ANALYTICA CHIMICA ACTA
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2026
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IF 6.1
Hai Li,Ping Guo,Min Li,Ming Ma,Wei Luo,Bo Chen
Background Thallium, a highly toxic heavy metal, is widely distributed in the environment. The substance poses a grave threat to human health through contamination of the food chain, drinking water, and environmental exposure. Consequently, the monitoring of thallium levels, particularly in water, is of critical importance. In this study, a novel analytical method was developed for the direct quantification of thallium ions (Tl + ) in aqueous samples. This method is based on the specific supramolecular interaction between cryptand[2.2.2] and Tl + , and it utilizes electrospray ionization tandem mass spectrometry (ESI-MS/MS). Results The method demonstrated remarkable analytical performance, exhibiting a linear range of 2.5 to 100 μg/L (R 2 > 0.999), a limit of quantification (LOQ) of 2.5 μg/L, and a limit of detection (LOD) of 0.8 μg/L. The recovery rates exhibited a range from 88.65% to 118.09%, with relative standard deviations (RSD) falling below 10%, thereby affirming the attainment of satisfactory accuracy and precision. It is noteworthy that this method necessitated only 5 μL of sample and did not require any preliminary separation steps. Despite the inhibitory effects exhibited by complex sample matrices, these effects were effectively mitigated through a straightforward dilution strategy. The method was successfully applied to the analysis of 66 real-world environmental water samples. Significance This work presents a novel tool that enables rapid and reliable detection of Tl + in water samples. Compared with traditional ESI methods for heavy metals, the application of cryptand[2.2.2] makes the developed method more selective and sensitive, since it has strong binding ability and selective to Tl + ion. The study introduces a novel design concept and practical application for the development of supramolecular recognition-based ESI-MS methods for metal ion analysis. These methods hold significant potential for environmental monitoring and related fields.
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ACS Sustainable Chemistry & Engineering
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2026
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IF 7.6
Wanqing Zhang,Xiaodong Su,Yaxin Lv,Xuelin Zhao,Zhou Zhang,Yuntong Du,Mengyu Fan,Heshan Zhao,Matthias Rögner,Felipe Conzuelo,Weining Zhao,Mei Li,Fangyuan Zhao
Developing efficient semiartificial photosynthetic systems is crucial for sustainable solar energy conversion. Photosystem I (PSI) is an ideal photoactive component for such systems due to its ability to perform light-induced charge separation with near-perfect quantum efficiency. We report a high-performance PSI-based biophotocathode by immobilizing PSI in a poly(vinyl)imidazole-Os(bispyridine)2Cl (POs) redox polymer hydrogel within a translucent, three-dimensional (3D) porous indium tin oxide (ITO) scaffold. This hierarchical architecture synergistically enhances the PSI/redox hydrogel loading, promotes light harvesting, and facilitates rapid mediated electron transfer (MET), leading to record-breaking steady-state photocurrent densities of 4068 μA cm–2. An outstanding incident photon-to-current conversion efficiency (IPCE) of up to 61% is observed at a light intensity of 0.14 mW cm–2. To create a self-sustaining system, this advanced photocathode was integrated with a bioanode featuring galactose oxidase that efficiently oxidizes glycerol, a low-cost byproduct of the biodiesel industry. The resulting two-compartment photoelectrochemical (PEC) cell operates as a biophotovoltaic cell, exhibiting an open-circuit voltage of 0.42 V and a maximum power density of 18.5 μW cm–2. This work not only presents a significant advancement in the performance of PSI-based biophotocathodes but also demonstrates a viable pathway for semiartificial photosynthetic systems that simultaneously convert solar energy and valorize a waste stream chemical.
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INTERNATIONAL IMMUNOPHARMACOLOGY
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2026
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IF 5.6
Yaqi Pu,Tianxin Li,Zihe Zhao,Qian Xu,Yi Jin,Huan Dou,Zhao Liu
Background Abdominal aortic aneurysm (AAA) is a prevalent and potentially fatal cardiovascular disease, yet the precise therapeutic mechanism of the bioactive compound Senkyunolide I (SEI) against AAA is not fully understood. Methods Utilizing an elastase/BAPN-induced AAA mouse model, this study employed integrated network pharmacology, proteomics (LiP-MS), and biophysical validation (molecular docking, MST) to identify and confirm PARP-1 as a direct target of SEI. The therapeutic effect of SEI was evaluated in vivo by monitoring aortic dilation and histopathology, and its inhibitory effect on TNF-α-induced macrophage migration was assessed in vitro . The functional role of the SEI-PARP-1 axis was further verified using PARP-1 inhibitors and macrophage-targeted PARP-1 overexpression. Results In the elastase/BAPN-induced AAA model, which mimics human AAA progression and rupture risk, SEI treatment attenuated disease progression by reducing aortic dilation, collagen deposition, and elastin degradation. SEI directly bound to and downregulated PARP-1 expression in both AAA tissues and large peritoneal macrophages (LPMs). It dose-dependently suppressed TNF-α-induced LPMs migration in vitro and restored the AAA-induced reduction in peritoneal LPMs proportion in vivo , an effect also seen with pharmacological PARP-1 inhibition. In contrast, macrophage-specific PARP-1 overexpression abolished SEI's protection and promoted LPMs migration into aortic lesions. Conclusion This study demonstrates that SEI attenuates AAA progression by targeting PARP-1 and inhibiting the migration of LPMs from the peritoneal cavity to the aortic lesion. These findings elucidate a novel pharmacological mechanism of SEI and underscore PARP-1 as a promising therapeutic target for AAA.
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CHEMICAL ENGINEERING JOURNAL
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2025
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IF 13.2
Ruiyang Qin,Fanyue Meng,Lijian Leng,Zhengyong Xu,Hailong Li,Shaowei Zhang
Thallium (Tl) and its compounds pose significant environmental risks due to their high toxicity and bioaccumulative potential, with industrial discharge standards mandating Tl concentrations below 5 μg/L. This study addresses the underexplored challenge of removing trace Tl(I) (≤1 mg/L) by investigating the efficacy of zinc sulfide (ZnS) as an adsorbent. Batch experiments, complemented by kinetic analyses (pseudo-second-order model), isotherm studies (Langmuir model, Qmax = 34.7 mg/g), and multi-technique characterization, were conducted to evaluate adsorption performance. Results show that ZnS achieves >99.9 % removal of trace Tl(I) at pH 10, reducing effluent concentrations to <0.4 μg/L—well below regulatory limits. Mechanistic investigations reveal a synergistic pathway: electrostatic attraction to negatively charged hydroxylated ZnS surfaces (zeta potential = −15.4 mV at pH 10), surface complexation via ≡ Zn-O-Tl bonds, and gradual formation of crystalline Tl₂S precipitates over prolonged contact. A two-stage treatment strategy, integrating sodium sulfide precipitation with ZnS adsorption, effectively purifies real-world matrices, including Tl-contaminated rainwater (Tl(I) from 352 μg/L to 0.440 μg/L) and high-salt industrial effluent (Tl(I) from 55.0 mg/L to 0.330 μg/L). This work provides experimental evidence for ZnS as a viable adsorbent for trace Tl(I) remediation, supporting the development of cost-effective heavy metal removal technologies.
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OPTICAL MATERIALS
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2025
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IF 4.2
Qi Chen,Fang Lei,Ying Shi
Perovskite light-emitting diodes (PeLEDs) employing CsPbX 3 nanocrystals (NCs) face persistent challenges in balancing emission efficiency and spectral stability due to surface halide vacancies, which trigger nonradiative recombination, halide phase segregation, and self-doping effects. In this work, we address these limitations by introducing 3,5-dicarboxyphenylboronic acid (3,5-DA) as a multifunctional bidentate ligand additive. The unique coordination architecture of 3,5-DA, featuring multiple chelating groups, enables strong binding affinity to perovskite NC surfaces. This interaction effectively passivates halide vacancies while suppressing ion migration and defect formation. The optimized CsPb(Br/I) 3 NCs exhibit enhanced stability and suppressed nonradiative losses, enabling high-performance white LEDs (WLEDs). At a driving current of 10 mA, the fabricated WLEDs demonstrate a luminous efficiency of 10.32 lm·W −1 , a CIE coordinate of (0.3379, 0.3391), a correlated color temperature (CCT) of 5260 K, and an external quantum efficiency (EQE) of 6.48 %. This work provides a ligand engineering strategy to concurrently resolve efficiency-stability trade-offs in PeLEDs.
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JOURNAL OF THE EUROPEAN CERAMIC SOCIETY
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2026
·Vol. 46
·期 9
·118212
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IF 6.3
Xinyu Wang,Ruipeng Wang,Jianli Jiang,Haining Meng,Haigang Hou,Jian Yang,Guiwu Liu,Guanjun Qiao
PbTe-based thermoelectric materials are promising for mid-temperature waste heat recovery, yet n-type PbTe underperforms its p-type counterpart. Herein, high-performance n-type PbTe is achieved through I/Ge co-doping and in-situ composite engineering with Sb 2 Te 3 prepared by melting combined spark plasma sintering. Sb 2 Te 3 alloying introduce in-situ formed Sb/Sb 2 Te 3 precipitates. Furthermore, iodine doping optimizes the carrier concentration to ∼3.4 × 10 19 cm –3 , boosting the room-temperature electrical conductivity to ∼1404 S cm −1 and yielding a high power factor of ∼17.4 μW cm −1 K −2 for the PbTe-Sb 2 Te 3 sample. Meanwhile, lattice thermal conductivity is synergistically suppressed to ∼0.37 W m –1 K –1 at 673 K through Ge-induced point defects/off-center anharmonicity and Sb/Sb 2 Te 3 precipitates. This synergistic strategy results in a peak ZT of ∼1.30 at 823 K and a high average ZT of ∼0.91 at 323–823 K. This work demonstrates that synergistic I/Ge co-doping and composite precipitation effectively enhance thermoelectric performance in n-type PbTe.
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AGING CELL
·
2026
·Vol. 25
·期 2
·e70378
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IF 7.1
Meiling Wang,Yumin Chang,Aojie He,Jing Yang,Ang Li,Hongqin Wang,Kah-Leong Lim,Xing Guo,Chengwu Zhang,Li Lu
Age-related memory decline is a hallmark of brain aging and a primary risk factor for neurodegenerative disorders. Microglia play a crucial role in preserving memory function by maintaining brain homeostasis through phagocytosis, yet the specific mechanisms governing this protective function remain elusive. In the present study, we identified a population of Secreted Phosphoprotein 1 (Spp1)-positive microglia in both aged mouse and human brains. To investigate the role of microglial Spp1 in aging, we generated microglia-specific Spp1 knockout (Spp1-cKO) mice. We demonstrate that Spp1 deficiency selectively precipitates memory deficits in aged mice, without affecting memory function in young mice, indicating an age-dependent reliance on Spp1 signaling. Microglial phagocytic capacity positively correlates with Spp1 levels and is diminished by Spp1 deficiency. Mechanistically, Spp1 deficiency leads to the downregulation of the AKT/mitochondrial complex I pathway, thereby compromising microglial oxidative phosphorylation and function. Notably, microglia-specific overexpression of Spp1 partially ameliorates the age-related phenotypes induced by Spp1 deficiency. In conclusion, this study is the first to reveal the crucial role of microglial Spp1 in brain aging and to uncover its underlying mechanism, providing novel insights into age-related memory decline.
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FOOD HYDROCOLLOIDS
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2026
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IF 12.4
Jiefen Cui,Xiaoxiao Zhang,Dan Liu,Jirong Wang,Yongkai Yuan,Jinkai Zheng
The relationship between pectin side chains and fermentability is crucial for understanding precision nutrition. In this study, α-L-arabinofuranosidase and β-galactosidase were used to remove arabinose and galactose side chains of citrus pectin. Effects of RG-I side chains on structural characteristics and in vitro fermentation property of pectin were investigated. The removal of arabinose and galactose side chains led to a decrease in molecular weight and branching degree of pectin, which in turn resulted in a loose spatial conformation. Based on correlation analysis and carbohydrate-active enzymes annotation, we concluded that the presence of arabinose in citrus pectin promoted the production of propionate and had no promoting effect on the proliferation of pathogenic bacteria of Escherichia and Klebsiella . The removal of the galactose side chain promoted proliferation of potentially beneficial bacteria ( Bifidobacterium , Faecalibacterium , Veillonella , and Parabacteroides ). We further found that arabinose produced propionate mainly via the succinate pathway and acrylate pathway, while galactose generated butyrate by activating phosphate butyryltransferase and butyrate kinase. Our results provide new insights into structure-function relationship between arabinose and galactose side chains and fermentability of pectin, while also offering a scientific reference for targeted design of pectin prebiotics with precise functionalities.
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MATERIALS SCIENCE IN SEMICONDUCTOR PROCESSING
·
2024
·
IF 4.2
Yonghua Wang,Ruilin Wang,Yucheng Hu,Lin Zheng,Ganhua Fu,Gang Wang,Yufeng Zhou,Qiaomu Xie,Jingong Pan,Shou Peng
In recent years, the study of Cu (Ӏ) precursors in high-performance CdTe thin-film solar cell devices has received increasing attention. However, few studies have been reported on nanoscale Cu (I) precursors in large-area CdTe devices (≥1 cm 2 ). Here, three different Cu (Ӏ) nano precursors have been rapidly prepared by solution method (CuCl ethanol solution, CuI acetonitrile solution, and CuSCN aqueous ammonia solution) and their effects on the performance of commercial large-area CdTe thin-film solar cells have been investigated. The results show that the distribution amount and uniformity of the nano precursor particles on the CdTe back surface have a large impact on the device performance. The CuCl nanoparticles are more uniformly distributed and the device performance is more excellent. CuI nanoparticles easily formed clusters at grain boundaries. Denser distribution of CuSCN nanoparticles . The thermal diffusion conditions (temperature, time and precursor concentration) have a significant effect on the device performance, but the most reasonable thermal diffusion conditions tend to be the same for all devices. This suggests that the thermal diffusion conditions are determined by the nature of the CdTe absorber layer itself and are not interfered by different nano precursors.
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INORGANIC CHEMISTRY
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2024
·
IF 4.3
Jingyu Guo,Xiangtong Zhan,Jiating Lan,Xin Liu,Shuang Zhao,Xi Xu,Li-Ming Wu,Ling Chen
Birefringent crystals are the key components of functional optics, contributing significantly to scientific and technological advancements. To enhance birefringence, the presence of stereochemically active lone pairs offers a unique opportunity. In fact, strengthening the stereochemical activity and aligning uniformly lone pairs face tough challenges. Herein, an anisotropic layered crystal, Sb4O5I2, is discovered to exhibit enhanced birefringence. The influence of crystal symmetry on the birefringence of Sb4O5X2 (X = Cl, Br, or I) is found to be minor. Instead, the asymmetric nature of ABUCBs (i.e., cis-X3[SbO3]6– and cis-X3[SbO4]8–) plays a crucial role in enhancing the optical anisotropy. And the orientation of these ABUCBs is equally important. We demonstrate that by adjusting the Sb/I ratio from 5:1 to 2:1, all of the intralayer Sb atoms in Sb5O7I-P63 are forced onto the surface position. This structural adjustment leads to strengthened ionic bonding interactions, enhanced activity of the lone pairs, and uniform alignments of the ABUCBs in Sb4O5I2. Consequently, this results in a 6-fold increase in birefringence.
研究领域:
材料科学
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光学
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无机化学
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晶体工程
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Environmental Science-Nano
·
2026
·
IF 5.1
Fengyang Jing,Shimeng Chang,Xingyu Zhang,Chen-Liang Zhou,Yao Weng,Xuewei Li,Hongmei Ye,Yuting Sun,Jiuyang Lin,Wenyuan Ye,Wenjing Yuan
In this study, double S-scheme heterojunctions were constructed by a simple hydrothermal and calcination method, accompanied by the special layered structure of BiOIO3 employed for its I- modification. This resulted in the formation of CeO2/[Bi6O6(OH)3](NO3)3·1.5H2O (BHN)/I--BiOIO3, which possesses double S-scheme heterojunctions. The improvement of photocatalytic degradation efficiency is derived from the result of the synergistic effect of double S-scheme heterojunctions and I- modification. In photocatalytic degradation experiment with norfloxacin as the target pollutant, the degradation efficiency of typical sample (CeO2/BHN/I--BiOIO3-2) reaches 97.50%, which is 9 times and 1.6 times than that of pure CeO2 and BHN/BiOIO3, respectively. Obviously, the CeO2/BHN/I--BiOIO3 double S-scheme heterojunctions significantly enhances its photocatalytic degradation ability of antibiotics in comparison to single-substance photocatalysts and simple two-phase composite. It is noteworthy that the CeO2/BHN/I--BiOIO3 double S-scheme heterojunctions are also capable of achieving a degradation rate of up to 70% for norfloxacin in river water. Furthermore, this double S-scheme heterojunctions demonstrate the degradation efficiencies of approximately 90% for quinolone antibiotics, including ofloxacin, enrofloxacin, ciprofloxacin, and norfloxacin. This research offers a novel approach to enhance the photocatalytic degradation of organic pollutants through double S-scheme heterojunctions and elemental modification.
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JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
·
2025
·
IF 2.7
Yun Li,Ruijin Pu,Meng Su,Ruiqin Mao,Yajun Zheng,Zhiping Zhang
Methimazole (MMI), which is primarily known as an antithyroid drug, has received considerable attention for its potent antioxidant properties in a copper(I)-mediated Fenton reaction. However, the antioxidant mechanistic details of MMI, particularly its structural analogy to the natural antioxidant ergothioneine (both of which feature an imidazole-2-thione moiety), remain largely unexplored due to the difficulty of in situ characterizing unstable reaction intermediates. In this study, we combined an in situ reactor-integrated paper-in-tip spray ionization source with mass spectrometry (PTSI-MS) to probe the protection mechanisms of MMI against the CuI-catalyzed Fenton reaction online. We present direct MS evidence of the antioxidant mechanisms of MMI (M) in its reduced form (MSH) and oxidized disulfide form (MSSM). The former can directly sequester H2O2 (i.e., a H2O2 scavenging mechanism). The latter tightly coordinates with CuI to form a CuI-MSSM complex that stabilizes CuI and prevents its oxidation by H2O2 and thus the formation of •OH (i.e., a metal ion coordination mechanism). The proposed reaction pathway of the CuI complexes from MMI disulfide (CuI-MSSM, m/z = 289 and 291) to MMI thiosulfonate (CuI-MSO2SM, m/z = 321 and 323) to MMI monosulfide (CuI-MSM, m/z 257 and 259) was verified by S–S oxidation, SO2–S bond cleavage, and extruded sulfur elimination, which confirmed the stable N,N′-bidentate binding of CuI to these intermediates, even when attacked by H2O2. These findings challenge the traditional radical scavenging mechanism and contribute to our understanding of the relationship between the structure and antioxidant activity of imidazole-2-thiones. Furthermore, the established in situ reactor-integrated PTSI-MS approach provides unique insights into reaction dynamics, offering the advantages of simplicity, speed, and low reaction volume (down to 20 μL).
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