3(μ3-η1-CCC6H4-4-NHC(O)NHC6H4-4-R)2]+ (dppm = bis(diphenylphosphino)methane; R = NO2 (1), CF3 (2), Cl (3), H (4), tBu (5), and OCH3 (6)) were prepared with F−, BF4−, or NO3− present as the anion. Eight 1-D anion coordination polymers (ACPs), 1·F, 2·F, 3·BF4, 4·F, 5·F, 5·BF4, 5·NO3 and 6·0.5F·0.5BF4, were clearly determined by X-ray diffraction. Diversity in the polymeric architecture is generated by both the choice of R-group used and anion present. 2·F, 3·BF4, 4·F, and 5·F show linear 1-D structures; 5·BF4 and 5·NO3 feature single-stranded helical structures; 1·F and 6·0.5F·0.5BF4 exhibit meso-helical structures. Solid state UV-vis absorption and luminescence properties are also discussed.
研究领域:
化学
·
材料科学
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高影响因子
JOURNAL OF COORDINATION CHEMISTRY
·
2012
·
IF 1.547
Li Zhang,Xiu-Ling Wu,An-Qi Wang,Fei Qin,Da-Wei Meng,Xiao-Yang Liu
A manganese(II) coordination polymer [Mn(TMB)2 · H2O]
n
(1) (HTMB = 3,4,5-trimethoxybenzoic acid) has been synthesized under hydrothermal conditions and characterized by single-crystal X-ray diffraction, elemental analysis, powder X-ray diffraction analysis, spectroscopic (IR, solid state UV-Vis), and thermal methods. The crystal belongs to orthorhombic system, space group P212121, with cell parameters a = 7.3001(8), b = 11.4146(13), c = 27.053(3) Å, α = β = γ = 90°, V = 2254.3(4) Å3, Z = 4. In 1, TMB in two different coordination modes bridges six-coordinate manganese(II) centers forming a 1-D infinite chain coordination framework. The spectral and thermal properties of the complexes have also been studied.
研究领域:
无机化学
·
配位化学
·
材料科学
·
晶体工程
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高影响因子
JOURNAL OF PORPHYRINS AND PHTHALOCYANINES
·
2024
·Vol. 28
·期 03
·166-172
·
IF 0.9
Min Cui,Sijie Zhu,Mengmeng Xiong,Huijie Zuo,Xiang Li,Kai Wang,Jun Jiang
As a non-invasive cancer therapy method, photodynamic therapy (PDT) shows tremendous promise in clinical cancer treatment. Light-activated singlet oxygen production of photosensitizers (PSs) is the prerequisite for cancer PDT, and the use of organic photosensitizers is always limited by visible light-based activation, hydrophilicity, biocompatibility, selectivity and quantum yield of singlet oxygen. Currently, both zinc porphyrin- and BODIPY-based structures have been widely used in the development of PDT PSs. Here, we developed a novel naphthalimide bridged zinc porphyrin/BODIPY molecule ( Por-BDP-1 ) with two poly(ethylene glycol) (PEG) chains, in which D-A structure was constructed between the naphthalimide group and porphyrin group. After self-assembly into nanoparticles, Por-BDP-1 NPs (Diameter: 122.4 nm) could quench fluorescence in 600–700 nm, bind with calf thymus-DNA, and produce singlet oxygen during light-irradiation (laser: 680 nm, 1.0 W/cm 2 ) . In addition, Por-BDP-1 NPs effectively killed HeLa cells with a IC 5 0 value = 44.8 μg/mL and showed a lower dark toxicity under the same conditions. All our results demonstrated that our naphthalimide bridged zinc porphyrin/BODIPY nano-photosensitizer is a promising nanoagent for PDT in the clinic.
研究领域:
材料科学
·
纳米医学
·
光动力治疗
·
有机化学
·
生物医学工程
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DOI
高影响因子
Journal of Macromolecular Science Part B-Physics
·
2017
·
IF 0.828
Shan Bai,Zhenzhong Ouyang
Direct graft copolymerization of maleic anhydride (MAH) onto poly(D,L-lactide-co-glycolide) (PLGA) was performed by use of benzoyl peroxide (BPO) as initiator. Fourier transform infrared spectra, nuclear magnetic resonance, titration analysis of maleation extent and water contact angle were employed to characterize the obtained MPLGA. The effects of monomer concentration, initiator concentration and reaction temperature on the degree of maleation were investigated. The MPLGA scaffold was obtained by using NaCl as the porogen. The results showed that maleic anhydride was successfully grafted onto the PLGA chains. The monomer and initiator concentrations played an important role in the graft copolymerization; the extent of maleation first increased with increasing content of MAH and BPO and then declined. The extent of maleation continuously increased with increasing temperature to 100°C, and then the rate of increase decreased. The extent of maleation could be controlled in the range from 0.15 to 0.71% by adjusting the graft copolymerization conditions. The introduction of anhydride enhanced the water contact angle of PLGA. The MPLGA scaffold showed a network of interconnected pores ranging from 50 to 300 μm.
研究领域:
高分子化学
·
生物材料科学
·
高分子改性
·
组织工程
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DOI
高影响因子
PHYTOMEDICINE
·
2026
·
IF 11.3
Xuehui Li,Yunxiao Qiao,Xinyi Xu,Jinyu Zhu,Chuang Xie,Shan Lin,Lingfan Xu,Fuwen Yuan
Background Natural products from traditional medicinal plants represent an important source of anti-cancer agents and lead compounds for drug development. Saikosaponin D (SSD), a triterpenoid saponin isolated from Radix Bupleuri, exhibits anti-tumor activity but is limited by a narrow therapeutic window and cytotoxicity. Objective This study aimed to evaluate the anti-tumor activity of 6′'-O-acetylsaikosaponin D (6′'-O-acSSD), a naturally occurring acetylated derivative of Saikosaponin D that is identified in Radix Bupleuri , and to elucidate its underlying molecular mechanisms. Methods The anti-cancer effects of 6′'-O-acSSD were assessed using multiple cancer cell models, three-dimensional tumor spheroids, and patient-derived tumor organoids. Transcriptomic and bioinformatic analyses were performed to identify regulated cell death pathways. Molecular docking, molecular dynamics simulation, cellular thermal shift assays, western blotting, and CUT&Tag profiling were used to identify molecular targets and define transcriptional reprogramming. Results 6′'-O-acSSD markedly suppressed cancer cell proliferation, migration, and invasion and elicited a transcriptional program distinct from that induced by SSD. Transcriptomic and biochemical analyses revealed preferential activation of ferroptosis-associated signatures, including enhanced lipid peroxidation. Mechanistically, 6′'-O-acSSD engaged STAT3, inhibited its phosphorylation, and extensively remodeled STAT3 chromatin occupancy. Functional analyses showed that STAT3 inhibition was required for the full anti-tumor activity of 6′'-O-acSSD. Notably, blockade of ferroptosis only partially rescued cell viability, whereas STAT3 targeting additionally triggered apoptosis-associated transcriptional and biochemical changes. The anti-tumor effects of 6′'-O-acSSD were further validated in patient-derived tumor organoids. Conclusion 6′'-O-acSSD exerts potent anti-tumor effects by targeting STAT3-dependent transcriptional programs and inducing coordinated ferroptosis and apoptosis. These findings highlight the therapeutic potential of structurally optimized natural products for anti-cancer treatment.
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高影响因子
Journal of Materials Chemistry C
·
2013
·Vol. 1
·期 30
·4556-4564
·
IF 0
Liang Pan,Benlin Hu,Xiaojian Zhu,Xinxin Chen,Jie Shang,Hongwei Tan,Wuhong Xue,Yuejin Zhu,Gang Liu,Run-Wei Li
Two donor–acceptor (D–A) polyazothines (PAs), incorporating the oxadiazole entity either acting as an electron acceptor (A) to form D–A structured PA-1 with the triphenylamine donor (D), or acting as a donor to form D–A structured PA-2 with the 3,3′-dinitro-diphenylsulfone acceptor, have been successfully synthesized via a polycondensation reaction. The variation in the role of the oxadiazole moiety in the D–A polymers, together with the use of different top electrode metals, leads to interesting electronic transport properties and various resistive switching behaviors of the present polyazothines. Pt-electrode devices based on a PA-1 active layer show a rewritable memory effect with poor endurance (less than 20 cycles), whereas the PA-2 based Pt devices exhibit write-once read-many-times (WORM) memory behavior. For the Al-electrode devices, both PAs demonstrate a much improved resistive switching effect, and the endurance of the PA-2 devices is better than that of the PA-1 devices. The difference in the electronic transport and memory properties of the four devices may originate from the different charge injection/extraction and electron transfer processes of the sandwich systems, and will provide guidelines for selecting both the proper D and A moieties in D–A polymers and electrode metals for high-performance resistance random access memories (RRAMs).
研究领域:
材料科学
·
有机电子学
·
高分子化学
·
电气工程
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DOI
CHEMICAL ENGINEERING JOURNAL
·
2019
·
IF 8.355
Xiaoxiao Zhu,Jianfa Li,Bin Xie,Dongqing Feng,Yimin Li
Biochar was mixed with natural pyrite to catalyze the Fenton-like oxidation of herbicide 2,4-dichlorophenoxyacetic acid (2,4-D), so as to accelerate the degradation reaction. The accelerating effects of two biochars with different adsorption capacities were compared. The biochar’s functions on accelerating the oxidation were investigated by using radical scavengers, electron spin resonance (ESR), and the chemical probe method. The results indicated that the rate constant ( k obs ) for the degradation reaction of 2,4-D was enhanced 1.98–2.39 times after the addition of 0.1 g/L of biochar in the pyrite (1.5 g/L) catalyzed system. However, the biochar with the higher adsorption capacity did not outperform the other biochar in accelerating the reaction. Biochar did not influence the Fe lixiviation from pyrite; instead, it accelerated the Fenton oxidation of 2,4-D catalyzed by the dissolved Fe 2+ . Hydroxyl radicals ( OH) were proved to be the major reactive species contributing to the oxidation of 2,4-D, and the addition of biochar increased the cumulative production of OH 2.72 times that in the pyrite-catalyzed system. The mechanism is related to the transformation of O 2 − to OH by biochar, in which the quinone-like structure acts as the electron shuttle. Based on the identified intermediates and products by gas chromatography-mass spectrometry (GC–MS), high performance liquid chromatography (HPLC), and ion chromatography (IC), as well as the released Cl − , a reaction pathway was summarized for mineralization of 2,4-D. Furthermore, the degradation of 2,4-dichlorophenol (2,4-DCP) was accelerated by biochar as well, indicating the wide feasibility of biochar for accelerating the Fenton-like oxidation of organic pollutants.
研究领域:
环境科学
·
化学工程
·
污染控制技术
·
高级氧化技术
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DOI
高影响因子
Neurotherapeutics
·
2026
·Vol. 23
·期 3
·e00909
·
IF 7.4
Liwang Lin,Longyu Li,Shiao Ren,Liping Liu,Ying Liu,Wenlei Zhang,Zengliang Gao,Xiaoting Ni,Haoxuan Li,Xinsheng Duan,Sijing Tao,Tianyu Zhao,Xin Hai
Trimethylamine N-oxide (TMAO), a co-metabolite of the gut microbiota and host, has been implicated in the pathogenesis of various neuropsychiatric disorders. However, its role in major depressive disorder (MDD) remains poorly understood. This study aims to verify the relationship between TMAO and MDD and elucidate the underlying mechanisms. Plasma TMAO concentrations were quantified by HPLC-MS/MS and compared between MDD patients and healthy controls. To explore the effects of TMAO on depressive-like behavior and cerebral d -serine metabolism, mice were administered TMAO via dietary supplementation. Finally, astrocytes were treated with TMAO to examine its impact on d -serine metabolism at the cellular level. Here, we found that plasma TMAO levels were significantly elevated in MDD patients and positively correlated with both HAMD-17 and HAMA-14 scores. Consistently, mice fed TMAO for seven weeks exhibited pronounced depressive-like behaviors. While TMAO exposure did not induce apparent astrocytic damage, it markedly promoted d -serine secretion and caused notable neuronal injury. Mechanistically, TMAO activated the AMPK/SIRT-1 signaling pathway in astrocytes, resulting in upregulated serine racemase expression. Furthermore, both exogenous d -serine and conditioned medium from TMAO-treated astrocytes triggered neuronal apoptosis. Collectively, these findings demonstrate that TMAO contributes to MDD pathogenesis by activating astrocytic AMPK/SIRT-1 signaling to enhance d -serine production, subsequently inducing neuronal apoptosis. TMAO may thus represent a promising therapeutic target for MDD.
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PubMed
高影响因子
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