CHEMICAL ENGINEERING JOURNAL
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2025
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IF 13.2
Meng Zeng,Ping Deng,Qin Li,Qi Tang,Jixiang Li,Liangke Zhang
Psoriasis, an immune-mediated disease, commonly utilizes topical drug administration in clinical treatments, yet the thickening of skin presents a challenge to conventional topical drug delivery methods. In this study, we have successfully developed a multifunctional composite ionic liquid (CIL) that enhances the local delivery of melittin (CIL@Mel) by modifying the fluidity of the stratum corneum and the structure of keratin. In addition, CIL@Mel can transport H 2 S to the psoriatic microenvironment, effectively regulating the redox imbalance within it. The in vivo experimental results demonstrated that CIL@Mel effectively mitigates the progression of psoriasis, provides relief from oxidative stress, reduces the production of inflammatory factors, and promotes the repolarization of macrophages. Computational simulations and experimental validation revealed that CIL@Mel exerts its effects by inhibiting the expression of EGFR, STAT3, IL-6, SRC, and HSP90AA1. In conclusion, this study unveils the transdermal promotion mechanism of CIL@Mel and validates its efficacy in psoriasis.
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INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2024
·
IF 3.8
Lijia Huang,Ge He,Yi Yuan,Tian Cheng Zhang,Yan Wang,Shaojun Yuan
Rationally regulating the photogenerated carrier transfer behavior and band structure of TiO2 through metal doping is an effective strategy for enhancing the photocatalytic activity in the removal of malodorous gas hydrogen sulfide (H2S). In this study, TiO2 modified with the doping of Group IIIA metal ions (Al3+, Ga3+, and In3+) was utilized as an efficient photocatalytic desulfurizer under ultraviolet irradiation. Among these samples, the 4% In-TiO2 exhibited the best photocatalytic H2S removal efficiency of 100% for a duration of 120 min, nearly 3 times higher than that of commercial P25 TiO2. The UV–vis DRS and PL spectra demonstrated that the incorporation of Group-IIIA metal ions into TiO2 resulted in the formation of a shallow acceptor level above the valence band in the energy band structure, which induced a slight redshift at the edge of the visible light absorption band and reduced the electron–hole recombination rate. In situ DRIFTS and DFT calculations revealed that the adsorption and activation of H2S occurred simultaneously on In-TiO2, facilitated by its strong oxygen vacancy formation and adsorption capability. The ln3+ doping into TiO2 promoted photothermal-catalytic oxidation reaction on the surfaces of In-TiO2, thereby significantly enhancing the desulfurization efficiency of H2S. This study not only offers a deeper understanding of the regulated band structure of TiO2 by doping of Group IIIA metal ions, but also provides a promising and green photocatalytic desulfurizer of In-TiO2 for efficient removal of H2S.
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SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2024
·
IF 4.3
Zixuan Teng,Huimin Shangguan,Longfei Liu,Shihu Zhang,Guanlin Li,Zishi Cheng,Fengpei Qi,Xingjiang Liu
The ubiquity of diverse material entities in environmental matrices renders the deployment of unifunctional fluorescent indicators inadequate. Consequently, this study introduces a ratiometric dual-emission fluorescent sensor ( Probe CP ), synthesized by conjugating phenothiazine coumarin to hydroxycoumarin through a piperazine linker for concurrent detection of HClO and H 2 S. Upon interaction with HClO, the phenothiazine unit's sulfur atom undergoes oxidation to sulfoxide, facilitating a shift from red to green fluorescence in a ratiometric manner. Concurrently, at the opposite terminus of Probe CP , 2,4-dinitroanisole serves as the reactive moiety for H 2 S recognition; it restores the blue emission characteristic of 7-hydroxycoumarin while maintaining the red fluorescence emanating from phenothiazine coumarin as an internal standard for ratio-based assessment. Exhibiting elevated specificity and sensitivity coupled with minimal detection thresholds (0.0506 μM for HClO and 1.7292 μM for H 2 S) alongside rapid equilibration periods (3 min for HClO and half an hour for H 2 S), this sensor was efficaciously employed in cellular environments and within zebrafish models as well as imaging applications pertaining to alcohol-induced hepatic injury in murine subjects.
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SEPARATION AND PURIFICATION TECHNOLOGY
·
2026
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IF 9.1
Zhiping Gu,Fen Liu,Wenxuan Bai,Jiang Yu
Recently, the oxidative removal of hydrogen sulfide (H 2 S) using chelated iron-based ionic liquids has garnered extensive research attention owing to high H 2 S conversion efficiency and no by-salts production. Nevertheless, for natural gas, biogas, H 2 S is typically accompanied by high concentrations of carbon dioxide (CO 2 ) where excess CO 2 molecules tend to occupy the binding sites of H 2 S, thereby limiting the desulfurization efficiency. Therefore, developing H 2 S/CO 2 selective absorption materials is of great significance. In this work, the COSMO-RS method was employed to systematically screen cation–anion pairs and evaluate 13 organic solvents for their H 2 S/CO 2 selectivity and solubility. The chelated iron-based ionic liquid (HDMIFeEDTA) was identified as the most promising candidate, and its composite with NMP at a 1:2 mass ratio was selected as the optimal absorbent. This composite exhibited excellent desulfurization performance under CO 2 -rich conditions. Interestingly, the presence of CO 2 significantly enhanced H 2 S removal in the composite. FT-IR, ESI-MS, and DFT calculation revealed that after [Fe(III)EDTA] − is reduced to [Fe(II)EDTA] 2− by H 2 S, the electrons of [Fe(II)EDTA] 2− transfer to CO 2 , resulting the charge of O (CO 2 ) more negative. This negative site provides an additional binding site for H 2 S, thereby promoting its uptake through hydrogen-bond interactions. These results not only clarify the promoting role of CO 2 in the desulfurization process but also provide a new strategy for developing high-efficiency chelated iron-based ionic liquid absorbents for fuel gas purification
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ACS Sensors
·
2026
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IF 10.9
Jie Hu,Yong Chen,Xuni Yin,Qi Zeng,Chang Chen,Jiu Yin
Although metal oxide semiconductors are promising candidates for practical disease diagnosis based on H2S detection, achieving high sensitivity and a low detection limit remains a considerable challenge. In this work, Ru-functionalized Mo-doped WO3 (Ru@Mo-WO3) nanosheets were successfully synthesized via a simple hydrothermal process followed by annealing and chemical reduction. The H2S sensing performances of all WO3-based sensors were systematically investigated. The optimized Ru@Mo-WO3 sensor exhibited a remarkable response of 120 to 5 ppm H2S at the optimal operating temperature, which was approximately 30 times higher than that of pristine WO3. Moreover, the Ru@Mo-WO3 sensor demonstrates short response times, excellent H2S selectivity, and remarkable long-term stability with a low detection limit (7.9 ppb). Comprehensive experimental analyses and density functional theory (DFT) simulations reveal that the significant enhancement in sensing performance originates from the synergistic effects of Mo doping and Ru sensitization. Meanwhile, a wireless gas-detection device based on the as-fabricated Ru@Mo-WO3 gas sensor was developed to achieve real-time monitoring of oral H2S for noninvasive oral hygiene assessment. This study offers a promising strategy for the rational design of high-performance WO3-based H2S sensors.
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ANALYTICAL CHEMISTRY
·
2025
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IF 6.7
Zhihua Zhao,Shixin Ma,Yao Wang
Hydrogen sulfide (H2S), a characteristic byproduct of sulfur-containing amino acid decomposition during fish spoilage, serves as a critical freshness indicator and poses substantial food safety risks. This study develops a novel H2S gas sensor using a ZnWO4/f-MWCNTs nanocomposite synthesized via one-step hydrothermal method. The incorporated functionalized multiwalled carbon nanotubes (f-MWCNTs) improve the sensing material’s conductivity, dispersion stability, and gas adsorption capacity. XRD, XPS, FTIR, SEM, TEM, and BET analyses verify the composite’s successful synthesis and optimal physicochemical properties. The ZnWO4/f-MWCNTs sensor demonstrates exceptional H2S detection at 120 °C, achieving a response value of 18.67 (Ra/Rg) to 50 ppm of H2S with fast response/recovery times (14 s/30 s) and excellent selectivity against interferents. Real-time monitoring of fish spoilage further confirms its practical utility, highlighting the sensor’s potential for meat freshness assessment and food safety applications.
研究领域:
材料科学
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传感器与检测技术
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食品安全
·
纳米技术
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环境监测
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SENSORS AND ACTUATORS B-CHEMICAL
·
2025
·
IF 7.7
Yuchen Jiang,Jiaru Yang,Linlin Dong,Xiaolian Liu,Lanlan Guo,Yingli Yang,Jianliang Cao,Yan Wang,Guodong Wang
Hydrogen sulfide (H 2 S), as a highly toxic gas, poses severe threats to human health when its concentration exceeds safety thresholds. Therefore, it is crucial to develop H 2 S sensors with high response, excellent selectivity and fast response characteristics. In this work, we successfully synthesized In 2 O 3 -based nanotubes through a synergistic strategy combining variable-valence metal ion doping (Ni, Mn) and oxygen plasma treatment, achieving ultra-sensitive H 2 S detection at a low operating temperature of 75°C. Remarkably, the oxygen plasma-treated Ni-doped In 2 O 3 nanotubes (denoted as Ni-In 2 O 3 -plasma) exhibited outstanding sensing performance to 5 H 2 S gas: An unprecedented response value of 6601.4, a low detection limit of 100 ppb and superior anti-interference selectivity. Moreover, in situ diffuse reflectance infrared Fourier transform spectra (DRIFTS) proves the possible products in the gas-sensing reactions. Mechanistic investigations through electron paramagnetic resonance (EPR) and X-ray photoelectron spectroscopy (XPS) revealed that the enhanced performance is mainly attributed to the two synergistic effects of abundant oxygen vacancies and high Ni 3 + /Ni 2⁺ ratio in the composite materials. This study provides an efficient and controllable optimization strategy for the development of high-performance metal oxide semiconductor (MOS)-based H 2 S sensors.
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FREE RADICAL BIOLOGY AND MEDICINE
·
2026
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IF 8
Meiyi Du,Lili Zhou,Yilian Lian,Xuqiang Wang,Zhaoxia Wu,Bing Bai
Thrombin (FIIa) is a pivotal serine protease in the coagulation cascade. Its aberrant activation drives pathological thrombosis, myocardial infarction, and stroke. Although garlic-derived sulfur compounds are known for cardiovascular protection, their redox-dependent regulation of key coagulation proteases remains largely undefined. In this study, we used a multi-scale approach combining enzymatic assays, structural characterization, molecular dynamics, and functional validation to elucidate how garlic-derived hydrogen sulfide (H 2 S) inhibits FIIa. Real-time activity assays demonstrated that garlic-derived H 2 S donors, including glutathione (GSH)-activated diallyl trisulfide (DATS), diallylthiosulfinate (Allicin), and diallyl disulfide (DADS), inhibited FIIa in an H 2 S-release-dependent manner, confirming H 2 S as the key bioactive FIIa inhibitor. Structural analyses showed that H 2 S binding induced global conformational rigidification of FIIa, with decreased β-sheet and increased α-helix contents. Mechanistically, direct evidence from matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF-MS/MS) confirmed that H 2 S cleaved the Cys42-Cys58 disulfide bond (S Cys42 -S Cys58 ) and specifically persulfidated Cys42-SH to Cys42-SSH. Computational modeling suggested this S Cys42 -S Cys58 cleavage may arrest the catalytic canyon's “self-chewing” motion, disrupt the oxyanion hole, decouple Na + -mediated allostery, and induce rigidity, potentially locking FIIa in an autoinhibited state. Functionally, in vivo assays verified the anticoagulant efficacy of garlic-derived H 2 S. Based on experimental and computational data, we proposed two interconnected mechanisms: the modeling-derived “Na + -coordination-gated allosteric catalytic canyon self-chewing cycle” governing FIIa-mediated fibrinogen cleavage, and the experimentally supported “FIIa cascade inactivation via S Cys42 -S Cys58 persulfidation cleavage” underlying H 2 S-dependent FIIa inhibition. This work identified a potential novel paradigm for redox-dependent regulation of the coagulation cascade, advanced natural product-based enzyme inhibition mechanisms, and provided a foundation for developing next-generation redox-targeted anticoagulants.
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Journal of Environmental Chemical Engineering
·
2022
·
IF 7.968
Ganchang Lei,Zhangjia Fan,Yufei Hou,Fangyi Liu,Shipping Wang,Lijuan Shen,Yingying Zhan,Lilong Jiang
Construction of metal-free carbon-based materials for efficient sulfur resource recovery in pollutant H 2 S is very critical for both applied environmental catalysis and fundamental material exploration. Herein, we report a template-free hydrothermal method to prepare hierarchical nitrogen-doped mesoporous carbon (HNMCs) materials with abundant nitrogen sites and large BET surface area. The representative HNMC-800 achieves a H 2 S conversion of ∼100% and sulfur selectivity of ∼95% at 150 °C in H 2 S selective oxidation. Moreover, HNMCs catalysts are resistant to sulfur poisoning, displaying good catalytic durability, with no significant loss of sulfur yield in the run of 80 h, outperforming the pure active carbon, g-C 3 N 4 , and commercial Fe 2 O 3 . This work provides the possibility of utilizing hierarchical nitrogen-doped carbon materials as metal-free catalysts for the selective oxidation of H 2 S.
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Nano Today
·
2022
·
IF 18.962
Kai Yuan,Kai Huang,Yiqi Yang,Yixuan Lin,Yihao Liu,Fupeng Li,Yakun Liang,Haishuang Chang,Yuhui Chen,Tingting Tang,Shengbing Yang
Increasing evidence has emphasized the pivotal role of antibiotic tolerance in the evolution of antibiotic resistance , refractory infection and infection recurrence. Moreover, satisfactory treatment of infection relies highly on early, precise detection and subsequent timely therapeutic interventions. In this study, the phenotype of increased production of H 2 S in antibiotic-tolerant Staphylococcus aureus ( S. aureus ) was identified and proven to be essential to the maintenance of antibiotic tolerance. Hence, a photoacoustic probe for detecting infection as well as an antibiotic enhancer targeting bacterial endogenous H 2 S to eradicate antibiotic-tolerant bacteria was successfully developed based on a bismuth metal-organic framework (Bi-MOF). Bi-MOF achieved early in situ and precise photoacoustic imaging of infection by generating Bi 2 S 3 inside bacteria. Moreover, Bi-MOF enhanced the eradication efficacy of methicillin against tolerant S. aureus by downregulating the intracellular H 2 S levels. Overall, Bi-MOF offers a promising diagnostic tool for early, precise infection diagnosis and a therapeutic strategy for tolerant bacteria-related refractory infection.
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CHEMICAL ENGINEERING JOURNAL
·
2022
·
IF 16.744
Jiayu Feng,Lijuan Jia,Fei Wang,Xin Sun,Ping Ning,Chi Wang,Yuan Li,Kai Li
In this work, we report a novel urea-modified copper-based material (XUrea@Cu) obtained by directly calcinating a mixture of urea and copper nitrate. This material enables the efficient purification of H 2 S under dry and anaerobic conditions. The performance test results showed that the H 2 S capacity of the optimal adsorbent (2Urea@Cu) could reach 364.2 mg(H 2 S)∙g sorbent -1 , which is much superior to those of other adsorbents in the literature. Further study demonstrates that the ultra-desulfurization performance of 2Urea@Cu is mainly attributed to the extensive alkaline site, the high concentrations of active oxygen, and the abundance of oxygen vacancy; which are quite effective for capturing H 2 S (acidic and strong reducibility). Interestingly, the deactivation adsorbent (De-2Urea@Cu) is mainly composed of high-purity CuS, which means that the Urea@Cu adsorbent can simultaneously achieve efficient purification of H 2 S and recovery of sulfur resources since CuS is a valuable product. In addition, in-situ FT-IR and theoretical calculation results indicate that H 2 S molecules dissociate on the CuO(1 1 1) surface by stepwise dehydrogenation, while S combines with adjacent Cu to form CuS. The consumption of active components (CuO) and the accumulation of reaction products (CuS) are the primary reasons for the deactivation of adsorbents. Considering the simple preparation process, low cost, and excellent H 2 S adsorption activity, these urea-modified copper-based materials are very promising H 2 S adsorbents.
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MICROCHIMICA ACTA
·
2019
·Vol. 186
·期 4
·1-8
·
IF 5.479
Wen Zhuoqi,Song Shanliang,Hu Tantan,Wang Chuanxi,Qu Fengdong,Wang Pei,Yang Minghui
A series of dual-emission fluorescent probes was prepared from copper nanoclusters (Cu NCs) and carbon dots (CDs). They show two emission peaks (blue at 469 nm and red at 622 nm) when photoexcited at 365 nm. Upon exposure to sulfide, the Cu NCs will be deteriorated because they react with sulfide to form CuS. This results in the quenching of the red fluorescence of the Cu NCs, while the blue fluorescence of the CDs remains constant. Thus, the color of the nanocomposite changes from red to blue. The ratio of the fluorescences at the two wavelengths decreases linearly in the 2–10 ppb (26–128 nM) sulfide concentration range, and the limit of detection is 0.33 ppb (4.3 nM). The nanocomposite also was placed in an agar gel and then incorporated into a paper strip for fluorometric monitoring of gaseous hydrogen sulfide.
Schematic presentation of the synthesis of Cu NCs (copper nanoclusters)-CDs (carbon dots) dual-emission nano-assembly, Cu NCs-CDs-agar fluorescent film and their application for the detection of sulfide and H 2 S.
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