COLLOIDS AND SURFACES B-BIOINTERFACES
·
2025
·
IF 5.6
Reyihanguli Alimu,Lanlan Dong,Patiguli Aihemaiti,Houfeng Jiang,Wurikaixi Aiyiti,Cijun Shuai
High-performance hydrogel biomaterials hold considerable promise for advanced wound care. However, the suboptimal mechanical properties of conventional hydrogel materials limit their practical application. In this study, Hyaluronic acid sodium salt (HA), xanthan gum (XG), and N-acryloyl-glycinamide (NAGA) hydrogels with porous structures were successfully fabricated using in-situ extrusion 3D printing technology, and a functionalization strategy involving tea polyphenol (TP) immersion was proposed to enhance material properties through additional hydrogen bonding. Systematic optimization of TP concentration and immersion time led to significant improvements in the resulting hydrogel: tensile strain increased from 95 % to 266 %, tensile stress improved 6.8-fold, and compressive stress increased 10-fold, with an elastic modulus of 0.68 MPa and toughness of 1.2 MJ/m³ . Furthermore, TP-treated hydrogels exhibited excellent biocompatibility and strong antioxidant activity and antibacterial activity. This study provides a simple yet effective secondary functionalization approach for enhancing the performance of 3D-printed hydrogels, offering a promising approach for multifunctional hydrogel biomaterials with integrated mechanical strength and biocompatibility. These findings open new avenues for advanced wound care systems and personalized medicine applications.
研究领域:
生物材料
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组织工程
·
3D打印
·
高分子科学
·
伤口愈合
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纳米技术
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生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2025
·
IF 6.2
Qianwei Liang,Qing Tian,Yifei Tan,Tianzhen Jiang,Zhen Li,Jianguo Feng
Drought stress causes a significant accumulation of reactive oxygen species (ROS) in crops, inhibiting their growth and development and threatening food security. This study constructs cerium-based metal–organic frameworks (CeMs) encapsulated with polydopamine (PDA), effectively eliminating ROS (O2•–, H2O2, ·OH, DPPH·, and ABTS·+). Experiments showed that CeMs@PDA exhibits superior wettability and outstanding translocation capabilities in wheat and rice. Under drought conditions, CeMs@PDA (12.5 mg L–1, 100 mg L–1) significantly increased the vigor index (71.84%, 224.83%) of seeds (wheat, rice). The application of 25 and 100 mg L–1 CeMs@PDA significantly alleviated drought-induced growth inhibition in wheat and rice seedlings, respectively. The inhibition of stem and root growth decreased from 28.07% and 38.15% to 3.72% and 4.43% in wheat seedlings, and the inhibition declined from 25.33% and 30.83% to 2.89% and 5.30% in rice seedlings, respectively. In addition, CeMs@PDA significantly increased the level of antioxidant enzyme activities in wheat and rice and showed better biosafety. This study opens valuable pathways for sustainable agriculture under water-limited conditions.
研究领域:
植物生理学
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纳米农业
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环境胁迫生物学
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作物科学
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分子生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INDUSTRIAL CROPS AND PRODUCTS
·
2025
·
IF 6.2
Jun Li,Xianling Yang,Pingcong Lv,Yuwei Zheng,Hongli Ou,Wanxia Wu,Xianggui Chen,Xiaoqi Yu
The high-value utilization of rice straw can not only unlock its potential economic and environmental benefits but also reduce greenhouse gas emissions, significantly enhancing resource efficiency and promoting sustainable agricultural development. In this study, rice straw was used as a biomass-derived carbon source to synthesize biocompatible rice straw-derived carbon dots (H 2 O-CDs) via a green hydrothermal method. The fluorescent sensor constructed based on H 2 O-CDs offered the advantages of wide range (8–100 μM), high sensitivity (2.27 μM), and wide pH stability (2.0–8.0), making it suitable for detecting ferric ions within cells. Additionally, H 2 O-CDs were innovatively studied the antioxidant properties and had been proven excellent antioxidant enhancement potential by 2 times, suggesting their future practical application as a cigarette filter additive for the efficient removal over 40 % of harmful oxidizing free radicals in cigarette smoke. With their low cost and outstanding biocompatibility, H 2 O-CDs not only enable the high-value utilization of rice straw but also provide new insights and technical support for sustainable agricultural development.
研究领域:
环境科学
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材料科学
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分析化学
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农业科学
·
纳米技术
✓ 已验证
产品关联
DOI
高影响因子
FOOD CONTROL
·
2025
·
IF 6.3
Xianrui Chen,Lin Wang,Lihong Lin,Nitong Bu,Di Zhang,Zhenzhen Wu,Wei Liu,Jie Pang
The development of advanced antimicrobial packaging is crucial for ensuring food safety. This paper reports a novel photodynamic antibacterial film (PVA-CM@TFQ) that effectively combats microbial contamination, delays food spoilage and minimizes the risk of foodborne diseases transmission. Quercetin (Que) was encapsulated within a tannic acid-ferric ion (TA–Fe 3+ ) coordination network and embedded into a biodegradable polymer matrix composed of polyvinyl alcohol (PVA) and carboxymethyl chitosan (CM). The TA-Fe 3+ network significantly improved the stability of Que, while the resulting PVA-CM@TFQ demonstrated excellent mechanical properties, barrier performance, and biocompatibility. Upon light irradiation, the film produced reactive oxygen species (ROS), exhibiting potent photodynamic antibacterial activity, with inhibition rates of 99.83%, 99.42%, 100%, and 100% against Escherichia . coli, Staphylococcus . aureus , Candida. albicans , and Saccharomyces cerevisiae , respectively. When applied to raspberries, hawthorn, goldenberries, and lime, the film effectively prolonged shelf life by suppressing microbial proliferation, minimizing weight loss, and maintaining fruit firmness. These findings highlight a sustainable, light-responsive strategy for fruit preservation with significant potential in enhancing food safety.
研究领域:
食品科学与技术
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高分子材料
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光动力疗法
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活性包装
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采后生物学
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抗菌技术
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2025
·
IF 8.2
Yafei Wang,Xiaowei Huang,Jiayi Jiang,Qi Meng,Yiran Li,Wenwen Zhao,Shaojuan Chen,Shaohua Wu
The healing of diabetic wounds is a complex process involving multiple physiological mechanisms, which necessitates an appropriate microenvironment to effectively facilitate the healing process. Recently, advanced wound dressings constructed by functionalizing cotton nonwovens with appropriate structures and biological properties have aroused intensive interest in chronic wound treatment and care. The present study fabricated composite dressings by coating cotton nonwoven webs with UV-cross-linked methacrylated gelatin (Megel) hydrogels containing Salvia miltiorrhiza–Radix Puerariae/polyhydroxyalkanoate-loaded short nanofibers (SP: 632 ± 191 nm diameter, 2.9 ± 2.7 μm length). The composite dressings exhibited a uniform microporous structure (pore size: 24.2 ± 9.2 μm), superior water retention (85.8 ± 0.3% after 2 h), and markedly improved mechanical properties (Young’s modulus: 6.8 ± 1.3 MPa; elongation at break: 153.8 ± 10.4%). Additionally, they demonstrated excellent performance in swelling, biodegradation, and free radical scavenging. All composite dressings demonstrated excellent biosafety and rapid hemostasis in liver bleeding models. Critically, the Cotton&Megel + SP-3% dressing accelerated diabetic mouse wound closure to ∼98% within 18 days, which also reduced early inflammation and markedly improved regenerated tissue quality by promoting collagen deposition, angiogenesis, and hair follicle formation. These results indicate that our composite dressings made from SP, Megel hydrogel, and cotton nonwoven hold significant potential as advanced dressing candidates for diabetic wound treatment.
研究领域:
生物材料学
·
伤口修复
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糖尿病并发症
·
药物递送系统
·
组织工程
·
纳米医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Yilan Xie,Xiangdong Geng,Xuejing Zheng,Jie Liu,Keyong Tang
Carbon quantum dots (CQDs) were synthesized via a one-step hydrothermal route using soluble soybean polysaccharide (SSPS) as a green and renewable precursor. The resulting SSPS-derived CQDs (SCQDs) were uniform nanodots with average diameters ranging from 2.66 ± 0.69 nm to 2.81 ± 0.57 nm, exhibiting strong blue fluorescence and excellent water dispersibility. Structural characterization by TEM, XRD, FTIR, and XPS confirmed the amorphous carbon structure and the presence of abundant hydroxyl, carboxyl, and carbonyl groups on SCQDs, which contribute to their distinctive optical and functional properties. The SCQDs exhibited excitation-dependent photoluminescence with a quantum yield of 12.0 %. They also demonstrated potent radical scavenging activities of 91.3 % for ABTS and 79.4 % for DPPH, along with notable antibacterial properties. Furthermore, the SCQDs showed good biocompatibility within the concentration range of 50–500 μg/mL, maintaining cell viability above 70 % after 7 days of exposure. The SCQDs were successfully utilized for cellular imaging, Fe 3+ and Pb 2+ ion sensing, and preservation of strawberries and bananas. These results demonstrate the suitability of SSPS for serving as an effective precursor in the sustainable synthesis of multifunctional CQDs with significant potential for applications in biomedical imaging, environmental sensing, and active food packaging.
研究领域:
纳米材料学
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生物医学工程
·
分析化学
·
食品科学
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环境科学
·
分子影像学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Kunying Yu,Bingyou Luo,Haiyu Yang,Jingjin He,Ziqi Zhu,Peiyuan Li,Haiyi Zhong
Conductive hydrogels have emerged as promising materials for flexible wearable electronics; however, their facile fabrication remains challenging. This study presents an antifreeze, antibacterial, and conductive hydrogel constructed from biomacromolecules sodium carboxymethylcellulose (CMC-Na) and polyvinyl alcohol (PVA). The hydrogel was synthesized via a simple one-pot method in an ethylene glycol/water (EG/H₂O) binary solvent system, incorporating lithium chloride (LiCl) and clove essential oil (CEO), followed by a single freeze-thaw cycle. The synergistic framework of CMC-Na and PVA endowed the hydrogel with robust mechanical flexibility and structural integrity. LiCl integration achieved high ionic conductivity (6.94Sm −1 ), while EG imparted exceptional freezing resistance, maintaining flexibility and conductivity at −50 °C. CEO provided potent antibacterial activity against common pathogens, significantly mitigating bacterial contamination risks. Owing to its high strain sensitivity, fast response time (<200 ms), and environmental resilience, the hydrogel served as an effective wearable sensor for real-time monitoring of human joint movements, subtle physiological signals. This work establishes a CMC-Na/PVA -based multifunctional hydrogel design paradigm, offering a scalable strategy for next-generation smart wearable devices.
研究领域:
材料科学
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生物医学工程
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柔性电子学
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高分子化学
·
传感器技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Foods
·
2025
·Vol. 14
·期 15
·2637
·
IF 5.1
Zhong Han,Pan He,Yu-Huan Geng,Muhammad Faisal Manzoor,Xin-An Zeng,Suqlain Hassan,Muhammad Talha Afraz
This study used fresh (young) and old (mature) ginger tissues as model systems to investigate how plant maturity modulates the response to pulsed electric field (PEF), a non-thermal processing technology. Specifically, the influence of tissue maturity on dielectric behavior and its downstream effect on juice yield and bioactive compound extraction was systematically evaluated. At 2.5 kV/cm, old ginger exhibited a pronounced dielectric breakdown effect due to enhanced electrolyte content and cell wall lignification, resulting in a higher degree of cell disintegration (0.65) compared with fresh ginger (0.44). This translated into a significantly improved juice yield of 90.85% for old ginger, surpassing the 84.16% limit observed in fresh ginger. HPLC analysis revealed that the extraction efficiency of 6-gingerol and 6-shogaol increased from 1739.16 to 2233.60 µg/g and 310.31 to 339.63 µg/g, respectively, in old ginger after PEF treatment, while fresh ginger showed increases from 1257.88 to 1824.05 µg/g and 166.43 to 213.52 µg/g, respectively. Total phenolic content (TPC) and total flavonoid content (TFC) also increased in both tissues, with OG-2.5 reaching 789.57 µg GAE/mL and 336.49 µg RE/mL, compared with 738.19 µg GAE/mL and 329.62 µg RE/mL in FG-2.5. Antioxidant capacity, as measured by ABTS•+and DPPH•inhibition, improved more markedly in OG-2.5 (37.8% and 18.7%, respectively) than in FG-2.5. Moreover, volatile compound concentrations increased by 177.9% in OG-2.5 and 137.0% in FG-2.5 compared with their respective controls, indicating differential aroma intensification and compound transformation. Structural characterization by SEM and FT-IR further corroborated enhanced cellular disruption and biochemical release in mature tissue. Collectively, these results reveal a maturity-dependent mechanism of electro-permeabilization in plant tissues, offering new insights into optimizing non-thermal processing for functional food production.
研究领域:
食品科学
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植物生理学
·
生物加工技术
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功能食品
·
非热加工
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF FOOD ENGINEERING
·
2025
·
IF 5.8
Bo Li,Tianchi Tang,Mengyue Jiang,Hui Chen,Yanhong Bai
Sustained-release nanofilms incorporated with oregano essential oil (OEO) were developed by emulsion electrospinning using polyvinyl alcohol (PVA) and quaternary-ammonium chitosan (QAC). The SEM, FTIR and XRD results showed that OEO was successfully encapsulated in the PVA/QAC nanofiber with a diameter range of 158.0–179.6 nm. The incorporation of OEO significantly enhanced the mechanical and barrier properties of PVA/QAC nanofilm, concomitantly mitigating its hydrophilic nature. The prepared PVA/QAC-OEO nanofilms demonstrated excellent antioxidant properties and antimicrobial activities against S. aureus and E. coli (the maximum inhibition zones achieving 23.13 ± 0.72 mm). The release kinetics results showed sustained release of OEO from the PVA/QAC nanofilms, and the release kinetics of OEO adhered to the Fickian + First order dynamics model (R 2 = 0.9570–0.9997), indicating that a combination of random diffusion and polymer structural relaxation influenced the release of OEO. Furthermore, preservation research showed that the PVA/QAC-OEO nanofilms significantly inhibited the rise in pH, total volatile base nitrogen (TVB-N), thiobarbituric acid reactive substances (TBARs), and total viable count (TVC) in chicken breasts stored at 4 °C, while also maintaining their color and texture properties. Particularly, chicken breasts wrapped in PVA/QAC-OEO 3 film exhibited an extended shelf life for 4 days. Therefore, the PVA/QAC-OEO nanofilms could be a prospective packaging material for meat preservation.
研究领域:
食品包装
·
纳米技术
·
食品科学
·
材料科学
·
抗菌技术
·
高分子科学
✓ 已验证
产品关联
DOI
高影响因子
Food Bioscience
·
2025
·
IF 5.9
Kaize Zheng,Xueling Qin,Lingchun Meng,Yusheng Liang,Junwei Qin,Zhenqiang Wu,Zhenfeng Huang
Natural Monascus yellow pigments (MYPs) have potential in the food industry due to their safety, but their application is limited by low biological activity and stability. Novel MYPs complexes, Monascus yellow pigments-tannic acid (MYPs-TA), were synthesized by spontaneously incorporating TA through intermolecular co-pigmentation in this work. Structural analysis revealed that multiple interactions contributed to the formation of complexes, including hydrogen bonding, π-π stacking, and hydrophobic interactions. The MYPs-TA exhibited characteristic ultraviolet signals of both MYPs (380 nm) and TA (276 nm), and the crystalline structure of MYPs transitioned to an amorphous form. These phenomena confirmed the tight combination of MYPs and TA. Color tonality, physicochemical stability as well as antimicrobial and antioxidant activities of MYPs were significantly improved after interaction with TA. Besides, MYPs-TA exhibited optimal stability and functionality in high-temperature processed foods such as baked goods or pasteurized products. This study provides a novel approach for synthesizing functional MYPs complexes with superior stability.
研究领域:
食品化学
·
食品科学
·
天然产物化学
·
功能食品
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
Food Bioscience
·
2025
·
IF 5.9
Ruoxin Chen,Jiahao Ren,Zhenlong Zhou,Wenjun Zhang,Jianyu Su
Gentiana rigescens Franch. extract have demonstrated various important bioactivities, however, their potential against photoaging has yet to be evaluated. This study explored the anti-photoaging effects of Gentiana rigescens Franch. root extract (GRFR) and stem (GRFS), along with their underlying mechanisms and bioactive components, using the UVB-induced zebrafish model. GRFS demonstrated superior anti-photoaging efficacy compared to GRFR. GRFS significantly alleviated UVB-induced tail fin damage, increasing the relative tail fin area from 31.23% to 80.92% (at 1mg/mL), and reducing ROS levels from 244.80% to 150.95%. It also inhibited lipid peroxidation, lowering malondialdehyde (MDA) levels from 202.87 nmol/g to 142.83 nmol/g. Furthermore, GRFS enhanced antioxidant enzyme activities, increasing superoxide dismutase (SOD) from 80.94 U/g to 104.06 U/g. Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) indicated substantial distinctions in the composition and content of major constituents between GRFR and GFRS, which may explain the differences in their anti-photoaging activities. And then network pharmacology was used to investigate possible mechanisms of GFRS, which identified five potential targets including CTNNB1, ESR1, AKT1, JUN and EGFR, as well as three key active compounds including aspartyl-phenylalanine (Asp-Phe), N-acetyl-L-phenylalanine (N-Acetyl-L-Phe), and phenylalanyl-tyrosine (Phe-Tyr). Finally, the molecular docking revealed that Phe-Tyr exhibited the strongest binding affinity for AKT1 (-8.86 kcal/mol), indicating that it may be the most potent anti-photoaging compound in GFRS. These findings suggest that G . rigescens , with its potent anti-photoaging properties, offers superior protection against UVB-induced photoaging and holds promise as a natural therapeutic agent.
研究领域:
药理学
·
植物学
·
皮肤科学
·
生物化学
·
计算生物学
·
天然产物研究
·
生物技术
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF FOOD ENGINEERING
·
2024
·
IF 5.3
Nitong Bu,Huanglong Lin,Di Zhang,Xianrui Chen,Pingping Tan,Yuanbo Zhong,Liying Huang,Jie Pang,Lin Wang,Ruojun Mu
Water-in-water (W/W) emulsions as innovative transport for hydrophilic functional ingredients inherently lack stability due to the ultralow interfacial tension and thick interfacial layer. In this work, we first proposed a simple strategy to construct stable dextran (DEX)-in-poly (ethylene glycol) (PEG) W/W emulsions by utilizing the unique phase preference of konjac glucomannan/tragacanth gum (KT) hydrogels formed based on the cooling-induced intermolecular hydrogen bonds. KT hydrogels were demonstrated to present selective partition to PEG phase and could form physically crosslinking network, thus significantly improving the rheological behavior and stability of DEX-in-PEG (D/P) emulsions with no flocculation after 31 d of storage at 25 °C. Meanwhile, the average droplet size of emulsions decreased from 15.37 to 8.48 μm with TG concentration tuning from 0.2 % to 0.8 %. When encapsulating riboflavin (RIB) in D/P emulsions stabilized by KT-4 hydrogel, the storage and lighting stability of RIB were enhanced with retention rate of 60.94 % and 21.89 %, respectively. In addition, the release of RIB in the simulate gastrointestinal environment substantially reduced and the antioxidant activity of RIB was maximumly protected due to the unique pH-responsiveness of KT hydrogel network. This work provides a feasible strategy for designing stable W/W emulsions stabilized by natural polysaccharide hydrogels, and biocompatible carriers for hydrophilic functional ingredients.
研究领域:
食品科学
·
材料科学
·
化学工程
·
药学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）